Trepiline Drug Information

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Teresa Says:

Can Trepiline cause water retention or swollen and painful lower legs where the skin and muscles are actually painful to the touch?

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Verwon Says:

Since this is not available in the US, it is not listed in our monograph, however I did find a page with some information on it for you:


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petra Says:

I have been using 25g trepiline per day for 30 days now, it has helped me to sleep normally again, it has also helped reduce my migraine attacks. I used to have at least 6 - 8 a month, this last month I only had 3, apparantly they will go away completely. This in itself has changed my life!! the only side effects i am experiencing are very sore joints during the night and early in the mornings in my hands and feet. I walk like an old lady for about 30 minutes before it goes away and i can start my day.

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bronwyn Says:

I have been perscribed Trepiline for Migraine attacks. I have been using it for the past 30 days. Although I am still experiencing 4 day long migraine attacks, I am told that this drug will eventually stop them. I really hope it works. i have experienced no side effects other than taking the dosage in the morning and not being able to function properly at work. it made me incredibly tired and irritable.

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petra Says:

i don't take my prescription in the morning - i take mine at night - it puts me to sleep - i wake to go to the bathroom as normal - or when i hear noises - but i go straight back to bed, it has really given me a new lease on life - no more insomnia, only a dry mouth in the morning which is quickly cured by a glass of water - i am also noticing some weight loss - which ofcourse is welcome!!

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DianeElm Says:

My doctor recently prescribed Trepiline 10mg for my migraines. I started taking them a few days ago, last night I took it after 10pm and i could not wake up this morning, I only woke up at 11.30am. And got to work late! Is this normal? Does my body need to get use to them?

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sam Says:

last nite was my first nite of using trepiline, and i didnt sleep all night long. this morning it felt like a train hit me, i struggled badly to get out of bed, driving to work i almost had a accident becuase i was falling asleep every 5min then quickly wake by sounds, lucklily someone hooted me awake just before there cudve been a accident. is this normal for the first nite or week? it is prescribed to help me sleep, as my docter doesnt feel comfortable that i take sleeping pills every nite

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Lucah Says:

This is a reply to Petra's comment:

Take your trepiline and hour or two before your usual bed time. Take one or two tablets have a warm bath. If you still feel groggy in the morning, reduce your tablets to just one per night. You will not feel drowsy and sleepy in the morning.

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pops Says:

i want to take trepiline but im afraid after reading all ulz messages...i cant sleep at night at all i feel like im suffering from insomnia its bad guys please help

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south african indian Says:

im 22 and was diagnosed with shingles two days ago, my doctor prescribed Synap Forte (twice daily) and Trepiline 10g(once a night). The pain is even worse and hardly slept lastnight, any suggestions?

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Joe Says:

Guys, play around with time you take the Trepiline. i find if I take it around 18h30, I go to bed normal time and its all worked out in the morning. If you are groggy in the morning, try taking it a little earlier at night. never ever take in the morning!

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Sans Says:

It's so funny reading all these posts coz I know exactly what y'all mean! I started with Trepiline 5 days ago,only a low dosage. I'm drinking it to sleep because my mind goes wild once my head hits the pillow-I can't shut down.Anyway-I'm suppose to drink it before dinner.The first night I kind of passed out at 7:30-wow!and woke up at 5:30.It's getting better now but it works wonders with the sleeping.I'm also told that it's gonna take a while for your body to get used to it......and to play around with when you have to take it (in the evening ;-)) that sutes your body. I have a question though- I have a kind of sandy paper feel to my skin around the chin area since taking the pill---have any one experienced this because I don't know if it is a reaction from Trepiline or something else??

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Graeme Says:

Somebody reported dehydration, so it could just be that. Drink some more water and see if that helps.

I just started on 10mg tables 4 days ago for my headaches. I hardly have a day go by where I don't have a headache. I sleep very bad as well, so am glad to hear that Trepiline works for insomnia as well. :-) Lets hope it's a two-in-one cure.

Is Trepiline a permanent thing, or do you only have to take it for a few months and then stop? I forgot to ask my doctor.

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Shawn Says:

My wife takes trepiline as she is bipolar. My question is: how many, taken at once, is considered an overdose and is it fatal?

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Roy Says:

The active ingredient of Trepiline is Amitriptyline, which is classified as a tricyclic antidepressant.

"Although there are differences in toxicity with the drug class, ingestions of 10 to 20 mg per kilogram of body weight are a risk for moderate to severe poisoning, however, doses ranging from 1.5 to 5 mg/kg may even present a risk.

The peripheral autonomic nervous system, central nervous system and the heart are the main systems that are affected following overdose. Initial or mild symptoms typically develop within 2 hours and include tachycardia, drowsiness, a dry mouth, nausea and vomiting, urinary retention, confusion, agitation, and headache. More severe complications include hypotension, cardiac rhythm disturbances, hallucinations, and seizures. Electrocardiogram (ECG) abnormalities are frequent and a wide variety of cardiac dysrhythmias can occur, the most common being sinus tachycardia and intraventricular conduction delay resulting in prolongation of the QRS complex and the PR/QT intervals. Seizures and cardiac dysrhythmias are the most important life threatening complications."

So this medication should be taken with care, following the instructions of the prescribing physician.

Source: http:/­/­­drug_information_online.asp?title=Tricyclic_antidepressant_overdose

You may also want to read the page for Amitriptyline Details.

Do you have any other questions or information to add? Please post back if you do...

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Sans Says:

Well,I stopped taking Trepaline 2 days ago now because it made me very depressed again and very tired in the morning. I'm also bipolar and I'm taking Epitec for it and it works wonderful because I don't have up's and down's any more and I haven't been depressed in a very long time...not until I started drinking Trepaline. So now I have to find something else for my sleeplesness.Any suggestions? My cousin also takes Trepaline to sleep and for anxiety and it works very well for it obviously doesn't work for everone.

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Gavin Says:

As with anything new - your body needs to make the adjustments. Morning drowziness is probably because your body isn't used to getting a full 8 hours sleep & should get better with time.
@ Sans: Maybe try Recepozine or similar Antihistamine tablet with Promethazine hydrochloride, they also work wonders :-)

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Caylie Says:

My doctor prescribed Trepiline to me because i had a c-section 5 weeks ago and they cut through a main nerve in my tummy and the pain is almost unbearable. I just want to know if this is even going to work ??

After reading all of this i'm petrified i won't wake up when my baby needs her feeds and i can't go on during the day a train wreck because of these tablets!

Any suggestions or comments?

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Meglyn Says:

I have recently been diagnosed with RSD and have been put onto a small dose of Trepiline to easy my body into taking it.

I have been extreamely tired and am taking it fairly early in the evening. I can't concentrate and am dizzy all the time.

I know my body has to get used to it but does anyone know how long this usually carrys on for cause it is starting to affect my work.

Please can someone let me know.


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gizmo Says:

Meglyn:- i also have RSD, and have been taking trepiline for about 5 years now. 25mg in the am, and 25mg in the pm. stick with it! I promise you, your body will get used to it, and eventually yur body returns to normal. you're not sleepy or dizzy, it just helps you get a good nights sleep, and definitely helps the pain of RSD. if you do not take an anti-depressant for RSD, you may as well get a gun and shoot yourself, because the pain and discomfort of RSD will drive you insane. RSD is no joke and there's no cure. an anti-depressant and pain medication that is NOT a morphone agonist. you can only take Ultram (tramadol) or Stadol. NOTHING ELSE FOR PAIN. anything else only makes the pain worse. trust me, I am a seasoned veteran of RSD. good luck!

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