Hysingla Experience (Top voted first)

This is day 3 of me taking Hysingla 20mg after taking Norco 10/325mg three to four times a day. So far I've noticed some wacky side effects. The pill seems to kick in at around 8hrs, and I can't keep my eyes open, I get a rush of anxiety and nausea. I've taken EVERY other ER opiate in the world and none of them did this to me. I do notice that it has lessened my extreme pain already and I have taken a few norcos on top of it thru out the day, but the 8hr mark seems to be like a different world kicking in. Has anyone been on this for awhile, went thru these side effects and then came out the other end actually liking this med? I can find NOTHING on the internet regarding much experience or reviews out there on people who are taking this med. I've woken up in the middle of the night with abdominal pains, anxiety and an overall feeling of weird. Then it passes and I fall back to sleep, and I just feel so hungover. Also it's like every three hours or so it will ''kick in'' again with the can't keep my eye open thing, the nausea, etc. I started out the first two days not eating much (took away my will to eat) so today I made sure I ate a large meal before the 8 hr mark kicked in, but still feel so freaking weird! Please, can anyone out there give me some feedback?

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Hi chronicbackpaingirl ,
I also was experiencing many problems with Hysingla in the beginning > see my other feed back here < . One thing I did do different was I starting taking it at night instead of the morning. I am now well into my second month and the pain relief is amazing for me. I still have to take 1 or 2 Norco's for breakthrough pain _ some days 0 . I am glad I hung in there because some of the things I thought were being caused by the drug turned out to be due to a infection from something else. I am having problems with constipation, but had that with the Norco as well and will work with my doctor on that. I only feel nausea occasionally now, I find I do better with eating small amounts throughout the day rather then large meals. But the bottom line is I now have better pain control and a sense of freedom from constantly watching the clock for my next dose_ I now have days I can actually do things without the constant interruption from pain. I am sorry that you are having so many problems on it and wondered if it has gotten any better for you? Wishing you the best~

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I also have no side affects and it seems to be working. I do still have some pain, but I take it at night and when I wake up I feel so much better. I was taking morphine sulfate 30 mg. 3 times a day but the constipation was just too much for me. I actually like the idea of just taking one pill a day. I did have nausea and headaches in the beginning but that has all gone away. A little constipation and not hungry but try to eat. I think I'll stick with this one. So tired of trying all these different medications.

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I have been on Hysingla 40 mg now for about 2 years and it has changed my life. I had been taking Hydrocodone 10/325 4 x daily for several years and it just wasn't helping as much as my body became so used to it, I had tried several other pain meds but had allergic reactions and so was limited in my choices. I did have some side effects when I first started it and did call my doctor about them_ which I urge everyone to do when in doubt. He told me to try and hang in there for a month and that did it :) after that it worked better and better. Yes I suffer from constipation but that was also a problem on Hydrocodone _ which I still can take one or two for break through pain. Yes my appetite went way down, but I just eat smaller little meals throughout the day and they put me on Linzess to help with the constipation. After trying taking Hysingla at different times of the day I found that when I get up in a.m. I take one Hydrocodone as it works fast and then two hours into that is when I take the Hysingla which then pretty much keeps me pain free for the day, occasionally I do have to take the second Hydrocodone that I am allowed. As to some people saying they can't sleep I never had that problem but that maybe due to the fact I have to take a muscle relaxer each night before bed. Here is the thing if you have been taking Hydrocodone without any problems then the Hysingla is basically the same thing just without the Acetaminophen which of course is bad for your liver. I am so thankful to have found this drug, but everyone is different _ wishing everyone the best.

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I have just started taking this medicine. I was taking norco 10/325 4/day with tramadol in between. That worked great but my liver ALT started to inflate so they moved to morphine(which was horrible) then to the hysingla. For me, maybe my metabolism runs at a really high rate but it works really well when it first kicks in. Started taking it about 10pm so it works when I first wake up. It was the best I have felt when waking up in a long time. but it seems like in the afternoon it wears off for me (60mg er). So the evenings and going to sleep aren't as easy as they were with the previous regimen. Up to lnch it takes away most of the pain. It is really hard to get and more expensive than most medications. I have had pharmacists say they would not order due to the risk of addiction and abuse. I have had pharmacists say they would not order due to the obnoxious price it costs to get it (over $1000 for a bottle of 60 for the pharmacy to buy). I will be speaking with my DR on Friday to see maybe other options. Does anyone have any experience with vicoprofen and know if that may be an option?

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Hi I'm on my third day of hysingla er and I too get that neauscious feeling a few times a day. 30 MLG. I have severevRa and it does help the pain. I have to admit I do miss the euphoric feeling of regular vicoprofin but I was taking too many. So this is definitely better for me. I plan on sticking with it.

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I have been on vicoprofin off and on (mostly on) for about three years. Omg its highly addictive. The withdrawals are dreadful all I did was cry. I finally fessed up to my Dr because i kept running out of meds way too early. He put me on hysingla er 30 mg. Its not great but at least I don't have the ups and downs like with vicoprofin. The pain is better but definitely no euphoric feeling at all. I may ask him to up the dose but I'm going to give it a little time. Peace

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I'm having a terrible time with this drug. They started me on 40mg and I suffered severe headaches and much more. I felt stoned. I hate it. Just changed to 30mg. The headaches are awful. I understand why the doc wants to change to hysingla, but I was so much better functioning with 4 10 MG Norco. This sucks.

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I've been on the hysingla er 20 for 1 month. Well for the last 3 weeks ive had the worst headache ever and nausea every minute of every day. Even ended up in ER over a week ago for the headache and nausea. After reading all the comments and the side affects, im not taking this stuff anymore. Ive lost over 20 lbs. Not good when I was only 130 to begin with. I dont eat. And I hurt worse now then I did before. This hysingla is horrible.

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Hysingla er 20 makes me so sleepy I can't stand it!! Like you I'll go a bit fine and then can't hold my head up! It's like I'm physically I'll!!

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Do try and stick with it for 4 weeks as Verwon suggested. Let your body get used to IT . Good luck

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I had been on hydrocodone 10-325, 3or 4 for several years. I have had an allergic reaction to every long acting pain med my doctor tried so when Hysingla became available I asked my doctor if I could try it. I have been on 40 mg now for almost a month and feel terrible. It has helped with my back pain, but I am now experiencing more joint and bone pain then ever before. I also feel like I have the flu all the time, plus itching, rash earaches, can't eat and feeling drowsy and yet keep waking through the night. Overall I feel terrible and am going to stop today to see if these things go away and will call my doctor and inform him. I wanted this to work so badly but the trade of isn't worth it. I just don't understand because I thought it was pretty much the same as what I was taking. Feeling very discouraged!

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Hi Ruth,
Sorry to hear your having such problems :( . I am so happy I stuck it out because now I hardly remember the problems I had in the beginning. My doctor asked me to try and stick with it for at least 4 to 6 weeks and things did get better. It has been about 8 months or so now and I am more stable then ever before. My pain relief has been amazing and I haven't had to increase the Hysingla or my break through Norco. But of course if your side effects do not get better then I'm sure your doctor will advise you as to what you should do. I wish you the very best as I know first hand the disappointment of trying a new pain med only to feel so sick due to side effects _ I have been through so many that didn't work for me. Please feel free to write me anytime.

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Re: SUSIE (# 34)

Thank you so much for your positive post! I just took my first 30 mg Hysingla today, and I took it right when I got it at 1:30 today. But if that doesn’t work out I will take your advice and try taking it at night. I am only wanting to read positive posts as I’m hoping this new med. helps me.

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I decided to stick with it, and it's been about a week. I still get very tired, but overall my pain level is so much better. I've stopped the nausea, I do get dizzy (orthostatic) when I get up fast or something like that, but all in all things are getting better.
I still have pain and need breakthrough, and I'd be very scared to up the dose of this stuff and go through that whole intro period again.

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I was on vicoorofin 7-325 about 6 pills a day. When I went through 120 in a month I knew I had a problem. I took two at a time three times a day. It helped my pain but I feel its highly addictive. So I told my doctor and he put me on hysingla er 30 MLG. Once a day. He also gives me 30 vicoprofin for breakthhrough pain. Its helped and I don't feel as addictive like with vicoprofin. Just be careful. Peace

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Been on the 30 mg of Hysinglia for about a month. Doctor put me on it to try to lessen breakthrough pain, but it is not working at all. Was taking Norco 10/325 which were useless. Goin to ask her today to take me off the hysinglia and maybe try Percocet as she first suggested? Hysinglia just makes me nauseous all the time, have gained weight, but I don't know how since I am not even hungry. Thought this was supposed to kick in when pain was felt, but all it does is make me sleepy while I am trying to watch TV with my family. Just tired all the time. They need to go back and fix this as it does not provide 24 hrs of pain relief as advertised.

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I am on hysingla about 4 weeks now. Note the pain level has stayed level about a 4. Severe constipation got me. I over compensated w miralax and correctol. ..don't suggest that. Now I use ducosae everythree days w Hugh if be diet. Guzzle water. I wonder if hysingla is making me gain weight. 7 lb. Since started a month ago. Really can't run can walk but have foot drop. Been doing water excercise but as seasons chan ge.. I used to compete in bodybuilding but have had man false starts do to chronic pain. I think w my latest knee replacement I should try and join gy? W bike or ellyptical. I hate to gain wait. Any clothe at the least tight hurt my back. Surgeon wants to do another fusion on l4 and L5 because they are non unioned. Anyone off aa tkr knows it is n for the faint of &eart. So back to hysingla question possibly u may b whole heartedly costipated. Jus sayinng

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I have been taking Hysingla ER 60 mg now for 2 days. I have not had any side effects other than it is just now at 0700 on day 2 making me feel a rush of pain relief. I am extremely drowsy bit cannot fall asleep. I laid in bed all night last night with my eyes closed but zero sleep. I was previously on Norco 10/325 qid. For almost 4 years. Started this horrific back injury journey 9 almost 10 year's ago. I am not taking any other medications for breakthrough pain. But I seem to get the same rush aka high as I did with the Norco. Maybe your dose isn't high enough. Dr. Started me on 60 mg due to my tolerance for the hydrocodone. Might ask about that.

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I have just started on HYD 20 I have been on NORCO-10 for a long time and they helped the pain but for only 3 hours I have 9 chronic pain diseases...The first time I took this I felt relief and relaxed....I have norco 7.5 for breakthrough I hope this med works

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I read seratonin syndrome can happen. The anxiety u are experiEncino should b told to doc. I take hysingla for many mo.s now. No real s.e. noted. It takes 3 days to get a normal plasma level in the blood stream. Depending on your metabolism.

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