Linzess

Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

linzess issues
9 Replies RSS
Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but doesn'tseem to resolve problem. It makes me go from feeling 9 months pregnant to 6 months pregnant. Also have a new side effect of the drug (or the consripation) which is acne on my shoulders and back. Tries lots of otc rremedies and natural remedies with no luck. Dr gave me linzess and like I said it works but not completely. The 145 dose seems to work while the 290 did not, so i went back to 145 and same results. I am fit. Used to do 1000 sit ups a day...now can't manage 20 due to the bloat and weight gain...frustrated and worried. I am a big guy...6'7"...should be 230# but am weighing in at about 280# which has been increasing over the past 6-7 months....
Updated 4 days ago.
 
Linzess with Vitamin D 50,000 IU
Post a Reply
Hi, I have been taking Vitamin D 50,000 IU because my doctor found that I was having a pretty bad Vitamin D deficiency, but now my gastroenterologist gave me a prescription for Linzess. I'm not sure if I can take Linzess and my Vitamin D together?
Updated 5 days ago.
 
Linzess stopped working
28 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 5 days ago.
 
lizness 145 mg
18 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 9 days ago.
 
Linzess in morning and night
2 Replies RSS
First time I tried it as prescribed once in the morning ...no luck. ## Hello, Vanessa! How are you? I'm sorry it didn't work for you. Did you make sure to take it on an empty stomach, with just water, at least a half hour before eating? Sometimes, people haven't been receiving the proper instructions with their prescriptions, so they don't know they have to take it that way. The FDA lists its typical side effects as possibly including nausea, dizziness, bloating and diarrhea. ## Reading some of the comments may be my answer. I take Linzess 30 minutes before breakfast and can go nowhere for 3 or 4 hours because of sudden diarrhea - so embarrassing! My hope is taking it at bedtime like a few said may be my answer. Pharmacists and doctors know little but trial & error. ...
Updated 18 days ago.
 
linzess weight gain
84 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 18 days ago.
 
Completely blocked bowels
2 Replies RSS
My 88 yr old mother was given linzess ,she's completely blocked with stool ,on top of this they were giving her enemas4 or more a day ,headaches,heart pain,plural infusion,high blood pressure followed,which she did not ever have I made them stop the linzess ,should she have been given this I read that elderly should not and not for anyone with this type of blockage? ## Is she impacted? In some cases, the stool becomes so hard due to medications, and diet, that it has to be removed, either manually, or by surgery, if nothing else works, according to NIH studies. What other medications is she on? There are many that the FDA warns can cause constipation, so if they are giving her a couple that cause it, it could be worsening the issue. What does her normal diet consist of? Does she get...
Updated 21 days ago.
 
Taking Linzess in the evening before bedtime
3 Replies RSS
Can you take Linzess before bedtime so that elimination takes place in the morning? I take 145mg on an empty stomach... usually with apple sauce. ## Hi Carol, Looks like you're not alone in asking this question, as I just stumbled upon another discussion thread relating to the same inquiry at: [1] Taking Linzess At Night According to the response in that thread, it seems like the individual has had success taking Linzess at night to help promote a morning bowel movement. Perhaps it would also be a good idea to post your thoughts there in order to increase your exposure and possibly receive more immediate feedback from other patients as well... Best wishes to you! ## My doctor told me to start taking linzess. He said to take it at night. Can anyone tell me the best time please? Is it...
Updated 21 days ago.
 
On Linzess for a week, NOT "Working" - HELP!
43 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 1 month ago.
 
linzess/linzess
7 Replies RSS
When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ## Hello, Jen! How are you? It would be best to double check with your doctor. Sometimes that doesn't fully cleanse, so something else may still be required. Other side effects of Linzess, as listed by the FDA, may possibly include nausea, dizziness, bloating and flatulence. Is there anything else I can help with? ## It's best to take Linzess 30 mins to an hour prior a meal and not with food, as directed by the label. My friend is a pharm rep for it and he says this is important. When I first started taking it I thought alternating days would help but he said it's important to take it every day and that eventually the severe diarrhea should subside. He was ri...
Updated 1 month ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 84 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 28 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 9 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 7 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 7 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
Linzess / Weight Gain and Other Meds Questions I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 5 replies




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