Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

On Linzess for a week, NOT "Working" - HELP!
46 Replies RSS Share
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 8 minutes ago.
Linzess coupons that work best
3 Replies RSS Share
Trying to simply find the best way to somehow get some serious price relief on this amazing but incredibly ridiculously priced pill. I understand a profit but the pricing I am finding is simply, for lack of a better way to put it, pure advantage taking of the public. Please help. ## Hello, Swanson8! How are you? These is a co-pay card available for eligible patients that helps you pay as little as $30 a month, if your eligible. You can check out the qualifications and print the card from their website at click here. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating, gas and diarrhea. Is there anything else I can help with? ## You can get 90 tablets for $430 via the Linzess Savings Program at: ## I we...
Updated 21 hours ago.
Linzess weight gain
89 Replies RSS Share
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 3 days ago.
Linzess in morning and night
5 Replies RSS Share
First time I tried it as prescribed once in the morning luck. ## Hello, Vanessa! How are you? I'm sorry it didn't work for you. Did you make sure to take it on an empty stomach, with just water, at least a half hour before eating? Sometimes, people haven't been receiving the proper instructions with their prescriptions, so they don't know they have to take it that way. The FDA lists its typical side effects as possibly including nausea, dizziness, bloating and diarrhea. ## Reading some of the comments may be my answer. I take Linzess 30 minutes before breakfast and can go nowhere for 3 or 4 hours because of sudden diarrhea - so embarrassing! My hope is taking it at bedtime like a few said may be my answer. Pharmacists and doctors know little but trial & error. ...
Updated 5 days ago.
linzess prescribed to help with weight loss
4 Replies RSS Share
Hi! My Dr. Gave me linzess to help with weight loss. HOWEVER, I am reading all the posts about horrible weight gain, I am confused!!!!!!! ## Hello, Twinckle! How are you? This medication isn't intended to be used for weight loss, it's actually used to treat chronic constipation. It can cause diarrhea, which could result in weight loss for some, as reported by the FDA, but it can also cause abdominal bloating and distention, which has caused many to think they were gaining weight on it. Can anyone that's been on it chime in with their experiences? ## Hello, Linzess can certainly be prescribed for the purpose of weight loss! People do not understand how medications can treat multiple...repeat MULTIPLE conditions, diseases and illnesses. Botox is FDA approved to also treat head...
Updated 7 days ago.
Linzess every two days?
2 Replies RSS Share
Great medicine, although I have only started. Can I skip two days before taking the next dosage? Also I am shocked at the cost. $400+ for a three month supply. Any ideas? ## How is it working for you? You should follow your doctor's prescribing instructions, skipping days may prevent it from working as well as it should. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating and diarrhea. There is a savings program available from the manufacturer. You can find information on it via the Linzess website at click here. Is there anything else I can help with? ## Call your insurance. Tell them doctor said you have to have it... be the squeaky wheel.
Updated 20 days ago.
parasite linzess
2 Replies RSS Share
I see you didn't get any answers I was just wondering how long you taking linzess and did you get ahead of the parasite issues? I'm having a lot of gastrointestinal issues in the doctors don't seem to care that I didn't have proof that I have parasites. Let me know if you can how things worked out with taking linzess and getting ahead of parasites. ## Hello, Tova! How are you? Since you didn't post this in response to a specific post, I am afraid I have to ask you for clarity. What parasite issues were you referring to? Linzess is most commonly used to chronic constipation and the FDA lists its typical side effects as possibly including nausea, dizziness, stomach cramps, and diarrhea. ## Sorry I thought I had posted this specifically to someone who would talked about...
Updated 24 days ago.
Linzess help
3 Replies RSS Share
I have been on linzess for a week now and no results yet besides bad bloating! Will the bloating go away? How long does it normally take to start working? ## How are you feeling? Have your symptoms improved any? It can take several weeks for a medication to reach its full efficacy level in your body and for the side effects to peak and begin to taper off, usually 4 to 6 weeks. ## I started linzess a few days before a colonoscopy and it worked. Now five days after the colonoscopy it hasn't worked yet. I have ibs c. ## I just took a bisacodyl laxative 2 days ago, I had a BM the first day but nothing since. My doctor gave me 290 mcg Linzess to take. Is it safe to take it 2 days after the bisacodyl laxative or should I wait a few more days?
Updated 26 days ago.
Linzess and Levothyroxine together
1 Reply RSS Share
How much time is needed between dosages of levothyroxine and linzess? I also take metformin. ## Hi Lynn, According to the University of Maryland Medical Center ( / drug interaction tool), there are no interactions or contraindications listed between Levothyroxine, Linzess or Metformin. While this doesn't necessarily mean that no interactions exist, it is my own personal opinion that a time gap between dosing isn't required. Nevertheless, I still feel that you should contact your prescribing doctor if you have any concerns about what he/she has recommended for you. Hope this helps!
Updated 27 days ago.
Linzess stopped working
29 Replies RSS Share
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 30 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Related Linzess Topics:

Linzess weight gain
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 89 replies
Linzess stopped working
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 29 replies
linzess issues
Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 9 replies
linzess causes weight gain
I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 8 replies
When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 7 replies
Linzess Allergy
I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess not working
I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 6 replies
Linzess, then other meds with breakfast
Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
Linzess in morning and night
First time I tried it as prescribed once in the morning luck. ## Hello, Vanessa! How are you? I'm sorry it did... 5 replies
Linzess / Weight Gain and Other Meds Questions
I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 5 replies

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