Linzess

Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

linzess weight gain
74 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 5 minutes ago.
 
Taking Linzess with food
8 Replies RSS
I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she will call in the higher dose. Took this morning before bed. (I work nights 7p-7a) I have had stomach pain all day. I haven't been able to sleep or get comfortable. I've had rumbling in my stomach, gas and an extremely hungry feeling with the 145mcg dose but no pain. It's been 8 hours since I took the 290mcg dose. I just ate something and I feel a little better. I read that I should take Linzess 30 minutes before eating but I usually don't eat until I get up in the afternoon. Could this pain be a result of not eating with the higher dose? ## Hi Krischris1, Sorry to hear about your situation. According to the manufacturer, you are right that it is recommend...
Updated 2 days ago.
 
linzess/linzess
6 Replies RSS
When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ## Hello, Jen! How are you? It would be best to double check with your doctor. Sometimes that doesn't fully cleanse, so something else may still be required. Other side effects of Linzess, as listed by the FDA, may possibly include nausea, dizziness, bloating and flatulence. Is there anything else I can help with? ## It's best to take Linzess 30 mins to an hour prior a meal and not with food, as directed by the label. My friend is a pharm rep for it and he says this is important. When I first started taking it I thought alternating days would help but he said it's important to take it every day and that eventually the severe diarrhea should subside. He was ri...
Updated 4 days ago.
 
Is taking Linzess long-term safe?
1 Reply RSS
Hi guys! I have been suffering from constipation for at least 10 years. I am 26 years old. Few years ago my symptoms got really bad, to the point where a stool movement left me weak and in pain all day. I fortunaltely found Linzess and it has significantly improved the quality of my life. Today, I have been taking it for 1 and a half years. I have to support Linzess with taking Macrogol (2 packs a day). My stools are very loose, but I am happy this way. Because of all damage the constipation has done, whenever I get an occasional normal-size stool, it breaks my butt! Other than that, I feel good and healthy, and I am able to eat everything (which is a dream come true). However, I am still young and want to have kids at some point. I know Linzess is not safe during pregnancy. What worrie...
Updated 22 days ago.
 
Linzess stopped working
27 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 23 days ago.
 
On Linzess for a week, NOT "Working" - HELP!
41 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 1 month ago.
 
Linzess / Weight Gain and Other Meds Questions
5 Replies RSS
I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds before they are in my system? I'm taking the thyroid meds 1 hour before (as required) the Linzess and the Topamax with my breakfast. Is that the right order? Also...I've been steadily losing weight successfully for a couple of months....have taken Linzess for 4 days because went low carb and stopped going to the bathroom....gained over 2 lbs in 4 days without changing any food intake and drinking 100 ounces of water a day and having diarrhea. How is that even possible. Will I just have to stop taking it to stop the weight gain? How does the med cause weight gain if it gets rid of waste? ## The Linzess should be taken by itself, at least half an hour before eati...
Updated 1 month ago.
 
Linzess is not working!!!!
3 Replies RSS
I started taking the low dose now I take too of them a day...only had one bowel movement when I started ...don't know what to do not #help ## Hello, Terri! How are you? Are you making sure to take it in the morning, with a full 8 ounce glass of water, at least a half hour, before eating or drinking anything else? It seems that some people weren't told that by their doctor or pharmacist. The FDA lists its typical side effects as possibly including nausea, bloating and diarrhea. ## Exactly right. That is how my doctor instructed me and it works, usually within an hour. ## Hi Terri, Linzess stopped working for me as well after about a year. One thing that did help me while on it was after taking it in the morning with a big glass of water, I would waite about 15 mins and drink a 6 ...
Updated 1 month ago.
 
Linzess not working
6 Replies RSS
I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my belly rumble, then I have to push to get anything out and it's still hard. ## Hi I agree.The first week I was on linzess it work to well vut it still helped but now that im back on it its been two days and still nothing.. what did you do or why is it my stomach just rumbling but im not going. ## It should be taken as prescribed by your doctor, which is usually daily. Additionally, it needs to be taken with water, on an empty stomach, at least 30 minutes before eating or drinking anything else. The FDA lists its typical side effects as possibly including nausea, dizziness, abdominal cramping, bloating and diarrhea. Does anyone else have any advice or ideas that may he...
Updated 1 month ago.
 
linzess issues
7 Replies RSS
Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but doesn'tseem to resolve problem. It makes me go from feeling 9 months pregnant to 6 months pregnant. Also have a new side effect of the drug (or the consripation) which is acne on my shoulders and back. Tries lots of otc rremedies and natural remedies with no luck. Dr gave me linzess and like I said it works but not completely. The 145 dose seems to work while the 290 did not, so i went back to 145 and same results. I am fit. Used to do 1000 sit ups a day...now can't manage 20 due to the bloat and weight gain...frustrated and worried. I am a big guy...6'7"...should be 230# but am weighing in at about 280# which has been increasing over the past 6-7 months....
Updated 1 month ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 74 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 27 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 7 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 7 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 6 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
Linzess / Weight Gain and Other Meds Questions I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 5 replies




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