Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

On Linzess for a week, NOT "Working" - HELP!

Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...

Linzess help

I have been on linzess for a week now and no results yet besides bad bloating! Will the bloating go away? How long does it normally take to start working? ## How are you feeling? Have your symptoms improved any? It can take several weeks for a medication to reach its full efficacy level in your body and for the side effects to peak and begin to taper off, usually 4 to 6 weeks. ## I started linzess a few days before a colonoscopy and it worked. Now five days after the colonoscopy it hasn't worked yet. I have ibs c. ## I just took a bisacodyl laxative 2 days ago, I had a BM the first day but nothing since. My doctor gave me 290 mcg Linzess to take. Is it safe to take it 2 days after the bisacodyl laxative or should I wait a few more days? ## If I'm unable to take Linzess before br...

Anybody else with these issues

Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...

Linzess Allergy

I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time, I was still hopeful. However, I woke up on a Wednesday with a swollen face and a bump in my eyebrow. I thought I had gotten bitten by something and didn't attribute it to the Linzess. Took Benadryl but didn't get any relief. I woke up with my eyes swollen almost shut on both Thursday and Friday morning and the bump in my eyebrow began to itch. By Saturday morning when I awoke to a swollen face and eyes again, I knew it was the Linzess. I am bummed since I was so hopeful that the Linzess would help me with my constipation. ## Oh wow! I am so very sorry about what happened. Did you consult your doctor? Has swelling gone away, yet? It is always possible to find o...

Linzess not working for me

I was on Amitiza 24 mcg twice a day and Miralax was switched to Linzess 3 weeks ago. I am having so many issues, feeling lightheaded a couple hours after taking it in the morning and very bloated and have not had a normal BM. A few days without anything and then diarrhea. I think I am going to switch to before dinner and take Miralax before bed. What is the opinion? ## This medication should be taken in the morning, at least half an hour, before ingesting anything else. The Side effects that you've experienced are listed as being normal ones, according to the FDA, you may also experience nausea, and stomach pain. It is not as effective, if taken later in the day, after you've already eaten throughout the day, so it is best to follow the manufacturers instructions. Is there anyth...

Linzess Issues

Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking it but doesn't seem to resolve the problem. It makes me go from feeling 9 months pregnant to 6 months pregnant. Also have a new side effect of the drug (or the constipation) which is acne on my shoulders and back. Tries lots of otc remedies and natural remedies with no luck. Dr gave me linzess and like I said it works but not completely. The 145 dose seems to work while the 290 did not, so i went back to 145 and same results. I am fit. Used to do 1000 sit ups a can't manage 20 due to the bloat and weight gain...frustrated and worried. I am a big guy...6'7"...should be 230# but am weighing in at about 280# which has been increasing over the past 6-7 ...

Linzess stopped working

I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...

Linzess has destroyed my hair no more

Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I started taking linzess. ## Hello, Pam! How are you? Almost any medication can cause problems with the growth of your hair and nails, since they are fed by dead cells in our body, thus anything that could affect our cells, can cause problems with our hair and nails, according to NIH studies. Other side effects as listed by the FDA may possibly include nausea, dizziness, headache, bloating, and diarrhea. One of my blood pressure/heart medications has caused my nails to become very brittle, so they crack and break very easily. Is there anything else I can help with? ## Hi I have been taking a few months & starting today I'm done !! Texture change & drier & ...

linzess have to skip two days

Hi, we're going away and sadly our two flights have to be in the morning. I usually take linzess @ 8am and by 12pm I'm done for the day. My concern is that those two days I can't take it as too uncertain about available facilities, will that completely mess me up? Once I get there I can start my normal dose and routine until home. How messed up will this make me and has any one else had experience? Any help or advice welcomed.

how long you need to take linzess

I have Hyperparathyroid Disease and have suffered with severe constipation for several years, caused by high Calcium levels. I recently became severely impacted and had a procedure in my Dr's office that was excruciatingly painful to de-impact me. He put me on Lizness 145 mg and it has helped me to have regular, pain free bowel movements every day. I was so relieved! Can I stay on Lizness for a long period of time safely? I feel like it is a miracle drug for me. ## You can stay on it for as long as your doctor feels it is safe for you to do so. The FDA does warn that it may cause side effects, such as nausea, dizziness, stomach cramping, flatulence, and diarrhea. You can find more details on Linzess by clicking this NDC code: 0456-1201 Is it still working well for you?


Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Related Linzess Topics:

Linzess weight gain
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 89 replies
Linzess stopped working
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 30 replies
Linzess Issues
Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking it but... 12 replies
Linzess Allergy
I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 8 replies
linzess causes weight gain
I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 8 replies
When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 7 replies
Linzess not working
I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 6 replies
Linzess, then other meds with breakfast
Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
Linzess has destroyed my hair no more
Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I s... 5 replies
linzess prescribed to help with weight loss
Hi! My Dr. Gave me linzess to help with weight loss. HOWEVER, I am reading all the posts about horrible weight gain, I a... 5 replies

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