Brintellix/trintellix Long Term Side Effects (Page 3) (Top voted first)

I have struggled with depression for most of my life, and am always in search of the perfect antidepressant. I work with a psych doctor who is always willing to try new things. 10 months ago I started 5 mg of Brintellix daily, within a week my mood was significantly elevated, I was sleeping better, waking up much earlier and was more motivated to do things in the morning. I went up to 10mg daily However the nausea was dreadful! I pushed through for a couple of weeks, changed to taking the brintellix at night and after a while it subsided. My mood got better and better, I had recently turned 50, and had gained a little weight, so with my new found morning energy I started working out 2times a week with a trainer, and then walking most other mornings! The walking then changed gradually to running, and after 6-7 months I was running 3-4 miles a few times a week and going to the gym twice a week. I was loving life, getting really into good shape and felt better than I had in years! Then I started getting pain in my shoulders and neck, I went for PT and it didn't help, the pain would move from shoulder to neck and down my traps, always changing. Then I started getting foot pain, which my doc said was Plantar Fasciatis from running, and extremely stiff muscles especially in the mornings. I stretched and stretched but to no avail, the foot pain turned to numbness and tingling in my lower legs, and still intermittent with the foot pain. I started backing off on exercise a bit, but nothing changed, I have been to a rheumatologist and infectious disease specialist and tested for everything but they don't know. Currently am undergoing tests for diabetes and ms and other neurological disorders, but the neurologist doesn't think it's that, and wants to blame my depression, or hormonal imbalance. Funny thing is I wasn't at all depressed when this started 3 months ago! now I am not able to even take a ten minute walk without some kind of pain. I tapered off Brintellix because I am terrified it's that, but of course I now have terrible depression and anxiety. I am starting cymbalta for depression today. My question is for anyone who has been on Brintellix did you start experiencing any of these problems after being on it for at least 6 months or more? Shoulder pain, joint pain, muscle cramping and stiffness, bottom of foot pain, numbness, coldness and tingling in feet and legs below knees, dreadfully stiff neck and neck pain. All of these symptoms change daily for me, they are intermittent, but there is never a time now when I am pain free or not stiff. I have been off Brintellix for 3 weeks now.

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Hi. I have taken Brintellix, now called Trintellix, for nearly 4 years. I take 30mg. I’m 68 years old. I have taken antidepressants for decades with no improvement in my depression. Trintellix is a life saver, for me, with my depression. I have experienced all the pain symptoms you describe since I was a teenager. It didn’t start with the Trintellix. I was diagnosed with Fibromyalgia, which causes the sporadic pain all over, and specifically my shoulders and neck. I now have arthritis which hurts my knees and other joints. It’s aging. Still, I’m never depressed. I had to go off my Trintellix for a while because we couldn’t afford it. That time was horrible, for me. Then we learned that the pharmaceutical company would help with the cost. God bless them. In my experience, your pain is not a result of Trintellix. It is very likely other age related things. Fibromyalgia is relentless. I would talk to my doctor about it. Keeping my depression under control helps me handle my pain. I am very anxious for my psychiatrist to give me medical marijuana. My sister tells me it helps her more than anything ever has. She is a psychologist. She is not just trying to get legal pot. Good luck and God be with you as you figure this out.

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Did you have a feeling of extreme discomfort in you neck, not just pain? Like a feeling of you can't get your neck muscles comfortable? I have that feeling on Trintillex and it's always there. I move and move my neck when I'm sitting and tilt my head back alot trying to get rid of the feeling but it won't go away and I'm worried it's being caused by the medication.

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Yesso has a friend of mine, I was only on 5mg and the pain in my neck and shoulders was becoming unbearable.psyciatrist took me off it. Cold Turkey and wants to see me in few weeks when withdrawal is over to see what improved and what didn't. My pains are alot better, muscle cramping and stiffness a lot better. Depression and anxiety are also a withdrawal symptom. It can pass. Takes anywhere from 7-8 weeks to finish withdrawal. I've gone through this many years. 30 to be exact. Have been on many antidepressants over the years. Cymbalta is a very scary one, research it well. Also 2 of my friends experience terrible side effects from that. Research CBD OIL. its helping me a lot.my friend who just stopped trintellix month and a half ago is still suffering extreme anxiety, chest leg shoulder neck back pain severely. Doctor won't admit to hobbits the meds. He never had that before meds. Also his first time on one. I also experience circulation problems on it has very cold all the time. Felt like cold was on the inside of my hands. That's gone now.

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Re: Avery (# 13)

Been on this 7 months caused weight gain bad anxiety and headaches i do better on st johns wort

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Re: Lynn (# 33)

Did you say your intercisial cystitis got worse taking Trintillex because this has happened to me.. l felt fine before l took it. Iam very sensitive to antidepressants, l was good with Trintillex for 7 weeks thought l would increase it to 5 mg a day ago maybe l should just stay on 2 and half mg. Also started having problems staying asleep. Jl

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Re: Jackie (# 16)

Hi! Yes those terrible pains everywhere will go away in time. I was on Trintillex for 7and half weeks. Stopped because of bad insomnia. I went off Trintillex to fast and the withdrawal was unbelievable pain every place. It takes 16 days to get out of your system. It's day 17 for me and lam still having odd pains but thank goodness most of its gone. Never again. Iam glad l feel normal again. Good Luck and hang in there! Jl

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Re: Dawn (# 43)

I know it's awhile since you posted your comment. I am just seeing it now. Can you tell me if St. John's Wart really helps with depression and how does it help. Thank you. Jl.

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l am off Trintellix thank goodness. But it left me with insomnia. When l awake it's impossible to go back to sleep. Since l am so sensitive to antidepressants my doctor put me on Abilify, 1mg then 5 mg one month later. This is my 3rd day I'll see how it goes, l would be interested in comments from any other person on Abilify for depression. Jl.

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Re: Danielle (# 24)

Igual lo estoy viviendo. Dolor en mandíbula permanente desde que inicié Brintellix, que a veces no puedo abrir la boca. Bruxismo. aún no lo puedo dejar. El COVID aumentó la ansiedad como efecto secundario.

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Re: Debbie (# 6)

Hi Debbie, have u ever tried cymbalta?

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Re: pmbourque (# 8)

I ended up being prescribed Pantoprazole to help with the GERD and nausea. It was the only way I could handle the trintellix.
I'm now a week off trintelix after tapering off over a month. My body, all my joints are achy, especially elbows, shoulders, hips and ankles. I also feel very stiff in my back and knees.
I am supposed to start Cipralex but I'm worried about how it will make me feel.
The nausea before was so miserable.
I'm eventually starting an ADD med but I need the depression under control first :(

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