Active Ingredient(s): Vortioxetine
FDA Approved: * September 30, 2013
Pharm Company: * TAKEDA PHARMS USA
Category: Antidepressant

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Brintellix Overview

Vortioxetine[note 1] is an antidepressant medication that is prescribed to treat depression. It is believed to work to relieve depression by increasing serotonin concentrations in the brain, by inhibiting its reuptake in the synapse and by modulating (activating certain receptors while blocking, or antagonizing, others) certain serotonin receptors. This puts it in the class of antidepressants known as serotonin modulators and stimulators. It is made by the pharmaceutical companies Lundbeck an...

Read more Brintellix Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Brintellix Forums: RSS Feed

Sleepy side effect of Brintellix
5 Replies RSS
I've been taking Brintellix (10 mg) for 18 days now. I was taking Effexor and then the generic version Venlafaxine since 2008 and was interested in a new medication. I thought that the Venlafaxine made me gain weight, not sure. So, since taking this Brintellix, I've been VERY groggy, and sleepy. Been having a hard time getting out of bed in the morning, and sleep later than usual. Hard to have energy to do things throughout the day. Does this go away with time? Overall, the medication works fine, however this sleepiness is too much. ## Hello, Sheva! How are you? I'm sorry about the problem that you're having. The excessive drowsiness may be due to stopping the other, coupled with side effects from starting the Brintellix. As listed by the FDA, other possible side effects...
Updated 9 minutes ago.
Brintellix (Trintellix) withdrawal
14 Replies RSS
Started 10 mg Trintellix 3 weeks ago. Vomiting at least 2x a day and constant nausea, fatigue, muscle and back pain. Trying to wean off it - doctor said take it every second day for a week then go see her. What is the normal time frame for withdrawal? I am terrified of this drug. I am diabetic and it is making my sugars wildly fluctuate too. ## Called Lundbeck (canadian office in Montreal) today to get advice on how to wean off/stop taking Trintellix. Shocked to be told "there is NO protocol for weaning/stopping this drug. You have to let your doctor decide how to proceed"! "Everyone has a different reaction". My doctor is away for a week so. My pharmacist and I are trying to figure something out, but I am absolutely stunned at Lundbeck's answer ## Hi Judy, Sorry to ...
Updated 4 days ago.
Stopped Brintellix
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I was on 10 mg of Brintellix for about 4 months and then my doctor added 10 mg of Rexulti. I felt like i was being stimulated. He then upped my Brintellix to 20 mg and my anxiety went crazy. I was having racing thoughts and couldn't sit still. In my mind i had to be doing something all the time. I also started having panic attacks. This was only over a 2 week period. I then dropped back to 10 mg and cut my rexulti to 5 mg. I told the doctor I wanted to switch back to celexa. He told me to just stop the Brintellix and start the celexa at 10 mg. It's been about 2 weeks now and I still have panic attacks and I wake every morning feeling anxious which last most of the day until the evening. I can't handle this anxiety. I feel amped up. It's like the side effects are continuing
Updated 13 days ago.
Trintellix and can't sleep
5 Replies RSS
I have been taking 10mg of Trintellix in the mornings for just under 3 weeks and it works well for me, but I can't sleep well and the lack of sleep alone is making me consider stopping this medication. Would it be better to take it at night? Is the sleep issue something that normally goes away? ## If the Trintellix is making you drowsy, it may be a good idea to try taking it at night, like you mentioned. Another issue is, were you already having difficulty sleeping before you started taking the Trintellix? If you were, it may not be the Trintellix. If you weren't, it probably is. You can also maybe lower it to 5 mgs for maybe 3 weeks, then jack it back up to 10 mgs if you feel you have to. That may help your body adjust to it. Good luck. ## Most medications in this class can cau...
Updated 15 days ago.
When do the side effects of Trintellix/Brintellix go away?
1 Reply RSS
I recently was prescribed Trintellix by my psychiatrist for anxiety and depression. I told her I cannot be on a medication that will cause weight gain and or fluid retention. Since starting this medication I've been on it for two days I feel really weird, lazy and like I just don't want to do anything. Low mood. I honestly have zero appetite, and my cognitive thinking is very slow. I honestly feel like I am on a super low dose of Vyvanse. She also gave me samples of Viibryd but I heard that medication is notorious for weight gain on here and I am scared to take it. Did anyone else have these side effects when starting this medication? Did they go away? Also, if this isn't the medication for me, does anyone else know what others are good that will not cause horrible weight ga...
Updated 19 days ago.
Brintellix/Trintellix Long term side effects
20 Replies RSS
I have struggled with depression for most of my life, and am always in search of the perfect antidepressant. I work with a psych doctor who is always willing to try new things. 10 months ago I started 5 mg of Brintellix daily, within a week my mood was significantly elevated, I was sleeping better, waking up much earlier and was more motivated to do things in the morning. I went up to 10mg daily However the nausea was dreadful! I pushed through for a couple of weeks, changed to taking the brintellix at night and after a while it subsided. My mood got better and better, I had recently turned 50, and had gained a little weight, so with my new found morning energy I started working out 2times a week with a trainer, and then walking most other mornings! The walking then changed gradually to...
Updated 28 days ago.
1 Reply RSS
I have been on Trintellix 20 mg for quite some time, my pshychiatrist started tapering me off gradually ,during this process i experience several symptoms that were listed but also noticed problems of paronoia and now that i have stopped taking trintellix the paronoia has sky rocketed as well as the anxiety and vomiting has anyone experienced a problem with paronoia while being TAPERED OFF of trintellix or once they completely STOPPED taking trintellix? ## That is possible, depending on how long you were taking it and how rapid the taper was, it might have been too fast for you. In many cases, stopping such a medication needs to be tapered very slowly, and occasionally, it must be adjusted according to how each individual reacts to the taper. The NIH also warns that stopping the medicat...
Updated 30 days ago.
Trying Brintellix
27 Replies RSS
I have been quickly tapered off of Pristiq 200 mg....and now am on Brintellix 10 mg. (Total time of taper 2 weeks) I feel like I have the flu. I hate trying new meds and wish there was something that would make these flu like symptoms go away! (Headache, queasy yet having horrible carb cravings, a weird sensation-aches) ## Hello, Mary! How are you? Most likely, you're experiencing both some withdrawal effects and some side effects, at the same time and it will probably take a couple of weeks, before they taper off and things start to improve. Learn more Brintellix details here. The Brintellix is fairly new and its side effects may include headache, nausea, vomiting, diarrhea and dizziness….which explains most of your flu-like symptoms. Was the Pristiq no longer working for you...
Updated 1 month ago.
can 10mg Brintellix be split?
11 Replies RSS
Recently (within the last 24-hours) I was FINALLY taken off my Effexor. My blood pressure has been terribly high (189/99 yesterday) for at least two years and I always suspected it was related to my Effexor. My first day off Effexor, my blood pressure was down to 132/75. The Effexor was replaced with 10mg of Brintellix. Sweet lord.... I cannot remember the last time I was, or have ever been, so violently ill. I was sick for HOURS. I tried to replenish my fluids. I was not successful. Well, more accurately, I was able to get some fluids down but they quickly reappeared. I read the enclosed product information and 100% of the Brintellix website. I was unable to find information about splitting the tablets. I realize there is a 5mg tablet, as a dosing option. However, I'm returning bac...
Updated 1 month ago.
brintellix side effects severe
61 Replies RSS
DESPERATELY NEED HELP ABOUT BRINTELLIX!!! I have been on 5mg Brintellix for last 10 weeks. About 9 days About 9 days ago I started to feel like i was coming down with flu. week progressed and flu like symptoms got worse every day: flushing, feeling like i had high fever but without actual fever, agitation, muscle cramps, bad nausea, diahrrea all day long, fast heart beat, headache, etc. after several days of symptoms getting worse, on Sunday last I had the feeling i was going to DIE!!! worst flu like symptoms and severe anxiety, depression and suicidal thoughts. I skipped the sunday dose and then cut the monday dose down to 2.5mg. it is wednesday, and most of bad symptoms have gone to mild or moderate. Dr thinks i had case of serotonin syndrome n this med. But, no one can explain why si...
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Tablet: 10mg, 15mg, 20mg, 5mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Brintellix: (5 results)

Sorted by National Drug Code
  • 64764-550 Brintellix 5 mg Oral Tablet by Takeda Pharmaceuticals America, Inc.
  • 64764-560 Brintellix 10 mg Oral Tablet by Takeda Pharmaceuticals America, Inc.
  • 64764-570 Brintellix 15 mg Oral Tablet by Takeda Pharmaceuticals America, Inc.
  • 64764-580 Brintellix 20 mg Oral Tablet by Takeda Pharmaceuticals America, Inc.
  • 69189-0560 Brintellix 10 mg Oral Tablet, Film Coated by Avera Mckennan Hospital

Other drugs which contain Vortioxetine or a similar ingredient: (1 result)

Possibly related Brintellix Topics:

brintellix side effects severe DESPERATELY NEED HELP ABOUT BRINTELLIX!!! I have been on 5mg Brintellix for last 10 weeks. About 9 days About 9 days ago... 61 replies
Brintellix/Trintellix Long term side effects I have struggled with depression for most of my life, and am always in search of the perfect antidepressant. I work with... 20 replies
Brintellix (Trintellix) withdrawal Started 10 mg Trintellix 3 weeks ago. Vomiting at least 2x a day and constant nausea, fatigue, muscle and back pain. Try... 14 replies
brintellix nausea & headache I've been on 5mgs for 2 weeks now. Having nearly unbearable side effects so no increase yet. Was supposed to up to m... 10 replies
brintellix...high blood pressure I was prescribed this for anxiety and it is working very well for me. I have been through several drugs and for the firs... 5 replies
Brintellix nauseated vomit vomiting Hi, I was hoping that I may find some people to with similar symptoms after taking Brintellix. 25th of June I began Brin... 5 replies
Brintellix 10mg I have been on brintellix 10mg for a little over a week and I feel worse. Flu symptoms, vomiting, very weak, tired but c... 4 replies
brintellix and zoloft Hi. I'm about to switch over to Brintellix from Zoloft. The Zoloft has been good for my depression, but my libido is... 4 replies
brintellix start up and dose increase Hello, I started Brintellix 4 weeks ago. I started with 5mg and tapered off Effexor over the next 2 weeks (bad reaction ... 4 replies
Brintellix and Migraines My wife has been on Brintellix/Trintellix for nearly a year now with great results. No other anti-depressant has been as... 4 replies

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