Prolia

Active Ingredient(s): Denosumab
FDA Approved: * June 1, 2010
Pharm Company: * AMGEN
Category: Osteoporosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Prolia Overview

Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody[1] for the treatment of osteoporosis,[1] treatment-induced bone loss, metastases to bone,[1] and giant cell tumor of bone.[2] Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[3] Denosumab is a RANKL inhibitor,[1] which works by preventing the development of osteoclasts which are cells that break down bone. It was developed by ...

Read more Prolia Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Denosumab

Recent Prolia Forums: RSS Feed

Prolia Side Effects Duration
115 Replies RSS
Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen? ## There have been many posts about people suffering side effects, which in theory should wear off in a few weeks, but it hasn't worked that way for many. Here's a link to a post with comments from several people that have been suffering problems: Are you also suffering from problems? ## First injection Feb. One week later could barely walk or use my arms due to pain. Now have back pain, musculoskeletal pain, cholesterol very high and walk with a cane or walker,very seldom drive now, due to arm weakness.AND my doctor said there were no side effects.!!! Will not take second shot in August. ## Have you rec'd any info on your question. Or since May can you...
Updated 4 minutes ago.
 
Prolia side effects
2188 Replies RSS
Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab. I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia. Read more: Is there anyone else with experience using this? ## How are you doing now? Still now side effects? Please let us know ## I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terribl...
Updated 2 days ago.
 
Prolia & Hair Loss
184 Replies RSS
I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractures on my feet and have also taken fosamax. My current problem is hair loss & I wondered if anyone else was having that problem? ## Hello, Gracie! How are you? No, this isn't listed from what I can find, but I'll check a couple more sources to be sure and post back. Are you on any other medications? How old are you? ## I'm 57. On no other meds except evista and a pill for reflux. A friend sent me a website that stated that there was a study with some hair loss ## Yes, after my second shot of Prolea, I had two UTIs, fatigue, huge bumps under the skin on my face and all over my scalp, an array of unexplained symptoms like peripheral neuropathy (not diabeti...
Updated 2 days ago.
 
Prolia - Abundance Of Cavities From The Shot
11 Replies RSS
after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they did x-rays. i suddenly have 9 cavities & 2 root canals. i never had this before. i contacted amgen, who produce the shot. they said no one has had trouble w/their teeth, just jaw problems. if anyone has had this type of problem, please write in. thank you ## How long of a time period was there between when you received the Prolia and the dental appointment? Are you on any other medications? The reason I'm asking is because many medications can cause dry mouth, which can allow the bacteria that would normally be washed away by saliva to remain on the teeth and cause higher and faster rates of decay, than normal. Therefore, it may not necessarily be directly rela...
Updated 13 days ago.
 
Prolia side effects ongoing
162 Replies RSS
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dry cough, near migraine type headaches, very severe weakness, trouble walking, constipation, had to have dental work that I usually have great teeth, some trouble sleeping. My rheumatologist did nothing to try to help me with the symptoms but my primary doctor gave me medication that help with the stomach pains, take Excedrin for Migraines and enteric aspirin for back and body, and other meds to try and find some comfort. I'm somewhat better than the few weeks after the infusion but still have a lot of problems. Hopefully this doesn't last for 6 months. ## Hello, Shirl! How are you? I'm so sorry about what you're going through. Everything you've list...
Updated 13 days ago.
 
Prolia side effects Skin rash
22 Replies RSS
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone else? ## Hello, Willy! How are you? That can be a side effect of Prolia, as listed by the FDA. You may also experience nausea, hypocalcemia, asthenia and fatigue. However, since it is itchy, you should have it checked out, because it could be an allergic reaction that requires medical treatment. Is there anything else I can help with? ## Willy, please look under Prolia side effects on this site. We have almost 900 people writing and talking about Prolia. You sort of worded your question wrong to land on the mega load of Prolia problems. Yes, it's from Prolia and requires medical attention. You will probably have to take written confirmation to make any MD believe yo...
Updated 14 days ago.
 
How long on Prolia therapy for -2.6 bone loss?
2 Replies RSS
My bone density loss was -2.6 on December 2015, but after my third shot, my bone scan came back as -2.0 and I am going for a 4th shot this month. Can you tell me how many more shots I can go for, in order to become normal? I know my doctor might not be able to tell me how long. Please give me advice. Thank you! ## It sounds like your bone density loss has improved since the third shot. Do you find that to be the case as well based on how you feel? Have you gotten your 4th shot yet? And have any bone density results came back after the 4th shot to help determine your progress? In regards to how many shots one may need in order for bone density to become normal, my conclusion based on other Prolia discussion threads here, is that there's no way to know for certain because we all respo...
Updated 16 days ago.
 
Prolia issues and side effects
46 Replies RSS
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered horrible side effects such as terrible constipation, leg and foot cramps, skin rashes, stomach pain,etc. I also found out that Prolia works by stopping the body's own bone production, causing old bone to become denser. This results in probable fractures due to old brittle bones, Prolia also causes low calcium levels in the blood, a weird side effect seeing it is supposed?to strengthen boned! ## I am sorry for your pain and suffering, I am on the "high risk list" for fractures, so having a product that has rebuilt bone mass in MY body is a blessing. No, I don't like the side effects, but I don't want to be in a wheel chair either.. Good Luck To You and...
Updated 18 days ago.
 
Prolia Jaw and gum pain, neck, shoulder arms and hip and thigh pain and tremors
9 Replies RSS
I took my first injection of Prolia mid April, I have gone to my dentist, he suggested a night guard. My rhuematologist does not beleive there is any connection between jaw bone/gum pain and Prolia. I have lost about 10 lbs due to not eating. I do not beleive I will be taking a second injection. Has anyone else had clenching of jaws to the point of not able to eat? ## Hi, Mimi! Sorry about the problems you're having, you must be miserable. And to be honest with you, I've read so many posts about people experiencing odd side effects from Prolia, that I don't remember if this was mentioned before, or not. Yes, there have been that many. Thus, yours do not surprise me and this is not a medication I would recommend to anyone as their first choice. Have you talked to your doctor?...
Updated 19 days ago.
 
what do prolia patients say about the side effects
28 Replies RSS
What does the pharmaceutical people of Prolia advised regarding its side effects? ## Hello, Lala! How are you? They do warn that it can possibly cause some potential serous side effects, such as low blood calcium, serious infections, jaw bone problems, thigh bone fractures and more. Have you had a bad experience with it? ## Yes, the discomfort in the mouth is the worst. Now I have to make a decision regarding what to do with my osteoporosis. I am afraid of Prolia but doctors say that Prolia is the best medicine offered. ## I HAD THE PROLIA INJECTION 5 DAYS AGO AND HAVE HAD BACK PAIN OR SORE BACK FROM THE INJECTION. IF I HAD BEEN TOLD ABOUT THE SIDE EFFECTS. I WOULD NOT HAVE HAD THE INJECTION. NOW , I DO NOT KNOW IF THE PROLIA EVEN HELPS THE BONE LOSS. THE FDA SHOULD BE SUED. THIS IS OUT...
Updated 21 days ago.
 

Possible Dosages for this and Related Drugs:

Denosumab
  • Injection: 60mg/ml, 70mg/ml
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Prolia: (1 result)

Sorted by National Drug Code
  • 55513-710 Prolia 60 mg/ml Subcutaneous Injection by Amgen Inc

Other drugs which contain Denosumab or a similar ingredient: (1 result)


Possibly related Prolia Topics:

Prolia side effects Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to... 2188 replies
Prolia & Hair Loss I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractur... 184 replies
Prolia side effects ongoing I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 162 replies
Prolia Side Effects Duration Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ... 115 replies
Prolia issues and side effects I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 46 replies
Prolia side effects Skin rash I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 22 replies
Prolia Injection Side Effects Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 13 replies
Prolia - Abundance Of Cavities From The Shot after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they ... 11 replies
Prolia Jaw and gum pain, neck, shoulder arms and hip and thigh pain and tremors I took my first injection of Prolia mid April, I have gone to my dentist, he suggested a night guard. My rhuematologist ... 9 replies
Prolia, strange side effects? I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 8 replies




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