Active Ingredient(s): Denosumab
FDA Approved: * June 1, 2010
Pharm Company: * AMGEN
Category: Osteoporosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Prolia Overview

Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody[1] for the treatment of osteoporosis,[1] treatment-induced bone loss, metastases to bone,[1] and giant cell tumor of bone.[2] Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[3] Denosumab is a RANKL inhibitor,[1] which works by prev...

Read more Prolia Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Prolia Forums: RSS Feed

Prolia side effects

Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab. I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia. Read more: Is there anyone else with experience using this? ## How are you doing now? Still now side effects? Please let us know ## I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terribl...

Prolia Side Effects Duration

Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen? ## There have been many posts about people suffering side effects, which in theory should wear off in a few weeks, but it hasn't worked that way for many. Here's a link to a post with comments from several people that have been suffering problems: Are you also suffering from problems? ## First injection Feb. One week later could barely walk or use my arms due to pain. Now have back pain, musculoskeletal pain, cholesterol very high and walk with a cane or walker,very seldom drive now, due to arm weakness.AND my doctor said there were no side effects.!!! Will not take second shot in August. ## Have you rec'd any info on your question. Or since May can you...

Prolia Scleroderma

Hi, has anyone had the prolia shot and have an auto immune disease? I have scleroderma and bones of a 101 year old woman, I am 57 years old. My Doctor wants me to take these shots for the osteo. I am scared to take it because I already have some of these symptoms with my scleroderma, but they are manageable if I am careful and take care of myself. This medication seems like it will kill me. My doctor keeps telling me it's safe..I don't want to take prolia but don't know what else to use in its place, or live my life as is and risk not taking it. I'm tired of taking this for that ailment but now you have this illness so now have to treat that and it goes on an on. Any feedback appreciated. Thank you for sharing your stories. ## DO NOT TAKE PROLIA. I had my first prolia in...

Prolia reviews and information

Manufactured by amgen for treating osteoporosis. ## Prolia, which uses the active ingredient Densoumab to treat post-menopausal Osteoporosis. As of writing this message, it has not yet been approved by the FDA for general use in the U.S., so the information I have on it is limited. Did you have any specific questions? ## I had been injected with prolia for three years, twice a year for a total of 6 shots which are quite expensive. My doctor wanted to inject me again, but I think I had to stop. So far, I had not any side effect.

Prolia & Hair Loss

I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractures on my feet and have also taken fosamax. My current problem is hair loss & I wondered if anyone else was having that problem? ## Hello, Gracie! How are you? No, this isn't listed from what I can find, but I'll check a couple more sources to be sure and post back. Are you on any other medications? How old are you? ## I'm 57. On no other meds except evista and a pill for reflux. A friend sent me a website that stated that there was a study with some hair loss ## Yes, after my second shot of Prolea, I had two UTIs, fatigue, huge bumps under the skin on my face and all over my scalp, an array of unexplained symptoms like peripheral neuropathy (not diabeti...

Bone loss after Prolia

My hip bone numbers are worse after the 6 month shot. ## Not all medications and treatments work for everyone that tries them, that's why they are usually several choices available in any given therapeutic category. The FDA lists the typical side effects of Prolia as possibly including bladder infection, arm/leg pain and back pain. You may need to speak to your doctor about trying an alternative. Is there anything else I can help with? ## This is a terrible drug. I only took 2 injections in 9/14 and 3/15, but still have the resulting hair damage and jaw pain. My ENT and Dentist both told me that my jaw is messed up...Prolia does mention that as a side effect, but not hair damage. My immune system is weaker too...even 3 years after stopping Prolia. Yeah I'll just take the Osteopo...


had prolia injection February17,2012 was hospitalized the 20th with calcium depleted and was told heart could stop had to wear heart monitor given bags of calcium 24/7 FOR DAYS then went to 12hrs and then down slowly had to have blood drawn daily to see what calcium levels were because calcium levels to high is deadly also had to take mega doses of vitamin D also thyroid was thrown off also in essence was in hospital 50 days with 2 pic lines also which got infected making me very ill when released had to return to hospital every day for weeks for calcium levels checked and calcium infusion and it has just been in the last few months of actually feeling better the area I reside has a medical school and all doctors had never heard of a case like this before it was searched thoroughly and ...

Prolia side effects ongoing

I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dry cough, near migraine type headaches, very severe weakness, trouble walking, constipation, had to have dental work that I usually have great teeth, some trouble sleeping. My rheumatologist did nothing to try to help me with the symptoms but my primary doctor gave me medication that help with the stomach pains, take Excedrin for Migraines and enteric aspirin for back and body, and other meds to try and find some comfort. I'm somewhat better than the few weeks after the infusion but still have a lot of problems. Hopefully this doesn't last for 6 months. ## Hello, Shirl! How are you? I'm so sorry about what you're going through. Everything you've list...

Severe constipation from Prolia injections?

Anyone have this problem? I was given two shots over the last year no problem. Third shot in November and I cannot resolve my severe constipation. Nothing helps. I eat enough fiber, drink enough water, and work out most days. Miralax doesn't help. Any suggestions? ## Heat some prune juice and drink it but make sure you have easy access to a bathroom. Also pitted prunes. Heat them also after adding water to cover and microwaving them till plump. Not all at once. It may work like dynamite!!! Just a cup of the juice at night, go in morning or whenever it wants you to! ## The antibody Denosumab® or Prolia® for skeletal/bone loss issues comes with a long list of side effects with some being very severe. Constipation is among the top three, so it happens quite often. These issue...

Side Effects Of Prolia & Zometa Are Similar

I'm a 59 year old female, diagnosed with Behcet's Disease and I use Prednisone for treatment for my weekly flares. The Prednisone is hard on my bones and has caused me to get osteoporosis in my hips. I had my first infusion of Zometa six days ago. I thought I was going to die from the side effects. I had 103 degree fever for five days, deep bone pain everywhere, muscle pain, flu like symptoms, migraine headache, burning eyes, pale skin, restlessness, and no appetite. Today six days later I'm still fatigued, pale, mild bone pain, mild muscle pain and no appetite. I reported these side effects to my doctor. His nurse suggested I maybe try Prolia injection in six months instead. I found this web site and was reading everything about Prolia and the side effects, they sound exact...


Possible Dosages for this and Related Drugs:

  • Injection: 60mg/ml, 70mg/ml
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Prolia: (1 result)

Sorted by National Drug Code
  • 55513-710 Prolia 60 mg/ml Subcutaneous Injection by Amgen Inc

Other drugs which contain Denosumab or a similar ingredient: (1 result)

Related Prolia Topics:

Prolia side effects
Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to... 2800 replies
Prolia & Hair Loss
I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractur... 383 replies
Prolia Side Effects Duration
Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ... 285 replies
Prolia side effects ongoing
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 182 replies
Prolia issues and side effects
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 118 replies
Prolia side effects skin rash
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 30 replies
Prolia - Abundance Of Cavities From The Shot
after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they ... 21 replies
Prolia Injection Side Effects
Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 15 replies
Prolia Jaw and gum pain, neck, shoulder arms and hip and thigh pain and tremors
I took my first injection of Prolia mid April, I have gone to my dentist, he suggested a night guard. My rhuematologist ... 10 replies
Prolia, strange side effects?
I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 9 replies

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