Prolia

Active Ingredient(s): Denosumab
FDA Approved: * June 1, 2010
Pharm Company: * AMGEN
Category: Osteoporosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Prolia Overview

Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.[1][2] Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[3] Denosumab is a RANKL inhibitor,[1] which works by preventing the development of osteoclasts,...

Read more Prolia Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Denosumab

Recent Prolia Forums: RSS Feed

Severe constipation from Prolia injections?

Anyone have this problem? I was given two shots over the last year no problem. Third shot in November and I cannot resolve my severe constipation. Nothing helps. I eat enough fiber, drink enough water, and work out most days. Miralax doesn't help. Any suggestions? ## Heat some prune juice and drink it but make sure you have easy access to a bathroom. Also pitted prunes. Heat them also after adding water to cover and microwaving them till plump. Not all at once. It may work like dynamite!!! Just a cup of the juice at night, go in morning or whenever it wants you to! ## The antibody Denosumab® or Prolia® for skeletal/bone loss issues comes with a long list of side effects with some being very severe. Constipation is among the top three, so it happens quite often. These issue...

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Effectiveness of AlgeaCal instead of Prolia

Need everyone’s advice, good or bad, on AlgaeCal or similar products. Latest DEXA for me is -3.6 which is the worst I’ve gotten. Will not do another Prolia shot due to side effects that have just begun to recede after 2 years. If I had to do one supplement and a couple of exercises, what would you suggest they be? Thanks to all ~

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Prolia side effects

Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab. I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia. Read more: Is there anyone else with experience using this? ## How are you doing now? Still now side effects? Please let us know ## I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terribl...

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Delaying Prolia injection

I had a tooth extraction. Can I delay my Prolia injection by one month? ## It would be best to discuss it with your doctor, and follow their instructions. The concern is that medications like Prolia have been known to cause osteonecrosis of the jaw, so proper dental care, and maintaining good dental hygiene while taking it are very important. Was your dentist aware that you are on it? The FDA lists other typical side effects as possibly including nausea, back ache, muscle aches, rapid weight gain, and swollen glands in the neck. Are you on any other medications? ## Do not take Prolia if you do not want to loose all of your teeth. I now have none of my natural teeth and in the middle of implants which is extremely expensive. Dentures are not working because of bone disfigurement. I alway...

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Prolia & Hair Loss

I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractures on my feet and have also taken fosamax. My current problem is hair loss & I wondered if anyone else was having that problem? ## Hello, Gracie! How are you? No, this isn't listed from what I can find, but I'll check a couple more sources to be sure and post back. Are you on any other medications? How old are you? ## I'm 57. On no other meds except evista and a pill for reflux. A friend sent me a website that stated that there was a study with some hair loss ## Yes, after my second shot of Prolea, I had two UTIs, fatigue, huge bumps under the skin on my face and all over my scalp, an array of unexplained symptoms like peripheral neuropathy (not diabeti...

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Prolia issues and side effects

I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered horrible side effects such as terrible constipation, leg and foot cramps, skin rashes, stomach pain,etc. I also found out that Prolia works by stopping the body's own bone production, causing old bone to become denser. This results in probable fractures due to old brittle bones, Prolia also causes low calcium levels in the blood, a weird side effect seeing it is supposed?to strengthen boned! ## I am sorry for your pain and suffering, I am on the "high risk list" for fractures, so having a product that has rebuilt bone mass in MY body is a blessing. No, I don't like the side effects, but I don't want to be in a wheel chair either.. Good Luck To You and...

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Side Effects Of Prolia & Zometa Are Similar

I'm a 59 year old female, diagnosed with Behcet's Disease and I use Prednisone for treatment for my weekly flares. The Prednisone is hard on my bones and has caused me to get osteoporosis in my hips. I had my first infusion of Zometa six days ago. I thought I was going to die from the side effects. I had 103 degree fever for five days, deep bone pain everywhere, muscle pain, flu like symptoms, migraine headache, burning eyes, pale skin, restlessness, and no appetite. Today six days later I'm still fatigued, pale, mild bone pain, mild muscle pain and no appetite. I reported these side effects to my doctor. His nurse suggested I maybe try Prolia injection in six months instead. I found this web site and was reading everything about Prolia and the side effects, they sound exact...

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Prolia Side Effects Duration

Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen? ## There have been many posts about people suffering side effects, which in theory should wear off in a few weeks, but it hasn't worked that way for many. Here's a link to a post with comments from several people that have been suffering problems: Are you also suffering from problems? ## First injection Feb. One week later could barely walk or use my arms due to pain. Now have back pain, musculoskeletal pain, cholesterol very high and walk with a cane or walker,very seldom drive now, due to arm weakness.AND my doctor said there were no side effects.!!! Will not take second shot in August. ## Have you rec'd any info on your question. Or since May can you...

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Prolia and Leg Tremors

I had a Prolia shot two weeks ago and am experiencing shaking and leg tremors. Are there others who have had this reaction? ## Hi Mary, Based on my research, I did find "tremors" to be a side effect of the Prolia shot. The side effect isn't specific to any particular body part, however I would definitely speak with your physician or the medical professional who administered the shot. I hoep this info helps! ## PUBLIC COMMUNICATION - Health Canada Endorsed Important Safety Information on Prolia November 21, 2012 Subject: Prolia® (denosumab) - Risk of Unusual Thigh Bone Fractures AMGEN Canada Inc., in association with Health Canada, would like to inform you of new important safety information related to the risk of unusual thigh bone fractures associated with the us...

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Prolia side effects ongoing

I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dry cough, near migraine type headaches, very severe weakness, trouble walking, constipation, had to have dental work that I usually have great teeth, some trouble sleeping. My rheumatologist did nothing to try to help me with the symptoms but my primary doctor gave me medication that help with the stomach pains, take Excedrin for Migraines and enteric aspirin for back and body, and other meds to try and find some comfort. I'm somewhat better than the few weeks after the infusion but still have a lot of problems. Hopefully this doesn't last for 6 months. ## Hello, Shirl! How are you? I'm so sorry about what you're going through. Everything you've list...

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Possible Dosages for this and Related Drugs:

Denosumab
  • Injection: 60mg/ml, 70mg/ml
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Prolia: (1 result)

Sorted by National Drug Code
  • 55513-710 Prolia 60 mg/ml Subcutaneous Injection by Amgen Inc

Other drugs which contain Denosumab or a similar ingredient: (1 result)

Related Prolia Topics:

Prolia side effects
Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to... 3120 replies
Prolia & Hair Loss
I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractur... 461 replies
Prolia Side Effects Duration
Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ... 317 replies
Prolia side effects ongoing
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 198 replies
Prolia issues and side effects
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 126 replies
Prolia side effects skin rash
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 33 replies
Prolia Injection Side Effects
Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 27 replies
Prolia - Abundance Of Cavities From The Shot
after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they ... 21 replies
Prolia, strange side effects?
I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 11 replies
Prolia Loss of Taste and Smell
I have been taking Prolia injections for 2 years now. Over time, I've noticed that my sense of taste and smell has d... 10 replies