Prolia

Active Ingredient(s): Denosumab
FDA Approved: * June 1, 2010
Pharm Company: * AMGEN
Category: Osteoporosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Prolia Overview

Denosumab (trade names Prolia and Xgeva) is a human monoclonal antibody for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.[1][2] Denosumab is contraindicated in people with low blood calcium levels. The most common side effects are joint and muscle pain in the arms or legs.[3] Denosumab is a RANKL inhibitor,[1] which works by preventing the development of osteoclasts,...

Read more Prolia Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Denosumab

Recent Prolia Forums: RSS Feed

Prolia side effects

Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab. I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia. Read more: Is there anyone else with experience using this? ## How are you doing now? Still now side effects? Please let us know ## I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terribl...

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Dental and jaw pain

I've been on Prolea for 1 month after multiple fractures of vertebrae . I've had a lot of dental problems since having my first shot... Increased cavities, one root canal and another one coming up tomorrow and a possible 3rd... My jaw pain gets almost unbearable, never had any of this before... I wish there would be a way to reverse that shot! there has to be something else to help my bones get stronger... ## Prolea, and most other osteoporosis treatments are known to possibly cause dental issues as side effects, along with joint aches, it could also make it slower for you to heal, after having dental work done, so please make sure your dentist is aware that you have been given Prolia. Yes, there are other options, but as I've already stated, they all carry the risk of causi...

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Prolia inj. - duration of treatment?

How many years are you able to take the prolia inj's.? I took it twice a year for 3 years. Once I received my 6th inj. I was told I was finished and to refer to my Dr. ## I was told that you should go off Prolia (take a holiday), then start taking it again. I cannot find any information that this is the case. Can Prolia be taken forever? ## They no longer recommend the holiday that's been mentioned, the official site from the manufacturer advises against it. As to how long one can continue Prolia, it is up to 10 years, depending on the patient's condition, medical history, insurance coverage, and etc. The typical side effects may include adminstation site reaction, hypocalcemia, increased risk of broken bones, and dermatitis. Did they give a reason why you were done after 3 ...

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Prolia side effects ongoing

I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dry cough, near migraine type headaches, very severe weakness, trouble walking, constipation, had to have dental work that I usually have great teeth, some trouble sleeping. My rheumatologist did nothing to try to help me with the symptoms but my primary doctor gave me medication that help with the stomach pains, take Excedrin for Migraines and enteric aspirin for back and body, and other meds to try and find some comfort. I'm somewhat better than the few weeks after the infusion but still have a lot of problems. Hopefully this doesn't last for 6 months. ## Hello, Shirl! How are you? I'm so sorry about what you're going through. Everything you've list...

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Prolia Side Effects Duration

Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happen? ## There have been many posts about people suffering side effects, which in theory should wear off in a few weeks, but it hasn't worked that way for many. Here's a link to a post with comments from several people that have been suffering problems: Are you also suffering from problems? ## First injection Feb. One week later could barely walk or use my arms due to pain. Now have back pain, musculoskeletal pain, cholesterol very high and walk with a cane or walker,very seldom drive now, due to arm weakness.AND my doctor said there were no side effects.!!! Will not take second shot in August. ## Have you rec'd any info on your question. Or since May can you...

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Prolia Injection Side Effects

Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a keen sense of smell developed. It was difficult to eat or smell cooked food. It has been months and these symptoms have decreased dramatically. In contacting their website they would not confirm or deny this as a side effect of the drug. Has anyone else experienced nausea w/this drug? ## Hi Bonnie, From what I could gather, the following side effects are associated with Prolia, that may be similar to what you had experienced: -nausea -tingling in your fingers, toes, or around your mouth -pain, numbness, swelling, or drainage from mouth, teeth, or jaw -vomiting Referenced from: nlm.nih.gov/medlineplus/druginfo/meds/a610023.html You or your doctor can also report various s...

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Side Effects Following Prolia Injection

I am 60 yrs old and suffer from osteoarthritis, osteoporosis, and myofascial pain syndrome. After discussing with my endocrinologist, I received my first injection of Prolia two days ago. Had diarrhea approximately 12 hrs later in the middle of the night. Awoke the next day with headache over entire head and face. That evening (12:30 am) I vomited approximately 10 times in succession. Awoke 5 hrs later with terrible pain and tightness from the top of my head down my neck, shoulders, and upper back. I am frightened to see where the pain will travel next, especially after reading the posts on this forum. Is there a drug out there to counteract the Prolia. I will definitely not be getting another shot in 6 mos. My doctor told me that the main side effect of this drug is worsening of skin c...

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Prolia, strange side effects?

I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER the skin of my legs and back. Only the back itches, which is strange! The main problem is the pimple like scabs that form in my hair, which will crust over and flake off if I scratch them. I only wonder what other problems are forming in the areas that can not be seen? I worry about the next shot, and my choose NOT to take it. ???? ## Yes, that is the Prolia rash they talk about. Some people here are using Prednisone but the problem with Pred is that it makes the Prolia stop building bones so you are suffering from problems with Prolia without getting any benefit from it. If one looks online, one can easily see that Prednisone is contraindicated for anyone on Prolia. Ma...

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Severe constipation from Prolia injections?

Anyone have this problem? I was given two shots over the last year no problem. Third shot in November and I cannot resolve my severe constipation. Nothing helps. I eat enough fiber, drink enough water, and work out most days. Miralax doesn't help. Any suggestions? ## Heat some prune juice and drink it but make sure you have easy access to a bathroom. Also pitted prunes. Heat them also after adding water to cover and microwaving them till plump. Not all at once. It may work like dynamite!!! Just a cup of the juice at night, go in morning or whenever it wants you to! ## The antibody Denosumab® or Prolia® for skeletal/bone loss issues comes with a long list of side effects with some being very severe. Constipation is among the top three, so it happens quite often. These issue...

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Prolia-Heart Palpitations and High Blood Pressure

Had a Prolia injection last week (thought it was a calcium supplement) Two days later woke 4am with heart palpitations and feeling light-headed. Went to Dr and my blood pressure was 139/85-normally it is 90/60. Still over a week later have to lie down mostly to keep my heart from racing. Never again! I was not told of any side effects or I would not have had it. ## I am very sorry about what you've had to deal with, after being given Prolia. Its typical side effects are listed as possibly including eczema, nausea, diarrhea, and afib. But, it is also well known to cause odd side effects in many people that try it, just like other medications used to treat osteoporosis. My mother-in-law's doctor talked her into trying one, and within half an hour, she couldn't control her bowe...

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Possible Dosages for this and Related Drugs:

Denosumab
  • Injection: 60mg/ml, 70mg/ml
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Prolia: (1 result)

Sorted by National Drug Code
  • 55513-710 Prolia 60 mg/ml Subcutaneous Injection by Amgen Inc

Other drugs which contain Denosumab or a similar ingredient: (1 result)

Related Prolia Topics:

Prolia side effects
Would like to know of side effects after Prolia infusion from other persons. Up to now I have none. ## Prolia is used to... 3057 replies
Prolia & Hair Loss
I've just recently had my second Prolia shot. So far so good...a little back pain. I continually have stress fractur... 440 replies
Prolia Side Effects Duration
Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ... 316 replies
Prolia side effects ongoing
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 191 replies
Prolia issues and side effects
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 125 replies
Prolia side effects skin rash
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 32 replies
Prolia - Abundance Of Cavities From The Shot
after my last dental hygiene appt. my dentist came in and stated the nurse who cleaned my teeth saw many cavities. they ... 21 replies
Prolia Injection Side Effects
Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 20 replies
Prolia, strange side effects?
I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 11 replies
Prolia Jaw and gum pain, neck, shoulder arms and hip and thigh pain and tremors
I took my first injection of Prolia mid April, I have gone to my dentist, he suggested a night guard. My rhuematologist ... 10 replies




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