Prolia Side Effects

Alexis Says:

Would like to know of side effects after Prolia infusion from other persons. Up to now I have none.

3153 Replies (158 Pages)

Page:1Next PageLast Page
Earliest Newest Votes
Verwon Says:

Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab.

I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia.

Read more:


Is there anyone else with experience using this?

Was this helpful? 12
Renee Says:

How are you doing now? Still now side effects? Please let us know

Was this helpful? 8
Lynne Says:

I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terrible and I am worried this may last a long time.

Was this helpful? 55
Mometter Says:

I had my first injection of Prolia on 4/1/11. I have not had any side effects

Was this helpful? 10
Norma Says:

I received my shot of prolio 9 days ago. By the third day, my left thigh felt uncomfortable. By the 8th day, it was extremely painful. I would like to know how long the side effects last.

Was this helpful? 17
auntylin Says:

a friend of 82 had a prolia jab nr 6month ago, due to osteo and pagets disease. She says she,s been no better with it, and thinks it has caused side effects making her feel worse, but its difficult to judge due to her many health problems, heamo, coeliac, others, but she wont have another, and is hoping when the 6month is up in two weeks she,ll feel better, time will tell, were all different, research and judge for yourself, as with all meds offered on trial.

Was this helpful? 3
Lynne Says:

I previously posted in March. It has been 3 months since having my Prolia shot. This has affected my digestive system, I am constantly bloated and miserable. Also I get pains in my arms andl egs and the worst menopausal symptoms which I had finished with two years ago. I do not sleep well and constanlty break out in a hot sweat. My calcium level is on the low side despite taking calcium and D3 supplements which seem to constipate me. I am 62 years old and do not think I will get another shot. In fact I cannot wait until this wears off in the next three months.

Was this helpful? 22
auntylin Says:

Thanks for your info lynne, will paste and send to my friend, as she,s had simular, and is just waiting till it gets out of her system, like you she has bad digestive problems before anyway, now a bit worse, along with other things including sleep probs.
Think some people cant tolerate strong chemicals in their system, think l,d be the same, as its often people with allergy immune probs who dont react well.

Was this helpful? 10
Sedona Says:

I took my first shot of Prolia On April 27, It has been 2 Months and I have felt terrible everyday. I will never take this shot again. I will Just take Calcium and Vit D from now on. I have been in Pain, I have been sick, I dont sleep well, I have had 2 UTI's ... I pray the side effects will go away when the 6 month's are up.

Was this helpful? 19
auntylin Says:

hi sedona, will copy and paste your reply also, as my friend says she,s glad to read them knowing she,s not on her own with how she feels, she thought she was going mad, anyway goo luckii

Was this helpful? 5
Sedona Says:

No Honey she is not alone, I talked to, of all person my Pharmacologist he stated he would never take any of this stuff they have out there. Sad isn't it ;-( Even Doctors don't trust this drug!!!

Was this helpful? 7
auntylin Says:

thanks for reply, just had email from her this morning saying she had a terrible night and feels rough with pain and nausea, so will once again post your reply, as it does help her feel better knowing she,s not alone and hopefully time will clear her system of it. l truly hope the authorities are doing a survey on the feedback.

Was this helpful? 6
Verwon Says:

Wow! I am astounded by all the problems people are having with this and very sorry to read of them all. I sincerely hope that everyone starts feeling better and finds some other solution.

I also strongly encourage you all to report your problematic experiences to the FDA, that is the only way they can learn about these types of issues with medications on the market and it is an important part of their considerations on drug safety. You can call them and report these problems at:



Does anyone else have any questions or experiences to share?

Was this helpful? 9
Sedona Says:

I will do this right away ... thanks for the info
Hugs Sed

Was this helpful? 3
Faith Says:

I have no osteoporosis, although I dislocated my wrist Dec 19th, 2010, was sent to Post Fracture Osteoporosis Clinic was not told about any side effects, nor was told it was a trial. It was Prolia that sent me brochure and told me to call if I need anything.
I started getting cramps in legs, very fatigued, hard of hearing on left side, was confused, walking was difficult, and on May 19th, I called their nurse. I received this injection by a doctor in the hospital.
She told me that I should go to ER, which I did, they took blood test, everything was OK, didn't know about Prolia,
Had neurologist look at me next day.
The cat scan showed fluid in my ear, nothing to be done there.
Then in June I developed large hard bumps on the gums, and swelling, I was sure I would lose my teeth,
saw the dentist at the hospital, they took pictures, am to see the dentist Aug 29th to see if the teeth have spread more.
In June, I developed red blood blisters on the both legs, dermatologist thought I had vasculitis, bleeding from organs and all veins, after blood tests etc, not so. Prolia will give you rashes, blood blisters and other marks on the body. Plus I have bloated breasts, and have developed the last week terrible pain in my right side of the stomach, nausea, don't sleep well, and wake in the middle of the night very hot, yet on the warmest days, I am cold.
My family doctor took the same blood test that was ordered that I should do 2 weeks before getting the 2nd shot of Prolia Oct 6. She wanted to see if I developed some things that might have surfaced because of Prolia.
In the meantime, I am counting the minutes before this 6 months are up. I am worried about my gums. I stopped calcium pills, as I see the big lumps on the gums are slowly receding.
This is the same poison as Fosamax, Actonal, and giving this to fairly healthy women who have no osteoporosis, is downright unethical. Saw my rheumatologist who now is giving Prolia, and right away he said, these are not side affects from Prolia, and with this he ended the meeting.
Sad to say, big Pharma is ruling and we are the guinea pigs that are paying the price.
Furthermore my heart is also trembling, and I am not a smoker, nor a drinker, in fact, I should be enjoying the spring and summer, but have so many problems, that I am in bed, with horrible pains, cramps in the muscles, and horrible gums.

The doctor who gave me the injection, considers himself a scientist, in his e-mail he said, failure is not an option, only success, he doesn't even want to see me.
Gave me a referral to see an ENR re fluid in the ear outside in the hallway.
So much for professionalism.

Was this helpful? 28
sheila ross Says:

I commenced Prolia 17 Aug 2011 so only one day on it so far so maybe a bit early to say no side effects ??

Was this helpful? 1
Lynne Herndon Says:

I posted a while back. I am now in my fifth month and things just keep getting worse. I do not sleep the hot flushes are terrible and I have all kinds of GI issues.I feel terrible all the time. Is there anyone out here whose six months are up an dfound the side effects went away. I am hoping that I will feel better after the six months - but how do we know?

Was this helpful? 15
Sedona Says:

I am only 3 months in and still feel terrible most the time ... I don't hardly sleep at all. I won't be taking this drug again.

Was this helpful? 6
Faith Says:

I feel the same, praying the 6 months will be up October 6th. Now I have gum issues, very sore, and the big lumps have not deminished. Dentist took imprints and will check Aug 29 to see how much the teeth have spread. I hope I won't lose my teeth, besides the bloating, the sore throat, the numbness and all the other symptoms that I had and wrote previously are still there,including had some blood in my left ear this morning, this is where the fluid was found, probably the jaw pushing the fluid into my eardrum. Horrible stuff, never, never again, will I take anything, Doctor's don't tell you, they are promoting the Pharma's trials and obviously their glory is more important then patients well being. Shame on them.

Was this helpful? 10
Sedona Says:

I agree the Doc's are pushing this drug way to fast ...
I used to work in a hospital pharmacy and the drug reps would come in a push certain drugs .... for cheaper prices to the pharmacy ... Shame on them too.

Was this helpful? 10
Page:1Next PageLast Page

Most Recent Replies:

Marion Says:

Re: Jmatt (# 3152) Expand Referenced Message

Good decision. Don’t fall for the Medicos opinions . I suspect that many of them are thinking of their hip pockets and not your hips or any other part of your bone structure

Was this helpful? -1
Jmatt Says:

Re: Nikki (# 3136) Expand Referenced Message

My gynecologist says: oh just a little shot twice a year.
I don’t trust this drug.
I took Forteo and it about killed me.
So, I am very hesitant about this drug.

Was this helpful? 1
Dawn Says:

Re: Lynne (# 3) Expand Referenced Message

Do not take anymore as this can last forever. Try something more natural to assist with your osteoporosis. I eat food with calcium and take 4,000 units of VitD a day. Yogurt is really good, cottage cheese certain veggies etc.

Was this helpful? 0
Dawn Says:

Re: Verwon (# 1) Expand Referenced Message

I have used it. One injection and am still suffering from side effects. Made my osteoporosis pain worse, affected my asthma so terribly that now I have attacks quite often and lung infections, impacted my endocrine system so now I have allergic type flares for nothing like inflammation of my face and right ear and mouth. So yes I Wish I had never believe my endocrinologist and will forever blame her for my current state. It is a drug that was modified from a drug for bone cancer and given to otherwise healthy women because it has made pharma lots of $$$. Everyone I have met have had reactions but did not know it because doctors connected their symptoms to other issues they had. I could write a book and will never recommend or support these drugs. I now am attending therapy called OSTEOSTRONG and will test my density at the six month mark to see if anything has changed. Will report back. Look up Osteostrong especially if you live in the US if Canada I think only 2 clinics so far.

Was this helpful? 2
Nikki Says:

Re: Darcy (# 3137) Expand Referenced Message

The PA I see at the rheumatologist's office took me seriously when I told her about the side effects of Prolia. She hadn't heard of any side effects. I don't know if anyone else has mentioned it to her but I made sure to let her know in case anyone else comes in with problems.

I think you're right about kick-backs or at the very least, something not right about the majority of doctors dismissing our concerns and for them not to do their homework about this drug in the first place.

Was this helpful? 1
Nikki Says:

Re: Jolly (# 3138) Expand Referenced Message

Thank you for letting me know how long it took for your hair to return to normal.

Was this helpful? 0
Nikki Says:

Re: Dawn (# 3140) Expand Referenced Message

I've had asthma since I was a child. After taking Prolia it gave me asthma-related COPD. Consider asking your pulmonologist if you have it too. COPD is one of the side effects of the drug.

Was this helpful? 0
Nikki Says:

Re: Gloria (# 3141) Expand Referenced Message

I have a friend who had breast cancer and they gave her Prolia. It gave her side effects, too. She told everyone she knew how bad it was. I told her I already knew how horrid it was because I already suffering side effects from it, too.

Was this helpful? 1
Laura Says:

My mother was on Prolia for 2 years. She developed non-hodgkins lymphoma, blood cancer.

Was this helpful? 1
Gloria Says:

Re: Nikki (# 3136) Expand Referenced Message

I had horrible side effects from Prolia, wish I had never taken it. Found out through research that it has been used for bone cancer patients since 2010, a form of Chemo. And no, they do not advertise that face!

Was this helpful? 2
Sort Thread by Most Recent

More Discussions:

Prolia Side Effects Duration

Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ...

Prolia side effects ongoing

I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr...

Prolia side effects skin rash

I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e...

Side Effects Of Prolia & Zometa Are Similar

I'm a 59 year old female, diagnosed with Behcet's Disease and I use Prednisone for treatment for my weekly flare...

Side Effects Following Prolia Injection

I am 60 yrs old and suffer from osteoarthritis, osteoporosis, and myofascial pain syndrome. After discussing with my end...

Prolia, strange side effects?

I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t...

Prolia Injection Side Effects

Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke...

Prolia issues and side effects

I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho...

Documenting Daily Prolia Side Effects

I am a 57 year old female who has -2.5 bone density scores on hips and -3.4 in the spine. I used Forteo for 2 years, but...

what do prolia patients say about the side effects

What does the pharmaceutical people of Prolia advised regarding its side effects? ## Hello, Lala! How are you? They do w...