Prolia Side Effects

3116 Replies Updated

Conversation Starter

Alexis Says:

Would like to know of side effects after Prolia infusion from other persons. Up to now I have none.

Showing Replies 1 - 20 of 3116 RSS Feed

of 156    Next Page    
Verwon Says:

Prolia is used to treat or prevent Osteoporosis, specifically in post-menopausal women, it contains the active ingredient Denosumab.

I'm glad to hear you've had no side effects, however, they can include: skin infections, jaw bone problems, irritation at the injection site and hypocalcemia.

Read more:


Is there anyone else with experience using this?

Was this helpful?     13     0  
Renee Says:

How are you doing now? Still now side effects? Please let us know

Was this helpful?     8     0  
Lynne Says:

I was given a shot of prolia 8 days ago. I am suffering from pains in my arms and legs, digestive discomfort and nausea. Has anyone had this shot as I would like to know how long these side effects last as I am unable to work at the moment. I really feel terrible and I am worried this may last a long time.

Was this helpful?     61     7  
Mometter Says:

I had my first injection of Prolia on 4/1/11. I have not had any side effects

Was this helpful?     12     2  
Norma Says:

I received my shot of prolio 9 days ago. By the third day, my left thigh felt uncomfortable. By the 8th day, it was extremely painful. I would like to know how long the side effects last.

Was this helpful?     25     9  
auntylin Says:

a friend of 82 had a prolia jab nr 6month ago, due to osteo and pagets disease. She says she,s been no better with it, and thinks it has caused side effects making her feel worse, but its difficult to judge due to her many health problems, heamo, coeliac, others, but she wont have another, and is hoping when the 6month is up in two weeks she,ll feel better, time will tell, were all different, research and judge for yourself, as with all meds offered on trial.

Was this helpful?     5     2  
Lynne Says:

I previously posted in March. It has been 3 months since having my Prolia shot. This has affected my digestive system, I am constantly bloated and miserable. Also I get pains in my arms andl egs and the worst menopausal symptoms which I had finished with two years ago. I do not sleep well and constanlty break out in a hot sweat. My calcium level is on the low side despite taking calcium and D3 supplements which seem to constipate me. I am 62 years old and do not think I will get another shot. In fact I cannot wait until this wears off in the next three months.

Was this helpful?     24     2  
auntylin Says:

Thanks for your info lynne, will paste and send to my friend, as she,s had simular, and is just waiting till it gets out of her system, like you she has bad digestive problems before anyway, now a bit worse, along with other things including sleep probs.
Think some people cant tolerate strong chemicals in their system, think l,d be the same, as its often people with allergy immune probs who dont react well.

Was this helpful?     10     0  

Sedona Says:

I took my first shot of Prolia On April 27, It has been 2 Months and I have felt terrible everyday. I will never take this shot again. I will Just take Calcium and Vit D from now on. I have been in Pain, I have been sick, I dont sleep well, I have had 2 UTI's ... I pray the side effects will go away when the 6 month's are up.

Was this helpful?     19     0  
auntylin Says:

hi sedona, will copy and paste your reply also, as my friend says she,s glad to read them knowing she,s not on her own with how she feels, she thought she was going mad, anyway goo luckii

Was this helpful?     5     0  
Sedona Says:

No Honey she is not alone, I talked to, of all person my Pharmacologist he stated he would never take any of this stuff they have out there. Sad isn't it ;-( Even Doctors don't trust this drug!!!

Was this helpful?     9     2  
auntylin Says:

thanks for reply, just had email from her this morning saying she had a terrible night and feels rough with pain and nausea, so will once again post your reply, as it does help her feel better knowing she,s not alone and hopefully time will clear her system of it. l truly hope the authorities are doing a survey on the feedback.

Was this helpful?     6     0  
Verwon Says:

Wow! I am astounded by all the problems people are having with this and very sorry to read of them all. I sincerely hope that everyone starts feeling better and finds some other solution.

I also strongly encourage you all to report your problematic experiences to the FDA, that is the only way they can learn about these types of issues with medications on the market and it is an important part of their considerations on drug safety. You can call them and report these problems at:



Does anyone else have any questions or experiences to share?

Was this helpful?     9     0  
Sedona Says:

I will do this right away ... thanks for the info
Hugs Sed

Was this helpful?     3     0  
Faith Says:

I have no osteoporosis, although I dislocated my wrist Dec 19th, 2010, was sent to Post Fracture Osteoporosis Clinic was not told about any side effects, nor was told it was a trial. It was Prolia that sent me brochure and told me to call if I need anything.
I started getting cramps in legs, very fatigued, hard of hearing on left side, was confused, walking was difficult, and on May 19th, I called their nurse. I received this injection by a doctor in the hospital.
She told me that I should go to ER, which I did, they took blood test, everything was OK, didn't know about Prolia,
Had neurologist look at me next day.
The cat scan showed fluid in my ear, nothing to be done there.
Then in June I developed large hard bumps on the gums, and swelling, I was sure I would lose my teeth,
saw the dentist at the hospital, they took pictures, am to see the dentist Aug 29th to see if the teeth have spread more.
In June, I developed red blood blisters on the both legs, dermatologist thought I had vasculitis, bleeding from organs and all veins, after blood tests etc, not so. Prolia will give you rashes, blood blisters and other marks on the body. Plus I have bloated breasts, and have developed the last week terrible pain in my right side of the stomach, nausea, don't sleep well, and wake in the middle of the night very hot, yet on the warmest days, I am cold.
My family doctor took the same blood test that was ordered that I should do 2 weeks before getting the 2nd shot of Prolia Oct 6. She wanted to see if I developed some things that might have surfaced because of Prolia.
In the meantime, I am counting the minutes before this 6 months are up. I am worried about my gums. I stopped calcium pills, as I see the big lumps on the gums are slowly receding.
This is the same poison as Fosamax, Actonal, and giving this to fairly healthy women who have no osteoporosis, is downright unethical. Saw my rheumatologist who now is giving Prolia, and right away he said, these are not side affects from Prolia, and with this he ended the meeting.
Sad to say, big Pharma is ruling and we are the guinea pigs that are paying the price.
Furthermore my heart is also trembling, and I am not a smoker, nor a drinker, in fact, I should be enjoying the spring and summer, but have so many problems, that I am in bed, with horrible pains, cramps in the muscles, and horrible gums.

The doctor who gave me the injection, considers himself a scientist, in his e-mail he said, failure is not an option, only success, he doesn't even want to see me.
Gave me a referral to see an ENR re fluid in the ear outside in the hallway.
So much for professionalism.

Was this helpful?     26     1  
sheila ross Says:

I commenced Prolia 17 Aug 2011 so only one day on it so far so maybe a bit early to say no side effects ??

Was this helpful?     2     1  
Lynne Herndon Says:

I posted a while back. I am now in my fifth month and things just keep getting worse. I do not sleep the hot flushes are terrible and I have all kinds of GI issues.I feel terrible all the time. Is there anyone out here whose six months are up an dfound the side effects went away. I am hoping that I will feel better after the six months - but how do we know?

Was this helpful?     15     0  
Sedona Says:

I am only 3 months in and still feel terrible most the time ... I don't hardly sleep at all. I won't be taking this drug again.

Was this helpful?     6     0  
Faith Says:

I feel the same, praying the 6 months will be up October 6th. Now I have gum issues, very sore, and the big lumps have not deminished. Dentist took imprints and will check Aug 29 to see how much the teeth have spread. I hope I won't lose my teeth, besides the bloating, the sore throat, the numbness and all the other symptoms that I had and wrote previously are still there,including had some blood in my left ear this morning, this is where the fluid was found, probably the jaw pushing the fluid into my eardrum. Horrible stuff, never, never again, will I take anything, Doctor's don't tell you, they are promoting the Pharma's trials and obviously their glory is more important then patients well being. Shame on them.

Was this helpful?     11     1  
Sedona Says:

I agree the Doc's are pushing this drug way to fast ...
I used to work in a hospital pharmacy and the drug reps would come in a push certain drugs .... for cheaper prices to the pharmacy ... Shame on them too.

Was this helpful?     16     5  

Viewing page 1 of 156     Reply

Next Page >

More Discussions:

Prolia Side Effects Duration
Would like to know if anyone had side effects from Prolia but they went away - and how long did it take for that to happ... 317 replies
Prolia side effects ongoing
I had my infusion Mar 4 2015. I have experienced severe stomach pains, leg pains that wake me up at night, a horrible dr... 198 replies
Prolia side effects skin rash
I developed a red burning itchy lumpy rash after one injection of Prolia. Mainly on face neck chest arms scalp. Anyone e... 33 replies
Side Effects Of Prolia & Zometa Are Similar
I'm a 59 year old female, diagnosed with Behcet's Disease and I use Prednisone for treatment for my weekly flare... 7 replies
Side Effects Following Prolia Injection
I am 60 yrs old and suffer from osteoarthritis, osteoporosis, and myofascial pain syndrome. After discussing with my end... 85 replies
Prolia, strange side effects?
I am 81 and had my first Prolia Shot May 7, 2015 and after three weeks I have developed a red rash looking sight UNDER t... 11 replies
Prolia Injection Side Effects
Aprox 2 weeks after the prolia injection I started to experience nausea and weight loss. Also, loss of appetite and a ke... 27 replies
Prolia issues and side effects
I am not going to have my next shot of Prolia due 11 June. I have already had two injections and lately have suffered ho... 126 replies
Documenting Daily Prolia Side Effects
I am a 57 year old female who has -2.5 bone density scores on hips and -3.4 in the spine. I used Forteo for 2 years, but... 15 replies
what do prolia patients say about the side effects
What does the pharmaceutical people of Prolia advised regarding its side effects? ## Hello, Lala! How are you? They do w... 28 replies

Post a Reply

No registration needed.
Simply fill out the form below.



 Optional, stays hidden.
Get notified when a reply is posted here.

4) Text Verification: *
Prevents SPAM.

Show Verification Text

with the privacy policy (20210315).

This form will be submitted securely
Privacy policy cookies information


Discussion Thread Guidelines: Any participation in the discussion threads signifies your agreement with the Terms of Use and Privacy Policy. (1) Act civilized and be respectful towards others. No profanity, vulgarity or lewd / suggestive content is allowed. (2) Posts encouraging, facilitating, or seeking advice about the abuse of medications or other substances are prohibited. (3) Personal contact information (such as telephone numbers, email addresses, etc) is not allowed to appear on our discussion threads. (4) We do not allow our forums to be used for buying, selling, trading, or for the promotion of a product or service. (5) Posting external links to other web sites is not allowed without our prior approval. (6) We reserve the right to edit or remove content which we find objectionable to the community at our sole discretion.

Note: All times displayed are GMT - 7.

This information has been independently compiled and is for informational purposes only. It is not intended to be a substitute for medical advice from a qualified healthcare professional; nor is it intended to diagnose, treat, cure or prevent any disease. For more details please see the Medical Disclaimer. This page was last updated on 16 July 2021.

We are committed to your privacy.

Copyright © 2005-2021 All Rights Reserved. MedsChat® is a registered trademark of Limelight Innovations L.L.C. 9888 W Belleview Ave #5000, Denver, CO, 80123, USA