Endocet Vs Oxycodone

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jim Says:

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rob Says:
in reply to jim, i have to agree, i have been taking oxycodone for a while now, and got a new script for endocet, and it does not do anywhere near as much as the last prescription did...

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Verwon Says:
Well, I am not sure what you were on previously, since you just say Oxycodone, but Endocet is a combination drug containing both Acetaminophen and Oxycodone.

The reason you may be having a problem, however, is due to the fact that generic meds ARE allowed, by law, to differ from name brands by as much as PLUS OR MINUS 20%. They also DO NOT HAVE TO BE EXACTLY IDENTICAL.

I know the doctors, pharmacists and FDA will tell you that they are, but this is just not true.

They only have to be biologically equivelent. Which means the active ingredients can be different, as long as they act in the body in the same way and provide the same therapeutic effects as the name brand drug did.

I am sure by reading this, you can guess how with some drugs this can cause a problem as your body is used to once substance and suddenly you might be getting another.

The inactive ingredients can also have an effect on how the medication works for some people.

You might want to speak to your doctor about having them write on your prescription that you have to have the pills that you had before. (Brand medically necessary and have them put the company name on there, for instance Watson if that was who made them!)

In addition if one pharmacy is out of the stuff you usually take, you are not obligated to get the prescription filled there. You can tell them that you are sorry, but the current brand they have does not work for you and ask them to return your prescription so you can get it filled elsewhere.

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ben Says:
I have been taking percocet 5 mg pills for a month and was ungraded to 10 mg 325 for pain. The pharmacist gave me endocet and let me tell you it does not work the same as regular percocet. When filling your script make sure you ask for brand name percocet and don't get stuck with endocet, its sucks. I had to take 3-4 times as much to feel the same as normal percocet. Everyones body is different but alot of other people have agreed with me, I wish I would have known this from the get go. Hope this helps

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mark Says:
Listen I don't know what you guys are talking about but I take percocet and endocet 10/325 and its the same pill and gives the same affect. If you get a prescription bottle for each from the manufactor endo pham. Makes both products the only difference is what is printed on one side of the pill. Percocet says 10/325 on one side and percocet on the other, and endocet has 10/325 and E712 on the other. Its all in people minds that they think its not the same because there difference names but in reality they are two alike.

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dowhatucan2stop Says:
All of you are incorrect, to an extent...even those of you who claim the amount of oxycodone in generic is allowed to be up to 20% off from the name brand manufacturer. I have in my hands, my latest prescription for Endocet 10/325. They DO in fact differ from Percocet not only in strength of pain relief, but also in PRICE. You will make a grave mistake if you have you Dr. write either medically necessary or name brand only on your scrip, because the cost per pill for brand name Percocet without the best insurance available, which I guarantee the vast majority of you do not have, is roughly $6.00 per pill. If you are fortunate enough to have very very good insurance, you will pay 50% of the cash price for the script....that is just simply the way these pharmacies work. So, on an order of 120 count 10/325 that your Dr. has written the above words, you will have a minimum charge of roughly $360.00, which is 50% of the cash price because Percocet is NOT considered a preferred drug....whereas several hundred other drugs are considered preferred and you would simply pay the $30.00 for the name brand. Trust me, crappy experience once you get to the pharmacy and find this out. Even worse is the fact that now, unless you find a wonderfully understanding pharmacist and they are willing to actually bend the law...your script is WORTHLESS. The pharmacist HAS to fill it as it is written. So-on to the generic strength vs. the name brand. My bottle of Endocet, which by the way is DIRECTLY from the manufacturer, clearly states the ingredients...read and weep=Each tablet contains Oxycodone/Hydrochloride, USP.....10mg* and Acetaminophen, USP.....325mg. Notice the * next to the Oxy dosage. Follow the bottle down to the very bottom and in VERY fine print, the * represents something else-Quote*10mg oxycodone HCI is equivalent to 8.9637 mg of oxycodone. Bottom line, PERCOCET is a full 10mg of oxycodone. THERE IS A DIFFERENCE.

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jojo Says:
Dowhatucan2stop! Even if you buy brand name percocet it will say oxycodone HCL 10mg=8.9637, this is because of the salt you know the HCL is a complex salt. So even with the brand name your are not getting a pure 10mg of oxycodone. This is with any narcotic that contains a complex salt. The salt helps in the absorbtion process in the body and metabolites. You are assuming because on the endocet bottle it says 10mg of oxycodone=8.9637 of oxycodone you are getting shorted on the opioid, this is your junkie mind spinning its wheels. Percocet and endocet are the same, you are getting the same ammount of the oxy, however the grade and quality may slightly differ, thus making you feel like you are not as high, or getting the same relief, YOU ARE STILL GETTIN THE SAME AMMOUNT OF OXYCODONE. Good try on being professor of the year award, but not enough to convince anyone with a little bit of sense.

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jojo Says:
Dowhatucan2stop here is the dosing information from the official website, I think you will enjoy this

(oxycodone and acetaminophen) Tablets, USP

Oxycodone, 14-hydroxydihydrocodeinone, is a semisynthetic opioid analgesic which occurs as a white, odorless, crystalline powder having a saline, bitter taste. The molecular formula for oxycodone hydrochloride is C18H21NO4•HCl and the molecular weight 351.83. It is derived from the opium alkaloid thebaine, and may be represented by the following structural formula:

Acetaminophen, 4'-hydroxyacetanilide, is a non-opiate, non-salicylate analgesic and antipyretic which occurs as a white, odorless, crystalline powder, possessing a slightly bitter taste. The molecular formula for acetaminophen is C8H9NO2 and the molecular weight is 151.17. It may be represented by the following structural formula:

Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen in the following strengths:

Oxycodone Hydrochloride, USP 2.5 mg*
Acetaminophen, USP 325mg
*2.5 mg oxycodone HCl is equivalent to 2.2409 mg of oxycodone.
Oxycodone Hydrochloride, USP 5mg*
Acetaminophen, USP 325 mg
*5 mg oxycodone HCl is equivalent to 4.4815 mg of oxycodone.
Oxycodone Hydrochloride, USP 7.5 mg*
Acetaminophen, USP 325 mg
*7.5 mg oxycodone HCl is equivalent to 6.7228 mg of oxycodone.
Oxycodone Hydrochloride, USP 7.5 mg*
Acetaminophen, USP 500 mg
*7.5 mg oxycodone HCl is equivalent to 6.7228 mg of oxycodone.

Oxycodone Hydrochloride, USP 10 mg*
Acetaminophen, USP 325 mg
*10 mg oxycodone HCl is equivalent to 8.9637 mg of oxycodone.
Oxycodone Hydrochloride, USP 10 mg*
Acetaminophen, USP 650 mg
*10 mg oxycodone HCl is equivalent to 8.9637 mg of oxycodone. THIS ONE IS WHAT YOU SHOULD SEE, THIS IS THE SAME AS ENDOCET, OR ANY GENERIC OR BRAND NAME 10/325 OXYCODONE/Acetaminophen

All strengths of PERCOCET also contain the following inactive ingredients: Colloidal silicon dioxide, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, pregelatinized cornstarch, and stearic acid. In addition, the 2.5 mg/325 mg strength contains FD&C Red No. 40 Aluminum Lake and the 5 mg/325 mg strength contains FD&C Blue No. 1 Aluminum Lake. The 7.5 mg/325 mg and the 7.5 mg/500 mg strengths contain FD&C Yellow No. 6 Aluminum Lake. The 10 mg/325 mg and 10 mg/650 mg strengths contain D&C Yellow No. 10 Aluminum Lake.

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jojo Says:
Even worse is the fact that now, unless you find a wonderfully understanding pharmacist and they are willing to actually bend the law...your script is WORTHLESS
Dowhatucan2stop! I also found this to be a stupid statement, considering the fact doctors know how exspensive brand name pain meds can be. 9.99 times out of ten doctors sign the script where it says subsititute permitted meaning the pharmacy can dispense a generic of their choice or yours. Considering you do not want Brand name, we all know that can cost a fortune.

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jojo Says:
I would also like to talk about the fact if you are out of your meds for a few days when you get them your body will try and catch up with the levels you are acustom to having in it. For example if I was taking percocet 10 4 times daily for a month and ran out for 3 days then got my script, my body would not feel the relief from just taking one, but after it got the level up to standard it would become comfortable there. Many people get this mixed up and think that it is generics suck, this is only true for the M brand generics Malicrodt pharmacuticals, they are terrible.

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jojo Says:
Rob, you are building up a tolerance to the meds this is why you do not get the same effects as before. This will continue to happen over the months and years until you cannot find a ned that helps, dont feel bad we are all in the same boat.

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Kathryn Says:
My experience thus far, endocet feels no different then vicodin for pain relief- percocet has killed pain the other two have not. Why this is, I don't know except perhaps varying proportions of the opiate drug. I'm not entering an opinion, I'm simply conveying my personal experience.

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woodstock 2009 Says:
the oxycodone shortage had the whole country looking for anything contain oxycodone, endocet, perocet, roxicodone, oxycontin, the year of 2008 has been the worse year for generic medications, they suppose to be the same active ingredeints but the inactive fillers can be a little different, the equilevencly of hydrocodone 10 is the same as oxycodone 15, meaning it takes that much more to receive the same releif, some people require less, this strictly my opinion

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lamagonzo Says:
I hads been taking Mallie Oxy 5/325 for about 6 months and noticed after the seventh fill that the strength had decreased roughly by HALF! I found a sympathetic pharmacist who carried two types of the Oxy: Mallie and a generic shorthand called RPh. These RPhs are approximately twice as strong as the Mallies. Does anybody know what RPh is? I'll never use MALLIE AGAIN EVER!

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Genie Says:
I read these comments and I sit here and cry, It is so sad that our Physicians are legal drug dealers, give you a med works a while and then you need more, Sad thing is they give it to you. A little more each time till you are so addicted that NOTHING works but DEATH. and that is exactly where it ends. My son died from legal drug pushers. Pain Clinic's What a laugh. God help me I am still grieving my loss. He took it the way it was prescribed, Then Fentanyl was ordered. upping the dosage each month.from 25mcg to 100mcg in 4 months. I am very bitter and I feel for family's who are going to experience the HELL of losing a child. I am on a mission to get these clinics closed. If you need meds that are strong enough for cancer pts. and dying pt's then go in a hosp. Or a rehab center, That is where you are headed. You have a choice. Rehab or Death.

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Nurse and Patient Says:
1) I've been on both ends: as a registered nurse and also a 'chronic' pain patient. Meaning my pain is not daily but recurring monthly for up to 10 - 12 days per month. I've never had a drug addiction problem but my body does respond to this 'back & forth-ness.' I write everything down for my own recording - because if I'm not careful I will sometimes experience physical symptoms of withdrawal for up to 4 days. Even if I taper down correctly......2) Verwon is right: Inactive ingredients will not always but **can** affect how a patient experiences medication. Factors vary but they can indeed get in the way of effectiveness. And generics are **not** all equal. Trust me when I say Big Pharma, the FDA, pharmacists, nurses & doctors are not all on the same page. They're not gods, only human and this means not perfect. Some pharmacists (our best resource for drug information actually - they know more about what should be happening, the ideal and also detailed drug information more than MD's) -- but some do know about this difference. Others are in denial or just brainwashed in a way, for lack of a better term. Just like other health professionals (including nurses)..... 3) I've experienced a few different brands of generic oxycodone/APAP & also brand name Percocet. Tolerance build ups notwithstanding, there is **definitely** a difference between brand & generic as well as generics themselves - re effectiveness and sometimes side effects. Again, factors vary. People who rarely take this kind of an Rx tend to be more sensitive and less likely to notice any such differences in terms of effectiveness. Percocet 2.5 can hit 'infrequent-flyers' like a big stone on the head. Vs. someone like me, 2.5 would not touch my pain at all (even my regular physician was horrified when I returned from a vacation once many years ago. Because I I'd had a very messy emergency and the clinician at the walk-in facility prescribed 2.5's after treating me. My doctor back home was actually very upset, almost called her. And I digress).....Anyway, this is based on my experience with med-surg in-patients reporting to me as well as my own personal feedback.....4) Since my Rx schedule is fairly regular and again, I'm aware of the tolerance factor, I believe I can tell the difference (subjective, of course) between the generics.....Last time I went to the pharmacy I was given Mallinckrodt oxy/apap 5/325 (4.48 mg oxycodone hydrochloride/325 mg Acetaminophen) and a few other times, too. I always go to the same pharmacy for this when in my current home city and they will also use other generic brands. Long way around to saying that in my experience Mallinckrodt is not as effective as others..... 5) There is no way any of us can know what goes on during manufacturing outside of inspection times. I still believe most people are good but all pharmaceutical companies are businesses and they want to make money, profits (we're talking billion$$ in the double digits + for them), same as most of us need to. Only they are not always 100% honest about what goes into pills & capsules, side effects, true effectiveness, etc. Google it, there have been lawsuits.....6) Re what Woodstock 2009 Says and only to clarify: Hydrocodone combination products are not as strong as oxycodone. Typically it is that 15 mg of hydrocodone mixed product (example: as in when blended with acetaminophen) is about the same as 10 mg of oxycodone. Less oxycodone blended product (per mg) is needed to get the same relief **if** they both would work at some dosage for a person's pain. Last I checked oxycodone + it's blended products are Schedule 2, 'plain' hydrocodone is also schedule 2. Hydrocodone blended products are Schedule 3. And if anyone is wondering, something like heroin is considered a Schedule 1 drug......7) Best to have your MD write a prescription so that you have a free & clear choice between brand name or generic.....8) It's kind of crazy sometimes from my perspective - because I'm trained to recognize drug seeking behavior so I'm always of 2 minds. To be honest (& so very human!) it's hard not to get a smidgen paranoid when I have to advocate for myself. When I once needed to ask a pharmacist about something related I could see the red flags in his eyes. He was polite but I could see & feel what he was thinking. Then twice in the last 3 years I had to go to the ER at a local hospital at night. I told the hospital physicians about my regular Rx (which I was in between) and comfortably it seemed, both times, they went on and prescribed pain meds. This was appropriate. But when I next saw my doc & told him it was very stressful. He was not thrilled but was really okay about it in the end.....At another much later time, after seriously delaying the reporting of feeling under-medicated: suffering motivated me to finally get honest and advocate for myself. We had a long discussion about the tolerance - dependency- potential addiction aspects and he said was not worried. But, naturally, he was now aware of this change Which is what should happen if a doctor is diligent & true. He did increase the number of tablets of my prescription. But I never want to experience that again.....10) In my 'world' there is a cure for all adverse medical conditions. They just have to be uncovered. This is my sincere belief. I've also been trained in the use of a short list of holistic treatments and make use of those for myself as well. combining methods can sometimes help. My doctors never mind this as long as I am not being harmed. I consider an integrated, holisistic approach to my health care since there is no legitimate need for modalities to be at war. Any MD or NP who is trained and experienced in additional therapies knows this.....I intend to be well - so to not need narcotic medication for the rest of my life. Incidentally, I do think that these kinds of strong, narcotic Rx's will be a thing of the past sometime within the next 100 to 150 years. That new discoveries & understandings will naturally allow for this. Until that time (and after, too): making use of our resources (including experienced, smartly educated professionals) & **self-education**, self-advocacy -- and no one being alone in this -- these things are key. The medical model will be very different in the next century and that will be a blessing for everyone.

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tragicend Says:
Was on Watson 10/325 oxy. Made the mistake of taking script to different pharmacy. They filled the script with endocet. I realize it's the same drug, but the generic Watson seemed to be much stronger. Just my opinion. Thanks for all you're interesting posts.

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Teresa Says:


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Lynn Says:
I began taking oxycodone 10/325 for extensive dental work. I had 3 scrips filled... First was the long white oxycodone, second was the round circle oxycodone, and third was the Endocet. The round oxycodone worked the best for me and had the fastest and most consistent results. The long white oxycodone hit me like a ton of bricks the very first time (not much of a pill taker), but never got that feeling again with them... maybe if I didn't eat... The Endocet takes over 2 hours to start working and makes me itch like crazy. I am now on percocet 10/325 due to extensive nerve and spine damage... I ONLY take one pill per night before bed to help function during the week, and nothing on the weekends. I intend to stay on this system for as long as possible (I went 11 months without any insurance and no help w/ pain and didn't realize how much pain I was in until the dentist prescribed them to me). Anyways, I rarely take medication, in no way abuse these pills and I notice a difference in them. The Endocets irritate me enough that I will be ensuring that I do not end up with them again, but the oxycodone... I will take the long ones one an empty stomach with a cup of milk... and the round ones are great, so either/or, I'll make it work.

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dmlogan Says:
Lamagonzo, I st your bubble but the RPh on your lable stands for the registered pharmacist who filled your RX. It is not a brand but where the pharmacist is suppose to put their initals for fill the that bottle.

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Charles Says:
From what I have read from some
of you. Most of you's got it made.
What I mean is that everytime I ask
my Doctor for the Endocet 7/325
she tries to redirect me to an Orthopedic whereas I know that even a regular Doctor can give you
a prescription. I have no problem paying for this GENERIC brand of
Endocet. When I was getting this
medication from my wife Surgeon,
I only had to pay $2.40 regarless of the amount. I have 3 herniated disks and you can believe it's no laughing matter. Any activities that I do in the household I definite need me a tablet or two in the aftermath. Anyway Endocet work fine for me. Try 7.5/325 or 10/325.
The 325 is only aspirin which does
nothing. So ask your Doctor for a
higher MG and less aspirin.

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