Oxycodone

Category: Pain Relief

Oxycodone is is a semi-synthetic opioid medication used for managing moderate to severe acute or chronic pain when other treatments are not sufficient. It may improve quality of life in certain types of pain. Oxycodone combination products are manufactured with Paracetamol (Acetaminophen), Ibuprofen, Naloxone, Naltrexone, and Aspirin.

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Boxed Warning

WARNING: ADDICTION, ABUSE, AND MISUSE; RISK EVALUATION AND MITIGATION STRATEGY (REMS); LIFE-THREATENING RESPIRATORY DEPRESSION; ACCIDENTAL INGESTION; NEONATAL OPIOID WITHDRAWAL SYNDROME; CYTOCHROME P450 3A4 INTERACTION; and RISKS FROM CONCOMITANT USE WITH BENZODIAZEPINES OR OTHER CNS DEPRESSANTS

Oxycodone Hydrochloride exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Each patient’s risk should be assessed prior to prescribing Oxycodone Hydrochloride, and monitored regularly for the development of these behaviors and conditions.

Contraindications

Oxycodone Hydrochloride is contraindicated in patients with:

  • Significant respiratory depression
  • Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment or hypercarbia
  • Known or suspected gastrointestinal obstruction, including paralytic ileus
  • Known hypersensitivity (e.g., anaphylaxis) to oxycodone

Possible Side Effects

  • Addiction, Abuse, and Misuse
  • Life-Threatening Respiratory Depression
  • Neonatal Opioid Withdrawal Syndrome
  • Interactions with Benzodiazepines or Other CNS Depressants
  • Adrenal Insufficiency
  • Severe Hypotension
  • Gastrointestinal Adverse Reactions
  • Seizures
  • Withdrawal

Other less frequently observed adverse reactions from opioid analgesics, including Oxycodone Hydrochloride Tablets may include:

  • Blood and lymphatic system disorders: anemia, leukopenia
  • Cardiac disorders: cardiac failure, palpitation, tachycardia
  • Gastrointestinal disorders: abdominal pain, dry mouth, diarrhea, dyspepsia, dysphagia, glossitis, nausea, vomiting.
  • General disorders and administration site conditions: chills, edema, edema peripheral, pain, pyrexia
  • Immune system disorders: hypersensitivity
  • Infections and infestations: bronchitis, gingivitis, infection, pharyngitis, rhinitis, sepsis, sinusitis, urinary tract infection
  • Injury, poisoning and procedural complications: injury
  • Metabolism and nutrition disorders: decreased appetite, gout, hyperglycemia
  • Musculoskeletal and connective tissue disorders: arthralgia, arthritis, back pain, bone pain, myalgia, neck pain, pathological fracture
  • Nervous system disorders: hypertonia, hypoesthesia, migraine, neuralgia, tremor, vasodilation
  • Psychiatric disorders: agitation, anxiety, confusional state, nervousness, personality disorder
  • Respiratory, thoracic and mediastinal disorders: cough, dyspnea, epistaxis, laryngospasm, lung disorder
  • Skin and subcutaneous tissue disorders: photosensitivity reaction, rash, hyperhidrosis, urticaria
  • Vascular disorders: thrombophlebitis, hemorrhage, hypotension, vasodilatation

Overdosage

Acute overdose with Oxycodone Hydrochloride Tablets can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and in some cases, pulmonary edema, bradycardia, hypotension, partial or complete airway obstruction, atypical snoring, and death.

Opioid antagonists, such as naloxone, are specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to opioid overdose, administer an opioid antagonist.

References:

  1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=96ad4352-fff3-46a7-85de-466cc161045e&audience=consumer
  2. https://en.wikipedia.org/wiki/Oxycodone

Dosage List

Oxycodone OP;10
Oxycodone Hydrochloride 10 mg Oral Tablet, Film Coated, Extended Release
NDC: 0093-5731
Labeler:
Teva Pharmaceuticals USA Inc
Oxycodone OP;20
Oxycodone Hydrochloride 20 mg Oral Tablet, Film Coated, Extended Release
NDC: 0093-5732
Labeler:
Teva Pharmaceuticals USA Inc
Oxycodone OP;40
Oxycodone Hydrochloride 40 mg Oral Tablet, Film Coated, Extended Release
NDC: 0093-5733
Labeler:
Teva Pharmaceuticals USA Inc
Oxycodone OP;80
Oxycodone Hydrochloride 80 mg Oral Tablet, Film Coated, Extended Release
NDC: 0093-5734
Labeler:
Teva Pharmaceuticals USA Inc
Oxycodone A214
Oxycodone Hydrochloride 15 mg Oral Tablet
NDC: 0228-2878
Labeler:
Actavis Elizabeth LLC
Oxycodone A215
Oxycodone Hydrochloride 30 mg Oral Tablet
NDC: 0228-2879
Labeler:
Actavis Elizabeth LLC
Oxycodone M;0552
Oxycodone Hydrochloride 5 mg Oral Tablet
NDC: 0406-0552
Labeler:
Mallinckrodt, Inc.
Oxycodone M;15
Oxycodone Hydrochloride 15 mg Oral Tablet
NDC: 0406-8515
Labeler:
Mallinckrodt, Inc.
Oxycodone M;30
Oxycodone Hydrochloride 30 mg Oral Tablet
NDC: 0406-8530
Labeler:
Mallinckrodt, Inc.
Oxycodone 4810;V
Oxycodone Hydrochloride 5 mg Oral Tablet
NDC: 0603-4990
Labeler:
Qualitest Pharmaceuticals

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