Mylan Mirtazapine Does Not Work (Top voted first)

Updated

Has any one else experienced this? I had to start using the Mylan version of Remeron / Mirtazapine and I now get sever leg cramps, headaches and the return of my depression. It’s as though it has NO active ingredient in it. The name brand Remeron puts me to sleep about 15 min after taking it, but the Mylan generic for of Remeron/Mirtazapine does not. I stay awake for hours. I can not afford the name brand remeron at $187.00 a month but I am to afraid if I try to use the Mylan version again the worse will happen. I am kind of between a rock and a hard place over this. But I have switched back and fourth enough times now that I know the Mylan version does not work. I get this from Walgreen’s in IL and I am looking for similar problems. Walgreen’s tell me they will not carry another generic brand. They say Mylan is a trusted company in the generic medication business…???

38 Replies (2 Pages)

Page:1Last Page
Earliest Newest Votes
4

I decided to get the real thing in the soluble tables (remeron rd) from canada. (Doc wrote prescription for Remeron SolTab (american name for remeron rd) I'm getting it for $93.50 for 90 day supply. It's the real deal, and since for the same time frame would have been $30 out of pocket for generic ($10 x 3mos), I'm alright paying the extra $20/month to not have to deal with begging the insurance company or dealing with generics. Mylan xanax also sucks for me. I don't know why Mylan makes such crap and no regulatory bodies even notice. They seem to make their tablets so coated that the meds never get into my system before the pills have been pooped out. Xanax and Remeron are two drugs I want working as soon as they are swallowed. I feel Mylan might as well just put chalk in their pills for all the good they do. BTW I use Greenstone for xanax, but have to shop around. Nothing wrong with asking what generic you'll be getting --before-- letting the pharmacy have your prescription. I've had to change from Safeway to Shoppers to RiteAid to Harris Teeter to keep a good xanax brand. Seems like price is the ONLY thing pharmacies and insurance companies care about. I believe the generics do have the same active ingredients, but I'd argue about the bio-availability of the meds from generics any day.

Was this helpful? 3
6

Walgreens just switched from Teva to Aurobindo. The Aurobindo Mirtazapine does not do a thing for me and now I can't sleep!

Was this helpful? 3
2

Mylan is a large and well known generic manufacturer - but what you're reporting is quite common as far as generic medications differing from their counterparts. Even generics with the same active ingredients coming from different manufacturers can react differently between individuals, and this is because the inactive ingredients and manufacturing process can actually differ. You might want to look around and see if you can obtain Mirtazapine from one of the other large generic manufacturers.

To name a few: Teva, Watson, EON Labs (now Sandoz), Roxane ... and there are more manufacturers of this medication than what I have just listed.

It's a pain that Walgreens only carries this particular brand. Check with other places to see who they carry it from.

To Amateur Neuropsych - Do you remember the manufacturer of the generic which you had that worked as well as the name brand?

Good luck !

Was this helpful? 2
3

YES! It is very true... the Mylan version of Mirtazipine causes so much stomach discomfort for me... I compared the ingredients of Mylan's and Teva and have noticed way more ingredients in the Mylan version than in the Teva. In addition, the ingredients are much different in the Mylan version than the Teva... I don't understand why this would be? in addition to the stomach cramps and pains, I've also noticed that it also doesn't seem to work at all... I would normally fall asleep on 30 mgs of any other generic brand but Mylans... It doesn't even seem to have the proper active ingredient... this is ridiculous!!! There is got to be more people than just the 2 of us here complaining about the difference...

Was this helpful? 3
5

I'm living in Europe and for what it's worth I will try my best in English to share my experience with mirtazapine. When I started it some years ago I used the Remeron (Sandoz) and this one put me to sleep in no time. I used 15mg and had to cut down to 7,5 mg because in daytime I would be to sleepy and sedated. I ended up taking 1/6 of a 15mg tablet to sleep properly, occasionally after drinking a few beers in the evening. Since they started only selling the soleTabs to dissolve in the mouth, it really didn't seem to work anymore. The I tried the Mylan brand but that didn't help me neither. Now I've looked for an alternative brand Eurogenerics and I'm sure hoping to get some sleep again. I'm really feeling desperate! So I end to agree that the generics have the same active ingredients but not the same bio-availability. I must add to the discussion that I take a PPI, proton pomp inhibitor, Omeprazole and perhaps I don't have enough stomach acid to break down to coating of the Mylan brand?? Are there other people that take some anti-acids along with the mirtazapine?

Was this helpful? 2
7

I have been taking Mirtazapine for 9yrs. I moved to Spain 4yrs ago and continued getting my prescriptions here. However, recently ALL the chemists in my town seem to only have Mirtamylan. I have had terrible side effects...not being able to sleep; tension: extreme fatigue; whole body hurting; fuzzy thinking; depression returning. It took me a while to work out that it is the generic 'Mirtamylan' causing this. I feel so fed up and yes, depressed which is what I was taking it for in the first place.

Is atge Mirtazapina Teva brand ok?

Was this helpful? 2
8

Mylan Fentanyl patches and Mylan Budesonide (generic for Entocort) are both not as effective as their counterparts. Watson patches last the 72 hours that they are supposed to - the Mylan, 48 hrs at best. Opiate withdrawals should not be tolerated to increase a companies (or some individuals) bottom line.

Was this helpful? 2
10

I was put on remeron once in treatment and it was horrible. Felt like was going to have a heart attack and put 30 lbs on. didnt help my issues either

Was this helpful? 2
11

yep it doesnt work. I've been depressed and awake long enough

Was this helpful? 2
21

I'd like to confirm that Mylan is an inferior product. Been taking mirtazapine for 7+ years, and always did OK with teva or aurobindo. the Aurobindo 30mgs work fine for me, i take one and a half. Recently I got a new script and the pharmacy gave me mylan 45mg. Five days later, I've been feeling like s*** and wondered if it's the change to Mylan.. I take other meds and nothing else has changed but the mirtazapine manufacturer. Guess it's true that such variation exists - where if Aurobindo isn't as good as brand name Remeron, it's still OK by me, and yet this Mylan is crap.

I know mirtazapine is chiral and has 2 steriosomers. The S- being more potent than the R-. Separation of chiral isomers is among the most difficult tasks in chemistry, so my guess is that the ratio of S:R enantiomers is what causes this discrepancy. The FDA prob only tests for potency, and they see 30mg of racemic mirtazapine present in a 30mg pill, not bothering to check the S:R ratio of enantiomers

So I wish to offer this as an explanation for why generic mirtazapines vary so much. And to confirm that mylans are inferior.

Was this helpful? 2
1

YES! I did notice a much reduced effect. There was some other generic I had before that worked like the name brand.

Was this helpful? 1
9

I also have had sleepless nights with generics for Remeron, but have found that the TEVA brand will work for me. The difficulty is always having to check each time to make sure that the pharmacy fills it with only the TEVA brand. I use CVS and the local pharmacy can't seem to get it right; however I've had great success with their mail order. Evidently they did not fill my new prescription with TEVA since it is not working tonight!

Was this helpful? 1
12

I've been taking Mirtazapine 45mg for 18 months and find the TEVA brand (orange box) of mirtazapine totally useless. I just spent the last few weeks in despair with no sleep and sinking deeper in to depression everyday.

I tried to think what had changed in my life to make me feel this way, that's when I realised I'd previously had the same brand of pills from my chemist up until my last prescription. I went back to my docs who dismissed this idea but after persisting somewhat eventually wrote me another prescription to try and find a chemist stocking a different brand to TEVA.

I was hoping to get the same manufacturer i'd had before but was given Medreich brand instead which I'd never heard of so was a little worried. That night I slept ok and instantly felt better the next day. Now 1 week later I'm back to how I was and getting proper sleep.

I also take Omeprazole to reduce stomach acid and as the other poster says, maybe this does have an effect on breaking down the TEVA brand. Either way, there is most definitely a difference between generics. I get the same with my Omeprazole, were only the Losec brand works.

Was this helpful? 1
15

Same thing happened to me! I now get the mirtazapine from CVS.

Was this helpful? 1
17

I've been on the Aurobindo generic Mirtazapine for 5 years now. I've only tried the brand name once and didn't see any difference to warrant paying out of pocket for it being I'm a military veteran. With that said 7 days ago I received Mylan Mirtazapine from the VA meds by mail. They changed their generic brand Aurobindo to Mylan. The first night I started this past Friday my heart started racing. Few nights later I started feeling extremely panicked & felt like I was having withdrawal symptoms. Just the slightest sounds would set me off. Needless to say I had to call my Pdoc and have him write a script outside the VA. I had to call three places before Walmart said they carried it at the tune of a $148.00. Which I might not be able to recoup if my Pdoc won't authorize it. The VA as well as civilian pharmacies change up brands to save a few cents on a order. I've had the pharmacist tell me on a order for a different medication in the past was like 53¢ difference between what was he was getting before. And it landed me paying for another drugs outta my pocket. Here's how this a works. The generic brands as many of you noted have different fillers in them. And the active ingredient doesn't have to be the same as its brand name counter part. Also they delivery system each drug has maybe different. Hence the side effects and not working proper for everyone. Some folks just don't have troubles with switching brands. And as you all can see a lot of us do. Here's the crazy thing. The Ativan I take in generic form is made by Mylan. And its the only generic I can take that works 1/2 of what Wyteh made back in the day. That was the best anxiety med I had ever taken. But a lot of you may not know there is no more brand name Ativan. It may look like the same pill but its not. A little research helped me out on that. Bottom line is its not fun being subject to lessor quality meds. Because right now I'm in withdrawal symptoms waiting for the Aurobindo to get back in my system. Don't be afraid to stand up for ya self's. Wish you all good thoughts. Regards Doc21

Was this helpful? 2
18

I have been on the Mylan version of Mirtazipine. It gives me the worst headache ever! I wish they wouldn't switch generic co meds around. The othe was from Meda ( I think) and I did fine with that. Do not try Mylan Mirtazapine.

Was this helpful? 1
20

I prefer Teva brand. It always worked better for me. Less headaches than Mylan Mirtazapine

Was this helpful? 1
24

It sounds like the consensus is that mylan is the worst mirtazapine. I have been on remeron for 10 years. I notice differences between brand and all the different generics, none seem to work the same. Lately I've been taking the mylan and it does put me right to sleep and helps with my appetite which is good for me, but the one thing about mylan is I feel really cranky and irritable during the day and my anxiety is higher than any of the others too. It's weird, they're all like slightly different meds. The brand is good but keeps me too sleepy all during the next day. The watson one didn't seem to work very well. The teva one for me was OK but my leg muscles felt numb and wobbly after awhile on it, it was really strange. I haven't tried the Aurobindo one yet but I think I might on my next refill since the mylan one I've been taking is making me irritable, even having chest pains the next day at times. Anyone who tells you there's not a difference between brand and generic or differences between all the generics just hasn't had the experience of being on a psych med long term where even slight differences can be very pronounced.

Was this helpful? 1
26

I've been taking the Aurobindo brand for a few weeks and I think it is more like the brand than any others. I really like it. The Mylan one still helped me sleep and eat but for whatever reason I was so edgy and angry all the time on it. I've been taking mirtazapine for over 10 years and tried almost all the generics as well as brand and I like Aurobindo the best. And I can assure you they're not all the same.

Was this helpful? 1
33

I have the same problem, didn't even know there were different brands but when I got my repeat prescription it didn't work, I couldn't sleep. Went back and chemist gave me Aurobindo and it was even worse. Now I don't know what to do. Will go back to chemist probably and try to explain neither of the two latest brands work. Unfortunately I had thrown the box away from my original prescription so I have no idea which brand worked.

Was this helpful? 1
Page:1Last Page

More Discussions:

Aurobindo Mirtazapine does not work

Is anyone experiencing the same symptoms? I am on Mirtazapine 15 mg for over 10 years, and I am taking Aurobindo Mirtaza...

1 REPLY
Does MIRTAZAPINE 15mgs CAUSE depression

My daughter was prescribed Mirtazapine for insomnia. Does it cause depression? ## It's actually a type of antidepres...

3 REPLIES
what does mirtazapine look like

this tablet is white and round. blank on one side and what looks to be a capital E on the other with the numbers 222 und...

1 REPLY
What does a 30mg Mirtazapine pill look like

I have found these 30mg Mirtazapine pills of mine and do not remember them being prescribed. So I just need to confirm w...

1 REPLY
Mirtazapine (remeron) - help me understand how it works!

Hello, I need help to understand how this antidepressant works for anxiety. I am suffering from severe anxiety (suspecte...

1 REPLY
I Have Been Taking Mirtazapine For Last 6 Days And Feel Very Dizzy Tired Stiff Neck Headache Migrane Musles Pain When Does It Dissapear

Mirtazapine for last 6 days. I feel very dizzy, sleepy, tired, anxious (it was actualy prescribed for my anxiety),quick ...

4 REPLIES
DO NOT TAKE MIRTAZAPINE

I was put on mirtazapine due to weight loss and am coming off it. IT is a difficult drug to come off and I am going thro...

2 REPLIES
does mylan oxy 15 mg work as good activis

My friend had been taking activis and had done good with it. Is the mylan brand just as As good?... ## It really depends...

1 REPLY
Buproprion SR 100 Mylan Not Working

Has anyone been experiencing a problem with their Buproprion SR 100 by Mylan recently? My spouse got her new prescriptio...

1 REPLY
Sinemet does not work in the afternoon

My father (63), PD patient for around 20 years. We always had hard time adjusting a perfect dosage for him. # Right now ...

1 REPLY