Fixcom 4

Side effects and use

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Sorry, this isn't available in the U.S. and other countries do not regulate their drugs as strictly, so I am unable to find any information on it.

I suggest you ask your doctor or pharmacist for more info.

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Fixcom 4 tab (ANTI-TB AGENT)
MANUFACTURER: Natrapharm -Phils.
DISTRIBUTOR: Natrapharm

CONTENTS: Rifampicin 150 mg, INH 75mg,
pyrazinamide 400 mg, ethambutol 275 mg

INDICATIONS: Treatment of pulmonary & extra-pulmonary TB.

DOSAGE: Patients weighing <55 kg 3 tab/day 55-70 kg 4 tab/day >70 kg 5 tab/day. Duration: 2 mth.
ADMINISTRATION: Should be taken on an empty stomach (Take 1 hr before or 2 hr after meals.).

US FDA PREGNANCY CATEGORY - Not established

CONTRAINDICATIONS: Rifampicin: Patients w/ jaundice. Pyrazinamide: Liver damage, acute gout or hyperuricemia. Ethambutol: Optic neuritis.

SPECIAL PRECAUTIONS: Pregnancy & lactation. Rifampicin: Monitor liver functions & blood count. Preexisting liver disease. W/draw therapy when thrombocytopenia, purpura, hemolytic anemia or renal failure occur. INH: Patients w/ convulsive disorders, history of psychosis, hepatic or renal dysfunction. Patients at risk of neuropathy or pyridoxine deficiency including diabetics, alcoholics, malnourished, uraemic, pregnant or infected w/ HIV. Discontinue upon manifestation of symptoms of hepatitis eg malaise, fatigue, anorexia & nausea & elevated serum aspartate aminotransferase conc. Perform periodic eye exam. Slow acetylator patients. Pyrazinamide: Patients w/ a history of gout; impaired renal function. Increased difficulty in controlling DM. Ethambutol: Patients w/ visual defects, elderly, childn. Discontinue when visual disturbances arise. Reduce dosage in patients w/ impaired kidney function.

ADVERSE DRUG REACTIONS: Rifampicin: Cutaneous syndrome, flu syndrome. GI disturbances & bleeding, erosive gastritis. Ulcerative, eosinophilic & pseudomembranous colitis. Transient liver function abnormalities, hepatitis, thrombocytopenia, purpura, eosinophilia, leukopenia, hemolytic anemia, renal failure, menstrual disturbances. Headache, drowsiness, ataxia, dizziness, numbness, edema, myopathy, muscular weakness. Orange-red discoloration of the urine & other body fluids. INH: Peripheral neuritis, psychotic reactions & convulsions, increase in liver enzymes, hepatitis, anemia, agranulocytosis, thrombocytopenia, eosinophilia, skin eruption, fever, casculitis, nausea, vomiting, pellagra, purpura, hyperglycemia, lupus-like syndrome, urinary retention & gynecomastia. Pyrazinamide: Hepatotoxicity. Ethambutol: Retrolobular neuritis, visual field constriction, central or peripheral scotoma, green-red color blindedness. Confusion, disorientation, hallucination, headache, dizziness, malaise, jaundice, transient liver function, peripheral neuritis, thrombocytopenia, pulmonary infiltrates, eosinophilia, GI disturbances. Hypersensitivity reactions.

INTERACTIONS: Rifampicin: Antacids, anticholinergics, opioids, ketoconazole, preparations containing bentonite. INH: Hepatotoxic drugs, carbamazepine, ethosuximide, phenytoin, diazepam, triazolam, chlorzoxazone, theophylline, enflurane, clofazimine, cycloserine, warfarin, alcohol, Al-containing antacids. Pyrazinamide: Probenecid.

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hi,
im currently taking fixcom 4, would it be advisable if i continue breastfeeding?

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hi im taking fixcom..can i still take l-glutathione + NAC supplements?? thank you!!

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i am taking fixcom 4 for 1 month now but will have a medical exam for my work, would that still be detected?

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what is next after taking Fixcom4 after 2 mos? Do i need to take another medicines? For how long again? Thanks...

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Hi. I was diagnosed to fave a mild TB after doing my chest xray. However, I have hepa B & fatty liver but my Pulmonologist prescribed for me to take 4 tabs of Fixcom 4 daily. She likewise adviced me if I noticed yellowish in my eyes, I would discontinue taking Fixcom 4 & report back to my her. Is it safe taking Fixcom 4 considering I have Hepa B & Fatty Liver? Or do I have to consult my Gastroenterologist first before taking Fixcom 4?

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I had been diagnose with pneumonia 2 months ago and i'd been prescribed with diff antibiotics. now i need to take fixcom 4 for 2 months, after that what would be the next? how long is the treatment for pneumonia? hope someone can help.

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i was hospitalized a week ago because of chills, extreme night sweating, and mild fever, the doctor thought it was swine flu (though I was thinking of asthma) so they confined me at the hospital. After a series of lab tests, including x ray and sputum test, I was diagnosed of PTB. The x ray revealed a TB spot on the upper portion of my left lung, the sputum test came out to be negative, but the doctor told me to start medications. Just this morning, I went to the pharmacy to buy FIXCOM 4, I drank three tabs, and ate my breakfast right away. Just now, while am browsing over the web, I found out that the tablets should be taken with an empty stomach. Im quite confused and somehow worried right now. You see, am also under medication for hyperthyroidism, am extremely worried about the side effects. Kindly help me get through this. Thanks

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hi, i was advised by my pulmo to take fixcom 4 for 4 times a day before meals.. i just want to ask will it be possible that i'm goin to be cured for two months 'cause i'm planning to go abroad as soon as possible. thanks

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I am taking Fixcom 4 one month ago. And i was advised by my doctor to take 4 tabs a day which in fact i only weigh 51 kg. Was this over dose? What would be the effect on this to my health? Reply please....

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my mom was diagnosed wd tb meningitis,diabetis mellitus and hypertension..4 her tb she was taking fixc0m 4...after several days she was experiencing cough..itchy in her throat...s 8 one of the side effect on the med fixcom4?tnank u.

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my father is taking fixcom 4 and was advised to by his doc to take for 6 months he has also diabetes mellitus

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I have been taking fixcom 4 for a month and after my monthly check up I am now taking Fixcom 3 but same 4 tabs a day

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my mother was diagnosed with PTB she was taking fixcom4 3x a day as per her pulmonologist. she experienced vomitting and is not eating well.are that side effects of the drug?do you have other option or replacement on that medicine cause we think her body is not responding well to that medication?

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hi!is it true that if a person is taking an anti-tb drug they are active to sex?coz my husband has a mild tb and working abroad i'm afraid he might do it w/other women there.thanks!hoping for your reply. PM me for your reply.

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hi! is it true that if a person is taking an anti-tb drug they are active to sex? coz my husband has a mild tb and working abroad i'm afraid he might do it w/other women there. thanks! hoping for your reply. PM me for your reply.

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im currently taking fixcom4 for 2wks and i will be taking it for 2months, if im going to have my chest xray after 2months would it be still visible (the spot) because im planning to go abroad before the year ends...pls reply thanks

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I was diagnosed to have TB and currently taking fixcom 4 for already a month. I was advised to take four (4) tabs daily for 2 months therapy and 4 months maintenance. I have some concern because I have cataract on my both 2 eyes for the last 2 years. Should I continue taking the medicine or further consult a doctor. Thanks

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hi..i'm taking fixcom 4 for almost a week..and im going to have a drug test next wek,will it show in my urine that i have TB?

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Hi, I am currently taking Fixcom4 tab every morning with empty stomach. I have my itchy skin rashes, yellowish in urine, my eyes turning yellow I don't have any health problem except for PTB (Mild) would it be possible to get heal for just a month or a weeks? I take medications as prescribed by my doctor. Thank You please I need an answer.

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Fixcom-2 tablets are hard to find in mercury drug stores. The pharmacist said there's no medicine by the name of Fixcom-2. He said that it is Fixcom-3 and 4 only, but my doctor prescribed me this medicine.

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My GF is taking Fixcom 4 for 1month now. we noticed that her skin color has gradually changed. her face to be exact but her body is still the same. she has a fair skin but we noticed he became almost tanned or brownish

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All you can see here are questions and never find an answer! What the heck!

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Same po tayu yan din po nararamdaman ko after 3weeks nakakaramdam ako ng pananakit sa may kaliwang bahagi ng likod as in makirot to da point minsan i can't breath..

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Hi.. I was diagnosed that i have PTB in the left upper lung when i took medical exam for my work. And now i am taking fixcom4 3tabs a day for one month. My sputum test is negative. When i started my medicine i feel my tummy is bloatedand a feeling of my eyes want tocclose.. After 2 3 weeks my eyes is colored red and yellow
. i feel pain on my chest and sometimeson my neck.. What would it be? Please reply thank you

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i take fixcom 4 but i have hep b..what happen to my liver is it worsen my illness or not plz help me

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Hi, I just want to ask, how if i missed to take 1 tablet of fixcom 4. What should I do? or What will happen to me? thank you..

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hi there, i am also have same case like yours i already finish the 6 months medication last month, i did xray after 2 months of taking fixcom 4, its still visible but less than the first xray i had,

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I had been taken Fixcom 4 for two months. I am now on Fixcom 3 for a month. I will need three months more in order to finish six months of TB meds. I have been reading about Fixcom online and found that people are really talking seriously about making sure that it's taken on an empty stomach. I actually haven't been following that rule. I take it daily on empty or not empty stomach. Should I restart everything all over again? Meaning, should I go back to Fixcom 4 again for two months?

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