Which Is Stronger: 30 Mg Of Morphine Sulphate Er Or 10 Methadone (Page 3)

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I am in a confusing debate with my ex husband: Which is stronger, 30 mg of morphine sulfate E.R or 10 mg of methadone?

124 Replies (7 Pages)

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41

Dude you are not right I've been on every pain killer out cause people discriminate against methadone.methadone is way stronger than morphine the ratio is 1mg of methadone to 10 mgs of ur garbage morphine.either you want a buzz or dnt know what ur talking about have a good day sir.

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42

I'm having a problem. I started taking opiates and I'm very upset I got this far. I wanted methadone to help wean myself off. I had to settle for morphine pills ...will the morphine pills help subside sickness? Please respond. Thank you.

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43

I'm in England, so apologies for 'gate-crashing' this forum :-) In my personal experience, as well as what I do know in pharmacology...
Methadone (particularly as hydrochloride salt) is more potent than morphine. Mainly due to - oral methadone having a higher bioavailability - up to 98%, oral morphine salt at around 50 - 60% (very approx.) But, it seems that the opiates that are directly-derived from opium, have a more noteable euphoric-effect than opioids which are synthetic or semi-synthetic. Once you've passed tolerance for the likes of morphine and codeine, you have to expect a 'less-natural' euphoric effect with the synthetic and 'altered' opioids. Compared to morphine, methadone acts on both u-opioid and o-opioid receptors. Morphine will occupy mainly u-receptors (higher concentration). And as diamorphine is twice more potent than morphine (both oral), logically methadone would be at least twice the potency of oral morphine. I believe taking the drug diphenhydramine along-side methadone, seems to increase effect just a little bit. But I think that due to its mimicking of a serotonergic action - like that of tramadol. Sorry, i'm blubbering! haha. This is only my opinion, and I know that I probably know very little compared to most of u, so please don't think i'm trying to come-across as though 'I know best'... lol. Lastly... (I promise!)... I can't imagine the difficulty and pain ur relatives are having to deal with, so I can only empathise :-( But, do inquire with their G.P. about introducing and axiolytic, even (surprisingly), and anti-psychotic - namely haloperidol or Levomepromazine - even if its a very small dose, and a drug that will increase serotonin-levels in the brain (particularly the SSRI's) as their sedative and anticholinergic effects and increased serotonin - both help deal with pain, incorporating a psycho-somatic affect of increased pain-relief from the opioid(s).

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44

I've been on both of these meds, and without question, Methadone is a much stronger drug and will make you dose off in the middle of the afternoon when you feel that you are completely aware of what's going on with your medication. My advise, STAY AWAY from METHADONE, It's a nightmare waiting to happen.

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45

Go to a methadone clinic. They will give you a raise until you feel comfortable. You must say that you have a problem with drugs. You do know the *****s won't give it to you. I have had to do this 3 times. Dr's promise me relief but after a yr I am still in excruciating pain. Methadone works like a charm.

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46

I AM A CHRONIC PAIN PATIENT. HAVE BEEN FOR OVER A DECADE. CAN SOMEONE EXPLAIN WHY AFTER BEING PRESCRIBED 130mg / day OF METHADONE FOR OVER 8 YEARS WITH NO PROBLEMS, I'M NOW BEING CUT DOWN TO 30mg/day ?? WHILE IF I CHOOSE I CAN GO TO A METHADONE CLINIC AND BE STARTED OF WITH 50mg/day AND QUICKLY MOVE UP TO 290mg/day. THIS IS THE REALITY HERE IN WA STATE. WHEN I BRING THIS FACT UP TO MY PAIN DOCTOR, THERE IS NO PLAUSIBLE EXPLANATION. THE DOCTOR ACTUALLY GETS PISSED OFF AT ME FOR ASKING THE QUESTION, AND HAS TOLD ME IF I DONT LIKE TO SEEK ANOTHER DOCTOR.

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47

Just in case anyone out there is considering taking on methadone....my advice is not to ever start...once started most will never get off...these methadone clinics are legal drug dealers... usually they will always increase ur dose...it will destroy your teeth...most people gain a lot of weight...besides the medical problems they have so much control on ur life..if u needed to leave town u need permission..if u get to the clinic one minute late they don't care ..if u think opiate withdrawal is bad..think again...if anything do a 30 day detox if u r trying to get off of other drugs. I was on alpha medical in Phoenix Az after 15 years I had enough...they don't care about u just ur money. ....I walked away after losing all my teeth and other health issues. Unfortunately most people never get off...I'm so thankful I did.

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48

This advice is my own and is not expected to be perceived to take the place of your personal physician or health care management team. Therefore, I accept no liability for my words here. This is general information: Depending on what it is being used for that is pretty equigesic or a similar dose of strength. However, each has it's own unique behavior in different people, with methadone lasting much longer in the body before it's fully metabolized and excreted verses even a long lasting morphine product. There are guides to equivalencies, however, they cannot be taken as gospel because of so many variables in both the medications, its formulation and, of course, each person injury of pain process and metabolism. It's not a simple thing to establish for each and every person. Proceed with caution.

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49

I would think the methadone is stronger been on both...the methadone definitely lasts longer

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50

You obviously have experience with neither medication.

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51

me to 10 yes of 80mgs and 7 yes of 100mgs 2 different clinic's but it's all about money.

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52

Wrong. It is all relative, but mg for my methadone is stronger, with fentanyl being among the strongest. Methadone's pain relieving ability is about 8 hrs, but it stays in your body for a very long time, which is what makes it so dangerous for drug abusers. This drug will put you in the ground quickly and you won't even think you took to much. It will sneak up on you. You can't pop methadone and drink beer. If you do it's a crap shoot. Methadone's half life is 8-59 hrs. That's right - up to 59hrs. You think its out of your system and take more then take more and everyone could be at your funeral two days later. If you are put on this drug take the dose you are prescribed. Don't drink.

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53

lets not get nasty. we are all here to get help. so don't let the pain come thru with what u say. a lot of talk is from the pain. I found that methadone was stronger than morphine at least in my body and we all know all bodies don't work the same with all drugs. It was easier to get off of methadone then it is the other pain meds. a lot affect your mental anguish. But i am on 10 3x a day of methadone and that works fine also i am on Dronabinol for eating problem. it has THC but not the high effect. but helps on eating. I get them thru the VA and they are also going thru changes on their drugs that they give out. but there are more people in great war pains that the VA is used to giving out the harder drugs but they check also with outside medical firms to see what u have seen drs for. if just for pain relief 40-60 mg of methadone should hold everybody out there. but everyone is different and u cant generalize people all the same.

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54

Mg for mg methadone is much stronger than morphine, eye was on MS-CONTIN (morphine sulphate) for 5 years Nn on OXY-CONTIN before MS am now ON Methadone Nn MG for MG METHADONE is much much more Powerful, Potent Nn LongerLasting Than MORPHINE

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55

This is very true. Stronger and last much longer but give u constipation big time. watch that and tell your Dr for meds to help to go to the bathroom. I find that a dose will last 2 days for one day dose. I find it works the best but u have to settle for the right dose. 40-60 is plenty to start but over years it will go up but i wouldnt go any higher then that. it is easy for me to get off it for i did it every month the last 3 days i would dry myself out. it helps with the mental part of stopping. good luck

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56

Your wronge..methadone is ten times stronger then morphine you might want to do your research better befor you say anything..why do u think methadone is controled as with morphine most docs write write scripts like crazy..but not when it comes to methadone..so once again research befor u speek

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57

who are you talking to? what comment did u think u saw. i dont see it. i agree methadone is way stronger than the morphine. next time write name the party u are talking to before u get defensive

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58

Just to share my life with u and it husband,first of all I'm glad that he's not suffering the pain no more,is like everything in life theres bad n there's good people the really need d methadone in their life for their opiate dependency ,i been on the clinic for over 15 years not once i have get notin for free,im a construction contractor,n if it wasnt for that medication I wouldn't be the man I am today,yes there is people that depends on d government but is like everything. unfortunately your husband became addicted cuz of is d only med da works for him,so now he has to problems hes pain n he's addiction

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59

I've been getting botox since 2004 and I haven't had one headache. I'm 53 and more people need to know about this. Insurance denies first try but when they compare emergency room visits they approved it.

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60

I have used both in past....I think they are about even in strength

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