Naproxen And Hydrocodone 10-325


I suffer from rheumatoid arthritis and fibromyalgia and was wondering if it is ok to take the Naproxen sodium and Hydrocodone 10-325 together.

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Hi Eve,

Based on my research there are no drug interactions found between Naproxen sodium and Hydrocodone. This does not necessarily mean no interactions exist, but my sources state that every effort has been made to ensure that the information provided is accurate. As such, I would personally think that it would be fine to take these two together whether you have those conditions or not.

On the contrary though, if you are taking these together and you notice any side effects that are unpleasant or intolerable (in conjunction with the rheumatoid arthritis and fibromyalgia), I would recommend that you stop taking them and contact your doctor about switching medications. This is "unlikely" to happen though if you're following the proper dosing schedule and other important guidelines for each of these medications; but it's always good to be aware.

You can view more information about these drugs by following the links below:


I hope this helps!

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I take the two meds w/o any problem whatsoever, since it was my doctor that prescribed the two meds for me. If you want to be certain about your concern(s) about the two meds, you should ask your doctor to make sure. Nowadays, it is very simple to ask your primary care giver w/o go in for an office visit, by sending your doctor(s) an emailing him/her. -Ella

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My husband is on the same dose of Hydro. Is your Naproxen over the counter or a script for a higher dose that you can not get over the counter? My husband's was a script for the highest dose. Two days after the script was filled the doctor called upon reviewing all his medications. The hydro 3/325 has the least amount of acetaminophen in it where as the other doses available have a higher amount of acetaminophen in them. The doctor realized that the script he had written for Naproxen that has a much higher dose of acetaminophen in than over the counter. It was written to take 2 a day. Acetaminophen can effect the LIVER and/contribute to liver failure in long term use. Between the two medications the doctor cut him down to one Naproxen a day. His hydro 3/325 is prescribed to take 2 three times a day. Ask your pharmacist at what level of acetaminophen a cause for concern. If they can not answer it, call your doctor. This is also true for Tylenol aka acetaminophen. Tylenol says right on the bottle "Do not use with use with other medications that have acetaminophen in it!".

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i'ts ok to take naproxen 500 and hydroco/apap 10-325

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Made a typo. Should have read 10/325 not 3/325. Sorry hope this didn't cause any confusion.

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My husband's script was to take 2 tablets twice a day of Naproxen 250 mg. That's 600 mg each time.

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Should I take 3 220mg aleve at same time or 1 10mg hydrocodone?

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