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Collagenases are enzymes that break the peptide bonds in collagen. They assist in destroying extracellular structures in the pathogenesis of bacteria such as Clostridium. They are considered a virulence factor, facilitating the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.[1] Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secret... [wikipedia]