I have just stated using methotrexate injections for RA after using tablets which gave me mouth ulcers and nausea. Have also used Arava and other RA meds without success . I am also on occasional predisalone as I gain too much weight and am a type 1 diabetic and blood sugars go up considerably. I also take 300mg of plaquenil each day for my arthritis. I would like to know how others are coping with the methotrexate, results and side effects???