manny Says:

My wife is been sick since childhood with chronic anemia and deficit iron absorption when her period comes was for more than 10 days with a lot of hemorrhage and drop her to the hospital to stopped now since she is been taking Immunocal her condition has been improve a lot and is in the Physician Desk Reference (PDR) is been scientific prove to work on u immune system by increasing u gluthatione

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Randy G. Says:

Methods of oral cystine delivery: Immunocal® is a specially prepared whey protein isolate which contains the thermolabile proteins serum albumin, alpha lactalbumin and lactoferrin. It is a patented form of bio-active, un-denatured whey protein isolate, and is described as a 'cystine delivery vehicle' and 'Glutathione precursor' by the Physicians' Desk Reference for Prescription Drugs (PDR 2001-2006). Serum albumin, alpha lactalbumin and lactoferrin proteins contain high levels of cystine residues that could be denatured by heat, low pH, or mechanical stress (inherent to most extraction processes). It is therefore recommended that high-speed mechanical blending or heating (above 118 degrees F) be avoided in the preparation of whey protein isolates such as Immunocal®. In serum albumin there are 17 cystine residues and 6 glutamylcystine (Glu-Cys) dipeptides; in lactoferrin, 17 cystine residues and 4 GluCys dipeptides; and in alpha-lactalbumin, 4 cystine residues. In particular, the Glu-Cys dipeptides very readily enter the cell to be synthesized into GSH. Of interest, the Glu-Cys dipeptide is an exclusive feature of the only obligatory foods in the early life of mammals and oviparous species, those being milk and egg white respectively. When subject to heat or shearing forces, the fragile disulfide bonds within these peptides are broken and the bioavailability of the glutathione precursors is greatly diminished. As an antioxidant, glutathione is essential for allowing lymphocytes to express their full potential, without being hampered by oxyradical accumulation during the oxygen requiring development of the immune response. In a similar fashion, GSH delays the muscular fatigue induced by oxyradicals during the aerobic phase of strenuous muscular contraction. As a detoxification agent, glutathione has been demonstrated to be effective against a number of xenobiotics, including chemical pollutants, various carcinogens and ultraviolet radiation.

Glutathione is a tightly regulated intracellular constituent and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage. [source: Physician's Desk Reference for Prescription Drugs (PDR) 2001, p. 1563].

Oral glutathione supplements as discussed previously, are virtually ineffective, since glutathione is a protein and is digested in the stomach before reaching the blood stream or tissues of the body.

N-acetyl-L-cysteine (NAC) is an amine protected version of cysteine that is rapidly hydrolyzed in the body to the amino acid cysteine. (Cysteine is the monomer amino acid).

NAC supplements are moderately effective, but dosing is limited due to toxic side effects (such as headache, dizziness, blurred vision) associated with cysteine supplementation.

Cystine is a disulfide linked dimer of cysteine, and a rich nutritional source of cystine in the diet is undenatured whey proteins. The link is a disulfide bond which is readily reduced to the corresponding thiol (-SH).

Scientifically, the best way to increase glutathione levels is to take a supplement rich in cystine (a disulfide-bonded form of cysteine). Immunocal® undenatured whey protein provides on of the richest sources of cystine known to science, and because cystine contains two weakly bonded molecules of cysteine, Immunocal® is a unique "cysteine delivery vehicle".
This form is virtually free of the toxic side effects associated with the single molecule (NAC). Two molecules of cysteine are connected by a weak disulfide bond to form a molecule of cystine. The disulfide-bonded cysteine is not digested, but is transported by the blood stream to the tissues of the body. Here, within the cells of the body, the weak disulfide bond between the two cysteine molecules is cleaved, and the cell has 2 molecules of cysteine from which glutathione can be manufactured. The greatest dietary source of cystine is bio-active, undenatured whey protein, and the only whey protein which has been studied in clinical trials at major Universities and Medical Schools and which is clinically proven to enhance or normalize glutathione levels is called "Immunocal". Immunocal is the only bioactive whey protein listed in the PDR Physicians Desk Reference for Prescription Drugs), even though it is available without a prescription.
A good, certified, and inexpensive blood glutathione test is available for about $40. Immunosciences testing laboratories.
"A review article published in the Annals of Pharmacology stated that glutathione is important in DNA synthesis and repair, protein and prostaglandin synthesis, amino acid transport, detoxification of toxins and carcinogens, enhancement of the immune system, and protection from oxidation and enzyme activations." The Immune System Cure, Lorna R. Vanderhaeghe & Patrick J.D. Bouic, Ph.D.
"Glutathione has potent anti-viral properties - if tissue and serum glutathione levels are significantly increased, the replication of most pathogens are slowed or stopped. Conversely, glutathione deficiency produces a pro-viral effect." Paul Cheney, M.D., Ph.D. and expert in the treatment of Chronic Fatigue Syndrome. Transcribed from a workshop presentation on the clinical management of Chronic Fatigue Syndrome.
Lymphocytes, cells vital for effective immune function, depend on GSH for their proper function and replication.
IMMUNOLOGY 61: 503-508 1987
As we age, there is a precipitous drop in GSH levels. Lower glutathione levels have been implicated in many diseases associated with aging.
Journal of Clinical Epidemiology 47: 1021-28 1994
Antioxidants are well documented to play vital roles in health maintenance and disease prevention. GSH is your cells' own major antioxidant.
Biochemical Pharmacology 47: 2113-2123 1994
GSH plays a role in eliminating many carcinogens as well as maintaining immune function.
Cancer Letters 57: 91-94 1991
Strong muscular activity, such as that experienced by athletes, generates oxyradicals [free radicals] leading to muscle fatigue and poorer performance. GSH neutralizes these radicals.
Sport Medicine 21: 213-238, 1996
GSH detoxifies many pollutants, carcinogens, and poisons, including many in fuel exhaust and cigarette smoke. It retards damage from radiation such as seen with loss of the ozone.
Annual Reviews of Biochemistry 52: 711-780 1983

What is Glutathione (GSH)?

Glutathione, or GSH, is a naturally occurring protein that protects every cell, tissue, and organ from toxic free radicals and disease. It is a tripeptide of three amino acids - glycine, glutamate (glutamic acid), and cysteine. These precursors are necessary for the manufacture of glutathione within the cells.
Find Out More About Glutathione

PubMed is the U.S. National Library of Medicine's search service to access the 10 million citations in Medline and other related databases, with links to participating online journals published since 1966. When you access the PubMed site, enter your search word(s) into the form and click on the "Search" button. A list of abstracts will appear. Click on the author's name to read the abstract.

Narrow your search by entering "glutathione and [your health concern]" or you'll get over 103,000 abstracts on Glutathione!

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WOW too much info and works great thanks for all this info

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