Can I Take Tylenol With Hydrocodone/acetaminophen?

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sue Says:

I take two 5-325 hydrocodne/acetaminephin every night for back pain. Today I have a stomach bug and a bad headache, is it ok to take two extra strength tylenols for my headache?

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notallbad Says:


I'm not a licensed physician but my informed opinion is yes that amount of acetaminophen will certainly not cause any long-lasting effects, so don't suffer, treat your headache. No worries.

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BL Says:

sue, that is a total of 1650 mg of Tylenol and that is Too Much. You are not suppose to take any more than 1,000 mg Tylenol once every 6 hours.

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David Says:

Hi Sue,

Depending on what dose of acetaminophen you supplement with, it may very well fall within safe guidelines. For example, only taking 1 additional 325mg tab would put you at 975mgs of Acetaminophen each night (or every 24 hrs). Not to mention the FDA Drug Safety guidelines list a maximum daily dosage of 4000mgs (though the lower the better in my opinion).


If you want a safer alternative I'd probably encourage you to look into Turmeric (curcumin) supplements, for it too has powerful anti-inflammatory effects and most people generally tolerate it well from what I understand.

Hope this helps!

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BL Says:

David, I know they have changed the recommended Tylenol dosage not to exceed 3,000 in 24 hrs, but i can't find the link right now.

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David Says:

Hey BL,

Thanks for bringing this to my attention. I see what you're saying now about the 3,000mg per day limit. This must be fairly recent, as I could only verify it through Tylenol's official webpage (apparently the FDA hasn't updated things on their end yet):

"To help encourage the safe use of acetaminophen, the makers of TYLENOL® have lowered the maximum daily dose for single-ingredient Extra Strength TYLENOL® (acetaminophen) products sold in the U.S. from 8 pills per day (4,000 mg) to 6 pills per day (3,000 mg). The dosing interval has also changed from 2 pills every 4 – 6 hours to 2 pills every 6 hours."


Hope this helps clear things up!

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BL Says:

David, Thank You for finding that. I was looking for verification through the FDA. I guess that's why I couldn't find it.

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Robin Says:

I took 1/2 of a Norco at 3pm. Can I take Tylenol PM now? It's 7.5 hours later?

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Marie Says:

I was given prednisolone 4 mg for plantar fasciitis and started itching terribly. So I stopped taking the meds and have been in extreme pain & unable to sleep. About 5 hours ago I took 1000mg of Tylenol. Can I safely take Hydrocodone 10-325 for relief?

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