Vemurafenib

Drug Index

Vemurafenib (INN, marketed as Zelboraf) is an inhibitor of the B-Raf enzyme developed by Plexxikon (now part of Daiichi-Sankyo) and Genentech for the treatment of late-stage melanoma.[1] The name "vemurafenib" comes from V600E mutated BRAF inhibition. Contents 1 Approvals 2 Mechanism of action 2.1 Resistance 3 Clinical trials 3.1 Side effects 4 References 5 Further reading 6 External links Approvals Vemurafenib received FDA approval for the treatment of late-stage...

I have a friend who has been on vemurafenib for the past 4 months, doctors have now found new cancer growths and have therefore ended his trial. Can anyone reccommend what treatment have to go for next?! Is Chemo the best option! Any help would be much appreciated! ## I really think his Oncologist is the best qualified person to suggest further treatment options. Much of it also depends on the type of cancer being treated. What does he have?

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Vemurafenib

Vemurafenib (INN, marketed as Zelboraf) is an inhibitor of the B-Raf enzyme developed by Plexxikon (now part of Daiichi-Sankyo) and Genentech for the treatment of late-stage melanoma.[1] The name "vemurafenib" comes from V600E mutated BRAF inhibition. Contents 1 Approvals 2 Mechanism of action 2.1 Resistance 3 Clinical trials 3.1 Side effects 4 References 5 Further reading 6 External links Approvals Vemurafenib received FDA approval for the treatment of late-stage...

Cobimetinib

Cobimetinib, sold under the brand name Cotellic, is an anti-cancer medication used in combination with vemurafenib (Zelboraf) alone or with both vemurafenib and atezolizumab (Tecentriq) to treat melanoma.[1][5] Cobimetinib is a MEK inhibitor.[1] Cotellic, Zelboraf, and Tecentriq are all marketed by Genentech, a subsidiary of Roche.[1][5][6] The most common side effects include diarrhea, rash, nause...

Drug Index

Cobimetinib, sold under the brand name Cotellic, is an anti-cancer medication used in combination with vemurafenib (Zelboraf) alone or with both vemurafenib and atezolizumab (Tecentriq) to treat melanoma.[1][5] Cobimetinib is a MEK inhibitor.[1] Cotellic, Zelboraf, and Tecentriq are all marketed by Genentech, a subsidiary of Roche.[1][5][6] The most common side effects include diarrhea, rash, nause...

I've been taking Zelboraf for about 2 weeks and have severe joint pain. I'm looking for a way to combat the joint pain as am very active and still work. ## Have you consulted your doctor? Zelboraf contains the active ingredient Vemurafenib and is used to treat late stage Melanoma. In light of your medical condition and being on such a medication for it, only a doctor will be able to properly advise of what you can try for the side effects.

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The other drug after vemurafenib is ipilumab it isn't a chemio and it has good results

NDC Database

Zelboraf 240 mg Oral Tablet by Genentech, Inc. ## Markings: VEM ## Shape: Oval ## Package Codes: 50242-090-01, 50242-090-02, 50242-090-86 ## Active Ingredients: Vemurafenib