TNKase
Active Ingredient(s): Tenecteplase, TNK-tPAFDA Approved: * June 2, 2000
Pharm Company: * GENENTECH
Category: Heart (Cardiac)
Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug. Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution... [wikipedia]
* May have multiple approval dates, manufacturers, or labelers.