Sinemet
Active Ingredient(s): Carbidopa + LevodopaFDA Approved: * May 2, 1975
Pharm Company: * BRISTOL MYERS SQUIBB
Category: Parkinsons
* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".
Sinemet Overview
Carbidopa/levodopa, also known as levocarb and co-careldopa, is the combination of the two medications carbidopa and levodopa.[1] It is primarily used to manage the symptoms of Parkinson's disease, but it does not slow down the disease or stop it from getting worse.[1] It is taken by mouth.[1] It can take two to three weeks of treatment before benefits are seen.[2] Each dose then begins working in about ten minutes to two hours w...
Read more Sinemet DetailsDetails May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Carbidopa/levodopa
Recent Sinemet Forums:
Sinemet cr 25/100 by Mylan Pharmaceuticals
Payless says Mylan is no longer making this generic Sinemet cr 25/100 tab. I cannot use Sun manufacturing company. I need help. I take 1 purple pill that has 88 on one side and Mylan on the other every 3 hours. I am 83 with advanced Parkinson's. ## Have you spoken to your doctor about the problem? If so, what have they advised? I see that the brand name of the time released formulation has been discontinued, but there are several generic options available, including one manufactured by Alembic Pharmaceuticals that was approved in 2019. Why can't you take the one manufactured by Sun? The FDA lists the typical side effects of Sinemet as possibly including nausea, dizziness, confusion, hallucinations, depression, and strange dreams.
Updated
Payless says Mylan is no longer making this generic Sinemet cr 25/100 tab. I cannot use Sun manufacturing company. I need help. I take 1 purple pill that has 88 on one side and Mylan on the other every 3 hours. I am 83 with advanced Parkinson's. ## Have you spoken to your doctor about the problem? If so, what have they advised? I see that the brand name of the time released formulation has been discontinued, but there are several generic options available, including one manufactured by Alembic Pharmaceuticals that was approved in 2019. Why can't you take the one manufactured by Sun? The FDA lists the typical side effects of Sinemet as possibly including nausea, dizziness, confusion, hallucinations, depression, and strange dreams.
Updated
Sinemet and Atrial Fibrillation
My dad just started Sinemet 1/2 pill of 25-100 once a day. I read from various websites that one of the side effects is Atrial Fibrillation from taking this medicine. I'd like to solicit your experience on the use of this drug, particularly related to possibility of causing Atrial Fib. Thanks. ## It has been known to cause irregular heart beats, according to FDA reports, along with nausea, dizziness, headache, and increased urination. Are you on any other medications? What does his doctor think has caused it? The NIH does list it as possibly being caused by various medications, as well as various medical conditions, thus there is a chance there might be more at play here than the Sinemet.
Updated
My dad just started Sinemet 1/2 pill of 25-100 once a day. I read from various websites that one of the side effects is Atrial Fibrillation from taking this medicine. I'd like to solicit your experience on the use of this drug, particularly related to possibility of causing Atrial Fib. Thanks. ## It has been known to cause irregular heart beats, according to FDA reports, along with nausea, dizziness, headache, and increased urination. Are you on any other medications? What does his doctor think has caused it? The NIH does list it as possibly being caused by various medications, as well as various medical conditions, thus there is a chance there might be more at play here than the Sinemet.
Updated
Sinemet dosage
I have been extremely lightheaded taking sinemet 25/100 3 and 4 times daily. Can it be taken once daily? ## Hello, Judy! How are you feeling? Has there been any change? You should take it according to your doctor's prescribing instructions. Side effects are typically transient and tend to go away, once your body gets used to a medication, but that usually takes about 4 to 5 weeks of taking it at the same consistent dose, as reported by the NIH. Other side effects may include nausea, and headache.
Updated
I have been extremely lightheaded taking sinemet 25/100 3 and 4 times daily. Can it be taken once daily? ## Hello, Judy! How are you feeling? Has there been any change? You should take it according to your doctor's prescribing instructions. Side effects are typically transient and tend to go away, once your body gets used to a medication, but that usually takes about 4 to 5 weeks of taking it at the same consistent dose, as reported by the NIH. Other side effects may include nausea, and headache.
Updated
what is the difference between cr and er Sinemet
I take generic Sinemet 25/100. What is the difference between Rytary and Sinemet, besides price? ## There is no different, both the CR and ER just designate them as being time released formulation of the medication, according to the NIH, otherwise, the active ingredients and the way they act in the body are the same. If one is too expensive, there is no harm in trying the cheaper versions, all are still approved by the FDA. The typical side effects of this medication are listed as possibly including nausea, dizziness, rash, hiccups, and weight changes. Is there anything else I can help with?
Updated
I take generic Sinemet 25/100. What is the difference between Rytary and Sinemet, besides price? ## There is no different, both the CR and ER just designate them as being time released formulation of the medication, according to the NIH, otherwise, the active ingredients and the way they act in the body are the same. If one is too expensive, there is no harm in trying the cheaper versions, all are still approved by the FDA. The typical side effects of this medication are listed as possibly including nausea, dizziness, rash, hiccups, and weight changes. Is there anything else I can help with?
Updated
Sinemet does not work in the afternoon
My father (63), PD patient for around 20 years. We always had hard time adjusting a perfect dosage for him. # Right now he is in 8 sinemet (25/100) pills 4 hrs apart. One every dose he takes 1 regular and 1 CR Problem: the only good onstate he gets is after first dose. But in the afternoon most of the time the meda dont work Other: he takes ropinirole (.25) 3 times and Amantadine (100) 2 times Need help, 1. Can i increase hos dosage? 2. Any other meds can improve Sinemet effectiveness? ## Hello, Muhammad! How is your dad doing? You shouldn't adjust the dosage of any of his medications, without his doctor's approval. What else is different in the afternoon that could be affecting it? Is he more active at that time of day? Less active? Does he eat more? Does he take his medication...
Updated
My father (63), PD patient for around 20 years. We always had hard time adjusting a perfect dosage for him. # Right now he is in 8 sinemet (25/100) pills 4 hrs apart. One every dose he takes 1 regular and 1 CR Problem: the only good onstate he gets is after first dose. But in the afternoon most of the time the meda dont work Other: he takes ropinirole (.25) 3 times and Amantadine (100) 2 times Need help, 1. Can i increase hos dosage? 2. Any other meds can improve Sinemet effectiveness? ## Hello, Muhammad! How is your dad doing? You shouldn't adjust the dosage of any of his medications, without his doctor's approval. What else is different in the afternoon that could be affecting it? Is he more active at that time of day? Less active? Does he eat more? Does he take his medication...
Updated
decreasing sinemet
I have been taking sinemet 25/100 for parkinsons. I was taking 8 a day with dr. permission. I began taking more without permission to ward off what i call parkinsons attacks. My dr scolded me and told me to try to go back to 8. I feel the need for another doe before time for the scheduled dose if i only take 8 a day. I realize its like withdrawl from drugs. but do you have any suggestions for me to keep feeling ok without the extra pills? ## Hello, Pam! How are you? Sinemet doesn't work that way, actually. You can't just randomly take more some days to ward off symptoms. For it to be effective a consistent dose needs to be taken daily for about 4 to 5 weeks. It also won't cause severe withdrawal symptoms, since it's not a habit forming medication and you're still tak...
Updated
I have been taking sinemet 25/100 for parkinsons. I was taking 8 a day with dr. permission. I began taking more without permission to ward off what i call parkinsons attacks. My dr scolded me and told me to try to go back to 8. I feel the need for another doe before time for the scheduled dose if i only take 8 a day. I realize its like withdrawl from drugs. but do you have any suggestions for me to keep feeling ok without the extra pills? ## Hello, Pam! How are you? Sinemet doesn't work that way, actually. You can't just randomly take more some days to ward off symptoms. For it to be effective a consistent dose needs to be taken daily for about 4 to 5 weeks. It also won't cause severe withdrawal symptoms, since it's not a habit forming medication and you're still tak...
Updated
carb/levo 25-100 MG for parkinsons
Are there any generic versions of this tablet either er or direct version which contain different coloring ingredients than the original sinmet product? ## @Dr. Perry, From what I could gather, Sinemet (Carbidopa + Levodopa) by Merck Pharma reportedly contains the following inactive ingredients: hydroxypropyl cellulose + pregelatinized starch + crospovidone + microcrystalline cellulose + magnesium stearate. NOTE: FD&C Blue #2 are also present in the 10mg/100mg and 25mg/250mg dosage forms; whereas D&C Yellow #10 Lake is used in the 25mg/100mg dosage form. As far as an alternative goes, I did notice that Sandoz makes a generic Carbidopa + Levodopa (w/ the addition of Entacapone) marketed for treating similar conditions, but does have a different list of inactive ingredients: corn ...
Updated
Are there any generic versions of this tablet either er or direct version which contain different coloring ingredients than the original sinmet product? ## @Dr. Perry, From what I could gather, Sinemet (Carbidopa + Levodopa) by Merck Pharma reportedly contains the following inactive ingredients: hydroxypropyl cellulose + pregelatinized starch + crospovidone + microcrystalline cellulose + magnesium stearate. NOTE: FD&C Blue #2 are also present in the 10mg/100mg and 25mg/250mg dosage forms; whereas D&C Yellow #10 Lake is used in the 25mg/100mg dosage form. As far as an alternative goes, I did notice that Sandoz makes a generic Carbidopa + Levodopa (w/ the addition of Entacapone) marketed for treating similar conditions, but does have a different list of inactive ingredients: corn ...
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How to Reduce Carbo-Levo and Stop Medication
My mother is showing undesirable side effects of this medication and is ready to stop taking it. She's taking one tablet of Sinemet, three times per day. What is proper strategy to stop? Gradually? All at once? Implications ## Hello, Mike! How is she doing? How long has she been taking it? Side effects are normal and should eventually taper off, once her body adjusts to the medication. Has she consulted her doctor about the problem? They would be the best person to advise her on this matter.
Updated
My mother is showing undesirable side effects of this medication and is ready to stop taking it. She's taking one tablet of Sinemet, three times per day. What is proper strategy to stop? Gradually? All at once? Implications ## Hello, Mike! How is she doing? How long has she been taking it? Side effects are normal and should eventually taper off, once her body adjusts to the medication. Has she consulted her doctor about the problem? They would be the best person to advise her on this matter.
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Is Sinemet Better Than Generic Carb Levo
The generic 50-200 carb/levo seems to not be as effective as sinemet. should I get only sinemet, not generics ## If the sinemet works better I would stay with that. Especially when u are not having good results on the generic. Talk to your doc & request "Dispense As Written" and have script written for sinemet. ## Great advice Tracy! I thought I'd mention that generic medications are allowed (by the FDA) to contain up to 20% more or less of the actual active ingredients. This factor, along with different inactive ingredients (binders/fillers) could enable you to have a completely different reaction to each medication. Therefore, that may be the cause of the problem you're having with the generic. I've also read that one pill amongst an entire pack/bottle of a gen...
Updated
The generic 50-200 carb/levo seems to not be as effective as sinemet. should I get only sinemet, not generics ## If the sinemet works better I would stay with that. Especially when u are not having good results on the generic. Talk to your doc & request "Dispense As Written" and have script written for sinemet. ## Great advice Tracy! I thought I'd mention that generic medications are allowed (by the FDA) to contain up to 20% more or less of the actual active ingredients. This factor, along with different inactive ingredients (binders/fillers) could enable you to have a completely different reaction to each medication. Therefore, that may be the cause of the problem you're having with the generic. I've also read that one pill amongst an entire pack/bottle of a gen...
Updated
Yellow Round Pill 93
what is this pill with teva on one side and the othe side with 93 on top part and 293 on bottom side ## This is a generic for Sinemet, it contains 25mgs of Carbidopa and 100mgs of Levodopa, it's used to treat the symptoms of Parkinson's Disease. You can learn more Sinemet details here. Side effects may include nausea, dizziness, gastrointestinal irritation and sleep disturbances. Is there anything else I can help with?
Updated
what is this pill with teva on one side and the othe side with 93 on top part and 293 on bottom side ## This is a generic for Sinemet, it contains 25mgs of Carbidopa and 100mgs of Levodopa, it's used to treat the symptoms of Parkinson's Disease. You can learn more Sinemet details here. Side effects may include nausea, dizziness, gastrointestinal irritation and sleep disturbances. Is there anything else I can help with?
Updated
Possible Dosages for this and Related Drugs:
Carbidopa + Levodopa
- Capsule, Extended Release: 23.75mg + 95mg, 36.25mg + 145mg, 48.75mg + 195mg, 61.25mg + 245mg
- Suspension: 4.63mg + 20mg, 4.63mg/ml + 20mg/ml
- Tablet: 10mg + 100mg, 25mg + 100mg, 25mg + 250mg, 50mg + 200mg
- Tablet, Extended Release: 25mg + 100mg, 50mg + 200mg
- Tablet, For Suspension: 10mg + 100mg, 25mg + 100mg, 25mg + 250mg
- Tablet, Orally Disintegrated: 10mg + 100mg, 25mg + 100mg, 25mg + 250mg
- Tablet, Orally Disintegrating: 10mg + 100mg, 25mg + 100mg, 25mg + 250mg
NDC Database Records for Sinemet: (13 results)
Sorted by National Drug Code- 0006-3915 Sinemet 10/100 Oral Tablet by Merck Sharp & Dohme Corp.
- 0006-3916 Sinemet 25-100 Oral Tablet by Merck Sharp & Dohme Corp.
- 0006-3917 Sinemet 25/250 Oral Tablet by Merck Sharp & Dohme Corp.
- 0006-3918 Sinemet CR (Carbidopa 25 mg / Levodopa 100 mg) Extended Release Tablet by Merck Sharp & Dohme Corp.
- 0006-3919 Sinemet CR 50-200 Extended Release Tablet by Merck Sharp & Dohme Corp.
- 0006-6722 Sinemet Oral Tablet by Merck Sharp & Dohme Corp.
- 0006-6723 Sinemet Oral Tablet by Merck Sharp & Dohme Corp.
- 0006-6724 Sinemet Oral Tablet by Merck Sharp & Dohme Corp.
- 0056-0521 Sinemet CR 50-200 Extended Release Tablet by Bristol-myers Squibb Pharma Company
- 0056-0601 Sinemet CR (Carbidopa 25 mg / Levodopa 100 mg) Extended Release Tablet by Bristol-myers Squibb Pharma Company
- 0056-0647 Sinemet 10/100 Oral Tablet by Bristol-myers Squibb Pharma Company
- 0056-0650 Sinemet 25-100 Oral Tablet by Bristol-myers Squibb Pharma Company
- 0056-0654 Sinemet 25/250 Oral Tablet by Bristol-myers Squibb Pharma Company
Drugs with one or more similar ingredients: (15 results)
- ATAMET Carbidopa + Levodopa
- CARBIDOPA + LEVODOPA 3 discussions
- CARBILEV Carbidopa + Levodopa4 discussions
- DUOPA Carbidopa + Levodopa
- PARCOPA Carbidopa + Levodopa
- RYTARY Carbidopa + Levodopa4 discussions
- CARBIDOPA 43 discussions
- CARBIDOPA + ENTACAPONE + LEVODOPA
- CARBIDOPA + LEVODOPA + ENTACAPONE
- INBRIJA Levodopa
- LARODOPA Levodopa
- LEVODOPA 18 discussions
- LODOSYN Carbidopa
- STALEVO Carbidopa + Levodopa + Entacapone5 discussions
- STALEVO 50 Carbidopa + Entacapone + Levodopa
Related Sinemet Topics:
Sinemet cr 25/100 by Mylan Pharmaceuticals
Payless says Mylan is no longer making this generic Sinemet cr 25/100 tab. I cannot use Sun manufacturing company. I nee... 1 reply
Payless says Mylan is no longer making this generic Sinemet cr 25/100 tab. I cannot use Sun manufacturing company. I nee... 1 reply
Sinemet and Atrial Fibrillation
My dad just started Sinemet 1/2 pill of 25-100 once a day. I read from various websites that one of the side effects is ... 1 reply
My dad just started Sinemet 1/2 pill of 25-100 once a day. I read from various websites that one of the side effects is ... 1 reply
Sinemet dosage
I have been extremely lightheaded taking sinemet 25/100 3 and 4 times daily. Can it be taken once daily? ## Hello, Judy!... 1 reply
I have been extremely lightheaded taking sinemet 25/100 3 and 4 times daily. Can it be taken once daily? ## Hello, Judy!... 1 reply
Sinemet does not work in the afternoon
My father (63), PD patient for around 20 years. We always had hard time adjusting a perfect dosage for him. # Right now ... 1 reply
My father (63), PD patient for around 20 years. We always had hard time adjusting a perfect dosage for him. # Right now ... 1 reply
Sinemet Side Effects 25/100
I'm on 25/100 of carb/levo for Parkinson, how long does it takeit to see if it is helping you?How come you won't... 1 reply
I'm on 25/100 of carb/levo for Parkinson, how long does it takeit to see if it is helping you?How come you won't... 1 reply
Is Sinemet Better Than Generic Carb Levo
The generic 50-200 carb/levo seems to not be as effective as sinemet. should I get only sinemet, not generics ## If the ... 2 replies
The generic 50-200 carb/levo seems to not be as effective as sinemet. should I get only sinemet, not generics ## If the ... 2 replies
mirapex/sinemet
Itake 1.5mg mirapex 3 times a day,i take 12 sinemet 25/100 through a course of a day i want to know how do i go about ge... 1 reply
Itake 1.5mg mirapex 3 times a day,i take 12 sinemet 25/100 through a course of a day i want to know how do i go about ge... 1 reply
neuratin/sinemet
Ive just spoken to an 8o yr old lady who has been prescribed neurantin2 for restless leg syndrome. I am queering this as... 4 replies
Ive just spoken to an 8o yr old lady who has been prescribed neurantin2 for restless leg syndrome. I am queering this as... 4 replies
decreasing sinemet
I have been taking sinemet 25/100 for parkinsons. I was taking 8 a day with dr. permission. I began taking more without ... 2 replies
I have been taking sinemet 25/100 for parkinsons. I was taking 8 a day with dr. permission. I began taking more without ... 2 replies
do you have a program to help get sinemet for free
i have no income and can no longer pay for meds can you help or have a program fr te needy ## this site does not prescri... 2 replies
i have no income and can no longer pay for meds can you help or have a program fr te needy ## this site does not prescri... 2 replies