NegGramActive Ingredient(s): Nalidixic Acid
FDA Approved: * March 6, 1964
Pharm Company: * SANOFI AVENTIS US
Nalidixic acid (tradenames Nevigramon, NegGram, Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics. In a technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom. Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s;... [wikipedia]* May have multiple approval dates, manufacturers, or labelers.