Active Ingredient(s): Estradiol
FDA Approved: * April 26, 1996
Category: Women's Health / Fertility

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Estring Overview

Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of female secondary sexual characteristics such as the breasts, widening of the hips and a female-associated pattern of fat distribution. It is also important in the development and maintenance of female reproductive tissues such as the mammary glands, ute...

Read more Estring Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

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Removing Estring

I can't reach far enough to remove my estring - I can barely touch it but not hook on to remove - any suggestions? ## Did you resolve this issue? For future reference, if you are unable to remove it, you should contact your doctor, or go to your nearest urgent care facility, where they can assist you. ## I can not remove my estring. I have tried but can not reach it... ## I removed the estring and forgot to reinsert it for about 22 hours. Is it still effective? ## Is there any harm in the Estring staying in for 2 weeks past 90 days? I cant get an rx appt any earlier and am totally frustrated that I cant remove it! ## My Gynecologist prescribed Estring due to my prolapse. I used the Estring on Nov 17th and on Dec 6th after almost 3 weeks, I removed it because of breast pain. Today is...

Bad vaginal smell with Estring

I am post menopausal. I was prescribed Estring because intercourse was becoming very painful. I used almost 2 rounds of Estring (3 months + 1.5) Estring really helped rebuild my atrophic vagina. Being intimate is not fine but I have a new problem: a terrible vaginal smell. When i remove the ring, the smell disappears. Interestingly, i didn't have this smell the first 3 months. I know that the smell comes from the ring because when i remove it, the smell disappears. I have since switched to Vagifem and the smell is about the same just that since i use Vagifem twice a week, the smell recedes between the two insertions of the vaginal ovule. I wonder if other women have experienced this issue with vaginal estrogen. ## I experienced the same thing recently. I had the Estring in for 2 mon...

Estring moves-uncomfortable

Ive been using the estring for about 1.5 years. I'm happy with it as far as relieving itching etc. but lately it is uncomfortable and seems to move around when I move and just doesn't feel good when I walk. Any suggestions. I have a dropped uterus. ## Hello Cherie oh, Really the only advice to give in this situation is to talk about it with your primary care doctor or OBGYN. I'm glad that it relieves your itching but if it has become uncomfortable it could be caused by a physical change or something to do with the ring shifting. Only a doctor would really be able to give you a reliable and accurate answer. Good luck hope you get this resolved soon. ## You are not inserting it far enough. I used to have this problem too.

How Long can you safely remove estring if needed

I had to take my ring out for a week due to an yeast infection.I washed the ring really good and dried it off put in plastic bag and put in a drawer. I called the company and they had no answers on how long it could be out ,there are no studies at $600 a ring I rinsed it off good and put it back in. Has anyone else done this

Estring stuck

I've only used one Estring so far, and it is time to change it. But it feels stuck when I hook my finger around it & tug on it. I can push part of the ring away from the vaginal wall lower down, but it won't budge from higher up. It totally helped my symptoms & I want to put in a new ring, but I don't know what to do. I hate to have to go to my gyne for this Any suggestions? ## I have difficulty removing the estring because my uterus is retro verged and my fingers are too short to reach. Easy solution, bear down like you are constipated and the ring moves down to where you can reach it! ## I usually struggle to get my ring out to change it, but this time was a real bear. Usually if I can get a finger under the edge, I can loosen it enough to pull it out, but not this...

Estring questions about side effects

Has anyone been hit with constipation after starting to use estring? So strange, but that's the only change that I can pinpoint to have affected things. Also, is anyone experiencing a successful diet experience as a result? I am having better luck than ever losing weight and controlling my appetite. I'm just trying to figure out if either of these things are due to the extra estrogen. ## Hello, Attie! How are you? Constipation can happen due to the slightest change in your body, so yes, that's highly possible. Other side effects, as listed by the FDA, may possibly include nausea, dizziness, headache, irritability, breakthrough bleeding and PMS-like symptoms. The losing weight, however, is unusual, as these usually tend to cause weight gain. Have you experienced any other sid...

what is the differance between vaginal ring estring estradiol and femring acetate?

I am using Femring now and wonder if I could change to Estring if it might cost less? My insurance doesn't cover Femring, I've had breast cancer and told this was the best way for me to get hormone replacement safely. ## It is always best to follow your doctor's instructions. The typical side effects may possibly include dizziness, headache, nausea, mood changes, weight changes, and irregular bleeding. They both really do the same thing, which is preventing pregnancy. Which one have you chosen to try?

Stomach problems

I inserted the Estring and within two hours had diarrhea and cramping, then chills. I kept it in for six more hours but was really feeling sick, so removed it. Literally felt better within the hour. I'd like to try it again but wonder if this would likely be a permanent issue or if this stomach thing will resolve itself as my body gets used to it? ## Those can be side effects of using a hormonal supplement, and it may take about 3 months for them to go away, according to FDA reports. Other side effects can include mood changes, weight changes, and irritability. Have you tried it, again? Are you on any other medications? How old are you?

Difficult removing and white substance on part of ring

I have been using Estring for several years and it has really helped with my vaginal dryness. The last time I went to take it out and replace it the Ring was very hard to remove. I pulled it loose from the vaginal wall and when I looked at it it had some white substance on it. I wasn't sure what that meant if anything. Since it has always been clean and easy to take out I wanted to find out if it was something to be concerned about or not. I have not put a new one in and won't until I get some answers. U ## How easy or hard it is to remove can depend on your hormonal cycle, since your cervix moves up and down throughout the month. Thus, if you're having a different hormonal surge, when the time comes to remove it, it could be harder to remove than at other times, as reported...

Muscle Pain and coughing

I started the Estring after I went into menopause from Chemotherapy. I started to feel a heaviness in my chest, coughing and a lot of mucous along with muscle pain. I contacted my OB and she said she didn't think the symptoms I had were from the Estring. Did anyone else have these symptoms? ## The chest tightness is actually listed by the FDA as being possible allergic reaction, which could also encompass coughing and etc. How long have you been on it? Are you still on any other medications? Has there been any change? Have the symptoms worsened, or improved? ## Shortness of breath is a serious side effect (it looks like SOB from your symptoms. That's an allergic reaction and you should stop (I'm not a doctor, but I've had similar symptoms with other drugs)


Possible Dosages for this and Related Drugs:

  • Cream: 0.01%
  • Emulsion: 0.25%, 2.5mg/g
  • Film, Extended Release: 0.014mg/24hr, 0.025mg/24hr, 0.025mg/day, 0.0375mg/24hr, 0.05mg/24hr, 0.06mg/24hr, 0.075mg/24hr, 0.1mg/24hr, n/a
  • Gel: 0.06%, 0.1%, 0.1% (0.25gm/packet), 0.1% (0.25mg/packet), 0.1% (0.5gm/packet), 0.1% (0.5mg/packet), 0.1% (1gm/packet), 0.1% (1mg/packet)
  • Gel, Metered: 0.06%, 0.06% (0.87gm/activation), 0.06% (1.25gm/activation)
  • Injection: 10mg/ml, 1mg/ml, 20mg/ml, 3mg/ml, 40mg/ml, 5mg/ml
  • Insert: 0.004mg, 0.01mg
  • Insert, Extended Release: 0.0075mg/24hr, 0.05mg/24hr, 0.1mg/24hr, 2mg
  • Powder: 100%
  • Spray: 1.53mg/spray
  • System: 0.014mg/24hr, 0.025mg/24hr, 0.025mg/day, 0.0375mg/24hr, 0.0375mg/day, 0.05mg/24hr, 0.05mg/day, 0.075mg/24hr, 0.075mg/day, 0.1mg/24hr, 0.1mg/day
  • Tablet: 0.45mg, 0.5mg, 0.9mg, 1.5mg, 1.8mg, 10mcg, 10ugm, 1mg, 25mcg, 25mcg + 25ugm, 25ugm, 2mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Estring: (3 results)

Sorted by National Drug Code
  • 0013-2150 Estring 2 mg/1 Vaginal Ring by Pharmacia and Upjohn Company
  • 54868-5538 Estring 2 mg/1 Vaginal Ring by Physicians Total Care, Inc.
  • 63539-021 Estring 2 mg/1 Vaginal Ring by U.S. Pharmaceuticals

Other drugs which contain Estradiol or a similar ingredient: (271 results)