Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Contrave Overview

Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.[1][2] It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[3] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Contrave Forums: RSS Feed

Splitting Contrave Pills
3 Replies RSS Share
I just started Contrave last Friday. I have really had no side effects, but because I have a narrowed esophagus, I have trouble swallowing the pill (it gets stuck). I cut the pills in half and take both halves at the same time and this makes it easier for me to get them down. My question - is this messing with the efficacy of the medicine? ## No, they are regular release tablets, so that will not cause a problem with their efficacy, according to NIH reports. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, nervousness, and insomnia. Are you on any other medications? ## You should not split the pills. They are an extended release tablet. This is copied from the Contrave literature: Extended-Release Tablets: 8 mg naltrexone HCl /90 mg bupropion HCl...
Updated 3 minutes ago.
Contrave and cold medicine
1 Reply RSS Share
Can cold medicine be taken with Contrave like Sudafed or Contac? Are there any side effects by taking cold medicine with it? ## It really depends on the specific cold medication, they are many available over the counter in the U.S., so I couldn't possibly research them all for you. Which one is your normal preferred choice? Can you please post back and clarify? This information would enable me to research an answer to your question. Is Contac available in the U.S., again? I know it had been removed from the market here for a number of years. The FDA warns that Contrave may cause side effects, such as nausea, dizziness, headache, mood changes, and weight changes.
Updated 14 hours ago.
contrave and sleepiness
63 Replies RSS Share
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sleepy I can't stand it. Days 1 and 2 I managed to fight it off until about 12-12:30, day 3 until about 1-1:30, and day 4 I fought it off until 3pm. If I take a 1-2 hour nap, I wake up fine, with energy and then cannot get to sleep until about 2am, sometimes 3am. Today is day 5, I'm having that "drunk" feeling and sleepy, but no where near how it has been. It seems this effect is slowly wearing off, but I haven't seen anywhere where this is a common side effect. I know all medications effect everyone differently, so I'm wondering if this is something I should be concerned about, or just another side effect that I will get used to as the weeks go o...
Updated 3 days ago.
Appetite returned after 6 weeks of use
2 Replies RSS Share
The first 5 weeks taking contrave I had no appetite. I dropped 24lbs in the first month and was only taking 1 pill twice a day. I just recently got a refill and it's not doing anything to decrease my appetite anymore. I upped to 3 pills a day still not working like it did the first month. Has anyone else have this same experience? If I keep taking it will it eventually decrease my appetite like before? ## This has happened to me and am looking for answers to this app can’t question. I am wondering if I got to complacent because the first few weeks seemed so easy. ## Many people have reported experiencing this, after awhile taking this medication, and the FDA does warn that it can happen. You may also experience other side effects, such as nausea, dizziness, headache, and irrit...
Updated 3 days ago.
Pain control while on Contrave
1 Reply RSS Share
I have had great success with Contrave! I feel bad for those that have had side effects and can't take it. My only question, (which my doctor could not give me an answer for) is: If in an accident, (car accident, God forbid).... what options would doctors have to control my pain if I actively taking contrave? And shoud I have some type of health notice in my billfold stating that I am taking this prescription? ## It is always a good idea to keep a list of your current medications, and medical conditions with you, in case of emergency. So, that is an idea you can't go wrong with, better safe than sorry. First responders can help you more, if they know what medications you are on and what medical conditions you are diagnosed with. Though normal doses of opiates may not work, while...
Updated 3 days ago.
contrave and surgery 911
1 Reply RSS Share
I was taking only 2 contrave pills in the morning for a couple of months. My last dosage was yesterday which was Monday. I'm having cosmetic surgery in two days which is Thursday. Is it safe to have surgery? I wasn't aware of any dangers with Contrave & surgery. I wasn't on this medication when I initially had my consult. Please help.. I'm worried. ## Has your surgeon provided any instructions regarding medications you should not take, before your surgery? Due to the Naltrexone in Contrave, some pain medications may not work for you, it usually takes about 3 days, after stopping the medication, for them to work, again. The FDA warns that this medication may cause other side effects, such as nausea, dizziness, headache, mood changes, and anorexia.
Updated 3 days ago.
Contrave and Vomiting
12 Replies RSS Share
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds. The pill seems to make everything taste bad. Coffee, spicy food, even just scrambled eggs taste bitter and gritty. I didn't have any other side effect. This past week, the nausea has moved on to vomiting. I've used Tumms and Dramamine as well as a prescription anti nausea med on and off for all three months. I truly feel poisoned. I feel ridiculous that I have used this knowingly for 3 months and endured feeling sick. I've spent a lot of money and feel terrible even a week after stopping the drug. Please don't take this. I feel that fairly soon enough folks will complain enough to take it off of the market. ## I dont feel that it should be taken off th...
Updated 5 days ago.
Contrave and Suboxone
44 Replies RSS Share
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...
Updated 6 days ago.
wanting to quit taking contrave
131 Replies RSS Share
I need to know how to stop taking contrave. Can I just quit cold turkey or do I wean off? If I wean off how do I do it? ## Hello, Janice! How are you? How long have you been taking it? Why do you want to stop it? The FDA lists Contrave as being used to aid in weight loss and its typical side effects may possibly include nausea, dizziness, nervousness, insomnia and anorexia. Have you consulted your doctor? It does require slow tapering for some people. ## I was looking up how to wean myself off of Contrave and found this comment on here. I've been taking Confrave for about a month or so. I just started the 2 pills in the morning and 2 pills at night dose Sunday (today is Friday). I've felt horrible all week since increasing it. Hot flashes in my face, horrible nausea, glands some...
Updated 7 days ago.
Stop contrave
4 Replies RSS Share
I have been on this for about a month. I was only taking 3 a day. I didn't feel comfortable taking 4. So my Dr said that was fine. Then Friday night I felt done swelling in my throat, but that subsided after a couple hours. I went to bed, got up to go to bathroom and my legs felt really heavy. So I laid back down and in about 5 minutes later got up, same thing. I also started feeling very nauseous. Thought maybe I was coming down with the flu. Never got sick, just felt bad. Finally was able to sleep. Still feeling bad the next morning. Decided to take only 1 the next morning. Decided to check my bp at Dillons. I know they are not real accurate, but give me an idea. My bp was 150/89. Went to minor med. They checked it, it was 130/90. So a little high. I am on bp meds. Didn't take...
Updated 9 days ago.

Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 71 replies
contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 63 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 50 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 44 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 40 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 29 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 15 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 12 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 10 replies
Contrave and pain meds
I've been on Vicodin for years due to chronic pain. My Doc prescribed this for me and said it was ok to take togethe... 7 replies

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