Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Contrave Overview

Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.[1][2] It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[3] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Contrave Forums: RSS Feed

Contrave and Suboxone
59 Replies RSS Share
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...
Updated 3 minutes ago.
Contrave and Vomiting
14 Replies RSS Share
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds. The pill seems to make everything taste bad. Coffee, spicy food, even just scrambled eggs taste bitter and gritty. I didn't have any other side effect. This past week, the nausea has moved on to vomiting. I've used Tumms and Dramamine as well as a prescription anti nausea med on and off for all three months. I truly feel poisoned. I feel ridiculous that I have used this knowingly for 3 months and endured feeling sick. I've spent a lot of money and feel terrible even a week after stopping the drug. Please don't take this. I feel that fairly soon enough folks will complain enough to take it off of the market. ## I dont feel that it should be taken off th...
Updated 20 hours ago.
Endless Headache after stopping Contrave.
4 Replies RSS Share
I have tried Contrave for two weeks now. While I did lose some weight I didn't feel very good. I started noticing that I was not able to think quickly like recalling names & somtimes when I would be talking my a random/ easy word would come out as if I was slurring my speech. So I stopped Contrave. Since stopping I have had pretty significant headache now for 6 straight days. Neither Advil or asprin seem to make it better. Was wondering if anyone else has stopped Contrave & experienced bad headaches? ## Hello, Meryl! How are you? I'm sorry about what you've experienced. I was just reading over the detailed side effects of Contrave, as listed by the FDA and it has been known to cause those, along with nausea, headache, mood swings, dry mouth and insomnia. As to the he...
Updated 2 days ago.
Contrave and Celexa
3 Replies RSS Share
I just filled my prescription and will be starting tomorrow. I'm excited but nervous as I'm on Celexa and I've read that there is a possibility of major side effects. Has anyone else experienced anything? ## The Bupropion in the Contrave can increase the effect of Celexa, so you do need to be careful of that and your doctor may need to adjust your dosage of it. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, insomnia, nervousness and anorexia. Is there anything else I can help with? ## I'm taking contrave and Celexa. I have been on for 2 months. My last period was very very light and this month not at all. I took a pregnancy test and it was negative. I use Nuva ring and usually start as soon as I take it out. Could this combo of ...
Updated 2 days ago.
Stopping Contrave
6 Replies RSS Share
How do you stop Contrave when you are at your goal weight? Do you go down in dosage or stop cold turkey? ## Follow the titration schedule in reverse. Just as you had to gradually increase the dosage you must gradually decrease it. ## At first I didn't realize that Contrave (bupropion/naltrexone) carried the risk of serious withdrawal symptoms associated with an abrupt cessation of treatment; similar to opioids, benzodiazepines, SSRI's, etc... Although with bupropion being an antidepressant I could certainly see how starting and stopping it might negatively impact the brain's chemical balance. But when it comes to naltrexone being an opioid antagonist (blocking the opioid receptors / endorphins) I had initially gotten the sense that discontinuing naltrexone under a cold turke...
Updated 3 days ago.
Can Contrave pills be cut in half?
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I have bad nightmares and a fever blister on my lower lip. I take 90mg contrave. Can I cut the dose in half?
Updated 3 days ago.
Contrave and smelly urine
7 Replies RSS Share
OMGOSH... I can not believe I am asking this, but.... I am on month 4 of Contrave and my urine has an odor. I have looked at the side effects and I do not see that as one of them.... Does anyone else have this issue or is it just me? ## Almost any medication can cause such a side effect, according to NIH studies, since you are adding a new chemical to your body. However, if you start experiencing other symptoms, such as pain, burning when urinating, or blood in your urine, please see your doctor, as soon as possible. Are you on any other medications? ## I’m having the same issue. Going to see doctor to make sure it isn’t another problem, but I’m almost positive it’s the Contrave. Started about a month in as well. ## Yes, yes, yes. I am entering my third month on ...
Updated 5 days ago.
Contrave / ringing in ears
31 Replies RSS Share
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! How are you? Yes, tinnitus is among the possible side effects that are listed by the FDA. Other symptoms you may experience could possibly include nausea, dizziness, constipation, headache, upper abdominal pain, irritability, rash and muscle strains. How long have you been taking it? Most side effects are transient and will taper off in severity as your body gets used to the medication and will go away entirely after about 4 to 6 weeks. ## yes - please beware this was one of the most horrible experiences of my life...I started contrave - was on it for about a month and started experiencing ringing in my became so loud that I couldn't even hear...I immediate...
Updated 7 days ago.
Does Contrave make anyone else's hands shake?
25 Replies RSS Share
I'm on my 4th week (2 pills each am & pm) of Contrave and I find my hands shaking when i'm holding something and my heart rate is way up. Anyone else go through this? Also, is it safe to stop Contrave all at once or should you gradually go down the same as it was started. ## Yes.. I have been on Contrave for about 5 months and I actually had a different symptom…I was having Phantosmia (Phantom Smells) like I smell smoke when there is none. It has been bothersome… but then I also started feeling shaky and even noticed a true tremor in my right ring finger. I started freaking out because I looked all over the Contrave sight and didn't see this as a side effect. If you look up those two symptoms its points to brain tumor or Parkinsons! I went to my Doc who presc...
Updated 7 days ago.
wanting to quit taking contrave
142 Replies RSS Share
I need to know how to stop taking contrave. Can I just quit cold turkey or do I wean off? If I wean off how do I do it? ## Hello, Janice! How are you? How long have you been taking it? Why do you want to stop it? The FDA lists Contrave as being used to aid in weight loss and its typical side effects may possibly include nausea, dizziness, nervousness, insomnia and anorexia. Have you consulted your doctor? It does require slow tapering for some people. ## I was looking up how to wean myself off of Contrave and found this comment on here. I've been taking Confrave for about a month or so. I just started the 2 pills in the morning and 2 pills at night dose Sunday (today is Friday). I've felt horrible all week since increasing it. Hot flashes in my face, horrible nausea, glands some...
Updated 8 days ago.

Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 68 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 59 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 51 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 40 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 31 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 19 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 14 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 10 replies
Contrave and smelly urine
OMGOSH... I can not believe I am asking this, but.... I am on month 4 of Contrave and my urine has an odor. I have looke... 7 replies

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