Contrave

Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Pharm Company: * OREXIGEN THERAPEUTICS INC
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Contrave Overview

Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity.[1][3] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant.[1] It is taken by mouth.[1] Both medications have individually shown some evidence of effectiveness i...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Bupropion/naltrexone

Recent Contrave Forums: RSS Feed

Contrave not working anymore

I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it has not been working after that 10 months. I don’t have any side effects, but have a ridiculous appetite now. Almost to the point of wanting to binge eat. Anybody else been on it a while and have it stop working? I’ve gained almost 10 pounds back in the last few months. I’m not sure whether to ask my doctor about stopping it, but I’m afraid my appetite will be even worse. Anybody? ## I had the same problem. I was starving hungry and wanted to eat and eat. Weirdest thing was that I felt constantly hungry even after a week? ## You are not the only people who have experienced such issues. Most people who have tried it have reported eventually hittin...

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Does Contrave make anyone else's hands shake?

I'm on my 4th week (2 pills each am & pm) of Contrave and I find my hands shaking when i'm holding something and my heart rate is way up. Anyone else go through this? Also, is it safe to stop Contrave all at once or should you gradually go down the same as it was started. ## Yes.. I have been on Contrave for about 5 months and I actually had a different symptom…I was having Phantosmia (Phantom Smells) like I smell smoke when there is none. It has been bothersome… but then I also started feeling shaky and even noticed a true tremor in my right ring finger. I started freaking out because I looked all over the Contrave sight and didn't see this as a side effect. If you look up those two symptoms its points to brain tumor or Parkinsons! I went to my Doc who presc...

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Contrave and alcohol consumption

I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and am weary about taking in and wanting to continue to socially drink (glass of wine, socially drink on weekends) ## @pnj, According to umm.edu's drug interaction checker, there ARE potentially dangerous interactions between Contrave and Alcohol. These statements go on to note the following: Consuming alcohol with Bupropion (one of the active ingredients in Contrave) may lead to an increased risk of seizures, decreased tolerance to alcohol, muscle spasms, confusion, and changes in cognitive awareness. For those reasons mentioned above, I would not encourage anyone to take the two together or even within the same day. Hope this helps! ## OK, I read the notice about alco...

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Contrave and Suboxone

I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...

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Taking Contrave after a gastric bypass

Can a bariatric patient who had gastric by pass take it? Gaining a few pounds don’t want to get it out of control. Also I take concerta for ADHD. Is it safe?

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Contrave Dosage Question

My doctor prescribed to take this as 2 pills 2x per day. Not a ramp up like I read about online - has anyone else done this? I have not started taking the pills yet. ## You really should gradually increase it. It isn't fun gradually, it has to really suck taking it all at once. I would think it could hurt you taking it all straight away. The dr will write the rx for the full amount but either tell the pt to gradually increase or give them a sheet of paper. He gave me a pamphlet from the company that makes it. Ive found this to be common with other medicines that had to be brought up to a full dose over time. You should call and ask your doctor what you should do and tell them about the titration schedule. He may not know about it. I've had to inform my doctors about a lot of thi...

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Stopping Contrave prior to surgery? How long???

I've been on Contrave for 6 months with some slight success. I've lost about 6 lbs, but I also have not gained any weight, which is at least a step in the right direction. I don't follow all the rules and don't exercise enough. I was initially scheduled to have ENT surgery for a severe sinus infection in 2 days (Wednesday). Surgery has now been moved to 8 days (following Tuesday). My GP told me today that I should off Contrave for 2 weeks prior to surgery because of the naltrexone, because it might interfere with anesthesia. I've looked online and cannot find any mention this. She also told be that because the naltrexone dose (8mg) is so I need to check with the anesthesiologist to be sure. I called the surgeon's office and his nurse called the anesthesiologist w...

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Wanting to quit taking Contrave

I need to know how to stop taking contrave. Can I just quit cold turkey or do I wean off? If I wean off how do I do it? ## Hello, Janice! How are you? How long have you been taking it? Why do you want to stop it? The FDA lists Contrave as being used to aid in weight loss and its typical side effects may possibly include nausea, dizziness, nervousness, insomnia and anorexia. Have you consulted your doctor? It does require slow tapering for some people. ## I was looking up how to wean myself off of Contrave and found this comment on here. I've been taking Confrave for about a month or so. I just started the 2 pills in the morning and 2 pills at night dose Sunday (today is Friday). I've felt horrible all week since increasing it. Hot flashes in my face, horrible nausea, glands some...

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Can I stop taking Contrave after a week without side effects

I've taken Contrave for a week, Can I stop taking it with? Well there be any side effects from stopping with out gradually ? ## Hello, Maria! How are you? No, there shouldn't be any problems after such a short period of time, but you should check with your doctor to be certain. Why are you stopping it, already? The FDA lists the typical side effects of Contrave as possibly including nausea, dizziness, insomnia, dry mouth and diarrhea. ## After reading all these posts, I have nearly waisted $ 70.00 because I a seriously wondering if Contrave is really worth it for me. I know how to lose weight without pills but this Contrave just made me not wanting any sweets at all, which is my weakness. Regardless I will do the scale down program. I wish all of you success on your weight loss ...

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Contrave - Liver function

I took Contrave for a few months and stopped a month ago because my hair started falling out. This had a blood test and results indicate liver disfunction (all enzymes measured are raised, my ALT the highest, about three times higher than normal range). My Dr is worried about cirrhosis/tissue death. I have a fibroscan and ultrasound tomorrow and have had anothed set of bloods taken - will have more answers this week. I have done a little reading and see Contrave can cause liver disease. I have never been healthier (otherwise) - eat well (Dr said tge dramatic rise in 6 months couldn't be diet related anyway), exercise five times a week, have consistently lost small amounts of weight (10kg since May). However, I am bloated aften, tired, dizzy, have muscle cramping and weaknesses, am itch

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Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 78 replies
Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 67 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 53 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 47 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 36 replies
Contrave not working anymore
I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it h... 29 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 23 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 20 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 13 replies




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