Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Contrave Overview

Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity.[1][3] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant.[1] It is taken by mouth.[1] Both medications have individually shown some evidence of effectiveness i...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Contrave Forums: RSS Feed

contrave and sleepiness

I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sleepy I can't stand it. Days 1 and 2 I managed to fight it off until about 12-12:30, day 3 until about 1-1:30, and day 4 I fought it off until 3pm. If I take a 1-2 hour nap, I wake up fine, with energy and then cannot get to sleep until about 2am, sometimes 3am. Today is day 5, I'm having that "drunk" feeling and sleepy, but no where near how it has been. It seems this effect is slowly wearing off, but I haven't seen anywhere where this is a common side effect. I know all medications effect everyone differently, so I'm wondering if this is something I should be concerned about, or just another side effect that I will get used to as the weeks go o...

Contrave / ringing in ears

Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! How are you? Yes, tinnitus is among the possible side effects that are listed by the FDA. Other symptoms you may experience could possibly include nausea, dizziness, constipation, headache, upper abdominal pain, irritability, rash and muscle strains. How long have you been taking it? Most side effects are transient and will taper off in severity as your body gets used to the medication and will go away entirely after about 4 to 6 weeks. ## yes - please beware this was one of the most horrible experiences of my life...I started contrave - was on it for about a month and started experiencing ringing in my became so loud that I couldn't even hear...I immediate...

Contrave and Suboxone

I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...

Contrave stopped working week 4

I am finishing up my fourth week on contrave. The first two weeks were pretty brutal with all of the terrible side effects. But my appetite was definitely diminished and I did not have the urge to binge eat. Now that I am on week four most of the side effects are gone but I also don't feel like contrave is working at all. My appetite is almost back to normal, I think about food all the time. I'm pretty disappointed. Has anyone else experienced this? ## Yes, most people do report experiencing a period of time where it seems to stop working, for a brief period, but then starts again, after a few weeks. (This is going by user reports as posted online.) The FDA lists its typical side effects as possibly including nausea, dizziness, nervousness, headache, and insomnia. How are you do...

Contrave and alcohol consumption

I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and am weary about taking in and wanting to continue to socially drink (glass of wine, socially drink on weekends) ## @pnj, According to's drug interaction checker, there ARE potentially dangerous interactions between Contrave and Alcohol. These statements go on to note the following: Consuming alcohol with Bupropion (one of the active ingredients in Contrave) may lead to an increased risk of seizures, decreased tolerance to alcohol, muscle spasms, confusion, and changes in cognitive awareness. For those reasons mentioned above, I would not encourage anyone to take the two together or even within the same day. Hope this helps! ## OK, I read the notice about alco...

Side effects of Contrave

I'm on my third day. Today I have a severe headache. But my question is this, has anyone had bad diarrhea? I get cramps, then bam. But I was feeling better by night. Today is the worst. Should I continue or stop? ## Hello, Shercon! How are you doing? I'm very sorry about the way you're feeling. Those can be normal side effects of Contrave and it may take about a month for them to wear off, as your body gets used to the medication. Other side effects, as listed by the FDA, may possibly include dry mouth, dizziness and nausea. Have you consulted your doctor? Unless they feel there is some reason to be concerned, you should most likely continue taking it. ## Verwon -- are you taking Contrave? ## I'm on Contrave and the stomach discomfort wore off, very mild headache left to...

Contrave and Liver function

I took Contrave for a few months and stopped a month ago because my hair started falling out. This had a blood test and results indicate liver disfunction (all enzymes measured are raised, my ALT the highest, about three times higher than normal range). My Dr is worried about cirrhosis/tissue death. I have a fibroscan and ultrasound tomorrow and have had anothed set of bloods taken - will have more answers this week. I have done a little reading and see Contrave can cause liver disease. I have never been healthier (otherwise) - eat well (Dr said tge dramatic rise in 6 months couldn't be diet related anyway), exercise five times a week, have consistently lost small amounts of weight (10kg since May). However, I am bloated aften, tired, dizzy, have muscle cramping and weaknesses, am i...

Contrave and Trazodone

Can I still take Trazodone at night when I take Contrave? I have insomnia and can’t sleep without Trazodone. ## Combining the two medications can create a risk of your experiencing potentially dangerous seizures, because the Bupropion doesn't play nice with the Trazodone, and combining the Trazodone with the Naltrexone increasedsyour risk of experiencing liver damage. You can use this interaction checker, and others that are available to read more details. What has your doctor advised? You may need to take a very low dose of the Contrave, or try a different medication for insomnia.

Took only one contrave pill and still feel bad 5 days later

Has any of you experienced this? I took my first and last pill of contrave last Thursday and shortly afterwards experienced extreme anxiety, dizziness and later diarrhea. The following day I got a very bad headache. I then thought it was over because the drug must definitely be out of my system. But no, I woke up today 5 days after taking the feeling dizzy and had another episode of diarrhea. I had barely eaten anything these past 5 days. I have no appetite whatsoever. Is it possible this is still the drug? I was feeling fine until I took it. ## Monica, I am sorry to hear that you have not been feeling well. Here is a list of reported side effects caused by Contrave - nausea, - headache, - vomiting, - constipation, - diarrhea, - dizziness, - trouble sleeping (insomnia), - dry mouth, - a...

Stopping Contrave for a week then restarting

I went on vacation from 3/27/16-4/2/16 and did not take my usual two doses (2 pills each dose) of contrave as I normally do. When I returned I began with 1 dose of 2 pills around 1pm on Sunday 4/3, then Monday I resumed the usual 2 doses/2 pills each. And now it's Tuesday, I have taken my morning dose and have since felt the nausea and headaches come on. Ibuprofen has not worked for the headaches, and as for the nausea, I simply am just drinking water. I have not been able to eat anything today (it's 2:48pm). These side effects feel like the 4th week when I originally started Contrave in October. I suppose I thought I could resume the normal dosage without issues. Has anyone had the same problems? Thanks in advance! ## Hello, Lauren! How are you feeling? Has there been any chang...


Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 79 replies
Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 70 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 54 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 47 replies
Contrave not working anymore
I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it h... 38 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 37 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 23 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 20 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 13 replies