Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Contrave Overview

Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.[1][2] It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[3] In September 2014, a sustained release formulation of the drug was approved for marketing in the United States under the brand name...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Contrave Forums: RSS Feed

Contrave - restarting and side effects

I've been taking Contrave for about 2 1/2 months. During week 6 or so I was hospitalized with a severe UTI and kidney infection (4 days). The hospital wouldn't give me Contrave during my stay but I resumed when I got home by taking 1 pill a day for a week, then back to the normal doesage of 4/day. I am not noticing any benefits from the Contrave now. 1. I'm wondering if the UTI was a side effect of the Contrave (it's listed as a possible side effect) and 2. Why am I not having any of the benefits? How do I get back to losing? ## Hello Kim, Sorry to hear about your severe UTI but I'm glad to hear that you're doing better now. I have been browsing the Contrave official website for a few minutes and I noticed that I don't see UTI listed as a potential side effec...

Is it worth it to continue?

I have been taking this pill now for 2 weeks. I lost the 3 lbs the 1st week. Since then I have gained like 6lbs. However, I can tell that it's curbing my appetite, but no more weight loss. I'm trying to decide if I continue. I'm totally sleep deprived and constipated to the max degree...Is it worth it to continue? ## Hello Meme, I would like to help you but I need some information to go off of. What medication are you taking and was it prescribed to you? Just some information that may help you. Eating less food does not necessarily mean that you will lose weight. The only way to lose weight is to burn more calories than you are consuming in a day, so no matter how low your intake is you could theoretically still gain weight if you were to burn less energy. If you don't f...

Plateau after losing 38 lbs

I've been on it since last July and have lost 38 lbs, but I hit a plateau about a month ago. I am trying to limit calories and walking 3 miles a day. I just seem to be getting very hungry in the evening again. Am I immune to the contrave now? It is costing me $60 dollars a month now. My insurance doesn't pay for it. ## Hello, Cheryl! How are you? Has there been any change? You're not likely resistant to it, already, most people taking it have reported hitting a plateau period for anywhere from a few weeks to a month, before it started working for them, again. The FDA lists its typical side effects as possibly including nausea, dizziness, insomnia, nervousness and anorexia. Is there anything else I can help with? ## The same thing is happening to me it's coming up on a ye...

Contrave, appetite control

I want to know about whether or not people experience appetite control? Everyone just keeps saying they lost a couple of pounds or they didn't. But I want to know did you have a decreased appetite? Did you see that piece of cake sitting there and able to say no thanks or just grab it and dig in... Did it help you feel less cravings or not? ## According to, "Naltrexone works by decreasing the craving for alcohol and blocking the effects of opiate medications and opioid street drugs" - "Bupropion works by increasing certain types of activity in the brain"... These are the two active ingredients present in Contrave. The drug monographs do not give any consideration to the idea of appetite control. However, my opinion is, one's own unique level of wil...

Can I stop taking Contrave after a week without side effects

I've taken Contrave for a week, Can I stop taking it with? Well there be any side effects from stopping with out gradually ? ## Hello, Maria! How are you? No, there shouldn't be any problems after such a short period of time, but you should check with your doctor to be certain. Why are you stopping it, already? The FDA lists the typical side effects of Contrave as possibly including nausea, dizziness, insomnia, dry mouth and diarrhea. ## After reading all these posts, I have nearly waisted $ 70.00 because I a seriously wondering if Contrave is really worth it for me. I know how to lose weight without pills but this Contrave just made me not wanting any sweets at all, which is my weakness. Regardless I will do the scale down program. I wish all of you success on your weight loss ...

Contrave and Suboxone

I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...

Contrave Side Effects - Kidney pain

On day 5 of my first dosage of Contrave, I started with low back/kidney pain. (I already had MOST of the common side effects such as NAUSEA, BAD HEADACHES, HOT FLASHES & SWEATS etc. How could we forget the often uncontrollable DIARRHEA! On day 9, I couldn't stand it. My doc sent me for a u/a and put me on Baytril for a UTI....but this is WAY WORSE than usual. I was so sick on days 10 and 11 that the doctor advised I STOP CONTRAVE! I hope I did not damage my kidneys during this brief episode. I'm drinking lots of water and hoping the Contrave leaves my body soon. Anyone else with a similar experience? ## How long have you been off of it, now? It can cause bladder pain, as a side effect, along with bloody or cloudy urine, according to FDA reports. It is unlikely that it has do...

Contrave / side effects

On Contrave six months and lost 44 lbs. I have also lost a tremendous amount of hair. I am female. Anyone else have this problem? ## Hello, Helen! How are you? The FDA does list that as being a possible side effect of this medication, though it is not considered a common one. Other side effects may include nervousness, dizziness, insomnia, and indigestion. Is there anything else I can help with? ## I have also lost a lot of hair taking contrave. Shocked how much. It is the Wellbutrin component of Contrave that is the cause. The dose of Wellbutrin in contrave is way at the upper limit of dosing for Wellbutrin if you were just taking Wellbutrin alone. I did not come across this side effect much when I read about Contrave prior to taking it but after the hair loss started I took a second l...

contrave / rash

what does the rash that a person might get while on this med look like? ## It depends on why they are getting the rash. If it's a side effect rash, it usually just looks like a systemic rash that covers a large portion of the body, but it isn't itchy and doesn't include hives. However, an allergic rash will usually be itchy and cause hives. The FDA lists the other typical side effects of this medication as possibly including nausea, dizziness, insomnia, nervousness and anorexia. Have you consulted your doctor? They should be able to let you know what has caused the rash. ## I have been on Contrave for 2 weeks. I didn't have any side effects until I started taking 2 pills a day. Now I am breaking out in bumps under my arms, under my belly, my back and on the inside of my ...

what can you take with the insomnia when taking contrave

I just start taking Contrave. I am on day 5 with one pill in the morning and haven't been sleeping much at all. Scared to take two pills a day. Any suggestions on what will help? Don't want to stop taking it because I can tell my cravings are more controlled. I already take a Melatonin a night. I also drank some sleepy time tea last night. Will this go away? ## Hi Ann, Sorry to hear about your challenges with insomnia. According to, a "sudden increase in energy, racing thoughts or trouble sleeping" is listed as a side effect of Bupropion (one of the active ingredients in Contrave). Source: They also list, "trouble sleeping or a big increase in energy" as a side effect of Naltrexone (the other active ingredient in ...


Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 75 replies
Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 63 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 52 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 46 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 34 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 22 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 20 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 12 replies
contrave not working anymore
I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it h... 12 replies

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