Contrave

Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Pharm Company: * OREXIGEN THERAPEUTICS INC
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Contrave Overview

Bupropion/naltrexone is a combination drug used for weight loss in those that are either obese or overweight with some weight-related illnesses.[1][2] It combines low doses of bupropion and naltrexone. Both drugs have individually shown some evidence of effectiveness in weight loss, and the combination has been shown to have some synergistic effects on weight.[3] In September 2014, a sustained release formulation of the drug was approved for mar...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Bupropion/naltrexone

Recent Contrave Forums: RSS Feed

contrave and sleepiness

I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sleepy I can't stand it. Days 1 and 2 I managed to fight it off until about 12-12:30, day 3 until about 1-1:30, and day 4 I fought it off until 3pm. If I take a 1-2 hour nap, I wake up fine, with energy and then cannot get to sleep until about 2am, sometimes 3am. Today is day 5, I'm having that "drunk" feeling and sleepy, but no where near how it has been. It seems this effect is slowly wearing off, but I haven't seen anywhere where this is a common side effect. I know all medications effect everyone differently, so I'm wondering if this is something I should be concerned about, or just another side effect that I will get used to as the weeks go o...

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Contrave and weight gain

I've only been on Contrave for 4 days and I've gained 6 pounds. My legs, feet and stomach are swollen, so I assume it's retention of water? Anyone else had this reaction? ## The FDA does list that as a possible side effect, along with nausea, dizziness, irritability, nervousness, and insomnia. Have you consulted your doctor? That is always the best thing to do to be sure. Such rapid weight gain can also be a sign of other potential risky health issues, such as congestive heart failure. Are you on any other medications? ## I have been drinking a ton of water since I started the meds last week. I would be sure you are drinking a lot. That will help with the fluid retention. ## Hello everyone, I am at the beginning of week 5 and have not really lost any weight. Maybe a pound or...

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Contrave and High Fat Foods

I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrave. All the warnings say is do not take with a high fat meal. Well, how long do you have to wait? There is no information on that! Has anyone heard? ## Hello, MrsMeck! How are you? Have you tried asking your doctor? Unfortunately, I'm only finding the same thing you are, not to take it with a high fat meal, but no specific time frame. Taking it with a high fat meal creates the risk of seizures. Other typical side effects, as listed by the FDA, may possibly include nausea, dizziness, headache, nervousness and anorexia. Does anyone know more? ## I spoke to a consultant at Takeda today and they recommended that I call my dr. But the problem would be that the doctor wou...

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Buproprion Users

I take Bupropion for depression already and it is the second of the active drugs in Contrave. I was concerned about that but the doctor knew I was on it at the time of prescription. I am only on day 3. I feel a tad less bloated and found I lost a pound already. Day 2 wasn't great - had nausea, but it finally passed. I'm wondering if high fat foods bring on nausea as I had 2 modest size servings of pizza but heavy on the cheese. I think that had something to do with it. I'm a little concerned as I kick up in dosage on Contrave with the Buproprion already in my system but we'll see and I'll update. Curious if anyone else uses Buproprion as well. BTW, yes it does curb smoking tendencies. ## The manufacturer does warn that it shouldn't be taken with other medications...

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Does Contrave make anyone else's hands shake?

I'm on my 4th week (2 pills each am & pm) of Contrave and I find my hands shaking when i'm holding something and my heart rate is way up. Anyone else go through this? Also, is it safe to stop Contrave all at once or should you gradually go down the same as it was started. ## Yes.. I have been on Contrave for about 5 months and I actually had a different symptom…I was having Phantosmia (Phantom Smells) like I smell smoke when there is none. It has been bothersome… but then I also started feeling shaky and even noticed a true tremor in my right ring finger. I started freaking out because I looked all over the Contrave sight and didn't see this as a side effect. If you look up those two symptoms its points to brain tumor or Parkinsons! I went to my Doc who presc...

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Contrave and Restless Leg Syndrome

Has there been any studies or anecdotal information on Contrave and Restless Leg Syndrome? ## Hello Walt, According to the NIH restless leg syndrome is not an adverse reaction that is associated with this drug, however that does not mean that it's impossible for it to be the root cause. According to the report given by the FDA only 3 individuals out of 2,778 reported restless syndrome as a condition they noticed after taking contrave. Are there any other medications that you are taking in addition to the contrave? ## Since taking contrave, my severe rls is much improved!

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Dosage after taking a break from Contrave

I took Contrave for about four months and lost 10 lbs. Decided I would stop and didn't take it for a month. I immediately started craving sweets again and started gaining weight, so I decided to start taking it again. Got a refill today but not sure if I should start over, with the minimum dosage, or go back to the maximum dosage. Or maybe somewhere in between..maybe two a day? I also seemed to develop a bit of a tremor when I was taking the medication and that got better when I stopped. However, I am diabetic and don't want to gain a lot of weight again. ## I would definitely start slow if I restarted at all. The dosage needs to build up in your system or you may be subject to more severe side effects. GLTU. ## @Rick, Ultimately I think it would be best to consult your doctor f...

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Wanting to quit taking Contrave

I need to know how to stop taking contrave. Can I just quit cold turkey or do I wean off? If I wean off how do I do it? ## Hello, Janice! How are you? How long have you been taking it? Why do you want to stop it? The FDA lists Contrave as being used to aid in weight loss and its typical side effects may possibly include nausea, dizziness, nervousness, insomnia and anorexia. Have you consulted your doctor? It does require slow tapering for some people. ## I was looking up how to wean myself off of Contrave and found this comment on here. I've been taking Confrave for about a month or so. I just started the 2 pills in the morning and 2 pills at night dose Sunday (today is Friday). I've felt horrible all week since increasing it. Hot flashes in my face, horrible nausea, glands some...

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Contrave and Suboxone

I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...

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Contrave and Celexa

I just filled my prescription and will be starting tomorrow. I'm excited but nervous as I'm on Celexa and I've read that there is a possibility of major side effects. Has anyone else experienced anything? ## The Bupropion in the Contrave can increase the effect of Celexa, so you do need to be careful of that and your doctor may need to adjust your dosage of it. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, insomnia, nervousness and anorexia. Is there anything else I can help with? ## I'm taking contrave and Celexa. I have been on for 2 months. My last period was very very light and this month not at all. I took a pregnancy test and it was negative. I use Nuva ring and usually start as soon as I take it out. Could this combo of ...

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Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 78 replies
Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 65 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 52 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 47 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 36 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 23 replies
contrave not working anymore
I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it h... 21 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 20 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 13 replies




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