Contrave

Active Ingredient(s): Bupropion Hydrochloride + Naltrexone Hydrochloride
FDA Approved: * September 10, 2014
Pharm Company: * OREXIGEN THERAPEUTICS INC
Category: Diet / Weight Loss

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Contrave Overview

Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity.[1][3] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone antidepressant.[1] It is taken by mouth.[1] Both medications have individually shown some evidence of effectiveness i...

Read more Contrave Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Bupropion/naltrexone

Recent Contrave Forums: RSS Feed

Dyspnea from Contrave

I am off contrave but still having breathlessness. How long will this last?

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Contrave not working anymore

I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it has not been working after that 10 months. I don’t have any side effects, but have a ridiculous appetite now. Almost to the point of wanting to binge eat. Anybody else been on it a while and have it stop working? I’ve gained almost 10 pounds back in the last few months. I’m not sure whether to ask my doctor about stopping it, but I’m afraid my appetite will be even worse. Anybody? ## I had the same problem. I was starving hungry and wanted to eat and eat. Weirdest thing was that I felt constantly hungry even after a week? ## You are not the only people who have experienced such issues. Most people who have tried it have reported eventually hittin...

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Nausea and nasty taste in mouth,post gastric bypass failure

I have been on Contrave over one month. I was so nauseous that I cut down from four pills a day to three,2 in the morning and 1 at night. I am still experiencing nausea,thinking of trying Dramamine. The " grazing" during the day has completely disappeared. I have lost a few pounds, so it's going very slowly. I also had gastric bypass 10 years ago and started to gain again in the last 5 years. Sure hope Contrave will continue to help,though the nausea seems to be winning at this point. Also have ringing in the ears. The nasty taste in my mouth is disgusting. Kind of like a metallic/ bitter taste. It's a reason why I cut down to 3 pills a day and have to say that did help! ## Those can be normal side effects of the medication, according to FDA reports, but typically such i...

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Contrave and bad breath

Hello, I am on week 4 of Contrave and have lost 11lbs. Ever since starting this medication my husband says my breath is bad. I drink a lot of water and have mints but this is like coming up from my stomach. Other than that I haven't had bad side effects. I do sweat more at the gym where as before I didn't. But anyone else experience this or have a solution? I'm very diligent about oral hygiene. ## Hello, Ginaye! How are you? I'm not seeing that listed among the side effects, but it can cause some gas and dry mouth, which may be contributing to the problem. Especially, since you said it seems to be coming up from your stomach. Other side effects may include nausea, dizziness, insomnia and anorexia. Has anyone else on Contrave experienced this? ## I am currently on week 5 ...

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Splitting Contrave Pills

I just started Contrave last Friday. I have really had no side effects, but because I have a narrowed esophagus, I have trouble swallowing the pill (it gets stuck). I cut the pills in half and take both halves at the same time and this makes it easier for me to get them down. My question - is this messing with the efficacy of the medicine? ## No, they are regular release tablets, so that will not cause a problem with their efficacy, according to NIH reports. The FDA lists the typical side effects as possibly including nausea, dizziness, headache, nervousness, and insomnia. Are you on any other medications? ## You should not split the pills. They are an extended release tablet. This is copied from the Contrave literature: Extended-Release Tablets: 8 mg naltrexone HCl /90 mg bupropion HCl...

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Stopping Contrave

How do you stop Contrave when you are at your goal weight? Do you go down in dosage or stop cold turkey? ## Follow the titration schedule in reverse. Just as you had to gradually increase the dosage you must gradually decrease it. ## At first I didn't realize that Contrave (bupropion/naltrexone) carried the risk of serious withdrawal symptoms associated with an abrupt cessation of treatment; similar to opioids, benzodiazepines, SSRI's, etc... Although with bupropion being an antidepressant I could certainly see how starting and stopping it might negatively impact the brain's chemical balance. But when it comes to naltrexone being an opioid antagonist (blocking the opioid receptors / endorphins) I had initially gotten the sense that discontinuing naltrexone under a cold turke...

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Contrave and Liver function

I took Contrave for a few months and stopped a month ago because my hair started falling out. This had a blood test and results indicate liver disfunction (all enzymes measured are raised, my ALT the highest, about three times higher than normal range). My Dr is worried about cirrhosis/tissue death. I have a fibroscan and ultrasound tomorrow and have had anothed set of bloods taken - will have more answers this week. I have done a little reading and see Contrave can cause liver disease. I have never been healthier (otherwise) - eat well (Dr said tge dramatic rise in 6 months couldn't be diet related anyway), exercise five times a week, have consistently lost small amounts of weight (10kg since May). However, I am bloated aften, tired, dizzy, have muscle cramping and weaknesses, am i...

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Does Contrave make anyone else's hands shake?

I'm on my 4th week (2 pills each am & pm) of Contrave and I find my hands shaking when i'm holding something and my heart rate is way up. Anyone else go through this? Also, is it safe to stop Contrave all at once or should you gradually go down the same as it was started. ## Yes.. I have been on Contrave for about 5 months and I actually had a different symptom…I was having Phantosmia (Phantom Smells) like I smell smoke when there is none. It has been bothersome… but then I also started feeling shaky and even noticed a true tremor in my right ring finger. I started freaking out because I looked all over the Contrave sight and didn't see this as a side effect. If you look up those two symptoms its points to brain tumor or Parkinsons! I went to my Doc who presc...

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Contrave and alcohol consumption

I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and am weary about taking in and wanting to continue to socially drink (glass of wine, socially drink on weekends) ## @pnj, According to umm.edu's drug interaction checker, there ARE potentially dangerous interactions between Contrave and Alcohol. These statements go on to note the following: Consuming alcohol with Bupropion (one of the active ingredients in Contrave) may lead to an increased risk of seizures, decreased tolerance to alcohol, muscle spasms, confusion, and changes in cognitive awareness. For those reasons mentioned above, I would not encourage anyone to take the two together or even within the same day. Hope this helps! ## OK, I read the notice about alco...

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Contrave and Suboxone

I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor stated that the interaction of the two should be minimal..yeah NO! I got diarrhea, hot flashes, chills, body aches, and pretty much every withdrawal symptom known to man. I now dont want to take the contrave because I am not ready to stop the suboxone. Should I just stop the contrave and continue the sub? Or how should I go about this? ## Hello, Kiat! How are you? I'm very sorry about what happened. Yes, the Naltrexone in Contrave can cause you to go into withdrawal from any opiate, as listed by the FDA, and you were doubling it up with the Naloxone in the Suboxone that does that same thing. As to how to continue, it usually takes about 3 days, before you can safely...

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Possible Dosages for this and Related Drugs:

Bupropion Hydrochloride + Naltrexone Hydrochloride
  • Tablet, Extended Release: 8mg + 90mg, 90mg + 8mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Contrave: (2 results)

Sorted by National Drug Code
  • 50090-2868 Contrave Oral Tablet, Film Coated, Extended Release by A-s Medication Solutions
  • 64764-890 Contrave Oral Tablet, Film Coated, Extended Release by Takeda Pharmaceuticals America, Inc.

Drugs with one or more similar ingredients: (5 results)

Related Contrave Topics:

contrave and sleepiness
I started contrave 4 days ago, today being my 5th dose. every day, i take the pill about 8am and by 9:30-10am I am so sl... 78 replies
Contrave vs Belviq
I was on free 2 weeks of Belviq followed by 1 mo out of pocket Belviq. Lost and felt good with NO side effects at all. T... 73 replies
Contrave and Suboxone
I started today with my first dose of contrave, 1 pill in the AM. I also take suboxone 8mg (4 1 time a day). My doctor s... 67 replies
Contrave and alcohol consumption
I have filled my prescription of Contrive but have not yet started taking it. I read all the possible side effects and a... 53 replies
Contrave and High Fat Foods
I ate a high fat meal (stuffed baked potato) tonight and am wondering when it is safe to take my evening dose of Contrav... 47 replies
Contrave not working anymore
I took Contrave and lost 52 pounds in 10 months, which has put me back to my ideal body weight. The problem is that it h... 36 replies
Contrave / ringing in ears
Has anyone suffered from ringing in ears from Contrave? I'm going insane :(. but losing weight :) ## Hello, Jojo! Ho... 36 replies
Contrave and Vomiting
I have been on Contrave for 3 months. I have battled nausea all along, hoping it would go away. I've lost 15 pounds.... 23 replies
Contrave and appetite control
I'm currently on week 3 of Contrave (2 pills in the AM/1 in the PM). When should I possibly be noticing a decrease i... 20 replies
contrave and cymbalta
On day two of Contrave but also on 30mg of cymbalta. My doctor didn't seem to have any worries on both together. Has... 13 replies




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