Efudex Forums

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Very Sore Lips

I am a new Efudix user (week 3) with solar keratosis patches on my face, 8 of them. I am coping OK though as expected, not feeling pretty at this stage! I've read and re-read patient info. but don't see anything about very swollen and sore lips as being a possible side effect of Efudix cream. My AK patches are down each side of my face, nowhere near my lips. My worst patch is starting to ulcerate/crust, so another fortnight to go at least. I can cope with the discomfort, all except for my lips - any ideas? Hats off to all you guys for your encouragement! ## Have you consulted your doctor? Efudex has been known to cause some generalized reactions, including skin pain, irritation, and sun sensitivity. Are you on any other medications? Are you making sure to stay out of bright sunl...

Allergic reaction?

Used Efudex on back of my hand a year ago with little reaction. Had to use again & this time hand turned into Krakatoa! Scabs & weeping spread beyond immediate application site but understand this can happen. However, also have tiny pin head size blisters among & around the crusting with accompanying itching which I haven’t noted in other experiences on here & wonder if it’s an allergic reaction or part of the “process” & I just need to find something to ease the itching. Any advice really welcome as this time of use is becoming quite scarey ## While those can be normal side effects, it is always best to have your doctor check things out to be sure. Other side effects to Efudex may include skin color changes, swelling, and dryness (the last of...

Efudex-40 (fluorouracil)

Need all information about this medication please. ## I have been told to apply Efudex to my lower lip, isn't this crazy? ## Not really. It is listed in the drug monograph that it can be used topically to treat certain cancerous or possibly cancerous conditions. ## Has anyone used it on their lips? Won't it just keep bleeding non-stop? ## Heidi- I've used it on my lips three times. Each time it was an application morning and at bedtime. Though about the second week it gets very sensitive and blister-like lesions appear that means it's working. I applied a product called Acquafor (like Vaseline Jelly) to seal it and protect). The healing takes some time but the outcome is worth it. ## I just used Efudex for 2 weeks on lower lip. from day 7 blistered and ulcerated and wept...

Treating wound after 12 weeks of Efudex

My wound is on my forearm & is about a 1 1/2” square. The skin is eroded and indented. Was told to use Neosphorin, keep covered & change bandages twice daily. Does this sound like good advice?

Efudex 5% and Silkis 3

My new dermatologist has prescribed a one-week per month treatment over four months, applying Silkis 3 in the morning and Efudex 5% at bedtime. I have used Efudex before in one spot, with the expected itching and scabs. What happens when I apply these creams all over my face and scalp, which don't have many particular keratosis spots? My job involves working with the public. ## My dermatologist prescribed Efudex and Desonide last week! Beginning tonight... 7 days Efudex and Desonide am and Desonide pm, followed by Desonide twice a day for 3 days, then stop for 3 weeks. Repeat 4 times after that !

Efudex with Dovonex

Just letting everyone know that I just did the newest Efudex treatment protocol which requires mixing 50% Efudex with 50% Dovonex (vitamin D) and it was very fast and easy. Four days of application of the combo "lit up" my face and 7 days later my face and scalp were virtually back to normal. Minimal pain, like a sunburn, and no scabbing, pus, etc. I was really scared to do the longer treatment after reading blogs and looking at pictures, but the new treatment is a piece of cake. Plus, according to related articles, it actually works better. A real win-win! "SCOTTSDALE, ARIZ. – A four-day topical combination regimen of 5-fluorouracil (5-FU) and calcipotriene removed almost 90% of facial actinic keratoses – significantly more than with 5-FU monotherapy, in a rando...

The 3-week Efudex / Fluorouracil nightmare is now unnecessary!!

Harvard Medical recently discovered a new treatment regime for AK. This new four-day Harvard Medical protocol is going to save us all from the Efudex & Fluorouracil nightmare: Adding calcipotriene to 5-FU dramatically reduced AKs I used this 4-day treatment for AK in Dec '18 and it works!! Save yourself from the 3 week fluorouracil nightmare and do this 4-day treatment instead. I made this Youtube video of my experience with this protocol: The treatment resolves actinic keratosis in only 4 days. No longer is the pain and discomfort of the commonly prescribed 3 week Flouracil necessary to clear your skin of these pre-cancerous lesions. Mix 5% Fluoroucil and Calcipotriene 50/50 and apply twice per day for four days. Both of these creams can be purchased through prescription. Your ...

Efudex, Dovonex and Desonide

My husband has been prescribed Efudex for 10 days (morning and evening on his scalp). Also, Dovonex twice daily and pop-Desonide twice daily (as needed). Which cream does he put on first, second...? Thank you.

Efudex treatment effects

I have used Efudex for four weeks and i now have a lump with a hard crust around it, and it is sore and itchy. What should i do? ## Hello, Judy! How are you? Have you informed your doctor, yet? The U.S. FDA does list the dryness/crusting as being possible side effects of using it. It may also cause abdominal pain, headache and mouth sores. How long has your doctor instructed you to use it? ## Medline Plus states "If you are using fluorouracil to treat actinic or solar keratoses, you should continue using it until the lesions start to peel off. This usually takes about 2 to 4 weeks. However, the lesions may not be completely healed until 1 or 2 months after you stop using fluorouracil. If you are using fluorouracil to treat basal cell carcinoma, you should continue using it until the...

Efudex 5%

Creme ## I have been taking applying 5% Efudex cream for two days to my lip per my Dr. Orders. So far, I have had no swelling or any sign of side effects. Does this mean the spot on my lip is non-cancerous? I was under the impression I was to have swelling and pain, and that this cream kills everything allowing the good cells to regrow. ## have to start the efudex 5% cream once a day on upper and lower lips. I am extremely worried about the pain. Is there anything besides aquafor or Vaseline to he help with pain? ## It contains the active ingredient fluorouracil, which is used to treat areas of skin that have been heavily exposed to the sun, or those that have been tested to have Basal Cell Carcinoma. The FDA lists its typical side effects as possibly including skin redness, irritation,...

Help with pain while using Efudex cream

I am on week 5 of using Efudex just above my baby toe. Really hard to wear shoes so pretty housebound. The pain has been excruciating the last few days. Tried Tylenol, Tylenol 3 and Ibuprofen - and nothing works. Can anyone recommend something? ## It might be best to speak to your doctor to find out what might help you the most, and do so safely. Efudex has been known to cause some pain, redness, and irritation, to the treated area as side effects, along with itching, and darkening of the skin. Has there been any change? Are you on any other medications?

Redness after Efudex treatment

I have used Efudex twice over several years. I wonder what will help the redness that happens after the crust has peeled away? The affected area is upper lip and side of nose. ## Hi Ren, have you finished taking the course of Efudex at this point? Medline Plus says "If you are using fluorouracil to treat actinic or solar keratoses, you should continue using it until the lesions start to peel off. This usually takes about 2 to 4 weeks. However, the lesions may not be completely healed until 1 or 2 months after you stop using fluorouracil." It also says that the redness is normal, except in cases of a severe red skin rash (which should be reported as a serious side effect). Would you consider your case severe? As to treating the redness, you may be able to apply an over the counte...

Efudex doesn't have to be a nightmare

I was prescribed Efudix to treat spots on the back of my hands. I have been applying a thin layer daily for 4 weeks. I have had no side effects, no irritation, burning sensations, blistering or pain. The spots have become slightly redder and that's all. Efudix does not have to a nightmare and every case is different. ## That is correct, we are all different, so not everyone will experience side effects while using it. The typical side effects may include skin redness, burning, sun sensitivity, and swelling. Are you still experiencing good results with it? ## Hi. I will touch base with you again early next week. I am meeting the skin doctor on Monday to get their opinion. Still little or no change after 6 weeks. The Pharmacist has suggested twice daily application but I will be guide...

Efudex (Fluorouracil) Cream 5%

I used this prescription on my forehead twice a day for 10 days. Removed all my ak's. Has now been about 1 year and a few are returning. You must apply a very thin film. It did turn bright red after about 7 days. Remains that way while peeling. About three weeks after stopping treatment. Not much pain for me. Just too much time hiding at home. Don't use any cosmetics while treating. Never do your whole face at once! ## I agree completely. I did the exact treatment in 2014 and have been using this product on and off since then. Only a few have returned to this day. Works great for me. I experienced minimum sting or itching. You must use a very fine touch of cream and then rub it in. Keep treated areas small. Never exceed over 9 x 9 inch or it will get into your blood and cause pa...

Fluorouracil stages?

Can anyone explain the stages and what to look for. I’ve been on Fluorouracil for 23 days suppose to do 4 weeks all over complete face . But face is peeling in some areas and turned a yellowiish crusty in some places. Also cracking and bleeding in tiny spots. Should I keep using it or is this the erosion phase. What to expect next?

Sun and Efudex

I have quit treating my face and neck with Efudex and I am still peeling and having breakouts and the usual recovery. I am still treating my arms and hands. My work commute is 45 mins to 1.5 hours each way depending on the traffic with the average time in my car 2 hrs per day. When can I start getting that much sun exposure and it be safe? Always wear sunscreen too. ## Hello Daisy, According to the [1] NIH Efudex page warnings section it says that exposure to ultraviolet rays should be minimized during and immediately following treatment with Efudex because the intensity of the reaction may be increased. To me this sounds like you should avoid exposing the treated areas to the sun until it has completely finished recovering. The NIH goes on to explain that the redness and peeling typica...

Shortness of breath using Efudex

After applying Efudex to the scalp after a shower I experienced shortness of breath at about 3.00am in the morning. This is not recommended - I should apply it mid to late afternoon. I have had no further effects since doing this. Has anyone else experienced this? My doctor said I may be allergic to Efudex. I hope not. ## Hello Ern, Your doctor is absolutely right, nowhere on the efudex website or the NIH/FDA warnings does it say that shortness of breath is a common effect of administering this medication. It sounds very much like you are allergic to this medication and I strongly suggest that you have your doctor run some tests to verify if you are safe to administer this medication. It would be tragic to have your throat completely close up because you were administering this medicati...

Efudex on scalp - side effects on hair?

Has anyone used Efudex on their head? I'm interested in any side effects on hair deterioration or loss. ## Hello Hoody, Reportedly this will be determined by the amount of efudex that you need to apply. If applied topically then the medicine will not be absorbed into the bloodstream and thus will not cause hair loss like other forms of chemotherapy treatment. If it is necessary to apply enough cream that it will absorb into the blood stream then you will start to experience typical symptoms associated with chemotherapy such as nasuea, vomiting, hair loss etc. Below is a link to the source of my information. [1] Efudex Treatment I hope this answers your question. Let me know if you would like to know anything else regarding this medication. ## Thanks so much Kevin. Will be a 14 light...

has anyone used this on just a small patch on face

hi i have been prescribed efudix for an ak on my cheek. i was give a leaflet which showed some really scary pictures of treatment, of course, when googled its even worse!! I wonder if anyone has used this on only a small patch on their face and if so did their whole face end up being affected as ii have read in some of the stories. has anyone not had any of the adverse side effects that the pictures show? ## My face has patches of dry skin on my forehead and on my chin is this cream good on face. And can it be used for vaginal itch or vaginal yeast infection. If it can be used on face and vagina how often should it be used on these areas? ## Hello June, Unfortunately it does seem to be that nearly all users experience the physical changes in their skin. I did do some research on how to ...

How long does one keep using efudex 40 on spots/sores

I have been using Efudex on spots on chest, arms and legs for 2 months now. Most spots have blistered and turned into weeping sores, some have crusted up and turned into scabs. They are all extremely itchy, the itching drives me crazy when I’ve got these sores arms, chest, legs. Around Some sores that have scabbed over further red spots/lumps have come up surrounding the original sore, like it is spreading. My doctor told me to keep using Efudex until the sores have completely healed and disappeared, is this correct? Putting Efudex on the crusty sores usually stings like mad ## Hello Glyn, According to the medlineplus government page the instructions are as follows. [1] MedLinePlus Gov "If you are using fluorouracil to treat actinic or solar keratoses, you should continue usin...


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