Efudex With Dovonex

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Paul Says:

Just letting everyone know that I just did the newest Efudex treatment protocol which requires mixing 50% Efudex with 50% Dovonex (vitamin D) and it was very fast and easy. Four days of application of the combo "lit up" my face and 7 days later my face and scalp were virtually back to normal. Minimal pain, like a sunburn, and no scabbing, pus, etc.

I was really scared to do the longer treatment after reading blogs and looking at pictures, but the new treatment is a piece of cake.

Plus, according to related articles, it actually works better. A real win-win!

"SCOTTSDALE, ARIZ. – A four-day topical combination regimen of 5-fluorouracil (5-FU) and calcipotriene removed almost 90% of facial actinic keratoses – significantly more than with 5-FU monotherapy, in a randomized, double-blind controlled study.

Calcipotriene (Dovonex) is a synthetic vitamin D3 derivative approved by the Food and Drug Association for treatment of scalp psoriasis. But calcipotriene is also an immunomodulator that induces thymic stromal lymphopoietin (TSLP), which suppresses the growth of early stage skin cancers, said Dr. Shawn Demehri, of Harvard Medical School, Boston."


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Marly Says:

Sounds amazing! I’m supposed to start efudex tomorrow and am dreading it. Any other similar experiences out there?

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paul Says:

Re: Marly (# 1)
Marly, PLEASE ask your doctor about this process - it is virtually painless and takes a couple of weeks. My skin is KSA free, tight and smooth as silk ;)

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Connie Says:

Re: Marly (# 1)

Cbd cream and lidocaine helped tremendously with my pain

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Dmarie Says:

I am on my 6th day also using this method on my face. It does speed the process up!
How are you doing? I can't wait to start healing!

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paul Says:

Re: Dmarie (# 4)

Good for you! Start to finish for me was two weeks. After about a week I was really read faced but had already stopped the treatment so I just shifted to a thin coat of Vaseline and I was completely cleared up about week later. Nothing but smooth skin - kinda look like Brad Pitt now :). Seriously, though, it was very easy and virtually painless. A bit of itching at night, but nothing worse than a typical sunburn.

Good luck with yours!

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Connie Says:

Re: Marly (# 1)

I would ask for the newest treatment with the addition of vitamin D, wow that girl had a good experience above!! It wasn’t fun for me but i did top half first and bottom second... used cbd and lidocaine and covered with make up during the day when i went out as my son said “I looked like the joker”. LOL. Totally worth the pain....

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psyched123 Says:

I used this 4-day treatment for AK in Dec '18 and it works!! Save yourself from the 3 week Fluorouracil nightmare and do this 4-day treatment instead. I made this Youtube video of my experience with this protocol:


The treatment resolves actinic keratosis in only 4 days. No longer is the pain and discomfort of the commonly prescribed 3 week Fluorouracil necessary to clear your skin of these pre-cancerous lesions.

Mix 5% Fluoroucil and Calcipotriene 50/50 and apply twice per day for four days. Both of these creams can be purchased through prescription. However, the Calcipotriene cream can also be bought on Ebay. {affiliate link added}

Here is a link to a description of the Harvard study:

Adding calcipotriene to 5-FU dramatically reduced AKs

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paul Says:

Re: psyched123 (# 7)

Excellent video! My face 'lit up' a bit more than yours, but I experienced basically the same timeline and the pain was very minimal, akin to a sunburn and only for a couple of days. As soon as the 4 day effudex was complete, I just started with a light coat of vasoline and within a few days late, I was all cleared up.

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Don Says:

hi, thanks for all the great info. I am finishing up on the straight Efudex treatment. On my face for 16 days, head 18 days and forearms 21 days. As we know, I went thru all the efudex treatment affects. I am now post 1 month of applying. Healed over etc. BUT my one question, can anyone advise something to use to do with the lasting redness ?? please. I really experienced severe redness, blister - peeling in and around the nose and cheeks. Looking for some help to reduce the redness on a permanent basis. thanks in advance Don

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