Dyskinesia Problem With Rytary

My wife has had PD for 15 years, during which time she has taken nearly every medication available, usually with success at first but with too many side effects eventually to cause her to look for other solutions. The latest is Rytary, which her neurologist prescribed her 62.5/245mg 16 pills per day (4 pills four times). At first she seemed fine with it, but now she has dyskinesia so bad that it is difficult to watch her even try to do simple things. My question is, have any of you found dyskinesia to be a worse problem with Rytary than it was with other PD meds? If so, what have you done about it?

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Hello, Steve! How is your wife doing? I'm sorry about the problems she's been experiencing.

I've not taken this personally, but I can tell you that the FDA does list these involuntary movements as being one of the top most common side effects of this medication. She may also experience bladder pain, confusion, lack of appetite and irritability.

Can anyone that's taken it chime in with possible solutions?

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Thanks, Verwon, for the advice. My wife is doing all right sometimes, and not so well other times. Unfortunately, she isn't getting much help from her PD neurologist, whose idea at first was to cut back the Rytary to 14 pills from 16 per day, but when that caused new problems with wearing off, we went back to the original 16. When that didn't help -- in fact, her wearing off problem seemed to be worse than before -- the advice we got from the neurologist was to add a Parcopa (the orally disintegrating version of levodopa, 100 mg per pill) in between the doses of Rytary. That hasn't helped yet, but we're still working on it. (I don't mean here to be blaming the neurologist, who is stuck with the medications that are available.) However, it suggests to me that with each of these modifications to the Rytary regimen, we are experiencing problems that all seem to reduce or eliminate the potential advantage of Rytary in the first place: an extended release version of Sinemet, which is what it is. Since we haven't uncovered anybody yet who has the same kind of problem with dyskinesia that my wife is having, perhaps we can ask for the next best thing: someone in this group with a story of something positive coming from Rytary. We had such high hopes for it, based on early reports several years ago, and have been disappointed so far.

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