Prucalopride Makes Me Very Hungry All The Time (Top voted first)

Is anyone taking prucalopride resolor? Im just worried because since i started it four months ago, i feel very hungry all the time even 10-15 minutes after a meal. Is anyone using having the same experience? help

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Hi, I am in UK. I have had CC for 16 years now and had every test that is available in the UK (I think) to try to see what is causing it. I have been told by one doctor a few years back that I just had a 'lazy bowel' 2 weeks ago I was put on Resolor 2mg. I kept a diary of my motions and, to be honest, it is rubbish. I still have use other ways to go. I know I need to go and can feel it there but unless I physically open my rectum myself and ease it out to start it off I can not go. (although for me to get to this point I must take a laxative of some sort, normally more than prescribed)
The Resolor 2mg does not make me hungry, but it must help hold water or something else because I was on a diet for the first week of taking it, and I was very good indeed, however when I got on scales week later I had put on 4//b!!!
I am also very moody, snappy and my patience is wearing thing quickly. Anything can start me in a mood, and that is not been me for a while now. I am also on Sertraline for my depression and mood swings but the Resolor seems to be counteracting the Sertraline.
I have today, 29/05/13 decided to stop taking the Resolor It really is not doing anything for my toilet needs at all and is causing atmospheres at home because of my moods.
I just want to be able to go to the toilet like a 'normal' person. If I do not take anything I could go days and still not go. Once I have taken something and I empty the toilet becames a 'no go' area because of the smell. I also bleed a lot. This I have been told is because of my haemorrhoids but again I have had these injected 3 times and rubber banded once - still doesn't make them go.
Because I have to take such a large amount of laxitives to relieve myself I am housebound quite a lot of the time - I could pass wind and it will pour out and it stinks like fish. I have given up buying new underwear, I now wear Tena lady pants.
I am 44 year old female and have had enough of all of this. It affects my whole family. We could be just walking out the door to go somewhere and I just have to go (after laxatives) and that would be it, I could be on the toilet for hours. Even if we are not going out it causes friction because I am always in the bathroom/toilet and everyone else needs to use it too.
I would love to hear from anyone that is having the same/similar problem and maybe advise me on something I do not yet no about.

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I am on day three of prucalopride . No motion yet but it is helping me pass wind which I was unable to do . How long before I get a bowel movement ? My rectum is empty at the moment which is the problem I have . My waste does not seem to move down the last part of my bowel to the rectum . Should I take laxative to clear me ? Any help please. Dr said lazy bowel. Have had diagnostics done to rule out nasties

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Hello all out there who are having a problem with an increased appetite on prucalopride. I can only suggest that as one who has suffered with a bowel not working correctly I had no appetite. why because I was impacted up to the eye balls even though I had daily small bowel movements. once the Prucalopride starts to take effect on the bowel and helps with the transition one begins to clear out the faeces so bringing back the appetite as one is no longer full of faeces. if impacted to the point it is pushing and putting pressure on the stomach it makes it difficult to have an appetite and eat well. also impaction can cause headaches and has even caused an increase in toxicity causing aggression and confusion. headaches caused due to the use of Prucalopride may possibly be counteracted by drinking water due to the fact that if the medication has caused diarrhea then headaches may be caused by dehydration. Look on the NICE site for more information and also the information that is not included on the medication information sheet including any trials.

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Not sure if this helps but I've been taking resotran for the past two years. For me it's been a life saving medication. I have not experienced hunger, usually only headaches but it's more infrequent and I don't notice them anymore as I take 2mg before bed at night. Works like clockwork every morning. I suffered for 25 years with chronic constipation and severe pain. My quality of life was in the toilet. I saw countless gastro specialists who wouldn't take me seriously. It took 25 years until I received genetic testing and was diagnosed with muscular dystrophy. Suddenly a new gastroenterologist who didn't even question me because of that diagnosis. He prescribed resotran and my quality of life in this regard has improved immensely. I know and fully comprehend the suffering you are all in. Please give this medication a try and drinks lots of water and eat good quality fruits and veggies. Cut out the white carbs or other constipating food. I pray you have relief like me.

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I'm glad it's not just me that's having the problem with 'hunger pangs'. I've been taking Prucalopride for 6 weeks now and whilst it is achieving results on the bowel movement front(more than half of my bowel doesn't function) I am eating more than normal and have gained 5lbs!!! I mentioned this to my consultant last week and he didn't seem too concerned and just said it wasn't a side effect of this drug. It has to be more than coincidence that so many of us are experiencing this problem. I know it's early days and hopefully things will settle down-I am also experiencing severe stomach rumbling and 'swimmy' heads(sometimes making me feel nauseous). At least all the awful side effects I experienced in the first 48hrs have vanished. I still think there is so little known about this drug,that only time will tell as to what the potential side effects could be. For me,it is achieving the required results, for now at least. I just hope this continues,as I have read that in many cases,its efficacy is reduced over time. Any one else's personal experiences would be most welcome.

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I just started a day ago and I have headaches and horrible abdominal pains. I take klysma's every four days to have some sort of constant bowel movement and my bowel reacts extremely to every sort of laxative (and fibre) with cramps. Bisacodyl isn't an option on daily base because of that pain. Forlax and Movicolon aren't enough with even 13 sackets a day.
Pain isn't listed as a side effect, but I get the feeling half of the side effects aren't listed....

What's your thought?

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Since I started take Resolor five months ago, I feel very hungry too!! All the time even after a meal! And only get worse wiht time...
I´ll take the test, and stop for a while.
Resolor worked for constipation, but I'm feeling really bad well, so hungry all the time.
Anyone else feeling this way?

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I have always had problems with CC but also with registering hunger. This is apparently linked as my system is sluggish my stomach doesn't empty properly and so I never get hungry until it is too late (crashing). Since I've been on this med I've suddenly started to get hungry ! This is actually great!.. And yes my stomach gurgles, but that is because my digestive system is working and I'm not used to it. It has been a huge relief, no more bloated stomach, no more painful abdomen and back. And yes, eating when I am supposed to. It has meant I have put on some weight and I am going to have to manage that. But now that I am eating better I will be able to exercise too without extreme fatigue. This medication has given me great hope for the future.

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This is just like me I'm a week in and apart from feeling really sick, nothing at all. I'm scared it's not going to work at all and that I need to have a subtotal colectomy How long does it normally to get things shifting I have appetite what so ever

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Hi Beatrice. I began taking resolar around 6 weeks ago now and have noticed that certain days I'm constantly hungry but not all the time. I haven't put on any weight since I've began taking the drug. Maybe talk to your gp if you are worried but I suppose it's better to be hungry then having the awful pain bloatedness and cramps.
I've began experiencing palpitations lately so I'm concerned that this is a side effec. My gp isn't too worried though but it's becoming a bit of a pain.

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Resolor, which contains the active ingredient Prucalopride is used to treat chronic constipation.

Increased hunger and appetite is not listed as a side effect, however, it does have an effect on the brain chemical seratonin, just as many antidepressants do and most of them do cause increased appetite and weight gain.

Its common side effects are listed as: headache, abdominal pain, nausea and worsening diarrhea.

Learn more:


https:/­/­rxchat.com/­wiki/­Prucalopride/­


Have you spoken to your doctor about it?

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I have the same problem. I have been taking Prucalopride for three weeks and I'm really hungry all the time. They are helping with the constipation but I may have to stop taking them because I'm literally eating double the amount I used to since I started taking them. I've tried really hard to eat less but it's impossible to control my appetite.

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Noni, I kept taking the tablets and eventually my appetite went back to normal. It takes a few weeks.

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Whiskey18, I am a little Similar to you, i was told i had a lazy bowel and to take fibre, lose weight, workout, prune juice etc, i did all the above i got so impacted i was afraid i was going to vomited out poo! I was put on movical and i couldnt leave the house in fear id need a loo. So i did research and i use a water enema, 3 days a week depending on the amount of food i have eaten.
My Doctor has now put me on 2mg of Resolor started on the 5 june 2013 and now four days later nothing, so last night i had to use the water enema and i feel great today.
But like others i am starving all the time and its not for proper food its for junk food.
I dont think the tablets will work for me, besides my chronic constipation and unable to go naturally having to resort to Enemas, there has to be a part of my bowel that doesnt get notified that i have to go!

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I started on pucalopride a week ago ,but I have no appetite so I feel there is nothing to poo out ,and I am still getting severe abdominal pain any one had this problem.

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Re: MikeZ (# 57)

Hi i didnt take them for long may be one or two a day for end of first week, i tried to do without them if the headaches were just background i only had the horrendous ones for about the first 3/4 days where i took about 3 each day in 3 separate doses and as it was the first week of taking the prucalopride and i wasnt really thinking id see any benefit in one week id say i saw no worsening of condition by taking the co dydramol. Hope this helps

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Re: Gabrielle (# 40)

RE: "My son went into the bathroom after me and it looked like world war 2 had taken place. The mortification of it. I'm so upset."

Did you not clean up after yourself? Bleach? Toilet brush? Disinfectant wipes? Air fresher? I don't know any self-respecting adult who goes to the loo and after a particularly explosive motion 'Doesn't clean up after themselves'. You should be mortified - not for what you produced, but for not cleaning up - and for your child having to see that.

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I have been on prucalopride just 6 days 1mg. I do not feel hungry nor as yet have I had a result. I have CC for along time. Does any one know how long the time factor before i can increase to 2mg?

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Hi Gus

Are you in the US? I know some Dr's in US are prescribing this even though it is not yet approved here. I have had CC for 8 years and my only relief was when I was on Zelnorm. I am tyring to locate a doctor to see who would be willing to work with me.

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Have been on resolor tabs for 14 days with no real relief from constipation. Tried to increase the dose to 2mg after 4 days and took a lot of fruit and vegetables then had a very loose bowel motion. After that have not had proper bowel motion and have gone back to laxatives. Don't know if I have given it enough time, my Dr only gave me one months supply. Am in UK.

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