Danaparoid
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Danaparoid sodium (Orgaran) is an anticoagulant[1] with an antithrombotic action due to inhibition of thrombin generation (TGI) by two mechanisms: indirect inactivation of Factor Xa via AT and direct inhibition of thrombin activation of Factor IX (an important feedback loop for thrombin generation). It also possesses a minor anti-thrombin activity, mediated equally via AT and Heparin Co-factor II producing a ratio of anti-Xa:IIa activity >22. [Meuleman DG. Haemostasis 1992;22:...
I am interested in any use of danaparoid during/after pregnancy (incl. breast-feeding) and for children up to 17 years. Information on what it was used for, its dosing and duration of administration, good and bad outcomes up to 6 weeks after its discontinuation would be very welcome. ## Hello, I am a physician and my reason for my request about danaparoid use in pregnancy and children stems from the fact that for 30 years I was responsible for the clinical development of this antithrombotic. Although retired since 2000 I retain an interest in collecting all published data on the drug so that I can update information I give in response to requests. In addition I also publish at intervals overviews of its use in specific patient groups, i.e. heparin-induced thrombocytopenia, pregnancy, ch...
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Danaparoid
Danaparoid
Danaparoid sodium (Orgaran) is an anticoagulant[1] with an antithrombotic action due to inhibition of thrombin generation (TGI) by two mechanisms: indirect inactivation of Factor Xa via AT and direct inhibition of thrombin activation of Factor IX (an important feedback loop for thrombin generation). It also possesses a minor anti-thrombin activity, mediated equally via AT and Heparin Co-factor II producing a ratio of anti-Xa:IIa activity >22. [Meuleman DG. Haemostasis 1992;22:...