Active Ingredient(s):Muromonab-CD3 FDA Approved: * September 14, 1992 Pharm Company: *ORTHO BIOTECH Category:Immunosuppressive
Muromonab-CD3 (trade name Orthoclone OKT3, marketed by Janssen-Cilag) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants. It is a monoclonal antibody targeted at the CD3 receptor, a membrane protein on the surface of T cells. It was the first monoclonal antibody to be approved for clinical use in humans.
3 Pharmacodynamics and chemistry
* May have multiple approval dates, manufacturers, or labelers.