Lupin Lisinopril Pill Size Change (Top voted first)

I take 10 miligram Lupin tables - have been taking them 2x a day for 20 years. Today, I opened the bottle and they were 1/2 the size. Same markings on the pill and container, same color, same manufacturer but 1/2 the size. I asked the pharmacy assistant about it and she said the company was making them smaller but they were the same. I asked how they were doing that - were they removing fillers? Why did they have so many fillers in the first place. She said she didn't know, but would transfer me to the pharmacist. I asked the pharmacist and she sounded like she had been asked what the weather would be like the next day - "oh, I don't know...yeah...I don't really know." I don't feel comfortable taking these.

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Follow up to my post above. This morning I called the Lupin complaint line (800-399-2561) and the rep went into a whole scripted scientific reason for the change in size on the 10, 20 and one other higher dose sizes. Seems they removed all the fillers, or inactive ingredients, and leaving only the active ingredients. As mentioned in my previous posting, my new 90 day prescription was filled yesterday and to my complete surprise, I received the original larger size Lisinopril that I had taken for years before the change. I brought the prescription back to Walgreens today and had a lengthy chat with my pharmacist. He has confirmed that Lupin has removed the fillers and will continue to manufacture the new smaller size for those doses. There are many warehouses that stock Lisinopril and here lies an answer to why I received the former larger size. The pharmaceutical warehouse that serves my local Walgreens continues to have the formerly large size in stock and it all depends on which batch my local pharmacy receives from a particular warehouse. My pharmacist checked his shelves for the 20mg and found both the large and small sizes. The pharmacist said most side effects come from the fillers, so since I was concerned about this, I decided to stay with the smaller size pill. The pharmacist was kind enough to replace my recently filled prescription with the smaller pills. I didn't want to take a chance. Hope this is helpful to Lisinopril users.

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The new 20mg is 1 half the size and weight they were. How could they be the same dose? Unlikly. It defies logic and physics. The active must be less. CVS when asked gave the same filler excuss and said they would call the manufacturer for a explanation. That was 2 days ago. No CVS response yet. I have picture of new and old lisinopril pills side by side. They are clearly not the same.

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Loris and others,

There is no difference between the large pill and the small pill. I noticed the change and just wanted to make sure that the pharmacist did not give me the wrong pills which is why I saw these posts. All the manufacturer did was remove the inactive ingredients that made the pill larger. Inactive ingredients by definition have no impact on how you absorb the Lisonoril. The pill is dissolved within your stomach between 15 to 30 minutes regardless and the medicine enters your bloodstream in the exact same way. Lisinopril can cause dizziness regardless of the pill size. Also, as human beings we ALL (that includes me) are subject to psychosomatic reactions caused by the fear that the changed pill (for example) can cause us harm. A common misconception is that psychosomatic means "all in your head" but that is not true. The symptoms are real, but the cause of the symptoms is psychological (like the fear of the changed pill). This leads to a chain reaction of others saying that something must be wrong because "everyone else" is having problems. Again, a very human reacation that we are all susceptible to. And just so you realize that my intentions are to be helpful, I will give you a personal example. I fell and hit my head on the ice. About a month before, my brother in law had emergency surgery and almost died from a head injury that occurred months prior. I started to have headaches and thought the same was happening to me and I ended up getting an unnecessary CAT scan. After the doctor told me it all looked good, my psychsomatic headaches went away. Hope this helps someone.

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I also take 10mg of Lisinopril - Lupin mfg - daily, and yes, I also noticed this month's supply was smaller. I called my pharmacy (Walgreens), and the pharmacist said I was the 2nd person this morning who called to ask about it, and all she knew was that the manufacturer has decided to make it smaller. That's all she knew unfortunately. But she said it should not affect the dosage. I also went on the Walgreens website and used their chat feature, and the representative there told me, "That is the correct description for the tablets. I have actually heard this same feedback from other patients about the medication, so it must be that the manufacturer has changed the way they made their tablets, possibly making them with less inactive ingredients. However, we have double-checked the imprint, so you can feel comfortable that is the correct medication." Maybe, someone just needs to go straight to the source - ie Lupin - to get the answer on why the smaller tablet size. Hope that helps!

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I started the smaller ones! My doctor said it would be fine. I've been nauseated, and dizzy every since. I'm calling tomorrow to see Doctor to make sure it's not something other then the drug. I also called FDA to file a complaint

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I also take 20mg of Lisinopril at bedtime and noticed several refills ago that the size had gotten much smaller even though the pill said Lupin and 20. Pharmacist had no answer. Last night I called in a refill and tonight after getting home I noticed two changes...not only did my pharmacy strangely give me a brand new prescription # when I clearly had a refill left on my "old" number, but also, my Lupin 20mg were strangely back to their original bigger size!! I will be headed back to the pharmacy tomorrow to check this out. Something screwy is definitely going on with Lupin. Almost seems like a big time error in their manufacturing and now they're trying to correct. Too many people experiencing side effects with the change (or error) to a smaller Lisinopril 20mg. Has anyone else found their 20 now back to the original size?

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Has the 20 mg changed size I just picked up my rx they are little

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Same problem as others.new size 10 mg.lightheaded .anxious.a little bit more tired.

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I have taken the 10mg lisinopril for many years now. 2 months ago when I purchased the medication the size of the pill was smaller. I took the pills and noticed that my blood pressure was rising, This concerns me very much. Is anyone else having this problem. I'm going to go back to my Doctor to see if she has heard anything from others. I don't understand when they make a drug that no one is having issues with and then they change it with no way back.

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I also take 10 mg of Lisinopril. Have taken it for 10 years and had no trouble at all. All of a sudden they changed the size{smaller} and I have been having light headedness and am very shaky. I have gone to 3 pharmacists and they all look at you like your making this stuff up! I am happy to see someone else is experiencing the same thing!

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This is exactly what happened to me. I was on the old Lupin lisinopril for 6 years with a water pill and no issues whatsovever. Now, I'm on the new version of the Lupin lisinopril and extremely dizzy every day. Not feeling right at all. I had to stop the water pill because the lisinopril was enhancing the dizzi effect and making it so I couldn't even work. Now, I'm just on the 10mg new small version of Lupin linsinopril and extremely dizzy. It can't possibly be the same as it was before. I will be calling my doctor tomorrow to see if I can switch to the Watson (non-generic) 10 mg. lisinopril. My mother takes this one and has no issues at all. It' unfortunate that a manufacturer would change a pill and cause so many who are on it to have such severe dizziness and other side effects they never experienced before.

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Started the 1/2 smaller size pill (lisinopril 20 mg twice a day) LUPIN manufacturer last week. BP went up to 140's/88. I have been on same dose, drug since 1999 and BP always 120/80. The new pill size does not seem to be controlling hypertension. Anyone else?

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Brian, I am having the same issue. I've been on this medication for 12 years but all of a sudden the pill got smaller and my blood pressure is 158/80. I just made a appointment to see my doctor about switching.

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No, I haven't had a problem with blood pressure while switching from the larger 20mg pill to the smaller size. Everything is suppose to be the same except the inactive fillers have been removed. My pharmacist said it's mostly the inactive ingredients/fillers that cause a side effect with any pill. In April, I was put on a couple of new meds for a new cardiac issue and needed to make an adjustment in the timing of my different meds so there'd be no interference. I moved the Lisinopril to bedtime and it works out just fine. For those people who say they're experiencing various side effects from the smaller pill, whether "psychosomatic" (as another person posted) or not, it might be worth trying to move your Lisinopril to bedtime, as well. Please post if it works for you.

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It was Lupin. Been on it 15 yrs no problem. After a week I'm in an ER.

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That's after I started taking the smaller version that was just the same! Also my creatinine levels went from .81 to 1.2 in two weeks. Has to be the BP Meds only change I've made.

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My 20 mg are smaller also. I think if they are going to change the pill in any way they should notify us.

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You're going to psychoanalyze this situation, and tell people it's all in their heads? That it's some form of mass hysteria or paranoia.That the smaller Lisinopril is the same as the larger one, and just had some fillers taken out? I am a Counselor, and I can say the smalller Lisinopril tabs have something else going on rather than a lack of "fillers." These are not up to standard and should be reported to the FDA. How hard did you say you hit your head?

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I just finished taking a 30 day supply of the new smaller 20 mg lisinopril (have been taking the older larger 20 mg pill for ~5 years with normal blood pressure and no side effects). About 2 weeks ago I began having pounding headaches, never thinking a bit about the pill size change. But yesterday I went to pick up my new prescription and check my pressure at the local pharmacy, and it was very high (149/99). Explains the headaches! I thought this was so strange, then the headaches continued and just feel strange, and a bit lightheaded. Checked pressure again and it's still high, and I am taking this faithfully every AM as I have for years. Something is definitely different about this new pill. Calling pharmacy and Dr. tomorrow to ask for the old larger generic pill again or requesting the non-generic version. This manufacturer changed something!

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Re: Lonnie (# 17)

Right, blame the patient. I received my new refill and just started taking it without noticing the size difference actually. I felt odd the second day and couldn't understand why. I started getting severe leg cramps and since the only drug I take is the 20mg Lupin Lisinopril I checked it carefully. It was smaller. I had a few of the larger ones left and took those. All was better. I called the worthless Humana Pharmacy and they didn't even know they changed but stated it couldn't be the pills. So I started back on the small ones and the next day I felt terrible with severe leg cramps. Sick and in pain last night I called poison control. Worthless. So now being a long holiday I'm stuck. I will not take these pills. Too painful and miserable. I don't use other drugs, alcohol, or smoke. I know it's these pills. If I don't get the answers I'll retain a lawyer. I won't be treated like an experiment. I've been taking this 20mg Lupin Lisinopril for two years previously without any problems and feeling good. This is poison as far as I'm concerned. Thank you.

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