Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

linzess weight gain
68 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 14 days ago.
linzess weight loss
4 Replies RSS
how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss, so there is no time frame I can give you for this. It is used to treat symptoms of IBS that are associated with constipation. And while that may cause weight loss, in some instances, it can be dangerous to try to lose weight via giving yourself diarrhea, since it creates the risk of malnourishment and dehydration. Common side effects to this drug may include nausea, dizziness and stomach pain. Was it prescribed for weight loss? ## I just received a sample from the dr to help with my weight loss, however, I am shocked at ALL the side affects from people of.horrible weight gain! I am confused, can you please help explain? ## I have IBS. Been taking linzesss for a month....
Updated 14 days ago.
Can Linzess be taken as needed?
3 Replies RSS
I just took my first dose of Linzess 145 and like the others posted...within 2 hrs of taking it (I took it on an empty stomach 30 minutes before breakfast) I had noticeable bloating and gas within an hr and it was working full on within 2 hrs. The entire experience seemed to work itself out within 3.5 hrs. Very unpleasant 3.5 hrs but now everything seems to have calmed down. Not ideal..but can Linzess just be taken every few days? 2-3 times per week? If it always has this effect it seems I would be able to manage calendar to allow for the time it needs and still be able to fully function the rest of the time. ## I was told by my gastro to take it when I need it. If you take it daily and it gives you diarrhea and you are purging your large GI tract to the point water comes out after, the...
Updated 20 days ago.
Accidently ate 10 minutes after taking Linzess
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I have been taking Linzess for 10 days now. I accidentally ate 10 minutes after taking Linzess today. It made my stomach and intestines feel like a washing machine for several hours and then I had diareaha with undigested food floating in the toilet. Should I be worried or will I be ok ?
Updated 22 days ago.
how long does it take for linzess to get out of your system
4 Replies RSS
how long does it take for linzess to be completely out of your system ## How long does it take linzess to get out of your system? ## @ike / sandy, From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes. [1] source: PubMed / PMC3638410 That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame. Hope this helps! ## How long does it take for linzess to get out of the body ## How lo...
Updated 23 days ago.
what time should you take linzess morning or night
1 Reply RSS
Hello! I have been on Linzess for almost a year and a half. I have always taken it right before dinner and I would have a bm before bed every night. However, just three weeks ago I had to have colon surgery and the linzess is not working as well. Some days I will go to the bathroom a million times and some days not at all. I was wondering if my surgery could anything to do with this problem? Also should I continue to take the linzess? If you could help me it would be greatly appreciated. ## Hi Jacky, I think the timing for taking Linzess can vary greatly for each individual, based on numerous personal factors. I've read other posts on here stating how they also take it at night to promote a morning bowel movement, whilst others take it in the AM or afternoon. You can browse through ...
Updated 25 days ago.
taking linzess at night
4 Replies RSS
So far I am having varied results with Linzess. One day I'm going all day, one day nothing, one day it is a "normal" one/two time bowl movements, and then another I'm rushing in my car to find a public restroom. I usually take it at the same time every morning. The varied results happen at varied times. Morning, afternoon, and/or evening. I was wondering if taking it at night would help with trying to get it on a regular schedule? ## I take mine at night all the time and it is working well. I go in the morning and have no problem through the day. If I have to go through the day I have plenty of time to find a bathroom but usually I just go in the morning ## @JulieAnn, I know you posted this back in April, so I hope you are doing well and all is good! RE: Taking Linzess a...
Updated 26 days ago.
Anybody else with these issues
21 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 29 days ago.
linzess every other day
1 Reply RSS
Hi I just been given linzess 290 for everyday. I suffer with tons of gas and constipation and bloating all the time.and it worked great the first few days of taking it however I noticed when I took it I had uncomtorble spasms in my lower belly so my doctor recommended to take it every other day. Do you think I should switch to the lower dose? I'm scared I won't have a BM and I'll have gas the days I don't take the 290 dose. ## It is always best to follow your doctor's instructions and the only way to know how it will work for you is by trying it. Some people have been doing quite well taking it every other day. The stomach cramping and spasms can be normal side effects of this medication, according to FDA reports. You may also experience nausea, dizziness, headache, ...
Updated 30 days ago.
Alternative dosing for Linzess?
1 Reply RSS
I've been taking Linzess 290 for about three months due to a maze of a colon because of abdominal adhesions. I am thrilled that it moves me out everyday, however, I feel like a prisoner to it. I can't go places certain times of the day because I have about an hour of explosive diarrhea each day and not sure when it will hit. And I cannot hold it in!! I'm paranoid it will hit at work, which is close quarters. Also, TMI, but my movements are FOUL smelling and runs my family gagging, out of the house. I was wondering if anyone has tried alternate dosing such as every other day, etc. FYI I have tried the 145 strength, all I get with that is severe cramping, bloating and no stool. Thank you!! I was thinking of maybe the 290 every other day and the 145 on alternate days. Thoughts?...
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 68 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 26 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 7 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 5 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 5 replies
Linzess / severe diaherra I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thir... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies

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