Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3][dead link]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related t...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

Amitza vs Linzess
2 Replies RSS
I have been taking Amitza for about 4 months. Works great but over time getting extremely tired and sharp pains throughout body. I'm in process of trying to loose weight as well giving up dairy,red meats, and carbs. Switched to linzess three days ago. Reading posts that worry me about weight gain. Can you clear up the subject on weight gain and which drug works best? I've had issues for 19 years and tried everything. These medications both work for me but I need to have energy, no sharp pains and no weight gain. ## I added a multi-vitamin and b-12 supplement to help with energy. So far I'm doing okay. Been on Linzess for a week. It only started to work for me yesterday. Best of luck to you! ## @Kgirl, Posted below is a link to another active discussion thread here relating t...
Updated 8 minutes ago.
linzess and lactulose
2 Replies RSS
I take 145mcg capsule of linzess with 8ounces of water 30 minutes before I eat and also take 45 ml of lactulose 3 times a day 30 minutes before I eat anything and still not having any bowel movement. stomach getting bigger and bloated,feeling miserable ## Hi Clyde, Sorry to hear about your experience with Linzess. According to, one of the side effects of Linzess is "swelling or a feeling of fullness or pressure in the stomach area". They recommend contacting your doctor if it becomes severe or doesn't go away. There's also another discussion thread here that associates Linzess with weight gain (I'm assuming as a result of this bloating effect): [1] Linzess Weight Gain From what I can gather, it seems like Linzess is the culprit and not Lactulose; howe...
Updated 10 hours ago.
linzess prescribed to help with weight loss
2 Replies RSS
Hi! My Dr. Gave me linzess to help with weight loss. HOWEVER, I am reading all the posts about horrible weight gain, I am confused!!!!!!! ## Hello, Twinckle! How are you? This medication isn't intended to be used for weight loss, it's actually used to treat chronic constipation. It can cause diarrhea, which could result in weight loss for some, as reported by the FDA, but it can also cause abdominal bloating and distention, which has caused many to think they were gaining weight on it. Can anyone that's been on it chime in with their experiences? ## Hello, Linzess can certainly be prescribed for the purpose of weight loss! People do not understand how medications can treat multiple...repeat MULTIPLE conditions, diseases and illnesses. Botox is FDA approved to also treat head...
Updated 4 days ago.
Can Linzess be taken as needed - 2-3 times per week?
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I just took my first dose of Linzess 145 and like the others posted...within 2 hrs of taking it (I took it on an empty stomach 30 minutes before breakfast). I had noticeable bloating and gas within an hr and it was working full on within 2 hrs. The entire experience seemed to work itself out within 3.5 hrs.Very unpleasant 3.5 hrs but now everything seems to have calmed down. Not ideal..but can Linzess just be taken just every few days? If it always has this effect it seems I would be able to manage calendar to allow for the time it needs and still be able to fully function the rest of the time
Updated 5 days ago.
On Linzess for a week, NOT "Working" - HELP!
31 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 7 days ago.
How fast
4 Replies RSS
How fast will the lizness begin to work? I have to go to work and don't want to be running up and down statues all day. ## Hi Gil, While some patients report having bowel movements on the first day from taking Linzess (Linaclotide), others mention that it took up to a few weeks before it really kicked into gear for them. With that said, the only real way to see if it will work for you is by actually trying it and committing yourself to a full course of treatment. I guess you're supposed to take it 30 minutes before eating or drinking in the morning, but I don't know if that has an impact on it's overall effectiveness throughout the rest of the day. The patient prescribing information notes that symptoms of diarrhea often begin within the first 2 weeks of treatment. So I...
Updated 11 days ago.
Linzess directions
3 Replies RSS
What happens if u take linzess on a empty stomach? ## Hi Chelle, Actually you are supposed to take Linzess on an empty stomach. Then you need to wait one hour following the meal for the drug to work best. If you eat before taking this medicine you need wait two hours to take it. I am not sure what issues might result from not following these rules? Hope this helps ## Hello, Chelle! How are you? Thank you, Steve for providing the correct information. As to what happens if you don't follow these instructions, the efficacy of the medication may be reduced, so it may not work. It is best taken on an empty stomach, with a full 8ounce glass of water, at least an hour before eating. The FDA lists its typical side effects as possibly including nausea, dizziness, diarrhea and bloating. Is th...
Updated 12 days ago.
30 Before Lunch?
1 Reply RSS
Would taking Linzess on an empty stomach 30 before be just as effective? I have an hour drive to work and then approx. 1/4 to 3/4 of a mile before I get to my work station.....and there are no restroom on the walk in. I usually straving firsting thing in the morning so waiting until before lunch would work out so much better for me. ## I would also like to know that. I can't always take it first thing either.
Updated 16 days ago.
Anybody else with these issues
19 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 17 days ago.
Linzess stopped working
16 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 17 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (4 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 52 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 16 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess has destroyed my hair no more Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I s... 4 replies
Linzess / Weight Gain and Other Meds Questions I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 4 replies