Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation predominant irritable bowel syndrome (IBS-C) in adults.[1] The National Institu...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

how good does liness clean colon
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Can you tell me does liness clean your whole colon? Are how much cleaning do you get y us Iiness ## Since the effects of any medication tend to vary for each individual, I think it may ultimately be best to work closely with your doctor on finding a safe and effective dosing regimen. Taking it in close proximity to food is something that might also affect how well it cleans. I'd recommend browsing through some of the related Linzess discussion broads here in order to get a better idea of what results are being reported. According to, Linzess is said to work by increasing the motion of food and waste through the stomach / G.I. tract as well as by blocking pain signals - but it goes without saying that the amount of movement or cleansing taking place can unfortunately only be ...
Updated 3 minutes ago.
lizness 145 mg
13 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 6 hours ago.
linzess weight gain
35 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 20 hours ago.
Linzess stopped working
1 Reply RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 3 days ago.
On Linzess for a week, NOT "Working" - HELP!
14 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 6 days ago.
how long does it take for linzess to get out of your system
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how long does it take for linzess to be completely out of your system
Updated 6 days ago.
Worked well on me
1 Reply RSS
I took linzess the next day after the doctor prescribed it to me and went pretty quick. Also cleaned me out. I take one every other day. So far so good. ## Hello, Debbie! How are you? I'm glad that it's working for you, some people haven't had good results with it. Have you experienced any of the side effects that the FDA warns you to expect, such as bloating, nausea, stomach pain and diarrhea?
Updated 7 days ago.
Linzess allergic reaction
2 Replies RSS
I had an awfull expierence with my first and only dose of Linzess. I expierenced severe dizziness, lightheadedness after the first 3 hours. Then I noticed a rash on my face, swollen eyes, wheezing, sneezing and severe itching. These symptoms lasted 18 hours + and I continue to have an itching face the next day. I took benedryl evey 6 hours for 2 days. After reading the Lizness website, I found I expierenced "Rare" side effects and I have called Actavis to report my adverse reaction. ## Yes, those are typical symptoms of an allergic reaction, as listed by the FDA and it usually means you will need to refrain from taking this medication in the future, as these types of reactions can get worse with repeated exposure. How are you doing, now? Has it cleared up? ## I have Been taking ...
Updated 17 days ago.
is there anything cheaper that works as well linzess
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Is there anything cheaper that works as well as linzess does
Updated 19 days ago.
Linzess every two days?
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Great medicine, although I have only started. Can I skip two days before taking the next dosage? Also I am shocked at the cost. $400+ for a three month supply. Any ideas? ## How is it working for you? You should follow your doctor's prescribing instructions, skipping days may prevent it from working as well as it should. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating and diarrhea. There is a savings program available from the manufacturer. You can find information on it via the Linzess website at click here. Is there anything else I can help with?
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (3 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 35 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 3 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies