Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US[1] and Mexico, and as Constella in Canada[2] and many other countries[3]) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment in adults of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).[4] Contents 1 Background 2 Clinical trials 3 Distribution and licensing 4 Chemistry 5 References 6 External links Background The N...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

Blood in toilet after bowel movement
4 Replies RSS
I was on the low dose Linzess and it wasn't working for my constipation. Now I'm on the higher dose but it is not really working either. When I finally had a bowel movement there was a lot of blood in the toilet. Has this happened to anyone? What would cause this? Anyone? ## Sue sometimes when your stool is hard from constipation it can tear your rectum and cause it to bleed. Because of the pressure in your rectum it will usually seal the tear. Watch out how hard you push the stool when you're constipated as it can cause a hemorrhoid. If you continue to have blood in your stool go see your doctor ASAP ## Years ago this did happen to me. It can be frightening to see that much blood in the toilet, but this can happen because of hemorrhoids. I took a diuretic that dried me out ...
Updated 10 days ago.
linzess weight gain
50 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 14 days ago.
Limit with meal-not hungry
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I took linzsee so it gotta to be surpised to lose weight really well quick also when is time i am ready to eat, it felt like 5 to 6 bites then is enough for me like im manage to full as not when took done small eating had dirrehea about 4 times or 5 .its help loss weight . i lost 21 pound least less 2 week by linzsee. ??? Wow not to sure about it.
Updated 16 days ago.
Linzess / Weight Gain and Other Meds Questions
2 Replies RSS
I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds before they are in my system? I'm taking the thyroid meds 1 hour before (as required) the Linzess and the Topamax with my breakfast. Is that the right order? Also...I've been steadily losing weight successfully for a couple of months....have taken Linzess for 4 days because went low carb and stopped going to the bathroom....gained over 2 lbs in 4 days without changing any food intake and drinking 100 ounces of water a day and having diarrhea. How is that even possible. Will I just have to stop taking it to stop the weight gain? How does the med cause weight gain if it gets rid of waste? ## The Linzess should be taken by itself, at least half an hour before eati...
Updated 21 days ago.
Linzess not working for me
1 Reply RSS
I was on Amitiza 24 mcg twice a day and Miralax was switched to Linzess 3 weeks ago. I am having so many issues, feeling lightheaded a couple hours after taking it in the morning and very bloated and have not had a normal BM. A few days without anything and then diarrhea. I think I am going to switch to before dinner and take Miralax before bed. What is the opinion? ## This medication should be taken in the morning, at least half an hour, before ingesting anything else. The Side effects that you've experienced are listed as being normal ones, according to the FDA, you may also experience nausea, and stomach pain. It is not as effective, if taken later in the day, after you've already eaten throughout the day, so it is best to follow the manufacturers instructions. Is there anyth...
Updated 1 month ago.
linzess_how can one best wean away from taking linzess
1 Reply RSS
have been taking this drug for about 5 months and now it causes me diarrhrea and gives me severe pain in the very middle of my bod and causes bloating plus now I have been dealing with severe heartburn at nite. I believe the miralax during the day and metamucil at nite and the fruit I eat at mealtime or snack time can now keep me from having bowel problems so I want to wean myself off this drug. ## Hello, Char! How are you? Unless your doctor has instructed otherwise, it isn't usually necessary to wean yourself off such a medication, you should be able to just stop taking it, but as reported by the FDA, you may experience rebound constipation for a few days. Are you on any other medications? Or just the ones you've mentioned?
Updated 1 month ago.
Constella or Linzess
1 Reply RSS
I am taking Constella for IBS but I also have a rectocele which seems to prevent a bowel movement unless I take laxatives and suppositories. Does this sound possible? Thank you ## Hello, Carole! How are you? Constella and Linzess both contain the same active ingredient, Linaclotide, so both are pretty much the same. The U.S. FDA lists the typical side effects as possibly including nausea, dizziness, bloating, stomach pain, and diarrhea. Rectoceles have been known to cause difficulty having bowel movements, according to the NIH, there are various treatment options that may help, including surgery. What has your doctor advised?
Updated 1 month ago.
Meds interacting with each other
1 Reply RSS
Can linzess and methylprednisolone interact with each other? How many hours after i take linzess can i take , the methyprednisolone? ## Hello, Maria! How are you? I didn't find any problems or interactions listed in the NIH database, but it is always best to double check to be sure. As to the dose spacing, you should stick with the normal gap of eating/drinking/ingesting anything else that you always do with the Linzess. The FDA lists the typical side effects of Methylprednisolone as possibly including nausea, dizziness, headache, insomnia, and acne. Is there anything else I can help with?
Updated 1 month ago.
I take linzess and it not working
4 Replies RSS
I was told by my gastro doctor to take linzess 30 minutes before I eat anything on a empty stomach. but it not working. he didn't tell me how much water to drink or whether I should drink something with my meal or not ## Hello, Clyde! How are you? I'm sorry that it isn't working for you. The manufacturer states that it can be taken with 1 ounce of water, or you can open the capsule and sprinkle the beads over a teaspoon of room temperature apple sauce, a half hour before eating or drinking anything else. And yes, when you do eat, you can have a beverage with your meal, as usual. The FDA lists the typical side effects as possibly including nausea, flatulence, cramping, and diarrhea. Has there been any change? ## No there hasn't been any change.I also take 45 ml of lactulo...
Updated 1 month ago.
Linzess, then other meds with breakfast
6 Replies RSS
Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Reading the other postings, I am somewhat afraid to take it. Nevertheless, I would take my levothyrox 1/2 hour before the Linzess, then would take my other meds with a meal. Will the Linzess "wash out" the other meds?? Also, is "unanticipated bowel leakage" a possibility with Linzess? ## Hi Molly, Sorry to hear about the constipation from pain meds. Looking at others feedback on Linzess it's easy to get discouraged and not want to take it. However it is also important to understand that these meds tend to affect each person differently, whereas patients who don't have any serious issues with it would be less likely to feel inclined to post about their...
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (4 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 50 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 5 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies