Linzess

Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) in adults.[1] Contents 1 Background 2 Clinical trials 3 Distribution and licensing 4 Chemistry 5 References 6 External links Background The National Institutes of Health (NIH) estimate that as many as 20% of Am...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

linzess and lactulose
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I take 145mcg capsule of linzess with 8ounces of water 30 minutes before I eat and also take 45 ml of lactulose 3 times a day 30 minutes before I eat anything and still not having any bowel movement. stomach getting bigger and bloated,feeling miserable
Updated 4 minutes ago.
 
How many days should you take Linzess to 1st bowel movement
1 Reply RSS
I am on Linzess 7 days now had 1 bowel movement after 1sst dose of 290 mg Is it save to continue taking it ## Hello, Sheila! How are you? It would be best to follow your doctor's instructions for whether or not to continue it. Most people do experience bowel movements, shortly after taking it, but it does not work for everyone. Have you made sure to take it on an empty stomach, at least a half hour, before eating or drinking anything else? The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating, and diarrhea.
Updated 15 hours ago.
 
lizness 145 mg
14 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 3 days ago.
 
Anybody else with these issues
18 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 3 days ago.
 
Correct way to drink Linzess
1 Reply RSS
Hello everyone. I've always had issued with construction growing up. Recently went to my gastroenterologist and he performed a colonoscopy with he didn't finish due to my colon having a curve. Now I need to get a CT scan colonoscopy. In the meantime he prescribed Kindness 145mg. I took it on Tuesday for the 1st time immediately after eating. My pharmacist didn't label the directions on it so I had no idea it was to be taken 30 minutes prior to eating. Wow! I had diarrhea about an hour later and lasted for 12 hours. I couldn't even drink water without running to the bathroom. Now I'm confused because I also drink Synthesis for my hypothyroidism disease. This also has to be taken on an empty stomach. I called the pharmacy and they recommended to take synthroid 30 minut...
Updated 3 days ago.
 
Linzess has destroyed my hair no more
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Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I started taking linzess.
Updated 3 days ago.
 
linzess weight gain
46 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 6 days ago.
 
On Linzess for a week, NOT "Working" - HELP!
27 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 6 days ago.
 
I take linzess and it not working
2 Replies RSS
I was told by my gastro doctor to take linzess 30 minutes before I eat anything on a empty stomach. but it not working. he didn't tell me how much water to drink or whether I should drink something with my meal or not ## Hello, Clyde! How are you? I'm sorry that it isn't working for you. The manufacturer states that it can be taken with 1 ounce of water, or you can open the capsule and sprinkle the beads over a teaspoon of room temperature apple sauce, a half hour before eating or drinking anything else. And yes, when you do eat, you can have a beverage with your meal, as usual. The FDA lists the typical side effects as possibly including nausea, flatulence, cramping, and diarrhea. Has there been any change? ## No there hasn't been any change.I also take 45 ml of lactulo...
Updated 7 days ago.
 
HELP! How long do you stay on Linzess?
1 Reply RSS
I'm confused (since my doctor did not clarify).... I've been taking Linzess for 2 months. Is this a forever pill? Do patients typically have a set amount of time or trial time to see if it's working for them... Just unsure if I should continue with this or if there's an end to taking Linzess in my foreseeable future. It has helped. Having insurance issues / billing claim issues so I haven't been able to go back to the prescribing doctor. Also since being diagnosed with IBS-C, I went gluten free and I'm having success with the stomach cramps. Any info would be greatly appreciated. The Rx ran out today... which means I would be technically stopping it cold turkey tomorrow. Not sure this is a good thing or bad. Not really wanting to stay on it forever anyways though...
Updated 10 days ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (3 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 46 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 5 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 4 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies