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Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

Anybody else with these issues
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Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 2 minutes ago.
dizziness, mental confusion
3 Replies RSS
Ive taken 145 mg linzess now for 12 months for idiopathic constipation, my daily dizziness and mental fog are becoming difficult to deal with. Is there any suggestion anyone has to reduce this problem. thanks for reading this. ## Hello, Dennis! How are you? I'm very sorry about the problem that you're having. Have you consulted your doctor about these symptoms? The dizziness is a very common side effect, as listed by the FDA, you may also experience fatigue, dehydration, rash and abdominal pain. However, you may need to take a break from it and try a different medication. Alternatively, your doctor may know of some way to help alleviate these symptoms. ## Duh! Take less meds. That should help. ## Take less meds. That should help.
Updated 3 days ago.
Stopped working for me
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Hello, I am taking the 290 and it has been about 1 month and a half taking this. The first 2-3 weeks were amazing and it worked. Great and now I am not going at all. Very hard to push and very bloated! Will it start to work again? I need some relief
Updated 7 days ago.
LInzess not working as well
2 Replies RSS
I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like small rocks and hard to pass. I sometimes go several times a day but only small amounts at a time. I take 290mcgs every morning at least 30 minutes before I eat. It's usually over an hour before I eat anything. I do drink coffee or Diet Dr Pepper. Can you think of a reason why I'm having problems? ## Hello, Kaye! How are you? Your body might just have become tolerant to the medication, this happens to everyone after having taken something for awhile, for some people one medication may last for years, but for others they can become tolerant much sooner. Linzess has also not been successful for everyone that's tried it, quite a few people reported that it didn...
Updated 10 days ago.
linzess weight gain
12 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 29 days ago.
2 Replies RSS
Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you? Is that more or less than usual for you? What has your doctor advised? Do you take any other medications? ## Why does it say to take Linzess in the morning? I would rather take it at night. If I take it in the morning, I don't dare leave the house for a few hours. I really like it, but would prefer to take it at bedtime
Updated 1 month ago.
help with side effects
2 Replies RSS
I just took my first dose (145 mcg) of Linzess this morning. Within 2 hours I had 2 normal bowel movements with no pain. After 5 hours, my head started feeling prickly and itchy, my ears plugged up and then my heart seemed to be slowing down to the point where I started to pass out. Now (7 hrs later) I am still feeling that way. Is there something I can take to counteract that and how long does Linzess stay in my body? ## Hi Linda, Sorry to hear about the symptoms you're experiencing on Linzess. I can't help but wonder though, if you've looked into any safer laxatives on the market that don't exhibit such strange side effects? (i.e. things like Epsom Salt, apple cider vinegar, etc). Concerning how long Linzess remains in the body, information I found online stated that i...
Updated 1 month ago.
lizness 145 mg
8 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 1 month ago.
5 Replies RSS
Can I take Lizness only as needed, maybe twice a week or do I have to take it every day. I do not like the idea of having to take a medication for the rest of my life daily so really only wanted to take it when it was really necessary since it works so quickly. I need it because of my IBS and have tried everything else but it still makes me nervous to be on it daily especially since it has not be around that long. ## Hello, Lori! How are you? You should take it according to your doctor's instructions. Many medications don't work as well, unless a steady regular level is maintained in the body. Typical side effects to this medication may include nausea, bloating, stomach pain and gas. Many people do take medications for their entire lives, for heart conditions or high blood press...
Updated 1 month ago.
linzess 290mcg
3 Replies RSS
I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going at all. Can I drink water the 30 minutes before my first meal. Most of the time I don't eat much. ## Hello, Donna! How are you? I'm very sorry about the problem you're having. It works best taken on an empty stomach, with just a sip of water. Typical side effects, as listed by the FDA may include nausea, dizziness, diarrhea and stomach pain. At this point, it would be best to consult your doctor, many people have reported a similar issue. For some people it only works for a few weeks, but sometimes it works longer, but few are having long-term good luck with it Are there any other questions or concerns? ## Thanks for replying. It is now giving diarrhea and ...
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act...  12
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ...  3
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm...  2
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?...  2
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ...  2
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,...  1
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ...  1
New on Linzess for IBS-C, slenic flexure syndrome Been on Linzess 2 weeks now. I take it before dinner, sometimes really watery stool or just normal stool. Can't take...  2
Taking Linzess with food I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she wi...  1
i am taking linzess at the wrong time will start tomorrow morning when I eat. I have been taking linzess at night before bed. great stools but very runny and causing burning in that area. Will start...  2