Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) in adults.[1] Contents 1 Background 2 Clinical trials 3 Distribution and licensing 4 Chemistry 5 References 6 External links Background The National Institutes of Health (NIH) estimate that as many as 20% of Am...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

Linzess Allergy
7 Replies RSS
I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time, I was still hopeful. However, I woke up on a Wednesday with a swollen face and a bump in my eyebrow. I thought I had gotten bitten by something and didn't attribute it to the Linzess. Took Benadryl but didn't get any relief. I woke up with my eyes swollen almost shut on both Thursday and Friday morning and the bump in my eyebrow began to itch. By Saturday morning when I awoke to a swollen face and eyes again, I knew it was the Linzess. I am bummed since I was so hopeful that the Linzess would help me with my constipation. ## Oh wow! I am so very sorry about what happened. Did you consult your doctor? Has swelling gone away, yet? It is always possible to find o...
Updated 4 minutes ago.
First month no differance in constipation
1 Reply RSS
2nd month diarrhea/bloating 24/7, up night, dizzy, it has been 5 days since I stopped taking daily 145 dose, still have diarrhea/bloating 24/7, ## Those can be side effects of this medication, as reported by the FDA. You may also experience nausea, dizziness and stomach cramping. Has anything changed, or do you still have diarrhea and bloating? Are you on any other medications?
Updated 21 hours ago.
Linzess occasional
1 Reply RSS
Can linzess be taken as needed. My antidepressant causes constipation? ## Hello, Jill! How are you? Some people do take it that way, depending on how it works best for them. There is no harm in trying it that way, if your doctor approves of your doing so. The FDA lists its typical side effects as possibly including nausea, dizziness, bloating, stomach pain and diarrhea. However, have you tried just using fiber supplements?
Updated 5 days ago.
Linzess, and heart problems
2 Replies RSS
I have been on Linzess since August 2015. By February 2016 I began having heart problems, short of breath, pounding, racing, and palpatating. I have seen a cardiologist, and had a echo cardiogram that showed problems. I went for a heart cath, but only had minminal blockage. I wore a holter heart moinitor for 24 hours, and there was many instances of pounding spontaneous rapid increase in my heart rate, which is what I had been experiencing. Additionally, my lips, tongue, and nose begin to feel tinglely, and numb feeling. I was put on heart meds, and they helped for a bit, but are not working now. Has anyone else experienced heart problems with linzess as well? ## Hello, Esther! How are you? The FDA doesn't list such issues as being among the known side effects for this medication, t...
Updated 13 days ago.
Linzess stopped working
2 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 14 days ago.
linzess weight gain
36 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 14 days ago.
how good does liness clean colon
1 Reply RSS
Can you tell me does liness clean your whole colon? Are how much cleaning do you get y us Iiness ## Since the effects of any medication tend to vary for each individual, I think it may ultimately be best to work closely with your doctor on finding a safe and effective dosing regimen. Taking it in close proximity to food is something that might also affect how well it cleans. I'd recommend browsing through some of the related Linzess discussion broads here in order to get a better idea of what results are being reported. According to, Linzess is said to work by increasing the motion of food and waste through the stomach / G.I. tract as well as by blocking pain signals - but it goes without saying that the amount of movement or cleansing taking place can unfortunately only be ...
Updated 29 days ago.
lizness 145 mg
13 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 30 days ago.
On Linzess for a week, NOT "Working" - HELP!
14 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 1 month ago.
how long does it take for linzess to get out of your system
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how long does it take for linzess to be completely out of your system
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (3 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 36 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 3 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 3 replies