Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

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Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

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3rd day on Linzess
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on 3rd day. Have bm' s in morning about 45/60 mins after taking Linzess. Those are only ones for the day. They are easier and formed. After I feel really good until afternoon when the bloating comes and feel full in bowel. Taking Gas X seems to help. When does full effect of Linzess happen? If IBS-C is the reason is this a 24/7 365 day or will there be periods of relief? Don't want to be on meds forever!!! Does it get better??? This is my first episode and it's been a month. 64 years old, would have thought it would have started when I was younger!
Updated 3 seconds ago.
Bloody diarrhea
2 Replies RSS
Bloody diarrhea everytime, this time bloody urine. Not worth it. ## I have to agree with you! It might be that it's just not the right medication to help you. Other side effects, as listed by the FDA, may possibly include nausea, dizziness, bloating and stomach cramps. How long have you been taking it? ## Three times in the last month.
Updated 1 day ago.
1 Reply RSS
I am a 20 year old female. 3 years ago I was diagnosed with "chronic constipation." I have a bowel movement probably 1-2 times a week. I have had 2 colonoscopies and a flex sig done, and everything appeared to be normal. I have tried every remedy there is: fruit, fiber, laxs, stool softener, enema, exercise, and nothing seems to do the trick. Recently my dr started me on Linzess. I have been taking it for 2 weeks now. So far my bowel movements have not improved while taking Linzess. I spoke with my dr and they suggested that I add miralax to my daily routine along with Linzess. I have not had any improvement with my bowel movements while taking miralax and linzess. Can anyone give me advice or their input? Has anyone else had the same issues? I WOULD LOVE TO HEAR FROM ANYONE!! P...
Updated 1 day ago.
Punched in the gut feeling for 3 weeks straight
2 Replies RSS
Took Linzess intermittently for the last few months from doctor provided samples, didn't work great but no real issues. Filled my first 30 day supply on June 11th and have been in agony ever since. feel like I've been punched in the gut, kidney area pain, bloating, distention, and fatigue. Doc said it wasn't from Linzess, so I kept taking it. Tested liver, pancreas, everything is normal but these stomach pains will not go away. Only thing that helps is sticking to a clear liquid diet, but I can't do that forever. Last 2 nights woke up around 4am and ran, literally ran to terlet and experienced a Dumb and Dumber type "evacuation". This morning I decided to stop the Linzess. Rather be constipated. I'll post an update. May not be the Linzess causing the issues b...
Updated 2 days ago.
Linzess not working
3 Replies RSS
I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my belly rumble, then I have to push to get anything out and it's still hard. ## Hi I agree.The first week I was on linzess it work to well vut it still helped but now that im back on it its been two days and still nothing.. what did you do or why is it my stomach just rumbling but im not going. ## It should be taken as prescribed by your doctor, which is usually daily. Additionally, it needs to be taken with water, on an empty stomach, at least 30 minutes before eating or drinking anything else. The FDA lists its typical side effects as possibly including nausea, dizziness, abdominal cramping, bloating and diarrhea. Does anyone else have any advice or ideas that may he...
Updated 3 days ago.
Can I drink a few cups of coffee during the 30 w/no food
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although I do not eat anything for at least 30 minutes before taking the medication, I do drink a few cups of coffee. Is this okay? Also, the Linzess worked the first day I took it and then 2 days later but has not worked for the last 7 days. Any ideas why? ## Hello, Troubled! How are you? No, you shouldn't drink coffee, either. The coffee, or anything else you ingest too soon may be preventing it from working properly. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating, abdominal cramps and diarrhea. Are you on any other medications?
Updated 3 days ago.
linzess weight gain
15 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 3 days ago.
Linzess/ severe diaherra
2 Replies RSS
I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thirty minutes with liquid type diaherra. Lots of times there is no pain or warning and I make a mess in my pants and I'm only 23. Ive only been taking Linzess on the days that I don't have to go out in public. I have lost a dramatic amount of weight, the days I don't take it, i'm in severe abdominal pain all day and feel like I have to go but never can. I was put on this medicine because I was on this medicine for constipation. What should I do? ## I experienced the exact same thing when I was taking it 1 year ago (I was 23 then as well). Although, I felt like my body was retaining mass amounts of water for those bowel movements, and it was debilitating. I...
Updated 4 days ago.
Anybody else with these issues
7 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 18 days ago.
Linzess results
3 Replies RSS
I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of miralax daily (which stopped working), amitiza (never worked) and now Linzess. The very first day it caused severe pain and I had pretty severe diarrhea. The next few days & nights I had severe abdominal pain, but now just cramping and lots of bloating. I have not had ANY movements at all since the diarhea on day 1. Is this normal? ## I hope your seeing a gastroenterologist and if so CALL the doctor. ## Hi GPcrusader, Sorry to hear about your situation. From what I've read on other related threads, the time it takes for Linzess to work actually varies greatly for each and every individual. However, I do agree with Amber in that it might be a good idea to touch base w...
Updated 30 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 15 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
Linzess/ severe diaherra I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thir... 2 replies
Linzess is great Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins ... 2 replies