Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) in adults.[1] Contents 1 Background 2 Clinical trials 3 Distribution and licensing 4 Chemistry 5 References 6 External links Background The National Institutes of Health (NIH) estimate that as many as 20% of Am...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

Side effects/problems with Linzess
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Hi, I have been taking Linzess 290mg for ibs-c. I have struggled with that since my hysterectomy. I have been taking linzess for some time now and initially it didn't work which is expected. Then.....I had got the diarrhea. I took it like I was supposed to once every day at the same time every day. The diarrhea is a side effect I know of but the side effect I got recently that I do not like is I'm always hungry. After I take linzess and I "empty" every thing because of diarrhea I feel like I am always starving even though my stomach feels full and bloated. I just want and feel like I have to eat. Is this normal? Also I talked to my doctor who said that I could have gastreoperis because my stomach could not be emptying properly when I am not on the meds and when I take it...
Updated 5 minutes ago.
linzess weight loss
3 Replies RSS
how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss, so there is no time frame I can give you for this. It is used to treat symptoms of IBS that are associated with constipation. And while that may cause weight loss, in some instances, it can be dangerous to try to lose weight via giving yourself diarrhea, since it creates the risk of malnourishment and dehydration. Common side effects to this drug may include nausea, dizziness and stomach pain. Was it prescribed for weight loss? ## I just received a sample from the dr to help with my weight loss, however, I am shocked at ALL the side affects from people of.horrible weight gain! I am confused, can you please help explain? ## I have IBS. Been taking linzesss for a month....
Updated 2 days ago. often?
4 Replies RSS
Hey yall.. wanted to know if lizness cleanses the colon and if i need to take it everyday. I was looking for something to clean my colon n not have to depend on medication on a daily. Any imput would b appreciated ## Hello, Jamie! How are you? No, it doesn't actually cleanse your colon, it is used as a laxative to induce bowel movements in people that have chronic constipation. The FDA lists its typical side effects as possibly including nausea, bloating, diarrhea and dizziness. There is actually no medical proof to the theory of colon cleansing, if there were, doctors would have us all doing it regularly. Is there anything else I can help with? ## Thank you so much for responding and helping me to understand. I will address this with my doctor and entertain other avenues. I truely ...
Updated 2 days ago.
On Linzess for a week, NOT "Working" - HELP!
17 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 9 days ago.
The way I took it
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I ate an orange then I took Linzess without realizing I just ate that orange...will it still work ?
Updated 11 days ago.
Linzess stopped working
5 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 11 days ago.
linzess weight gain
44 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 14 days ago.
linzess 145 mg
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I have tried taking Linzess as needed and everyday. My experience was more often used less lt will works. Taking a break from your Linzess just for one day can make it work better. But need to use fiber drink or stool softener in place of . Do not eat bananas or any food that will cause constipation. Drink 100% pure apple juice and orange juice high pulp and fresh oranges . Also eat activia yogurts with fiber one everyday will help .
Updated 1 month ago.
Linzess Allergy
7 Replies RSS
I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time, I was still hopeful. However, I woke up on a Wednesday with a swollen face and a bump in my eyebrow. I thought I had gotten bitten by something and didn't attribute it to the Linzess. Took Benadryl but didn't get any relief. I woke up with my eyes swollen almost shut on both Thursday and Friday morning and the bump in my eyebrow began to itch. By Saturday morning when I awoke to a swollen face and eyes again, I knew it was the Linzess. I am bummed since I was so hopeful that the Linzess would help me with my constipation. ## Oh wow! I am so very sorry about what happened. Did you consult your doctor? Has swelling gone away, yet? It is always possible to find o...
Updated 1 month ago.
First month no differance in constipation
1 Reply RSS
2nd month diarrhea/bloating 24/7, up night, dizzy, it has been 5 days since I stopped taking daily 145 dose, still have diarrhea/bloating 24/7, ## Those can be side effects of this medication, as reported by the FDA. You may also experience nausea, dizziness and stomach cramping. Has anything changed, or do you still have diarrhea and bloating? Are you on any other medications?
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (3 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 44 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 5 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,... 3 replies