Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] The National Institutes of ...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

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I read somewhere that Linzess BLOCKS PAIN SIGNALS. If that is so...I'm concerned. Pain is our bodies way of letting us know something is wrong. I'm afraid that something may be going on and I will not know until it's too late. I started Linzess about 3 weeks ago. I was disappointed the first two weeks because I saw very little to almost no change. I stuck with it and now it is working. But again; I'm concerned about the Blocking of Pain Signals. ## Hello, Lidia! How are you? It does block them, but in the intestines, where it works, not systemic throughout your entire body, so I hope this information helps alleviate your concerns. The FDA lists its other typical side effects as possibly including nausea, dizziness, bloating and diarrhea. Is there anything else I can help...
Updated 7 minutes ago.
Using Linzess with success
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I have suffered from constipation for over fifteen years. I have tried all the usual over-the-counter remedies for constipation and found that I was using a suppository with Miralax daily just to get minimal relief. My doctor prescribed Linzess because I was getting frustrated with the abdominal discomfort. I have been on Linzess for approximately two months now. It has definitely helped with the constipation, usually working within two hours. It is typically a very watery discharge. However, there have been a few days that I have had explosive diarrhea and several times I have had to plan my day around where the bathrooms are. There are pros and cons with taking this medication but the pros have the upper hand with me since it has given me relief. ## Hello, Mike! How are you? I'm v...
Updated 21 hours ago.
Linzess interferes with thyroid medication
2 Replies RSS
After taking linzess for 8 months I gained 20 pounds and developed every symptom for hypothyroidism again. For the past 12 years I have been on synthroid 75. I have not had any hypothyroid symptoms once I began taking synthroid until taking the linzess medication. I stopped taking linzess and hoping it will exit my body quickly so my synthroid meds will begin working again. Why don't doctors tell you it prevents your thyroid meds from working? Why don't they tell you it will make you gain weight? I just hope I can get my thyroid and my weight under control again. ## A follow up on my hypothyroidism symptoms that was caused by Linzess: dr ran a TSH, T4, and a T3 blood test and the results showed I was on the low end but still within the acceptable range of the T3, the T4 and TSH ...
Updated 6 days ago.
muscle aches and linzess
2 Replies RSS
I have been on Linzess for a month. My dose is now 1 every other day. I am still waiting to see if the diarrhea subsides on the new dose. I have had another problem which started about 5 days in. My hips started aching. Since then I have having muscle tension in my shoulders and upper back. I dont' want to give up on the Linzess, but am concerned about the muscle aches. Is the diarrhea caused by the Linzess dehydrating me. My urine output seems normal. Or could I be reacting to something in the Linzess? ## Hi Karen, Sorry to hear about the muscle aches/diarrhea. From what I could gather, both diarrhea and stomach pain are reported to be common but potentially severe side effects of Linzess (Linaclotide) that you should talk with your doctor about if the symptoms do not go away on th...
Updated 15 days ago.
Linzess review- my experiences
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I have suffered constipation for years- sometimes no BM for weeks. Eventually- I just stopped all BM completely. I resorted to bisacodyl once per week. Eventually, I had to take 4 at a time- until that stopped working. Scheduled colonoscopy but the prep didn't work. Second prep did only because I mixed it with large amounts of bisacodyl. Results showed nothing. Doctor gave me linzess. 145 mg didn't work. 290 mg also didn't work. So, again, I took lots of bisacodyl. After that, I started the linzess again- after the clean out, I am now having BM every other day. Very loose but after the BM it's not like I'm running to the bathroom all day. I suspect I will have to periodically take the bisacodyl to keep things moving- but maybe only once every couple weeks instead of ...
Updated 17 days ago.
To Answer Questions About Linzess
2 Replies RSS
I been on Linzess for like 2-3yrs. It is the best that has happened since Zelnorm. I seen everyone's Q&A's and tp answer those in question. I work 8-4pm and usually take it around 3pm giving it an hr or so before eating and by 6 or 7pm it works wonders. For those having severe constipation like myself, I take another before bedtime which is 11/1130pm and by 530am it also releases the rest of stool. So in short, take one around 11pm or bedtime AND another the next day around 3pm (ASK your doctor first if two is suitable- as im not sure and never asked) AND (depending on your work schedule). Just make sure it's an hour before you leave work. ## I believe if you take it twice a day you may desensitize. I cannot site the NIH page I read this on but you could Google it. Best ...
Updated 22 days ago.
Linzess coupons that work best
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Trying to simply find the best way to somehow get some serious price relief on this amazing but incredibly ridiculously priced pill. I understand a profit but the pricing I am finding is simply, for lack of a better way to put it, pure advantage taking of the public. Please help. ## Hello, Swanson8! How are you? These is a co-pay card available for eligible patients that helps you pay as little as $30 a month, if your eligible. You can check out the qualifications and print the card from their website at click here. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating, gas and diarrhea. Is there anything else I can help with?
Updated 23 days ago.
Effects of taking Linzess and running
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I started taking this meds in the summer. I am a distance running. I am experiencing heavy legs after running 13 or more miles. I want to know if anyone has had this happen to them... ## Hello, Lynn! How are you? There are a couple of possibilities that may explain it due to Linzess side effects. As listed by the FDA, it can cause weakness, dehydration, fatigue and hypokalemia (low potassium.) Thus, you may be experiencing one or more of those side effects. Have you consulted your doctor? They should be able to help you determine which one(s) is/are causing the problem.
Updated 25 days ago.
Just started taking Linzess
2 Replies RSS
I just started taking Linzess. I am on day 4 of this medication. I am on a low dose for the first week; then I am supposed to start a much higher dose of Linzess. I have yet to have a BM. However, I have severe gas and abdominal pain. I how to get super dizzy and nauseated. I have cerebral palsy so the dizziness and listlessness are dangerous. I am afraid I will lose my balance. Will these symptoms subside? I am afraid that I will never get back to work substitute teaching because my bms. By the way this is been going on for almost 2 years. I have tried several different medications. ## Hello, Lisa! How are you doing? I'm very sorry about the problem you're having. Given that you have CP, I think it would be best if you returned to your doctor and spoke to them about these side ...
Updated 25 days ago.
linzess weight gain
16 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 27 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (2 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 16 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 3 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
Linzess interferes with thyroid medication After taking linzess for 8 months I gained 20 pounds and developed every symptom for hypothyroidism again. For the past ... 2 replies