Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation predominant irritable bowel syndrome (IBS-C) in adults.[1] The National Institu...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

lizness 145 mg
11 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 9 hours ago.
linzess weight gain
33 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 2 days ago.
Linzess every two days?
1 Reply RSS
Great medicine, although I have only started. Can I skip two days before taking the next dosage? Also I am shocked at the cost. $400+ for a three month supply. Any ideas? ## How is it working for you? You should follow your doctor's prescribing instructions, skipping days may prevent it from working as well as it should. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating and diarrhea. There is a savings program available from the manufacturer. You can find information on it via the Linzess website at click here. Is there anything else I can help with?
Updated 3 days ago.
On Linzess 2 weeks with only 2 small bms
1 Reply RSS
I started on the lower dosage 2 weeks ago, and I didn't go the whole week. Doctor bumped me up to the 290 dosage and have only had 2 very small bms a little loose. That is it! I keep reading about how everyone is getting diahhrea several times a day. I take it every morning 30 minutes to one hour before I eat or take any other medicine. It's like everything has stopped working. Even hard to pass gas. My stomach is distended and I have rumbling, but nothing coming out. Do I just continue to take and wait for it to work? So far, not very impressed with Linzess! ## I'm sorry about the problem you're having. Are you making sure to take it a full glass of water? Unfortunately, this medication doesn't work for everyone that tries it. The FDA lists its typical side effects ...
Updated 3 days ago.
Anybody else with these issues
16 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 3 days ago.
On Linzess for a week, NOT "Working" - HELP!
11 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 6 days ago.
how good does liness clean colon
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Can you tell me does liness clean your whole colon? Are how much cleaning do you get y us Iiness
Updated 14 days ago.
took before i ate dinner
1 Reply RSS
i was wondering when it will start working? i took it before dinner ## Hello, Kayla! How are you? Unfortunately, many people aren't receiving the correct instructions on how to take this medication. It must be taken in the morning, at least half an hour before eating or taking any other medications. Thus, this first dose may not work as it should. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating and diarrhea. Is there anything else I can help with?
Updated 1 month ago.
1 Reply RSS
I have other prescription meds.. I take them in the mourning. Is it ok to take lizness with them together? I just worry about linzess flushing my meds out of my body before they work. Thank you. ## Hello, Lee! How are you? Unless your doctor instructs otherwise, you should take the Linzess at least a half an hour before eating or taking other medications. The FDA lists its typical side effects as possibly including nausea, dizziness, headache, bloating and diarrhea. What other medications are you on?
Updated 1 month ago.
linzess in morning and night
1 Reply RSS
First time I tried it as prescribed once in the morning luck. ## Hello, Vanessa! How are you? I'm sorry it didn't work for you. Did you make sure to take it on an empty stomach, with just water, at least a half hour before eating? Sometimes, people haven't been receiving the proper instructions with their prescriptions, so they don't know they have to take it that way. The FDA lists its typical side effects as possibly including nausea, dizziness, bloating and diarrhea.
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (3 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 33 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 3 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies