Linzess

Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

Linzess results
3 Replies RSS
I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of miralax daily (which stopped working), amitiza (never worked) and now Linzess. The very first day it caused severe pain and I had pretty severe diarrhea. The next few days & nights I had severe abdominal pain, but now just cramping and lots of bloating. I have not had ANY movements at all since the diarhea on day 1. Is this normal? ## I hope your seeing a gastroenterologist and if so CALL the doctor. ## Hi GPcrusader, Sorry to hear about your situation. From what I've read on other related threads, the time it takes for Linzess to work actually varies greatly for each and every individual. However, I do agree with Amber in that it might be a good idea to touch base w...
Updated 41 seconds ago.
 
Anybody else with these issues
3 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 5 hours ago.
 
2 days without a movement
1 Reply RSS
I have been on Linzess for 2 days and no movement, I think I am going back to milk of magnesia, I was using this and it worked great until my doctor put me on a water pill, and I told her I could not take them, they dried me out so bad and was so weak that I stopped taking them. could the water pill dried me out so bad that my lower colon is twisted. I am so upset. I take pain medicine. ## Hello, Footsie! How are you? I'm sorry about the problem that you're having. Have you been taking the Linzess on an empty stomach? For it to be effective, it can't be taken with food. The FDA lists its typical side effects as possibly including nausea, dizziness, abdominal bloating, diarrhea and heartburn. What pain medication do you take? Many of them can cause constipation, so it could b...
Updated 3 days ago.
 
Linzess and strange dreams
4 Replies RSS
Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days in the AM...nothing, just more bloating but it did help some with the pain. However after reading up some, and considering my work schedule, I thought I should switch to a bedtime dose. WELL...Its working now! But thats ok! I think most of us agree after suffering with being back up for years, hey, whats a lil diarrhea. Problem is, I awoke...well tried to..from a most horrific dream, right upon drifting off. Im usually not a vivid dreamer. Anyone else have this AT ALL? ## Hello, Kris! How are you? Yes, others have reported having this happen, while taking Linzess and it's actually fairly common with most medications, since they often have a direct effect on brain c...
Updated 4 days ago.
 
linzess/linzess
1 Reply RSS
When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ## Hello, Jen! How are you? It would be best to double check with your doctor. Sometimes that doesn't fully cleanse, so something else may still be required. Other side effects of Linzess, as listed by the FDA, may possibly include nausea, dizziness, bloating and flatulence. Is there anything else I can help with?
Updated 7 days ago.
 
Linzess, then other meds with breakfast
5 Replies RSS
Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Reading the other postings, I am somewhat afraid to take it. Nevertheless, I would take my levothyrox 1/2 hour before the Linzess, then would take my other meds with a meal. Will the Linzess "wash out" the other meds?? Also, is "unanticipated bowel leakage" a possibility with Linzess? ## Hi Molly, Sorry to hear about the constipation from pain meds. Looking at others feedback on Linzess it's easy to get discouraged and not want to take it. However it is also important to understand that these meds tend to affect each person differently, whereas patients who don't have any serious issues with it would be less likely to feel inclined to post about their...
Updated 11 days ago.
 
linzess causes weight gain
6 Replies RSS
I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. I was holding my weight before this prescription. I'm gonna stop this for a week and see what happens. I actually fasted for 1 1/2 days taking weight in A.M. and P.M. only having water and fruit juice (Low Sugar) and didn't lose anything? ## Hi Chuck, I don't know if this is would accurately describe the type of weight gain you mentioned, but according to nih.gov, Linzess (Linaclotide) is known to cause swelling or a feeling of fullness/pressure in the stomach region that may appear as added weight. It can also cause excess gas to from, which may also contribute to feeling bloated. I'm thinking perhaps either of these side effects could be the culprit, ...
Updated 22 days ago.
 
Linzess how many days before it starts to work?
1 Reply RSS
How long should it take for linzess to start working. It is my second day and so far nothing. Also I see some people say it causes weight gain. I would have thought the opposite. Can you tell me about that? ## Hello, Bella! How are you? I'm sorry that it hasn't worked for you, yet. Has there been any change? Please make sure that you are taking it with a full glass of water at least half an hour before eating. The time it takes to work can vary from person to person, some have found it to work right away and others have had to take it for a couple weeks. The typical side effects as listed by the FDA as possibly including nausea, abdominal pain, diarrhea, vomiting and weakness. If there is no change soon, then you'll need to contact your doctor.
Updated 1 month ago.
 
Linzess is great
2 Replies RSS
Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins before your first meal of the day or you could have some of the side effects worsen. ## Taking it closer to a meal could also result in it not being as effective. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating and diarrhea. Is it still working well for you? ## Hi, I've had terrible bloating along with the constipation for a while and I started up on lizness about 4 days ago. I was curious if you had bloating when starting out and then it got better after the 2 weeks or was it just good since you started? (Sorry for writing so much)
Updated 1 month ago.
 
muscle aches and linzess
1 Reply RSS
I have been on Linzess for a month. My dose is now 1 every other day. I am still waiting to see if the diarrhea subsides on the new dose. I have had another problem which started about 5 days in. My hips started aching. Since then I have having muscle tension in my shoulders and upper back. I dont' want to give up on the Linzess, but am concerned about the muscle aches. Is the diarrhea caused by the Linzess dehydrating me. My urine output seems normal. Or could I be reacting to something in the Linzess? ## Hi Karen, Sorry to hear about the muscle aches/diarrhea. From what I could gather, both diarrhea and stomach pain are reported to be common but potentially severe side effects of Linzess (Linaclotide) that you should talk with your doctor about if the symptoms do not go away on th...
Updated 1 month ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 14 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
Linzess is great Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins ... 2 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 2 replies
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ... 2 replies