MedsChat.com

The People's Medicine Community ®
Drug Index: 

Linzess

Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative

Welcome to the Linzess information hub. Scroll down to read supplemental details and discuss this drug.


Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is an peptide agonist of guanylate cyclase 2C that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well.[1] The drug was developed by Ironwood Pharmaceuticals, based in Cambridge...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: http://en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

Rumbling in tummy are pretty intense...
I have been on Linzess for 2 months and continue to have constant rumbling in my stomach and intestine if I eat 30 minutes after taking the medication. Sometimes it gets pretty intense and I get sick to my stomach. If I don't eat until lunch, it happens and by then I am nauseous from not eating so it's even worse. Anyone else have this problem and what do you do??? ## Hey tummytrouble, Hope you've managed to tame the rumbling in your stomach. From what I could gather, most of the side effects associated with Linzess are gastrointestinal related... with symptoms ranging from unusual & severe stomach pain, gas, swelling, or pressure in the stomach region. Ref: nlm.nih.gov/medlineplus/druginfo/meds/a613007.html#side-effects If it hasn't gone away yet, I would suggest co...
Updated 6 minutes ago.
   1  Subscribe to thread 273876
When will the bloating Stop
I have been on Linzess for about a month. I have not had any of the severe side effects mentioned, just the bloating and gas. Does anyone know when those side effects will stop? For the most part the Linzess has worked, I am having regular bowel movements. Since I am so bloated it is hard to eat and therefore I have lost weight that I did not need to loose. Any way any insights would be appreciated! ## Hello, Ag! How are you? I'm sorry about the problem that you're having. Have you looked into taking anything that may ease the gas and bloating? I'm not sure, but you may be able to take Simethicone with it, if your doctor approves it.
Updated 3 hours ago.
   1  Subscribe to thread 270314
Itching and rash
I started taking Linzess in early August and around the end of August I broke out with a rash and had severe itching and had to go to a dermatologist. She thinks I had a allergic reaction so I am taking the linzess twice a week. Its not owrking as well as before, but I was miserable for a month with the itching. ## Hello, Lulu! How are you? The problem is that even just taking it twice a week may not be safe, if you are allergic to it, because such reactions tend to get worse with time. Have you consulted an allergist or immunologist? That might be a good idea, in order to get a better idea of what's going on. ## Thanks Verwon, I will talk to my doctor about seeing a allergist. I am allergic to aspirin, penicillin, so I need to check into this. again thanks!
Updated 1 day ago.
   2  Subscribe to thread 273863
Medicationstogether
I take my Linzess in the morning, I love it. I was wondering if I could take the rest of my morning medication at the same time as I take the Linzess? I see no food or drink for 30 minutes but other than that... ## What other medications do you take? I'm sorry, but I'll need more details in order to answer your question. ## Strattera and verapamil are the two main ones that get me going in the morning, also I take vitamin D, magnesium, tramadol, meloxicam, and biotin. I have dysautonomia so the strattera and verapamil are important for get up and go.
Updated 5 days ago.
   2  Subscribe to thread 273415
How long before Linzess starts to work?
I was prescribed Linzess for my IBS-C. I have been taking Linzess for two days now and very bloated with no bowel movement. From what I had read, it would work rather quickly, but for me that is not the case. I took one 145 mcg the first morning as directed and 2 of the 145 mcg the second morning and still nothing. How long does it usually take before I will start seeing results. I have the urge to have a bowel movement, but nothing is produced. Any advise will be appreciated. ## Hello, CJ! How are you doing? Has it worked, yet? There's really no way to give a time frame, it can vary from person to person. Some people have good luck with it, some don't. One person posted recently that it was only resting in one BM a week for them. Have you consulted your doctor for advice?
Updated 7 days ago.
   1  Subscribe to thread 273446
linzess
Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you? Is that more or less than usual for you? What has your doctor advised? Do you take any other medications?
Updated 9 days ago.
   1  Subscribe to thread 272985
Linseed
Is it okay to take linzess every other day or when needed dose linzess cause weight gain ## Hello, Bailey! How are you? This medication will work best if you take it exactly as prescribed by your doctor. Side effects may include heartburn, loss of appetite, weakness and diarrhea, so no, it doesn't usually cause weight gain. Is there anything else I can help with?
Updated 29 days ago.
   1  Subscribe to thread 271399
linzess weight gain
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 1 month ago.
   10  Subscribe to thread 247630
How fast
How fast will the lizness begin to work? I have to go to work and don't want to be running up and down statues all day. ## Hi Gil, While some patients report having bowel movements on the first day from taking Linzess (Linaclotide), others mention that it took up to a few weeks before it really kicked into gear for them. With that said, the only real way to see if it will work for you is by actually trying it and committing yourself to a full course of treatment. I guess you're supposed to take it 30 minutes before eating or drinking in the morning, but I don't know if that has an impact on it's overall effectiveness throughout the rest of the day. The patient prescribing information notes that symptoms of diarrhea often begin within the first 2 weeks of treatment. So I...
Updated 1 month ago.
   3  Subscribe to thread 269253
Linzess and strange dreams
Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days in the AM...nothing, just more bloating but it did help some with the pain. However after reading up some, and considering my work schedule, I thought I should switch to a bedtime dose. WELL...Its working now! But thats ok! I think most of us agree after suffering with being back up for years, hey, whats a lil diarrhea. Problem is, I awoke...well tried to..from a most horrific dream, right upon drifting off. Im usually not a vivid dreamer. Anyone else have this AT ALL? ## Hello, Kris! How are you? Yes, others have reported having this happen, while taking Linzess and it's actually fairly common with most medications, since they often have a direct effect on brain c...
Updated 2 months ago.
   1  Subscribe to thread 267913

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act...  10
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?...  1
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ...  1
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ...  1
How long before Linzess starts to work? I was prescribed Linzess for my IBS-C. I have been taking Linzess for two days now and very bloated with no bowel moveme...  1
How effective is Linzess I was diagnosed with impacted bowels today and prescribed 290 mcg of Linzess. My pcp indicated this would get my bowels ...  1
Itching or rash while taking Linzess?? Has anyone experienced itching or a rash while taking Linzess? ## Hello, Louloubell! How are you? Yes, those can be side...  1