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Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

lizness 145 mg
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I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond
Updated 1 hour ago.
linzess 290mcg
3 Replies RSS
I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going at all. Can I drink water the 30 minutes before my first meal. Most of the time I don't eat much. ## Hello, Donna! How are you? I'm very sorry about the problem you're having. It works best taken on an empty stomach, with just a sip of water. Typical side effects, as listed by the FDA may include nausea, dizziness, diarrhea and stomach pain. At this point, it would be best to consult your doctor, many people have reported a similar issue. For some people it only works for a few weeks, but sometimes it works longer, but few are having long-term good luck with it Are there any other questions or concerns? ## Thanks for replying. It is now giving diarrhea and ...
Updated 19 hours ago.
Anybody else with these issues
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Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms?
Updated 13 days ago.
Dr. and Pain
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Why are Dr's giving this out like CANDY and it doesn't help it just makes the matter act up MORE. I don't see why they give this for everyone? They don't test us for having IBS they just say I think you have it maybe and like they told me after I used it for over two weeks and nothing but Pain in the Belly and sharp pain and all the bloating, keep taking it as it some times takes up to six weeks before it starts working. Why should my Dr. tell me that and knowing I am in lots of pain and he needs to do something for the PAIN and not just go by what this Drug may or may not do. ## Most doctors will have you try the medication before doing any tests for IBS. Reason being that the test is actually more painful and uncomfortable than just trying the medication (scope up the ...
Updated 17 days ago.
i am taking linzess at the wrong time will start tomorrow morning when I eat.
2 Replies RSS
I have been taking linzess at night before bed. great stools but very runny and causing burning in that area. Will start taking tomorrow morning after breakfast. I am feeling very bloaty after the 3rd day of taking it. ## Hello, Dana! How are you doing? Side effects to this medication can include nausea, diarrhea, stomach pain and stomach distention, so that explains the bloating. Several others have posted about experiencing the same thing with this medication. Have you experienced any other side effects? Does anyone else have experience using this mediation? ## I've been taking Linzess for awhile now. I follow two rules. One, recommended by my physician. First, I take it a minimum 1 hour before breakfast. Second, I take it if I have gone a full day without a BM. There are times wh...
Updated 18 days ago.
linzess weight gain
11 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 1 month ago.
how long can you take linzess?
1 Reply RSS
How long can you take linzess?? Can you take it for a long period of time??? ## Hello, Patty! How are you? Has this been prescribed for you? If so, how is it working for you? Some people had good results with it for the first week or 2, then it seemed to stop working for them. There appears to be no set treatment time frame, according to the FDA information, though most evaluation trials were for 12 weeks periods. However, your doctor would be the best judge of how long you can safely take it. Typical side effects may include nausea, bloating and diarrhea. It should also be taken on an empty stomach, at least a half hour before eating.
Updated 1 month ago.
the timing of taking Linzess
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I was told by my gastroenterologist to take linzess on an empty stomach. So I actually take it at night before I go to bed and I usually make my BM the next morning just about every day. Once in a blue moon I may skip a day, but I never go more than a day without making a BM. I wonder if linzess may be affecting the way my body digest food. Because I'm having issues with being very hungry about 45 minutes after I eat. & I wonder if Linzess forces my digestion to speed up. After I eat. I also have a disease called insulin resistance which makes me very carbohydrate sensitive. Also wondering if linzess has any effect on the metformin I take for my insulin resistance? ## @Dee, To answer your initial question about Linzess possibly affecting the way your body digests food, s...
Updated 1 month ago.
Worked first time I used it but no longer - in fact, more constipated!
1 Reply RSS
I do not have IBS but have constipation due to vaginal floor problem. I normally have a small bowel movement or two daily but do not clean out completely. The first time I tried it it worked wonderfully, although quite a bit of cramping. Next 2 days / doses, some rumblings but nothing. Now I am more constipated than before. Is this possible / been reported? ## Hello, Felice! How are you? I'm sorry about the problem that you're having. Many people have had similar issues with it, it tends to work great at first, then just seems to stall. The instructions on the Linzess website state that it should be taken on an empty stomach, at least 30 minutes before your first meal of the day. Have you been doing that? Typical side effects are listed as diarrhea, gas, abdominal pain and abdom...
Updated 1 month ago.
2 Replies RSS
Can I take Lizness only as needed, maybe twice a week or do I have to take it every day. I do not like the idea of having to take a medication for the rest of my life daily so really only wanted to take it when it was really necessary since it works so quickly. I need it because of my IBS and have tried everything else but it still makes me nervous to be on it daily especially since it has not be around that long. ## Hello, Lori! How are you? You should take it according to your doctor's instructions. Many medications don't work as well, unless a steady regular level is maintained in the body. Typical side effects to this medication may include nausea, bloating, stomach pain and gas. Many people do take medications for their entire lives, for heart conditions or high blood press...
Updated 1 month ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act...  11
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ...  3
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ...  2
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm...  1
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,...  1
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?...  1
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ...  1
New on Linzess for IBS-C, slenic flexure syndrome Been on Linzess 2 weeks now. I take it before dinner, sometimes really watery stool or just normal stool. Can't take...  2
Taking Linzess with food I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she wi...  1
i am taking linzess at the wrong time will start tomorrow morning when I eat. I have been taking linzess at night before bed. great stools but very runny and causing burning in that area. Will start...  2