Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

what is linzess
1 Reply RSS
Linzess was prescribed by my pcp, 1 capsule every other day for oic. It works within about 4 to 5 hrs and works just fine, no sidefects what so ever. The medicine works just fine for OIC. So whatever you people are experiencing has got to be a fluke, the medicine works just fine. ## We are all different, so a medication that works well for you may not work great for someone else that tries it. Have you experienced any side effects, such as nausea, dizziness, bloating, diarrhea, and abdominal pain that the FDA lists as being common with this medication?
Updated 1 minute ago.
linzess weight gain
59 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 18 hours ago.
taking linzess at night
Post a Reply
So far I am having varied results with Linzess. One day I'm going all day, one day nothing, one day it is a "normal" one/two time bowl movements, and then another I'm rushing in my car to find a public restroom. I usually take it at the same time every morning. The varied results happen at varied times. Morning, afternoon, and/or evening. I was wondering if taking it at night would help with trying to get it on a regular schedule?
Updated 2 days ago.
Linzess stopped working
22 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 2 days ago.
On Linzess for a week, NOT "Working" - HELP!
33 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 4 days ago.
Linzess coupons that work best
2 Replies RSS
Trying to simply find the best way to somehow get some serious price relief on this amazing but incredibly ridiculously priced pill. I understand a profit but the pricing I am finding is simply, for lack of a better way to put it, pure advantage taking of the public. Please help. ## Hello, Swanson8! How are you? These is a co-pay card available for eligible patients that helps you pay as little as $30 a month, if your eligible. You can check out the qualifications and print the card from their website at click here. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating, gas and diarrhea. Is there anything else I can help with? ## You can get 90 tablets for $430 via the Linzess Savings Program at:
Updated 6 days ago.
how long does it take for linzess to get out of your system
3 Replies RSS
how long does it take for linzess to be completely out of your system ## How long does it take linzess to get out of your system? ## @ike / sandy, From what I could gather, Linaclotide (Linzess) doesn't remain in your system very long at all. According to a study on, the parent drug (Linaclotide) completely degrades to its metabolite within 30 minutes, with a first-order half-life of only 3 minutes. [1] source: PubMed / PMC3638410 That said, my understanding is that Linzess should be completely out of one's system within 1-3 days easy. However there are other important variables outside of the half life that may prolong or otherwise have some sort of impact on the estimated time frame. Hope this helps! ## How long does it take for linzess to get out of the body
Updated 7 days ago.
Linzess Diarrhea
Post a Reply
I was on the 290mcg Linzess and the diarrhea and abdominal pain was unbearable. Doctor has since switched me to Trulance which just came out. Having regular bowel movements with no pain or diarrhea. Doesn't need to be taken with food either. I have fought this for years and for the first time in a long time it's manageable.
Updated 10 days ago.
Linzess with fried foods or fast food
Post a Reply
I'm taking Linzess 30 minutes before food every morning...and I went out to eat and ordered fried shrimp...and then my stomach felt like something literally kicked me... Could it be from too much grease in my stomach?
Updated 11 days ago.
Linzess interferes with thyroid medication
3 Replies RSS
After taking linzess for 8 months I gained 20 pounds and developed every symptom for hypothyroidism again. For the past 12 years I have been on synthroid 75. I have not had any hypothyroid symptoms once I began taking synthroid until taking the linzess medication. I stopped taking linzess and hoping it will exit my body quickly so my synthroid meds will begin working again. Why don't doctors tell you it prevents your thyroid meds from working? Why don't they tell you it will make you gain weight? I just hope I can get my thyroid and my weight under control again. ## A follow up on my hypothyroidism symptoms that was caused by Linzess: dr ran a TSH, T4, and a T3 blood test and the results showed I was on the low end but still within the acceptable range of the T3, the T4 and TSH ...
Updated 14 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 59 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 22 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
Linzess / severe diaherra I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thir... 4 replies
Linzess has destroyed my hair no more Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I s... 4 replies