Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US[1] and Mexico, and as Constella in Canada[2] and many other countries[3]) is a peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency (EMA)[4] for the treatment in adults of constipation-predominant irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC).[5] Contents 1 Background 2 Clinical trials 3 Distribution and licensing 4 Chemistry 5 Ref...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

muscle aches and linzess
3 Replies RSS
I have been on Linzess for a month. My dose is now 1 every other day. I am still waiting to see if the diarrhea subsides on the new dose. I have had another problem which started about 5 days in. My hips started aching. Since then I have having muscle tension in my shoulders and upper back. I dont' want to give up on the Linzess, but am concerned about the muscle aches. Is the diarrhea caused by the Linzess dehydrating me. My urine output seems normal. Or could I be reacting to something in the Linzess? ## Hi Karen, Sorry to hear about the muscle aches/diarrhea. From what I could gather, both diarrhea and stomach pain are reported to be common but potentially severe side effects of Linzess (Linaclotide) that you should talk with your doctor about if the symptoms do not go away on th...
Updated 6 hours ago.
Linzess stopped working
15 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 3 days ago.
Passing Parrasites
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I've been taking Linzess for a few months now and I must say it gets the job done. Sometimes after taking Linzess I have diarrhea. I've noticed that when I do have diarrhea I pass parasites! Has anyone else experienced this? I have detoxed before with natural herbs and didnt pass a thing. I know Linzess itself kill off parasites but there is def something in it that pushes them out. Has anyone else experienced this?
Updated 4 days ago.
took 2 Linzess capsules by accident
2 Replies RSS
Hello. I forgot I had taken a pill earlier and just took another, will this hurt me? I have been on this medication for a while and just totally forgot I had already taken one. Thanks! ## Were you ok in the end? I'm getting tired of it not working and am considering doubling my 290 dose so I'd like to know what you experienced... ## A single occasion of a double dose could possibly mean an increased risk of it's typical side effects in that moment; but I have my doubts that anything serious or long term would manifest as a result of this one time mishap. However, I too would be interested in hearing how things turned out for you Liz? Hopefully all is good! Have any other patients here had a similar experience on Linzess? For any newcomers on this medication, I see there are ...
Updated 19 days ago.
linzess weight gain
52 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 25 days ago.
Linzess not working completely
2 Replies RSS
I've been taking Linzess about every other day for 2 months. Does anyone else experience some runny spurts than nothing like you're still constipated, like you're not completely relieved? I'm always so cramped up because I never seem to be complete. I try not to even eat because it seems it would just pack up more. :-( ## I had that happen after a hemmrroidectomy and the reason why the watery stool was squirting out was because of an impaction. Mine was at the rectal opening but some can have it further up. It can cause serious problems and a lot of people end up in the hospital from the impactions. I did oil enemas to break up the impaction. Once it is soft enough to remove you can use a glove and try and sweep the stuck stool out. Once the impaction was gone I was able...
Updated 27 days ago.
Linzess / Weight Gain and Other Meds Questions
4 Replies RSS
I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds before they are in my system? I'm taking the thyroid meds 1 hour before (as required) the Linzess and the Topamax with my breakfast. Is that the right order? Also...I've been steadily losing weight successfully for a couple of months....have taken Linzess for 4 days because went low carb and stopped going to the bathroom....gained over 2 lbs in 4 days without changing any food intake and drinking 100 ounces of water a day and having diarrhea. How is that even possible. Will I just have to stop taking it to stop the weight gain? How does the med cause weight gain if it gets rid of waste? ## The Linzess should be taken by itself, at least half an hour before eati...
Updated 1 month ago.
I take linzess and it not working
5 Replies RSS
I was told by my gastro doctor to take linzess 30 minutes before I eat anything on a empty stomach. but it not working. he didn't tell me how much water to drink or whether I should drink something with my meal or not ## Hello, Clyde! How are you? I'm sorry that it isn't working for you. The manufacturer states that it can be taken with 1 ounce of water, or you can open the capsule and sprinkle the beads over a teaspoon of room temperature apple sauce, a half hour before eating or drinking anything else. And yes, when you do eat, you can have a beverage with your meal, as usual. The FDA lists the typical side effects as possibly including nausea, flatulence, cramping, and diarrhea. Has there been any change? ## No there hasn't been any change.I also take 45 ml of lactulo...
Updated 1 month ago.
Blood in toilet after bowel movement
4 Replies RSS
I was on the low dose Linzess and it wasn't working for my constipation. Now I'm on the higher dose but it is not really working either. When I finally had a bowel movement there was a lot of blood in the toilet. Has this happened to anyone? What would cause this? Anyone? ## Sue sometimes when your stool is hard from constipation it can tear your rectum and cause it to bleed. Because of the pressure in your rectum it will usually seal the tear. Watch out how hard you push the stool when you're constipated as it can cause a hemorrhoid. If you continue to have blood in your stool go see your doctor ASAP ## Years ago this did happen to me. It can be frightening to see that much blood in the toilet, but this can happen because of hemorrhoids. I took a diuretic that dried me out ...
Updated 1 month ago.
Limit with meal-not hungry
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I took linzsee so it gotta to be surpised to lose weight really well quick also when is time i am ready to eat, it felt like 5 to 6 bites then is enough for me like im manage to full as not when took done small eating had dirrehea about 4 times or 5 .its help loss weight . i lost 21 pound least less 2 week by linzsee. ??? Wow not to sure about it.
Updated 2 months ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (4 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 52 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 15 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess / Weight Gain and Other Meds Questions I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies