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Linzess

Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is an peptide agonist of the guanylate cyclase 2C enzyme that is undergoing clinical trials for use in treating abdominal pain in patients with irritable bowel syndrome (IBS) accompanied by constipation. The drug also has promising outlooks for the treatment of gastroparesis, ulcerative colitis, chronic intestinal pseudo-obstruction (CIPO), and inertia coli as well.[1] The drug was developed by Ironwood Pharmaceuticals, based i...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

Stopped working
I have been on Linzess 145 mg for a month. it worked great the first 2 weeks and now it just stopped. I don't know if my body got use to it already or what could cause it.
Updated 7 hours ago.
   0 
Taking Linzess with food
I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she will call in the higher dose. Took this morning before bed. (I work nights 7p-7a) I have had stomach pain all day. I haven't been able to sleep or get comfortable. I've had rumbling in my stomach, gas and an extremely hungry feeling with the 145mcg dose but no pain. It's been 8 hours since I took the 290mcg dose. I just ate something and I feel a little better. I read that I should take Linzess 30 minutes before eating but I usually don't eat until I get up in the afternoon. Could this pain be a result of not eating with the higher dose? ## Hi Krischris1, Sorry to hear about your situation. According to the manufacturer, you are right that it is recommend...
Updated 4 days ago.
   1  RSS Feed for thread 277167
can I take my synthroid at same time I take linzess
I take synthroid and,belviq in the morning at same time I take linzess.? ## Hi Judy, Upon looking up potential drug interactions, I did find an article noting how Linzess (Linaclotide) has been known to cause diarrhea, which in-turn may affect the absorption of other medications that are taken orally, such as Synthroid (Levothyroxine)... essentially not allowing it to work as well as it should. So if you do decide to take them together, I think it would be equally important to watch for signs/symptoms of decreased thyroid function as a result of this interaction. Have you been taking the Linzess long enough to know how it affects you (i.e. regarding diarrhea)? ## The Linzess does cause some diarrhea ,if I take the synthroid and belviq 2hours later (after the linzess ) would that be long...
Updated 6 days ago.
   3  RSS Feed for thread 277009
is this working?
Hi. My Dr gave me the lower lose and the first day I had 3 bm's but nothing has happened in the three days after that. I'm discouraged. Is this normal? ## Hello Ekt! How are you? I'm sorry about the problem you've had. It seems to do that to many people, it works well at first, then just stops, but I'm not sure why. You may need to try the higher dosage. Are you making sure to take it on an empty stomach, at least 30 minutes before a meal? Are you on any other medications that might affect it? Side effects may include stomach pain, gas and bloating. ## I take it in the morning but not always 30 minutes before eating or drinking. My bottle just said take each morning. What might this cause. My only other med is wellbutrin 300 mg. ## Some medications don't work as ...
Updated 7 days ago.
   3  RSS Feed for thread 276494
how long can you take linzess?
How long can you take linzess?? Can you take it for a long period of time???
Updated 10 days ago.
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LInzess not working as well
I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like small rocks and hard to pass. I sometimes go several times a day but only small amounts at a time. I take 290mcgs every morning at least 30 minutes before I eat. It's usually over an hour before I eat anything. I do drink coffee or Diet Dr Pepper. Can you think of a reason why I'm having problems? ## Hello, Kaye! How are you? Your body might just have become tolerant to the medication, this happens to everyone after having taken something for awhile, for some people one medication may last for years, but for others they can become tolerant much sooner. Linzess has also not been successful for everyone that's tried it, quite a few people reported that it didn...
Updated 20 days ago.
   1  RSS Feed for thread 276192
i am taking linzess at the wrong time will start tomorrow morning when I eat.
I have been taking linzess at night before bed. great stools but very runny and causing burning in that area. Will start taking tomorrow morning after breakfast. I am feeling very bloaty after the 3rd day of taking it. ## Hello, Dana! How are you doing? Side effects to this medication can include nausea, diarrhea, stomach pain and stomach distention, so that explains the bloating. Several others have posted about experiencing the same thing with this medication. Have you experienced any other side effects? Does anyone else have experience using this mediation?
Updated 1 month ago.
   1  RSS Feed for thread 275651
linzess weight loss
how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss, so there is no time frame I can give you for this. It is used to treat symptoms of IBS that are associated with constipation. And while that may cause weight loss, in some instances, it can be dangerous to try to lose weight via giving yourself diarrhea, since it creates the risk of malnourishment and dehydration. Common side effects to this drug may include nausea, dizziness and stomach pain. Was it prescribed for weight loss?
Updated 1 month ago.
   1  RSS Feed for thread 275238
How long before Linzess starts to work?
I was prescribed Linzess for my IBS-C. I have been taking Linzess for two days now and very bloated with no bowel movement. From what I had read, it would work rather quickly, but for me that is not the case. I took one 145 mcg the first morning as directed and 2 of the 145 mcg the second morning and still nothing. How long does it usually take before I will start seeing results. I have the urge to have a bowel movement, but nothing is produced. Any advise will be appreciated. ## Hello, CJ! How are you doing? Has it worked, yet? There's really no way to give a time frame, it can vary from person to person. Some people have good luck with it, some don't. One person posted recently that it was only resting in one BM a week for them. Have you consulted your doctor for advice? ## I ...
Updated 1 month ago.
   3  RSS Feed for thread 273446
Rumbling in tummy are pretty intense...
I have been on Linzess for 2 months and continue to have constant rumbling in my stomach and intestine if I eat 30 minutes after taking the medication. Sometimes it gets pretty intense and I get sick to my stomach. If I don't eat until lunch, it happens and by then I am nauseous from not eating so it's even worse. Anyone else have this problem and what do you do??? ## Hey tummytrouble, Hope you've managed to tame the rumbling in your stomach. From what I could gather, most of the side effects associated with Linzess are gastrointestinal related... with symptoms ranging from unusual & severe stomach pain, gas, swelling, or pressure in the stomach region. Ref: nlm.nih.gov/medlineplus/druginfo/meds/a613007.html#side-effects If it hasn't gone away yet, I would suggest co...
Updated 1 month ago.
   1  RSS Feed for thread 273876

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act...  10
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm...  1
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,...  1
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?...  1
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ...  1
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ...  1
Taking Linzess with food I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she wi...  1
i am taking linzess at the wrong time will start tomorrow morning when I eat. I have been taking linzess at night before bed. great stools but very runny and causing burning in that area. Will start...  1
How long before Linzess starts to work? I was prescribed Linzess for my IBS-C. I have been taking Linzess for two days now and very bloated with no bowel moveme...  3
How effective is Linzess I was diagnosed with impacted bowels today and prescribed 290 mcg of Linzess. My pcp indicated this would get my bowels ...  1