Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related therapeutics...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

do u drink water when taking linzess
1 Reply RSS
I didn't have many wrinkles until I started taking linzess. So I need to know how much water to drink every day while taking linzess? ## There is no specific amount, it depends on what it takes to keep you from becoming dehydrated, which the FDA warns as being a possible side effect. You should also be made aware that it doesn't have to be just water, other fluids also help, such as juices. The NIH released reports on this last year. Is there anything else I can help with? How old are you?
Updated 36 seconds ago.
Blood in toilet after bowel movement
5 Replies RSS
I was on the low dose Linzess and it wasn't working for my constipation. Now I'm on the higher dose but it is not really working either. When I finally had a bowel movement there was a lot of blood in the toilet. Has this happened to anyone? What would cause this? Anyone? ## Sue sometimes when your stool is hard from constipation it can tear your rectum and cause it to bleed. Because of the pressure in your rectum it will usually seal the tear. Watch out how hard you push the stool when you're constipated as it can cause a hemorrhoid. If you continue to have blood in your stool go see your doctor ASAP ## Years ago this did happen to me. It can be frightening to see that much blood in the toilet, but this can happen because of hemorrhoids. I took a diuretic that dried me out ...
Updated 1 day ago.
Linzess stopped working
24 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 2 days ago.
5 Replies RSS
I am a 20 year old female. 3 years ago I was diagnosed with "chronic constipation." I have a bowel movement probably 1-2 times a week. I have had 2 colonoscopies and a flex sig done, and everything appeared to be normal. I have tried every remedy there is: fruit, fiber, laxs, stool softener, enema, exercise, and nothing seems to do the trick. Recently my dr started me on Linzess. I have been taking it for 2 weeks now. So far my bowel movements have not improved while taking Linzess. I spoke with my dr and they suggested that I add miralax to my daily routine along with Linzess. I have not had any improvement with my bowel movements while taking miralax and linzess. Can anyone give me advice or their input? Has anyone else had the same issues? I WOULD LOVE TO HEAR FROM ANYONE!! P...
Updated 3 days ago.
Linzess / severe diaherra
5 Replies RSS
I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thirty minutes with liquid type diaherra. Lots of times there is no pain or warning and I make a mess in my pants and I'm only 23. Ive only been taking Linzess on the days that I don't have to go out in public. I have lost a dramatic amount of weight, the days I don't take it, i'm in severe abdominal pain all day and feel like I have to go but never can. I was put on this medicine because I was on this medicine for constipation. What should I do? ## I experienced the exact same thing when I was taking it 1 year ago (I was 23 then as well). Although, I felt like my body was retaining mass amounts of water for those bowel movements, and it was debilitating. I...
Updated 6 days ago.
why would linzess cause weight loss
1 Reply RSS
I have been on linzess for 2 months. I have lost 8 pounds (last time I checked). I'm a heavy female. Suffered with constipation my whole life. Is this a normal thing to happen while taking linzess? Now I'm getting a squishy flabby belly. ## Yes, that can be normal, on top of the fact that the FDA lists it as possibly causing diarrhea and dehydration, as side effects, it is also know to cause a decrease in appetite, in some people that take it. Are you making sure to get lots of exercise? That can help with the belly issues. Are you on any other medications?
Updated 7 days ago.
On Linzess for a week, NOT "Working" - HELP!
35 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 7 days ago.
Can Linzess be taken as needed - 2-3 times per week?
2 Replies RSS
I just took my first dose of Linzess 145 and like the others posted...within 2 hrs of taking it (I took it on an empty stomach 30 minutes before breakfast). I had noticeable bloating and gas within an hr and it was working full on within 2 hrs. The entire experience seemed to work itself out within 3.5 hrs.Very unpleasant 3.5 hrs but now everything seems to have calmed down. Not ideal..but can Linzess just be taken just every few days? If it always has this effect it seems I would be able to manage calendar to allow for the time it needs and still be able to fully function the rest of the time ## I was told by my gastro to take it when I need it. If you take it daily and it gives you diarrhea and you are purging your large GI tract to the point water comes out after, then you can't ...
Updated 12 days ago.
Taking Linzess in the evening before bedtime
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Can you take Linzess before bedtime so that elimination takes place in the morning? I take 145mg on an empty stomach... usually with apple sauce.
Updated 13 days ago.
Help with Linzess dosage times
1 Reply RSS
I have been taking 145mgs of linzess for a while now. I usually take it at about 6:30 in the morning then I go back to sleep until 9 where it starts to kick in. I am in and out of the bathroom until 12 or 1. Lately it hasn't been working until maybe 11 in the morning, making me waste my afternoon in the bathroom. I go to college and my first class is at 1. Can anyone give me an explanation as to why the linzess is suddenly taking longer to work? I've always ate most of my calories in the evening and I can barely eat throughout the day due to IBS and severe bloating. But my diet has been consistent for the most part. Thank you. ## Are you taking the liness first thing in the morning with a full glass of water, You need to take it even before any other medication that you are on, ...
Updated 15 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 61 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 24 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess / severe diaherra I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thir... 5 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
Linzess has destroyed my hair no more Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I s... 4 replies

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