Linzess

Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Linzess Overview

Linaclotide (marketed under the trade name Linzess in the US and Mexico, and as Constella in Canada[2] and many other countries[3][dead link]) is an oligo-peptide agonist of guanylate cyclase 2C. It was approved by the FDA in August 2012 and by the European Medicines Agency[4] for the treatment in adults of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation.[5] Contents 1 Background 1.1 Medical need 1.2 Structure 1.3 Mechanism of action 1.4 Related t...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

linzess weight gain
56 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 14 hours ago.
 
Linzess / severe diaherra
3 Replies RSS
I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thirty minutes with liquid type diaherra. Lots of times there is no pain or warning and I make a mess in my pants and I'm only 23. Ive only been taking Linzess on the days that I don't have to go out in public. I have lost a dramatic amount of weight, the days I don't take it, i'm in severe abdominal pain all day and feel like I have to go but never can. I was put on this medicine because I was on this medicine for constipation. What should I do? ## I experienced the exact same thing when I was taking it 1 year ago (I was 23 then as well). Although, I felt like my body was retaining mass amounts of water for those bowel movements, and it was debilitating. I...
Updated 3 days ago.
 
Taking Linzess with food
3 Replies RSS
I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she will call in the higher dose. Took this morning before bed. (I work nights 7p-7a) I have had stomach pain all day. I haven't been able to sleep or get comfortable. I've had rumbling in my stomach, gas and an extremely hungry feeling with the 145mcg dose but no pain. It's been 8 hours since I took the 290mcg dose. I just ate something and I feel a little better. I read that I should take Linzess 30 minutes before eating but I usually don't eat until I get up in the afternoon. Could this pain be a result of not eating with the higher dose? ## Hi Krischris1, Sorry to hear about your situation. According to the manufacturer, you are right that it is recommend...
Updated 4 days ago.
 
Stopped working for me
2 Replies RSS
Hello, I am taking the 290 and it has been about 1 month and a half taking this. The first 2-3 weeks were amazing and it worked. Great and now I am not going at all. Very hard to push and very bloated! Will it start to work again? I need some relief ## Hello, Linds! How are you doing? I'm very sorry about the problem you're having. Many people have reported experiencing this same thing, it seems to work great for a brief period of time and then just suddenly stop. Are you making sure to take it on an empty stomach at least a half hour before eating? The FDA lists the typical Linzess side effects as possibly including nausea, dizziness, diarrhea, bloating and gas. ## Can you take stool softener while on linzess I've been taking Linzess for about a month going from 145 to 290,...
Updated 5 days ago.
 
took 2 Linzess capsules by accident
3 Replies RSS
Hello. I forgot I had taken a pill earlier and just took another, will this hurt me? I have been on this medication for a while and just totally forgot I had already taken one. Thanks! ## Were you ok in the end? I'm getting tired of it not working and am considering doubling my 290 dose so I'd like to know what you experienced... ## A single occasion of a double dose could possibly mean an increased risk of it's typical side effects in that moment; but I have my doubts that anything serious or long term would manifest as a result of this one time mishap. However, I too would be interested in hearing how things turned out for you Liz? Hopefully all is good! Have any other patients here had a similar experience on Linzess? For any newcomers on this medication, I see there are ...
Updated 5 days ago.
 
Help with Linzess dosage times
Post a Reply
I have been taking 145mgs of linzess for a while now. I usually take it at about 6:30 in the morning then I go back to sleep until 9 where it starts to kick in. I am in and out of the bathroom until 12 or 1. Lately it hasn't been working until maybe 11 in the morning, making me waste my afternoon in the bathroom. I go to college and my first class is at 1. Can anyone give me an explanation as to why the linzess is suddenly taking longer to work? I've always ate most of my calories in the evening and I can barely eat throughout the day due to IBS and severe bloating. But my diet has been consistent for the most part. Thank you.
Updated 8 days ago.
 
Can Linzess be taken as needed - 2-3 times per week?
1 Reply RSS
I just took my first dose of Linzess 145 and like the others posted...within 2 hrs of taking it (I took it on an empty stomach 30 minutes before breakfast). I had noticeable bloating and gas within an hr and it was working full on within 2 hrs. The entire experience seemed to work itself out within 3.5 hrs.Very unpleasant 3.5 hrs but now everything seems to have calmed down. Not ideal..but can Linzess just be taken just every few days? If it always has this effect it seems I would be able to manage calendar to allow for the time it needs and still be able to fully function the rest of the time ## I was told by my gastro to take it when I need it. If you take it daily and it gives you diarrhea and you are purging your large GI tract to the point water comes out after, then you can't ...
Updated 12 days ago.
 
Linzess stopped working
18 Replies RSS
I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for the first time in 30 years, regular BMs. The past few months have not been so great, though. Constipation, bloating and cramps have returned. I saw my Gastro a few weeks ago, and she upped my dosage to the 290. No change. Has anyone else experienced anything similar? So frustrating! ## Unfortunately, many people have reported the same experience, though the amount of time have varied. Are you making sure to take it with a full glass of water, at least half an hour, before eating or drinking anything else, as directed by the FDA? The bloating and cramps can be side effects of this medication, but it usually causes diarrhea, rather than constipation. Are you on any other ...
Updated 22 days ago.
 
Amitza vs Linzess
3 Replies RSS
I have been taking Amitza for about 4 months. Works great but over time getting extremely tired and sharp pains throughout body. I'm in process of trying to loose weight as well giving up dairy,red meats, and carbs. Switched to linzess three days ago. Reading posts that worry me about weight gain. Can you clear up the subject on weight gain and which drug works best? I've had issues for 19 years and tried everything. These medications both work for me but I need to have energy, no sharp pains and no weight gain. ## I added a multi-vitamin and b-12 supplement to help with energy. So far I'm doing okay. Been on Linzess for a week. It only started to work for me yesterday. Best of luck to you! ## @Kgirl, Posted below is a link to another active discussion thread here relating t...
Updated 30 days ago.
 
linzess and lactulose
2 Replies RSS
I take 145mcg capsule of linzess with 8ounces of water 30 minutes before I eat and also take 45 ml of lactulose 3 times a day 30 minutes before I eat anything and still not having any bowel movement. stomach getting bigger and bloated,feeling miserable ## Hi Clyde, Sorry to hear about your experience with Linzess. According to MedlinePlus.gov, one of the side effects of Linzess is "swelling or a feeling of fullness or pressure in the stomach area". They recommend contacting your doctor if it becomes severe or doesn't go away. There's also another discussion thread here that associates Linzess with weight gain (I'm assuming as a result of this bloating effect): [1] Linzess Weight Gain From what I can gather, it seems like Linzess is the culprit and not Lactulose; howe...
Updated 30 days ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg, 72mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (5 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1203 Linzess 72 ug/1 Oral Capsule, Gelatin Coated by Allergan, Inc
  • 55700-409 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Lake Erie Medical Dba Quality Care Products LLC
  • 69189-1202 Linzess 145 ug/1 Oral Capsule, Gelatin Coated by Avera Mckennan Hospital

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 56 replies
Linzess stopped working I have been on the 145 dose of Linzess for several years now, and it was like a miracle drug. No side effects, and for t... 18 replies
Linzess Allergy I've been on Linzess for constipation for two weeks. While it has only produced one bowel movement during this time,... 7 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 6 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
linzess/linzess When I take linzess with food it gives me severe diarrhea Will this be sufficient to clear me out for a colonoscopy ? ##... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 5 replies
Linzess has destroyed my hair no more Has anyone had the problem with linzess changing the structure of their hair. My hair wish shopping and healthy when I s... 4 replies
Linzess / Weight Gain and Other Meds Questions I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds ... 4 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 4 replies