MedsChat.com
The People's Medicine Community ®

Linzess

Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

Linzess, then other meds with breakfast
2 Replies RSS
Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Reading the other postings, I am somewhat afraid to take it. Nevertheless, I would take my levothyrox 1/2 hour before the Linzess, then would take my other meds with a meal. Will the Linzess "wash out" the other meds?? Also, is "unanticipated bowel leakage" a possibility with Linzess? ## Hi Molly, Sorry to hear about the constipation from pain meds. Looking at others feedback on Linzess it's easy to get discouraged and not want to take it. However it is also important to understand that these meds tend to affect each person differently, whereas patients who don't have any serious issues with it would be less likely to feel inclined to post about their...
Updated 4 minutes ago.
 
Linzess is great
2 Replies RSS
Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins before your first meal of the day or you could have some of the side effects worsen. ## Taking it closer to a meal could also result in it not being as effective. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, bloating and diarrhea. Is it still working well for you? ## Hi, I've had terrible bloating along with the constipation for a while and I started up on lizness about 4 days ago. I was curious if you had bloating when starting out and then it got better after the 2 weeks or was it just good since you started? (Sorry for writing so much)
Updated 4 days ago.
 
Linzess how many days before it starts to work?
Post a Reply
How long should it take for linzess to start working. It is my second day and so far nothing. Also I see some people say it causes weight gain. I would have thought the opposite. Can you tell me about that?
Updated 6 days ago.
 
muscle aches and linzess
1 Reply RSS
I have been on Linzess for a month. My dose is now 1 every other day. I am still waiting to see if the diarrhea subsides on the new dose. I have had another problem which started about 5 days in. My hips started aching. Since then I have having muscle tension in my shoulders and upper back. I dont' want to give up on the Linzess, but am concerned about the muscle aches. Is the diarrhea caused by the Linzess dehydrating me. My urine output seems normal. Or could I be reacting to something in the Linzess? ## Hi Karen, Sorry to hear about the muscle aches/diarrhea. From what I could gather, both diarrhea and stomach pain are reported to be common but potentially severe side effects of Linzess (Linaclotide) that you should talk with your doctor about if the symptoms do not go away on th...
Updated 11 days ago.
 
can I take my meds together?
1 Reply RSS
I take Linzess 1/2 hr. before breakfast. When should I take my other meds. Levothyroxine I take alone. I also take Furosemide, Januvia, Ramopri, Atenanal, insulin, and Duloxetine . THANK YOU ! ## Hi Eileen, According the University of Maryland's drug interaction checker, there are interactions listed between the following drug combinations: Furosemide + Ramipril: Taking the two together can reportedly cause low blood pressure. It may also increase your risk of certain side effects. Umm.edu recommends contacting your doctor if you experience diversions from your usual blood pressure or unusual weight gain. Januvia (Sitagliptin) + Levothyroxine: Taking Levothyroxine with anti-diabetic agents such as Januvia / Insulin, may cause them to not work as well. Umm.edu recommends contacting y...
Updated 13 days ago.
 
Not Working for me
1 Reply RSS
This is only day 3. the first two days made me have loose bowels but only on time a day. Now today I took it at 9am then waited to eat at almost 10. I still haven't used the bathroom. I have tried twice to no avail. Its very frustrating. I feel a little rumbling and a bit of gas but that's about it. I thought this medication was supposed to relieve you of constipation not team up with it. ## Hi Eve, Sorry to hear about the Linzess not working. Your not alone though, as I have stumbled upon several reviews reporting similar issues in that regard. Some medications just don't work well for certain people and it may just come down to trying a number of different options until you find one that works best. Some remedies I've had success with in the past for alleviating consti...
Updated 25 days ago.
 
Stopped working for me
1 Reply RSS
Hello, I am taking the 290 and it has been about 1 month and a half taking this. The first 2-3 weeks were amazing and it worked. Great and now I am not going at all. Very hard to push and very bloated! Will it start to work again? I need some relief ## Hello, Linds! How are you doing? I'm very sorry about the problem you're having. Many people have reported experiencing this same thing, it seems to work great for a brief period of time and then just suddenly stop. Are you making sure to take it on an empty stomach at least a half hour before eating? The FDA lists the typical Linzess side effects as possibly including nausea, dizziness, diarrhea, bloating and gas.
Updated 29 days ago.
 
linzess
3 Replies RSS
Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you? Is that more or less than usual for you? What has your doctor advised? Do you take any other medications? ## Why does it say to take Linzess in the morning? I would rather take it at night. If I take it in the morning, I don't dare leave the house for a few hours. I really like it, but would prefer to take it at bedtime ## It isn't a problem to take at night but let me tell you. I does take hours to work for some. I need to have up to 1/2 gallon of liquids to get going often. Anyway, if you party don't drink up and take it at bedtime. You may have an uncontrollable BM overnight... Like me....
Updated 1 month ago.
 
linzess weight gain
14 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 1 month ago.
 
linzess causes weight gain
5 Replies RSS
I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. I was holding my weight before this prescription. I'm gonna stop this for a week and see what happens. I actually fasted for 1 1/2 days taking weight in A.M. and P.M. only having water and fruit juice (Low Sugar) and didn't lose anything? ## Hi Chuck, I don't know if this is would accurately describe the type of weight gain you mentioned, but according to nih.gov, Linzess (Linaclotide) is known to cause swelling or a feeling of fullness/pressure in the stomach region that may appear as added weight. It can also cause excess gas to from, which may also contribute to feeling bloated. I'm thinking perhaps either of these side effects could be the culprit, ...
Updated 1 month ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 14 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 5 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 2 replies
Linzess is great Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins ... 2 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 2 replies
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ... 2 replies
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,... 1 reply
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 1 reply