Linzess

Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation predominant irritable bowel syndrome (IBS-C) in adults.[1] The National Institu...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

linzess weight gain
22 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 5 minutes ago.
 
Anybody else with these issues
12 Replies RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 2 days ago.
 
How long does lizness work
3 Replies RSS
I've been taking lizness for almost 2 or 3 weeks.. But when I take it I do have results like a hour or so after but towards the night time I get bloated and can't go to the restroom and urinating even starts to become hard to do. And I also have cramping and pain with bloating towards the end of the day. ## Hello, BRead! How are you? Those can be normal side effects of Linzess, as listed by the FDA and most other users have reported similar experiences. Other side effects may include nausea, dizziness, abdominal cramping and diarrhea. However, the problem urinating is concerning and you should consult your doctor about that. Can anyone else that's been on it chime in? ## I too have issues urinating sometime when I take linzess and severe cramping and bloating,dizziness and n...
Updated 11 days ago.
 
Lizness
7 Replies RSS
Can I take Lizness only as needed, maybe twice a week or do I have to take it every day. I do not like the idea of having to take a medication for the rest of my life daily so really only wanted to take it when it was really necessary since it works so quickly. I need it because of my IBS and have tried everything else but it still makes me nervous to be on it daily especially since it has not be around that long. ## Hello, Lori! How are you? You should take it according to your doctor's instructions. Many medications don't work as well, unless a steady regular level is maintained in the body. Typical side effects to this medication may include nausea, bloating, stomach pain and gas. Many people do take medications for their entire lives, for heart conditions or high blood press...
Updated 11 days ago.
 
On Linzess for a week, NOT "Working" - HELP!
8 Replies RSS
Hi all! I'm new here, but not new to constipation... However, I only got my first *prescription* medication to treat it a week ago when my new PCP finally related enough to my digestive woes and the frustration that comes from years of living through the futile cycle of Miralax, MoM bombs, evil teas, and throwing my hands in the air. She gave me samples of Linzess (low and high dose) and thoroughly educated me on how to take it properly, along with a fair warning to remain near the bathroom those first few days. Honestly, I was pumped! And I know beyond a shadow of a doubt I've taken, and stored, this medicine correctly because I was all in on making this work, as gruesome as those first days might be. But alas, radio silence. I started with the low dose a week ago (a Wednesday)...
Updated 11 days ago.
 
lizness 145 mg
9 Replies RSS
I just started taking liznes 3 days ago. I am major swelled in my colon from infectious diverticulitus and ibs and infectious colitis. Its not doing nothing but spurt here &thats there. Im so bloated i cant eat my colon is spasmimg. I look 6 months pregnant. Can I take 2excellent at a time or sennakot or anuthing else to help me go. Its making me sick. Please respond ## @KR, Sorry to hear about your condition. If you plan on taking an extra laxative medication along with Linzess, I would encourage you to talk with your doctor first just to play it safe with the dosing. However there are other home remedies such as Apple Cider Vinegar and Epsom Salt that might make for good alternatives. Have you also considered taking any probiotics or digestive enzymes to help better metabolize cer...
Updated 13 days ago.
 
Timing of Linzess and Armour
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Just read some info on taking linzess and armour together. I have been taking linzess, armour, vitamin D and a probiotic together in the a.m. since I was first prescribed the armour. Now I'm wondering if I've had the full effect of any of the medications. How do I time all of this since both need to be taken on an empty stomach?
Updated 13 days ago.
 
Excessive Bloating on Linzess
1 Reply RSS
I've been on Linzess for about a week now and the bloating is unbearable. The medication has produced several BM's and I had severe diarrhea the first two days on the medication. The diarrhea has subsided but the bloating continues to get worse. I is painful and it looks like I am 6 months pregnant. My clothes don't fit anymore and I can't find any helpful solutions to the distention. Has anyone had these similar symptoms and do they typically go away? ## Hello, Kristy! How are you? I'm sorry about the problem you're having. Yes, that has been reported by many people and is a known side effect as listed by the FDA. You may also experience weight changes, nausea and dizziness. Can anyone that's taken in chime in on whether or not it's gone away as your bod...
Updated 28 days ago.
 
linzess prescribed to help with weight loss
1 Reply RSS
Hi! My Dr. Gave me linzess to help with weight loss. HOWEVER, I am reading all the posts about horrible weight gain, I am confused!!!!!!! ## Hello, Twinckle! How are you? This medication isn't intended to be used for weight loss, it's actually used to treat chronic constipation. It can cause diarrhea, which could result in weight loss for some, as reported by the FDA, but it can also cause abdominal bloating and distention, which has caused many to think they were gaining weight on it. Can anyone that's been on it chime in with their experiences?
Updated 29 days ago.
 
Linzess - 2 months of diarhea ending with nausea
1 Reply RSS
I suffer from trapped gas in my left upper quadrant. difficult to have good bowel movements except with coffee, been that way for years. Doc put me on linzess 145 once a day - immediate and severe diarrhea but I was actually getting to a point of feeling "empty" - I suffered through 2 full months of this diarrhea until getting a bad bout of nausea and have stopped it cold turkey. Now I seem to not be able to "empty" my colon and get relief. I've also had muscle aches and gagging type of nausea recently. Even after 7 days I still feel those symptoms. Went to the ER to check for blockage and they found none (which is good) but that leads me to blame the linzess and question if it might have withdrawal side effects for some people. ## Hello, Brian! How are you doing? I...
Updated 1 month ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (2 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 22 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 4 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
linzess issues Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but do... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,... 2 replies