Active Ingredient(s): Linaclotide
FDA Approved: * August 30, 2012
Pharm Company: * FOREST LABS INC
Category: Laxative

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Linzess Forums: RSS Feed

How long does lizness work
1 Reply RSS
I've been taking lizness for almost 2 or 3 weeks.. But when I take it I do have results like a hour or so after but towards the night time I get bloated and can't go to the restroom and urinating even starts to become hard to do. And I also have cramping and pain with bloating towards the end of the day. ## Hello, BRead! How are you? Those can be normal side effects of Linzess, as listed by the FDA and most other users have reported similar experiences. Other side effects may include nausea, dizziness, abdominal cramping and diarrhea. However, the problem urinating is concerning and you should consult your doctor about that. Can anyone else that's been on it chime in?
Updated 2 minutes ago.
linzess issues
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Chronic constipation with 40-50 lbs weight gain... Linzess works with explosive diarrhea within an hour of taking but doesn'tseem to resolve problem. It makes me go from feeling 9 months pregnant to 6 months pregnant. Also have a new side effect of the drug (or the consripation) which is acne on my shoulders and back. Tries lots of otc rremedies and natural remedies with no luck. Dr gave me linzess and like I said it works but not completely. The 145 dose seems to work while the 290 did not, so i went back to 145 and same results. I am fit. Used to do 1000 sit ups a can't manage 20 due to the bloat and weight gain...frustrated and worried. I am a big guy...6'7"...should be 230# but am weighing in at about 280# which has been increasing over the past 6-7 months...
Updated 1 day ago.
Gas and constipation
1 Reply RSS
The past several times I have taken Linzess I have become extremely gassy about an hour later, but still no BMs. Does this happen to anyone else? ## Hello, Susan! How are you? Have you been making sure to take it a half hour, before eating or drinking anything else? Some doctors and pharmacist didn't inform people that it must be taken in the morning on an empty stomach, with just an 8 ounce glass of water. The gas can be a normal side effect, you may also experience dizziness, bloating and abdominal cramping. Can anyone that's on this medication chime in?
Updated 6 days ago.
Worried about taking Linzess before work
1 Reply RSS
I am going to start Linzess tomorrow morning I will take it at 4:30 and eat breakfast at 5:15. If I haven't had a bowel movement by 6:30 do you think it would be safe to drive to work? I have an hour drive. ## Hello, Sandy! How are you? Unfortunately, I can't say. It may actually be best to speak to your doctor about starting it on the weekend, or whenever you have a few days off. The FDA lists the typical side effects of this medication as possibly including nausea, dizziness, abdominal cramping, bloating and diarrhea. Can anyone that's taking it chime in with their opinions?
Updated 6 days ago.
Linzess is not working!!!!
1 Reply RSS
I started taking the low dose now I take too of them a day...only had one bowel movement when I started ...don't know what to do not #help ## Hello, Terri! How are you? Are you making sure to take it in the morning, with a full 8 ounce glass of water, at least a half hour, before eating or drinking anything else? It seems that some people weren't told that by their doctor or pharmacist. The FDA lists its typical side effects as possibly including nausea, bloating and diarrhea.
Updated 6 days ago.
Linzess / Weight Gain and Other Meds Questions
1 Reply RSS
I take thyroid meds and Migraine Meds....How do I ensure that the Linzess isn't "getting rid of" these meds before they are in my system? I'm taking the thyroid meds 1 hour before (as required) the Linzess and the Topamax with my breakfast. Is that the right order? Also...I've been steadily losing weight successfully for a couple of months....have taken Linzess for 4 days because went low carb and stopped going to the bathroom....gained over 2 lbs in 4 days without changing any food intake and drinking 100 ounces of water a day and having diarrhea. How is that even possible. Will I just have to stop taking it to stop the weight gain? How does the med cause weight gain if it gets rid of waste? ## The Linzess should be taken by itself, at least half an hour before eati...
Updated 13 days ago.
Severe cramping, instant diarrhea
1 Reply RSS
Taking 290mg of Linzess 40 minutes before first meal on an empty stomach. Before I'm even finished eating I get severe cramps and run to the bathroom and have bad diarrhea. Should I be taking a lower dose? I only take the Linzess every other day. I have IBS with constipation and colitis. ## Hello, Shirley! How are you? Yes, you may want to speak to your doctor about trying to lower dosage, for awhile to see how it works for you. The cramping and diarrhea can be normal side effects, as listed by the FDA, but the lower dose may help mitigate them. Other side effects may possibly include nausea and dizziness. Is there anything else I can help with?
Updated 13 days ago.
4 Replies RSS
I am a 20 year old female. 3 years ago I was diagnosed with "chronic constipation." I have a bowel movement probably 1-2 times a week. I have had 2 colonoscopies and a flex sig done, and everything appeared to be normal. I have tried every remedy there is: fruit, fiber, laxs, stool softener, enema, exercise, and nothing seems to do the trick. Recently my dr started me on Linzess. I have been taking it for 2 weeks now. So far my bowel movements have not improved while taking Linzess. I spoke with my dr and they suggested that I add miralax to my daily routine along with Linzess. I have not had any improvement with my bowel movements while taking miralax and linzess. Can anyone give me advice or their input? Has anyone else had the same issues? I WOULD LOVE TO HEAR FROM ANYONE!! P...
Updated 14 days ago.
timing of linzess & food
1 Reply RSS
Has anyone played around with the amount of time they leave between taking linzess and eating? if i eat an hour after taking it rather than 30 minutes, will i experience more or less diarrhea? ## Hi Sarah, According to the manufacturer, it is recommended that Linzess be taken on an empty stomach, "at least" 30 minutes before your 1st meal of the day. Apparently taking Linzess on an empty stomach allows it to work more efficiently; whereas taking it closer to meal-time may result in it not being quite as effective. So the notion of taking it an hour before a meal shouldn't be a problem - at least in my opinion. Also, since diarrhea is listed as a general side effect of Linzess, I think the possibility of it occurring may be independent of whether or not you take it too close ...
Updated 17 days ago.
Linzess side effects
1 Reply RSS
Hi, I've been taking Linzess about 1-2 times a week for about a year. Usually get several loose BMs when I take it, but sometimes I feel great and other times severe bloating, gas and heartburn. Also have gained 5 lbs in 6 months, could that be from the med? Is it really necessary to wait 30 mins after taking it to eat or drink coffee? Thanks!! ## Hello, Nicole! How are you? Yes, those can be normal side effects of it, as listed by the FDA. Other users have reported experiencing them, as well. You may also experience abdominal cramping. And yes, it is also necessary to wait that 30 minutes to allow it to have its full beneficial effect. Is there anything else I can help with?
Updated 18 days ago.

Possible Dosages for this and Related Drugs:

  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Linzess: (2 results)

Sorted by National Drug Code
  • 0456-1201 Linzess 0.145 mg Oral Capsule by Forest Laboratories, Inc.
  • 0456-1202 Linzess 0.29 mg Oral Capsule by Forest Laboratories, Inc.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)

Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 15 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 6 replies
Linzess, then other meds with breakfast Just prescribed Linzess for pain med related constipation, to be taken every day in place of my previous regimen. Readin... 5 replies
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 4 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
Linzess not working I have been taking linzess off and on for a few months. The first few times it worked great, but now it just makes my be... 3 replies
Linzess results I have Gastroparesis, pelvic floor dysnersia, and chronic ideopathic constipation. I had been taking 4 capfuls of mirala... 3 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
Linzess/ severe diaherra I've been on Linzess for almost a week now and every day that I take it, I end up running to the bathroom every thir... 2 replies
Linzess is great Taking linzess for two weeks. I feel great. No more bloating. No side effects, although do make sure you take it 30mins ... 2 replies