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Linzess

Active Ingredient(s): Linaclotide
FDA Approved: August 30, 2012
Pharm Company: FOREST LABS INC
Category: Laxative



Linzess Overview

Linaclotide (marketed under the trade name Linzess and Constella) is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.[1] It was forecast by a market...

Read more Linzess Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Linaclotide

Recent Linzess Forums: RSS Feed

can I take my meds together?
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I take Linzess 1/2 hr. before breakfast. When should I take my other meds. Levothyroxine I take alone. I also take Furosemide, Januvia, Ramopri, Atenanal, insulin, and Duloxetine . THANK YOU !
Updated 4 minutes ago.
 
linzess
3 Replies RSS
Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you? Is that more or less than usual for you? What has your doctor advised? Do you take any other medications? ## Why does it say to take Linzess in the morning? I would rather take it at night. If I take it in the morning, I don't dare leave the house for a few hours. I really like it, but would prefer to take it at bedtime ## It isn't a problem to take at night but let me tell you. I does take hours to work for some. I need to have up to 1/2 gallon of liquids to get going often. Anyway, if you party don't drink up and take it at bedtime. You may have an uncontrollable BM overnight... Like me....
Updated 5 days ago.
 
linzess weight gain
14 Replies RSS
I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Actually, since it usually causes gastrointestinal side effects, including diarrhea, it's usually known to cause the opposite problem of weight loss. You should also be informed that some people develop serve, ongoing diarrhea, so you need to watch out for that and contact your doctor if it happens. Learn more Linzess details here. Is there anything else I can help with? ## I've gained 4 pounds in 3 days since I started taking Linzess. I am on weight watchers so I count points so I know it is not my food intake. I don't usually fluctuate in pounds so I think it's the new meds. I am still taking Miralax but it doesn't seem like either are working. I loo...
Updated 5 days ago.
 
linzess causes weight gain
5 Replies RSS
I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. I was holding my weight before this prescription. I'm gonna stop this for a week and see what happens. I actually fasted for 1 1/2 days taking weight in A.M. and P.M. only having water and fruit juice (Low Sugar) and didn't lose anything? ## Hi Chuck, I don't know if this is would accurately describe the type of weight gain you mentioned, but according to nih.gov, Linzess (Linaclotide) is known to cause swelling or a feeling of fullness/pressure in the stomach region that may appear as added weight. It can also cause excess gas to from, which may also contribute to feeling bloated. I'm thinking perhaps either of these side effects could be the culprit, ...
Updated 5 days ago.
 
linzess 290mcg
4 Replies RSS
I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going at all. Can I drink water the 30 minutes before my first meal. Most of the time I don't eat much. ## Hello, Donna! How are you? I'm very sorry about the problem you're having. It works best taken on an empty stomach, with just a sip of water. Typical side effects, as listed by the FDA may include nausea, dizziness, diarrhea and stomach pain. At this point, it would be best to consult your doctor, many people have reported a similar issue. For some people it only works for a few weeks, but sometimes it works longer, but few are having long-term good luck with it Are there any other questions or concerns? ## Thanks for replying. It is now giving diarrhea and ...
Updated 15 days ago.
 
Anybody else with these issues
1 Reply RSS
Been on Linzess 145 for 2 months. Was having lots of allergy issues-hives and itching on scalp, runny nose, sinus pain, extreme fatigue. Also shortness of breath and heart palpitations. Hadn't had major allergy attack in months but thought that was what was going on. Steroids, inhaler, Benadryl no help. Started paying real close attention to symptoms and realized I never woke up with hives, they always appeared sbout half hour after Linzesse was taken and improved by end of the day. Stopped taking it and 48 hours later no hives, itching or sinus symptoms. Still dealing with fatigue. It did helps constipation problem although I came real close to more than one accident. Not worth the side effects. Has anyone else experienced any if these symptoms? ## Hello, Brenda! How are you? I...
Updated 21 days ago.
 
dizziness, mental confusion
3 Replies RSS
Ive taken 145 mg linzess now for 12 months for idiopathic constipation, my daily dizziness and mental fog are becoming difficult to deal with. Is there any suggestion anyone has to reduce this problem. thanks for reading this. ## Hello, Dennis! How are you? I'm very sorry about the problem that you're having. Have you consulted your doctor about these symptoms? The dizziness is a very common side effect, as listed by the FDA, you may also experience fatigue, dehydration, rash and abdominal pain. However, you may need to take a break from it and try a different medication. Alternatively, your doctor may know of some way to help alleviate these symptoms. ## Duh! Take less meds. That should help. ## Take less meds. That should help.
Updated 25 days ago.
 
Stopped working for me
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Hello, I am taking the 290 and it has been about 1 month and a half taking this. The first 2-3 weeks were amazing and it worked. Great and now I am not going at all. Very hard to push and very bloated! Will it start to work again? I need some relief
Updated 28 days ago.
 
LInzess not working as well
2 Replies RSS
I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like small rocks and hard to pass. I sometimes go several times a day but only small amounts at a time. I take 290mcgs every morning at least 30 minutes before I eat. It's usually over an hour before I eat anything. I do drink coffee or Diet Dr Pepper. Can you think of a reason why I'm having problems? ## Hello, Kaye! How are you? Your body might just have become tolerant to the medication, this happens to everyone after having taken something for awhile, for some people one medication may last for years, but for others they can become tolerant much sooner. Linzess has also not been successful for everyone that's tried it, quite a few people reported that it didn...
Updated 1 month ago.
 
help with side effects
2 Replies RSS
I just took my first dose (145 mcg) of Linzess this morning. Within 2 hours I had 2 normal bowel movements with no pain. After 5 hours, my head started feeling prickly and itchy, my ears plugged up and then my heart seemed to be slowing down to the point where I started to pass out. Now (7 hrs later) I am still feeling that way. Is there something I can take to counteract that and how long does Linzess stay in my body? ## Hi Linda, Sorry to hear about the symptoms you're experiencing on Linzess. I can't help but wonder though, if you've looked into any safer laxatives on the market that don't exhibit such strange side effects? (i.e. things like Epsom Salt, apple cider vinegar, etc). Concerning how long Linzess remains in the body, information I found online stated that i...
Updated 2 months ago.
 

Possible Dosages for this and Related Drugs:

Linaclotide
  • Capsule: 145mcg, 290mcg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

Other drugs which contain Linaclotide or a similar ingredient: (1 result)


Possibly related Linzess Topics:

linzess weight gain I was just prescribed Linzess for my IBS. I am wondering if others on this medicine have experienced wieght gain? ## Act... 14 replies
linzess causes weight gain I am the same. I have lost 85 lbs over the last 1 year. I have gastroparesis. After 120 days on linzess I am up 15 lbs. ... 5 replies
linzess 290mcg I have gastroparesis and have been on Linzess for a year and a half. It worked ok until recently. Now I'm not going ... 4 replies
linzess Have been taking linzess two weeks only got two bowel movements, should I keep taking it? ## Hello, Brenda! How are you?... 3 replies
LInzess not working as well I have been on Linzess for about 9 months. It was working really well until about a month ago. Now my stools are like sm... 2 replies
linzess help I have been on linzess fir a week now and no results yet besides bad bloating! Will the bloating go away? How long does ... 2 replies
linzess weight loss how long does it take to work ## Hello, Oscar! How are you? Linzess is not actually intended to be used for weight loss,... 1 reply
Linzess and strange dreams Has anyone had any realistic, but odd dreams upon just drifting off to sleep? I just started the 290mcg. Took it 2 days ... 1 reply
New on Linzess for IBS-C, slenic flexure syndrome Been on Linzess 2 weeks now. I take it before dinner, sometimes really watery stool or just normal stool. Can't take... 2 replies
Taking Linzess with food I started Linzess 145mcg 9 days ago. Only had one bm. Called Dr she said take 2 pills at a time and if that works she wi... 1 reply