Bacopa Monierra
UpdatedBacopa Monniera has several primary clinical uses- its a powerful free radical scavenger within the CNS and contributes to increased cognitive performance if taken consistently for 3months. It's second adventitious property is its ability to attenuate the development of tolerance to morphine and therefore increase effective chronic administration therapeutic benefit(s). How exactly this occurs is not entirely known, but it is important to note here that MORPHINE is not the same as other opiates that are not mu agonists and/or are not excreted by the body via conjugation phase I/phase II glucuronidation reactions. Whether BM (haha) works similarly with all variations of agonist/partial agonist/agonist-antagonist opiates is not known. Four other ethneogens associated w/attenuating or preventing the development of tolerance are Resevetrol, Cats Claw(NMDA antagonism), Ashwaganda (multiple pathways), Gotu Kola and the cation Mg2+. As a side note, a powerful inhibitor of phase/phase II hepatic metabolism of morphinan opiates is the ubiquitous herb, Cinnammon- 80% inhibition!!!!! This is NOT the much talked about CYP3a4/CYP2D6 enzyme inhibition but conjugation/glucuronidation. Have fun, be safe and keep munchin on that ego sandwich till humility sets in with a sprinkling of crumbs...
