Pi

Ingenol Mebutate

Ingenol mebutate, sold under the brand name Picato, is a substance that is found in the sap of the plant Euphorbia peplus,[1] commonly known as milkweed, and is an inducer of cell death. A gel formulation of the drug has been approved by the U.S. Food and Drug Administration (FDA)[2] and by the European Medicines Agency (EMA)[3] for the topical treatment of actinic keratosis. Two different strengths of the gel have been approved for use on eithe...

Pleconaril

Pleconaril (Picovir[1]) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections.[2] Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus[3] and Rhinovirus.[4] It has shown useful activity against the dangerous enteroviru...

Doravirine

Doravirine, sold under the brand name Pifeltro, is a non-nucleoside reverse transcriptase inhibitor medication developed by Merck & Co. for use in the treatment of HIV/AIDS. Doravirine was approved for medical use in the United States in August 2018.[5] References .mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-col...

Pilocarpine

Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth.[1][4] As eye drops it is used to manage angle closure glaucoma until surgery can be performed, ocular hypertension, primary open angle glaucoma, and to bring about constriction of the pupil following its dilation.[1][5][6] However, due to its side effects it is no longer typically used in the long term management.[7&...

Drug Index

Pilocarpine is a medication used to reduce pressure inside the eye and treat dry mouth.[1][4] As eye drops it is used to manage angle closure glaucoma until surgery can be performed, ocular hypertension, primary open angle glaucoma, and to bring about constriction of the pupil following its dilation.[1][5][6] However, due to its side effects it is no longer typically used in the long term management.[7&...

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Adrenaline, also known as epinephrine, is a hormone and medication[7][8] which is involved in regulating visceral functions (e.g., respiration).[7][9] Adrenaline is normally produced both by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart by acting on the SA node,[10] pu...

Potassium Iodide, KI

Potassium iodide is a chemical compound, medication, and dietary supplement.[3][4] As a medication it is used to treat hyperthyroidism, in radiation emergencies, and to protect the thyroid gland when certain types of radiopharmaceuticals are used.[5] In the developing world it is also used to treat skin sporotrichosis and phycomycosis.[5][6] As a supplement it is used in those who have low intake of iodine in the ...

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Pimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug.[1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase. It acts to reduce levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, glyoxal, methylglyoxal, and related dicarbonyls. These reactive species are converted to less reactive heterocycles by this co...

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Pimavanserin (ACP-103; BVF-036), sold under the brand name Nuplazid, is an atypical antipsychotic which is approved for the treatment of Parkinson's disease psychosis and is also being studied for the treatment of Alzheimer’s disease psychosis, schizophrenia, agitation, and major depressive disorder.[3] Unlike other antipsychotics, pimavanserin is not a dopamine receptor antagonist.[4] Contents 1 Pharmacology 1.1 Pharmacodynamics 2 History 2.1 Devel...

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Pimecrolimus is an immunomodulating agent[clarification needed] of the calcineurin inhibitor class used in the treatment of atopic dermatitis (eczema). It is available as a topical cream, once marketed by Novartis (however, Galderma has been promoting the compound in Canada since early 2007) under the trade name Elidel. Contents 1 Medical uses 2 Side effects 3 Pharmacology 4 References 5 External links Medical uses It has been proven to be effective in various inflammat...

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Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. It was discovered at Janssen Pharmaceutica in 1963. It has a high potency compared to chlorpromazine (ratio 50-70:1). On a weight basis it is even more potent than haloperidol. It also has special neurologic indications for Tourette syndrome and resistant tics. The side effects include akathisia, tardive dyskinesia, and, more rarely, neuroleptic malignant syndrome and prolongation of the Q...

Desogestrel + Ethinyl Estradiol

Desogestrel is a progestin medication which is used in birth control pills for women.[1][12] It is also used in the treatment of menopausal symptoms in women.[1] The medication is available and used alone or in combination with an estrogen.[1][12] It is taken by mouth.[1] Side effects of desogestrel include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increase...

Pyrantel

Pyrantel is a medication used to treat a number of parasitic worm infections.[2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis.[2] It is taken by mouth.[2] Side effects include nausea, headache, dizziness, trouble sleeping, and rash.[2] A lower dose should be used in people with liver disease.[2] While it does not appear to be harmful durin...

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Pindolol, sold under the brand name Visken among others, is a nonselective beta blocker which is used in the treatment of hypertension.[1][2] It is also an antagonist of the serotonin 5-HT1A receptor, preferentially blocking inhibitory 5-HT1A autoreceptors, and has been researched as an add-on therapy to selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression.[3][4][5] Contents 1 Medical u...

Pyrantel

Pyrantel is a medication used to treat a number of parasitic worm infections.[2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis.[2] It is taken by mouth.[2] Side effects include nausea, headache, dizziness, trouble sleeping, and rash.[2] A lower dose should be used in people with liver disease.[2] While it does not appear to be harmful durin...

Drug Index

Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes.[2] It may be used with metformin, a sulfonylurea, or insulin.[2][3] Use is recommended together with exercise and diet.[3] It is not recommended in type 1 diabetes.[3] It is taken by mouth.[3] Common side effects include headaches, muscle pains, inflammation of the throat, and s...

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Pioglitazone/metformin, sold under the brand name Actoplus Met among others, is a fixed-dose combination anti-diabetic medication used to improve glycemic control in adults with type 2 diabetes.[3][2] It contains pioglitazone, a thiazolidinedione, and metformin, a biguanide.[2] Contents 1 Mechanisms 2 Indication 3 Dosage and administration 3.1 Use in pregnancy and lactation 3.2 Precautions 4 Side-effects 5 Contraindications 6 Drug interacti...

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Pipecuronium (Arduan) is a bisquaternary aminosteroid muscle relaxant[1] which blocks nicotinic acetylcholine receptors[2] at the neuromuscular junction. It is also an antagonist of M2 and M3 muscarinic receptors[3] and is the most potent neuromuscular blocking agent of the aminosteroid class.[citation needed] It is sold under the trade names Arduan and Pycuron. [4] See also Pancuronium bromide References .mw...

Drug Index

Piperacillin is a broad-spectrum β-lactam antibiotic of the ureidopenicillin class.[1] The chemical structure of piperacillin and other ureidopenicillins incorporates a polar side chain that enhances penetration into Gram-negative bacteria and reduces susceptibility to cleavage by Gram-negative beta lactamase enzymes. These properties confer activity against the important hospital pathogen Pseudomonas aeruginosa. Thus piperacillin is sometimes referred to as an "anti-pseu...