Br

Encorafenib

Encorafenib (trade name Braftovi) is a drug for the treatment of certain melanomas. It is a small molecule BRAF inhibitor [1] that targets key enzymes in the MAPK signaling pathway. This pathway occurs in many different cancers including melanoma and colorectal cancers.[2] The substance was being developed by Novartis and then by Array BioPharma. In June 2018, it was approved by the FDA in combination with binimetinib for the treatment of patients with unresect...

Drug Index

Amino acids are organic compounds that contain amino[a] (.mw-parser-output .template-chem2-su{display:inline-block;font-size:80%;line-height:1;vertical-align:-0.35em}.mw-parser-output .template-chem2-su>span{display:block}.mw-parser-output sub.template-chem2-sub{font-size:80%;vertical-align:-0.35em}.mw-parser-output sup.template-chem2-sup{font-size:80%;vertical-align:0.65em}−NH+3) and carboxylate −CO−2 functional groups, along with a side chain (R group) spec...

Drug Index

Brasofensine (NS-2214, BMS-204756) is a phenyltropane that had been under development by Bristol-Myers Squibb for the treatment of Parkinson's and Alzheimer's diseases. In animal models of Parkinson's disease, brasofensine was effective in stimulating LMA[expand acronym] and reversing akinesia.[1] Phase II trials in humans were conducted in 1996 and brasofensine was shown to be both effective and well tolerated at a dose of 4mg;[2] however, dev...

Urofollitropin, FSH

Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified[1] to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.[2] It is also used with in vitro fertilization method...

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Bremelanotide, sold under the brand name Vyleesi, is a medication used to treat low sexual desire in women.[2] Specifically it is used for low sexual desire which occurs before menopause and is not due to medical problems, psychiatric problems, or problems within the relationship.[3][4][2] It is given by an injection just under the skin of the thigh or abdomen.[2][4] Common side effects include nau...

Drug Index

Brentuximab vedotin (INN; trade name Adcetris) is an antibody-drug conjugate medication used to treat relapsed or refractory Hodgkin lymphoma (HL) and systemic anaplastic large cell lymphoma (ALCL), a type of T cell non-Hodgkin lymphoma. It selectively targets tumor cells expressing the CD30 antigen, a defining marker of Hodgkin lymphoma and ALCL.[2] The drug is being jointly marketed by Millennium Pharmaceuticals outside the US and by Seattle Genetics in the US.[3&...

Fluticasone Furoate + Vilanterol Trifenatate

Vilanterol (INN, USAN) is an ultra-long-acting β2 adrenoreceptor agonist (ultra-LABA), which was approved in May 2013 in combination with fluticasone furoate for sale as Breo Ellipta by GlaxoSmithKline for the treatment of chronic obstructive pulmonary disease (COPD).[1][2]. The combination is also approved for the treatment of asthma in Europe, Japan[3] and New Zealand.[4] Vilanterol is available in following combinations: ...

Guaifenesin

Guaifenesin, sold under the brand name Mucinex, among others,[3] is a medication used as an expectorant, intended to help cough out phlegm from the airways.[3] Chemically it is an ether of guaiacol and glycerine. It is unclear if it decreases coughing.[3] Use is not recommended in children less than 6 years old.[4] It is often used in combination with other medications.[3] It is taken by mouth.[3] ...

Terbutaline

Terbutaline, sold under the brand names Bricanyl and Marex among others, is a β2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours. This time can then be used to administer steroid injections to the mother which help fetal lung maturity and reduce complications of prematurity.[1] It should not be used to prevent preterm labor or delay lab...

Terbutaline

Terbutaline, sold under the brand names Bricanyl and Marex among others, is a β2 adrenergic receptor agonist, used as a "reliever" inhaler in the management of asthma symptoms and as a tocolytic (anti-contraction medication) to delay preterm labor for up to 48 hours. This time can then be used to administer steroid injections to the mother which help fetal lung maturity and reduce complications of prematurity.[1] It should not be used to prevent preterm labor or delay lab...

Drug Index

Bretylium (also bretylium tosylate) is an antiarrhythmic agent.[1] It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is considered a class III antiarrhythmic. The dose is 5–10mg/kg and side effects are high blood pressure followed by low blood pressure and ventricular ectopy. Originally introduced in 1959 for the treatment of hypertension.&am...

Bretylium

Bretylium (also bretylium tosylate) is an antiarrhythmic agent.[1] It blocks the release of noradrenaline from nerve terminals. In effect, it decreases output from the peripheral sympathetic nervous system. It also acts by blocking K+ channels and is considered a class III antiarrhythmic. The dose is 5–10mg/kg and side effects are high blood pressure followed by low blood pressure and ventricular ectopy. Originally introduced in 1959 for the treatment of hypertension.&am...

Esmolol

Esmolol, sold under the brand name Brevibloc, is a cardioselective beta1 receptor blocker with rapid onset,[1] a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. It is a class II antiarrhythmic.[2] Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart and other organs of th...

Ethinyl Estradiol + Norethindrone

Ethinylestradiol/norethisterone (EE/NET), or ethinylestradiol/norethindrone, is a combination birth control pill which contains ethinylestradiol (EE), an estrogen and norethisterone (NET), a progestin.[1] It is used for birth control, symptoms of menstruation, endometriosis, and menopausal symptoms.[1][2] Other uses include acne.[1] It is taken by mouth.[1] Some preparations of EE/NET additionally contain an iron ...

Methohexital

Methohexital or methohexitone (marketed under the brand names Brevital and Brietal) is a drug which is a barbiturate derivative. It is classified as short-acting, and has a rapid onset of action.[2] It is similar in its effects to sodium thiopental, a drug with which it competed in the market for anaesthetics. Contents 1 Pharmacology 2 Indications 3 Synthesis 4 References 5 External links Pharmacology Methohexital binds to a distinct site which is associated with ClW...

Drug Index

Ascomycota p. p. Saccharomycotina (true yeasts) Taphrinomycotina p. p. Schizosaccharomycetes (fission yeasts) Basidiomycota p. p. Agaricomycotina p. p. Tremellomycetes Pucciniomycotina p. p. Microbotryomycetes Yeasts are eukaryotic, single-celled microorganisms classified as members of the fungus kingdom. The first yeast originated hundreds of millions of years ago, and at least 1,500 species are currently recognized.[1][2][3&#9...

Ibrexafungerp Citrate

Ibrexafungerp, sold under the brand name Brexafemme, is an antifungal medication used to treat vulvovaginal candidiasis (VVC) (vaginal yeast infection).[1] It is taken by mouth.[1] Ibrexafungerp is a triterpenoid antifungal.[1] Ibrexafungerp was approved for medical use in the United States in June 2021.[1][2] It is the first approved drug in a novel antifungal class.[2] Contents 1 Medical uses 2...

Drug Index

Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone.[9][10] As a medication, allopregnanolone is referred to as brexanolone, sold under the brand name Zulresso,[6][11] and used to treat postpartum depression.[10][12][13] It is used by injection into a vein over a 60-hour period under medical supervision.[10]&...

Drug Index

Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). The drug was approved by the U.S. Food and Drug Administration (FDA) on July 10, 2015, for the treatment of schizophrenia, and as an adjunctive treatment for depression.[4][5] It has been designed to provide improved efficacy and tolerability (e...