Trovafloxacin, Alatrofloxacin

Trovafloxacin (sold as Trovan by Pfizer and Turvel by Laboratorios Almirall) is a broad spectrum antibiotic that inhibits the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV.[1] It was withdrawn from the market due to the risk of hepatotoxicity. It had better Gram-positive bacterial coverage and less Gram-negative coverage than the previous fluoroquinolones. Contents 1 Adverse reactions 2 Manufacturing 3 Society an... [wikipedia]