Active Ingredient(s): Desvenlafaxine Succinate
FDA Approved: * February 29, 2008
Pharm Company: * WYETH PHARMS INC
Category: Antidepressant

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Pristiq Overview

Desvenlafaxine (brand name: Pristiq, Desfax), also known as O-desmethylvenlafaxine, is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class developed and marketed by Wyeth (now part of Pfizer). Desvenlafaxine is a synthetic form of the major active metabolite of venlafaxine (sold under the brand names Effexor and Efexor). It is being targeted as the first non-hormonal based treatment for menopause.[1] Contents 1 Medical uses 2 Adverse effects 3 Pharmacology...

Read more Pristiq Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Pristiq Forums: RSS Feed

Pristiq comming off it
Post a Reply
Hi, there, was taking Pristiq for 2 yrs 50mg, was good but very big weight gain. So i decided to come off it. Not too bad. For 5 days i cut tablet in half, for 5 days went to quarter, then stopped. Had a little stomach cramping for a day or so, my head felt a little wobbly at times while on quarter, only down fall is really bad dreams. Been free from Pristiq for about 1 week now and all is well.
Updated 9 minutes ago.
Switched from Pristiq to Wellbutrin XL
21 Replies RSS
I'm adding a post to hopefully help someone as reading other people's posts has been very helpful/comforting to me! I have been on 50 mg of Pristiq for 5 years and I just made the transition to Wellbutrin xl at 300 mg. My doc switched me because my libido was becoming obsolete and wellbutrin is not supposed to adversely effect this. He had me start by overlapping the two meds for Week 1...Maintaining 50 mg of pristiq and adding Wellbutrin XL at 150 mg. I felt completely fine, didn't notice anything different. Week 2-I was to go up to 300 mg of Wellbutrin XL and completely stop taking the Pristiq. That didn't work. 1.5 days in I was dizzy, minor brain zap feeling (but not as intense as when i would miss a pristiq pill in the past) feeling super emotional (weepy) so much t...
Updated 4 days ago.
pristiq is it a narcotic
5 Replies RSS
is pristiq a narcotic I NEED TO KNOW ## Hello, Joe! How are you? No, Pristiq contains the active ingredient Desvenlafaxine, is it an SNRI antidepressant. Side effects may include nausea, dizziness, headache, dry mouth and weight changes. Is there anything else I can help with? ## is it safe to take butal-50-apap-325-caff-40. And pristiq at the sametime? ## Hello, Carla! How are you feeling? I didn't find any interactions listed in the databases, such as the one provided by MedScape, but it's always best to double check such information for you own safety. You may experience a worsening of some side effects, such as the nausea, dizziness, drowsiness and dry mouth that they both could cause. Are there any other questions or concerns? ## Joe, I take for a week and feel awful ## i t...
Updated 4 days ago.
Weight gain on Pristiq??
540 Replies RSS
I have been on Pristiq now since November of 2008...not quite 5 months...and I have put on 15 lbs since starting it. DESPITE working out with a trainer at the gym twice a week weight training, 3 days a week of cardio AND counting calories. My doc assured me that I would also have a decreased appetite on Pristiq, which I have yet to find he has now increased my dosage to 400 mg. Does anyone have anything to add to this?? I'm just frustrated! ## i was switched to pristiq a few months ago and just recently wellbutrin was added - i take 1 of each pill per day - it has done nothing to me in gaining weight - i am continuously losing but i have some emtional things going on right now which i believe the weight loss is contributed too - unfortunately i have run into many that have...
Updated 10 days ago.
pristiq 50 mg can I ?
1 Reply RSS
Is it ok to take cialis once a day 5 mg while taking pristiq 50 mg ?? ## Hello, Jack! How are you? I didn't find any problems or interactions listed, but it's always best to double check such information to be sure. However, it should be fine, if your doctor approves of your taking both. The FDA lists the typical side effects of Cialis as possibly including nausea, dizziness, stuffy nose and priapism. Is there anything else I can help with?
Updated 25 days ago.
Weight gain and depression AFTER getting off Pristiq
3 Replies RSS
I weaned myself off Pristiq over the summer and felt fine for a couple months. Then I gained 40 POUNDS in what couldn't have been more than two months. Waist grew 2 inches during that time. Now it's almost March and I've been more depressed over the last couple of months than ever in my life. I rarely have any energy and can't lose the weight. The reason I weaned myself off is because I mistakenly thought I didn't need it any more (the doctor who prescribed it said it "teaches" the brain how to produce whatever it does after a couple years and you don't need it any more). I'm going back on it and praying I feel like myself again - this is a miserable existence. Also, I haven't been able to find weight gain as a symptom of discontinuing Pristiq. ##...
Updated 27 days ago.
Weaning off pristiq
387 Replies RSS
I just wanted to tell all of you trying to get off pristiq, its possible. I was on pristiq for severe panic attacks for 6 months. It saved my life. It gave me a chance to slow down my career, gave me a huge wakeup call. This drug put a cloud over my brain. I was not my happy, fun loving self. I was like a step ford wife. You cant wean off this pill. I was on 50mg. I did every other day for a month. Every third day for two weeks then cold turkey. It really was not so bad. I layer on my couch for three days, cried a bit and watched movies. I'm happily on all holistic medications, no longer a slave to pristiq. If I can beat anxiety, anyone can. My biggest advice.. Exercise. Next, surround yourself with positive people. Three, talk out your problems. Good luck. ## Fantastic advice and v...
Updated 1 month ago.
Pristiq Is Hell
Post a Reply
I've been on Pristiq for seven years. It worked for about a year or so but the last 6 years have been horrible. It's been like living in a bubble devoid of happy or strong emotions to anything. I'm now trying to come off Pristiq to switch to a new drug. It's my third day off Pristiq and I'm a horrible mess. I weened for two weeks all the while taking new drug without problem. Now that I do not have Pristiq in my system the side effects are too much to bear. I have severe headache, brain zaps, the swooshing when I move my eyes, anxious, horrible dreams, sweating, cold/hot, nausea, crying, and last but not least irritable. I don't know how I'm going to make it through this. Please, please if you know what I know...never get on this drug!
Updated 2 months ago.
Pristiq - Just Started 25MG 1 Week Ago
1 Reply RSS
Thank you for all the information and taking the time to post experiences and feedback. I generally DO NOT have good results with these types of medications so my doctor thought we'd try this but I started taking it a week ago today (08.31.15) and have been having side effects as others have mentioned. I have increased pain in the mornings that is causing me to take other pain medications that I didn't have to take before, weird dreams when I NEVER used to dream before along with cloudy feeling brain and blurry vision. I think based on these side effects that have already started on just 25MG that I am going to quit cold starting tomorrow. My doctor was going to keep me on this dose for another week and then increase it to 50MG but I'm already having issues now and don't...
Updated 2 months ago.
pristiq did anyone succesfull stopped with it
1 Reply RSS
Till now I can't find any story about someone who succesfully stopped with taking pristiq. I was on 50 mg for 4 years and I took 3/4 for about 3 1/2 months. That went fine. Then another 3 1/2 months I took a half. Also that went fine. (in both situations I needed some weeks with some side effects but not too bad). Now I started with a quarter and the side effects are huge. I have a constant pain in my head. I sweat a lot and so on. (I know it's not good to cut the tablets but the first two steps were ok for me). We all know how we suffer to get off from pristiq so I hope there are some people with possitive results in stopping with it. What I really want to know is this : Does anyone succesfully stopped and HOW LONG did you need before the side effects were gone. Thanks so much ...
Updated 2 months ago.

Possible Dosages for this and Related Drugs:

Desvenlafaxine Succinate
  • Tablet: 100mg, 50mg
  • Tablet, Extended Release: 100mg, 25mg, 50 Mg. And 100 Mg., 50mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Pristiq: (6 results)

Sorted by National Drug Code
  • 0008-1211 24 Hr Pristiq 50 mg Extended Release Tablet by Wyeth Pharmaceuticals Inc., a Subsidiary of Pfizer Inc.
  • 0008-1222 24 Hr Pristiq 100 mg Extended Release Tablet by Wyeth Pharmaceuticals Inc., a Subsidiary of Pfizer Inc.
  • 35356-491 24 Hr Pristiq 50 mg Extended Release Tablet by Lake Erie Medical & Surgical Supply Dba Quality Care Products LLC
  • 35356-567 24 Hr Pristiq 100 mg Extended Release Tablet by Lake Erie Medical Dba Quality Care Products LLC
  • 54868-2932 24 Hr Pristiq 50 mg Extended Release Tablet by Physicians Total Care, Inc.
  • 55154-4230 24 Hr Pristiq 50 mg Extended Release Tablet by Cardinal Health

Other drugs which contain Desvenlafaxine Succinate or a similar ingredient: (3 results)

Possibly related Pristiq Topics:

pristiq and weight gain I started pristiq approx 5 weeks ago and altho my doctor assured me that it was a weight neutral drug I have easily gain... 73 replies
Pristiq This is NOT a good medicine. I felt more depressed on it and had several side effects, nausea, lack of appetite, dizzine... 40 replies
pristiq for depression and anxiety did not work My Son went to the Dr. for anxiety and depression, pristiq created more problems for him, panic attacks, insomnia, loss ... 12 replies
pristiq is it a narcotic is pristiq a narcotic I NEED TO KNOW ## Hello, Joe! How are you? No, Pristiq contains the active ingredient Desvenlafaxi... 5 replies
pristiq withdrawl Hi all, I was on 150 of pristiq and have been tapering off for two months. Last week I went from 50 to 25 for about 4 da... 5 replies
Pristiq an Libido- Advice Needed! I have been taking Pristiq for about 3 years now due Anxiety attacks. After taking the drug for afew days I had the wors... 5 replies
Pristiq Withdrawls I have been on Pristiq for about 4 years and was on levoxyl for a few years prior. I had started taking Sarafem 925mg) a... 4 replies
Pristiq and hot flushes/flashes I have been on this for 5 days. The last 3 days I have been having hot flushes and they have been getting more frequent.... 4 replies
Pristiq - fatigue I have started taking pristiq about 6 weeks ago and I have noticed in the last week or so that I have been extremely fat... 4 replies
pristiq withdrawal I am going through menopause and my doctor switched me from Prestiq to Zoloft. The Prestiq wasn't helping the anxiet... 3 replies