Active Ingredient(s): Dalfampridine
FDA Approved: * January 22, 2010
Pharm Company: * ACORDA
Category: Multiple Sclerosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Ampyra Overview

4-Aminopyridine (4-AP, INN fampridine, USAN dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis,[1][2] and is indicated for symptomatic improvement of walking in adults with several variations of the disease.[3] It was undergoing PhaseI...

Read more Ampyra Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Ampyra Forums: RSS Feed

Going off Ampryra after 3 months
18 Replies RSS
I got off ampyra after taking for 3 months because I felt it did not help my walking and caused other problems. I was not happy putting up with insomnia but was willing to tolerate if it was a tradeoff with walking. Since being off the medicine for one week my walking is terrible and balance worse than when I started. Has anyone else noticed problems when they stopped taking medicine after a 3 month period. I still feel the ampyra did not help but do not understand why I am worse off now than when I started the med. ## Sounds like we had the same results. I tried Ampyra for three months, during which time my walking actually seemed to slow a bit. I stopped using it when I got a nasty UTI, which gave me symptoms similar to an MS exacerbation. It took two rounds of antibiotics to finally ...
Updated 3 minutes ago.
improvement, dosage
2 Replies RSS
First of all, let me say that taking Ampyra has DEFINITELY helped my walking. I haven't felt the need to use my cane since almost day one. Speed, gait, balance all improved. Since insomnia has been an issue for me all my life, my Dr. suggested I just take one pill in the morning. I've been taking Ampyra now for 4 months, and still have only taken one pill a day, usually around 8am. That seems to working very well for me - is there any reason I SHOULD be taking the evening dose? Most evenings, I'm not on my feet much, so there doesn't seem to be much point. Your thoughts? ## Hello, Julia! How are you doing? I am so glad that this medication is working so well for you. If one pill is working for you, then no, you should go with what your doctor instructed and stick with yo...
Updated 14 days ago.
How long before Ampyra is out of system
1 Reply RSS
My aunt stopped taking Ampyra this am per her doctor. Dobyou know-how long before it will be out of her system. ## Hello, Suzanne! How is you aunt doing? It really depends on which aspect you're talking about, because there is a difference between when it may be processed out of her body, and when any unwanted side effects might go away. It only takes about 24 hours for it to be processed out of her body, according to the FDA, but some side effects could still linger for a week, or more, after stopping it. What caused her to have to stop taking it? The FDA lists its typical side effects as possibly including nausea, dizziness, headache, dry mouth, constipation, and itching.
Updated 4 months ago.
Ampyra did not work, walking much worse
37 Replies RSS
I took Ampyra for 9 weeks--twice a day for one week but the insomnia was so bad my neurologist took me off for 1 week, then 1/day a.m. for two more months, but walking was worse, not better, I thought possibly because I was getting so little sleep Since stopping it 8 weeks ago my walking has gotten significantly worse. Over the past several years, my MS has been stable according to MRIs with walking deteriorating very slightly, but after stopping Ampyra, walking and balance are significantly and increasingly worse. I hope my MS has not kicked up again after all these years. In addition to insomnia, the most significant side effect was terrible stomach pains, way beyond the "indigestion" listed in the side effects, and I lost several pounds I didn't want to lose. That pain en...
Updated 4 months ago.
88 Replies RSS
I have been taking Ampyra for 4 days.I have noticed a decrease in fatigue but headaches daily. The question is will they eventually go away on their own, or do I skip a day and see if they stop or quit til I see the doc ? ## Since last posting I have reduced amount to 1 per 24 hr. headaches are still occuring.2 Excedrin migraine seems to help.I have noticed an improvement in energy. ## I have been taking Ampyra for 4 days now I am feeling like the walking is slightly easier. My backpain has increased slightly but it isn't intolerable, it's ignorable. I'm liking. I have posted and will continue to post updates about my experiences with it on check it out if you'd like ## I have been taking Ampyra for a little over two weeks now, and I have experienced a marked improvement...
Updated 5 months ago.
Ampyra efficacy
2 Replies RSS
I quit Ampyra as I only saw a difference for a bit of time. I'm on LDN now and getting my dosage correct. Things improving, it takes time. ## I started taking ampyra 2 1/2 years ago, and initially I improved a lot, because of a mix up with the third timed walk, my insurance did not approve the refill for about a month and a half. I deteriorated rapidly and in fact began walking WORSE than before I started taking it initially. That month and a half without it, I started using a cane and although I improved a little after starting up again, I continue to need a cane. When I don't take it on time, I see a small difference in my ability to walk. I take it it in order to walk marginally better, but I'm way worse than I ever was before it. Knowing what I know now, I would have bee...
Updated 6 months ago.
Ampyra's working... oh no, it stopped =(
5 Replies RSS
My level in this MS journey is - very weak and stiff on my left side of my body. I use a walker and wheelchair when going places. I started Ampyra about 3 months ago. Within 2 days I really started to feel it! I was able to turn over @ night in bed (I usually can't), I had more strength when I'd get up from a chair or sofa. Then about 3 weeks or so into starting Ampyra I had so many stressful situations happen in my life. Then I lost every good symptom relief I had. I know, I know... the drug works for some better than others.. blah, blah, blah. I just wanted to know if anyone out there can relate and if so, what was your outcome. Thanks =) ## Ampyra is a very new medication, just recently approved by thee FDA, it contains the active ingredient Dalframpridine. It is most commonl...
Updated 6 months ago.
Patient Assistance Program - Ampyra
2 Replies RSS
This call center is HORRIBLE - don't they understand they are dealing with people with MS? What JERKS ## Hi, Deb! Very sorry you had problems when you called. Where they generally unhelpful, uniformed or was there some other problem? I've found that when I call the one I use, they are usually very helpful. I never had a problem until recently, when they were switching to a different company to fill prescriptions. Do they have a website you can use, rather than calling? ## I had the worst experience with the Ampyra patient assistant. It was the only phone number I had. My insurance specialty pharmacy sent out my Ampyra and teffedera in a regular cardboard box. Both medications arrived in bad shape. It is the end of June. Which means it is hot. The bottles were too hot to even tou...
Updated 7 months ago.
can ampyra make balance worse after stopping use
6 Replies RSS
was able to walk unassisted early in the day but had to use a walker later in the day. Neuro prescribed Ampyra, but when balance issue prevented walking unassisted at all after about a week of use, Dr. said to discontinue immediately. Balance issue continues for almost a year after discontinuing the drug and cannot walk unassisted. Could Ampyra possibly cause some lingering issues, even after its use has been discontinued for a long time? ## Hello, DJ! How are you? I'm more inclined to think it's due to an MS flare, rather than the medication, since it was discontinued so long ago. The FDA lists its typical side effects as possibly including nausea, insomnia, headache, weakness and stuffy nose. Are you on any other medications? ## Thanks for the response Verwon! The company (and...
Updated 7 months ago.
loss of bladder control
1 Reply RSS
have been taking ampyra 10mg twice daily for 6 wks. the headaches went away after 4wks,the dyspepsia is tolerable but during the last 2 wks bladder control or rather, lack of it, has become a huge issue for me. recently I had 2 episodes of urine incontinence, I can live with the other side effects as a trade off for the improvements in walking but cannot face living in fear of wetting myself in public or having to wear protective products. before ampyra I had minor urgency/ hesitancy episodes but now it's horrible. considering stopping ampyra .advice? ## Hello, Jane! How are you? I'm sorry about the problem that you've had, I agree, that would be horrible. Have you consulted your doctor? You may be able to take something to counteract this side effect, rather than give up th...
Updated 1 year ago.

Possible Dosages for this and Related Drugs:

  • Tablet: 0.0
  • Tablet, Extended Release: 10mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Ampyra: (1 result)

Sorted by National Drug Code
  • 10144-427 12 Hr Ampyra 10 mg Extended Release Tablet by Acorda Therapeutics, Inc.

Other drugs which contain Dalfampridine or a similar ingredient: (1 result)

Possibly related Ampyra Topics:

AMPYRA I have been taking Ampyra for 4 days.I have noticed a decrease in fatigue but headaches daily. The question is will they... 88 replies
Ampyra did not work, walking much worse I took Ampyra for 9 weeks--twice a day for one week but the insomnia was so bad my neurologist took me off for 1 week, t... 37 replies
Ampyra and balance My neuro is putting me on ampyra, and I am excited about this. My biggest MS problem is lack of balance. Anyone seen a d... 21 replies
ampyra I took my first dose of ampyra today and after 7 hours I had a terrible reaction. I have bad neuropathic pain in my legs... 14 replies
Ampyra Warning I have to inform everyone I can about this issue. My doctor wants me to take Ampyra and she handed me the Ampyra Patient... 9 replies
Ampyra's working... oh no, it stopped =( My level in this MS journey is - very weak and stiff on my left side of my body. I use a walker and wheelchair when goin... 5 replies
Ampyra On ampyra 2 days.Severe dizziness/lightheadedness. Does this get better with continued treatment? Ambien for insomnia? A... 5 replies
Ampyra Er 10 Mg Tablet new walking Treatment for MS. ## Hi! i AM AN MS PATIENT FROM POLAND (UE). I CAN'T BUY AMPYRA FROM THE US BUT I'L... 5 replies
Ampyra caused an MS exacerbation Hi everyone. I was hopeful that Ampyra would help my walking, which has been challenged these past months (though I have... 3 replies