Active Ingredient(s): Dalfampridine
FDA Approved: * January 22, 2010
Pharm Company: * ACORDA
Category: Multiple Sclerosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Ampyra Overview

4-Aminopyridine (4-AP, INN fampridine, USAN dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis,[1][2] and is indicated for symptomatic improvement of walking in adults with several variations of the disease.[3] It was undergoing PhaseI...

Read more Ampyra Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Ampyra Forums: RSS Feed

Ampyra did not work, walking much worse
33 Replies RSS
I took Ampyra for 9 weeks--twice a day for one week but the insomnia was so bad my neurologist took me off for 1 week, then 1/day a.m. for two more months, but walking was worse, not better, I thought possibly because I was getting so little sleep Since stopping it 8 weeks ago my walking has gotten significantly worse. Over the past several years, my MS has been stable according to MRIs with walking deteriorating very slightly, but after stopping Ampyra, walking and balance are significantly and increasingly worse. I hope my MS has not kicked up again after all these years. In addition to insomnia, the most significant side effect was terrible stomach pains, way beyond the "indigestion" listed in the side effects, and I lost several pounds I didn't want to lose. That pain en...
Updated 17 hours ago.
can ampyra make balance worse after stopping use
5 Replies RSS
was able to walk unassisted early in the day but had to use a walker later in the day. Neuro prescribed Ampyra, but when balance issue prevented walking unassisted at all after about a week of use, Dr. said to discontinue immediately. Balance issue continues for almost a year after discontinuing the drug and cannot walk unassisted. Could Ampyra possibly cause some lingering issues, even after its use has been discontinued for a long time? ## Hello, DJ! How are you? I'm more inclined to think it's due to an MS flare, rather than the medication, since it was discontinued so long ago. The FDA lists its typical side effects as possibly including nausea, insomnia, headache, weakness and stuffy nose. Are you on any other medications? ## Thanks for the response Verwon! The company (and...
Updated 1 month ago.
amphyra effects
1 Reply RSS
istarted amphyra six weeks ago after completing eligibality test over an initial four week trial super vised by my neuro the out come of the walking test was a thirty percent improvment in walking speed also some balance and cognitive improvments icommenced full time use two weeks later and apart from the exorbiant cost 195 dollars every four weeks i fully recommend any one prescribed it persist with the trearment ## Hello, Ross! How are you doing? I'm so very glad that this medication is working for you. Have you had any problems with the side effects that the FDA lists, such as nausea, bladder pain, forgetfulness, depression or muscle cramping?
Updated 2 months ago.
so happy to walk a straight line
5 Replies RSS
i am now on my 2nd week of taking Amprya and everyone is noticing my walking better.the left drop foot though is a drag (no pun intended lol) but has gotten alittle better my over all walking has side effects of pain in throat and neck was 2 days,my abdominal pain was 2 days,the itching and tingling was 2 days and all so far passsed.the numbness i normaly have in both my hands that was an MS episode that i never recovered from,was alittle more enhanst,but i would rather deal with all that if my walking approved not that im sprinting over hurls,but feeling really good so far!! good luck to everyone who is taking it. ## That's great, I am so glad that it's working so well for you. So often what gets posted on sites like this are just the complaints about a certain medi...
Updated 5 months ago.
Going off Ampryra after 3 months
15 Replies RSS
I got off ampyra after taking for 3 months because I felt it did not help my walking and caused other problems. I was not happy putting up with insomnia but was willing to tolerate if it was a tradeoff with walking. Since being off the medicine for one week my walking is terrible and balance worse than when I started. Has anyone else noticed problems when they stopped taking medicine after a 3 month period. I still feel the ampyra did not help but do not understand why I am worse off now than when I started the med. ## Sounds like we had the same results. I tried Ampyra for three months, during which time my walking actually seemed to slow a bit. I stopped using it when I got a nasty UTI, which gave me symptoms similar to an MS exacerbation. It took two rounds of antibiotics to finally ...
Updated 6 months ago.
Patient Assistance Program
4 Replies RSS
This call center is HORRIBLE - don't they understand they are dealing with people with MS? What JERKS ## Hi Deb, I'm sorry to hear about the bad experience you had with the Ampyra patient assistance program. What exactly made it so horrible? Could you elaborate? Any information or details you can provide could very well help others who are experiencing similar issues. Thank you! ## Patient assistance for Ampyra SUCK!!! Two months and I still don't have an application!! Had 2 different people call and tell me they were sending out apps still haven't received either. If your going to screw me you should at least kiss me!! ## I experiencing the same crap. But it's between the insurance the foundation that gives money and all the bs in between. I'm on this site becau...
Updated 7 months ago.
ampyra side effect - knee pain
1 Reply RSS
I have SPMS and have been taking Ampyra for a month. in the beginning I felt nothing but the side effects of lower back pain and increased balance issues. Those stopped, and I thought maybe it was helping me walk a bit stronger. Then the knee pain started. I didn't connect it to Ampyra at first. But I've found it listed as a side effect in a users forum. getting up from chairs is very painful and I believe the pain has made my walking worse. this is counterproductive and I wonder if I should continue. ## Knee pain isn't listed among the side effects reported by the FDA. Back pain is, as well as insomnia, dizziness, headache and constipation. Have you consulted your doctor to be sure? It would be best to have this checked out to rule out other possible causes. Is this the onl...
Updated 7 months ago.
mpyra less than a week
1 Reply RSS
Been taking ampyra for. 4 days now. I have never had pain with my ms , just mobility & cognitive issues,occasional swallowing difficulty. Since taking ampyra my legs are aching enough to where I feel like I need to take something. Also my lips are trying to go numb. Anyone else with these side effects? ## Yes, those can be side effects of taking Ampyra, along with MS relapse, seizures and balance issues. They should improve in a few weeks, after your body gets used to the medication, but you should have this checked out to be sure. Is there anything else I can help with?
Updated 1 year ago.
Ampyra and balance
21 Replies RSS
My neuro is putting me on ampyra, and I am excited about this. My biggest MS problem is lack of balance. Anyone seen a difference with balance issues on ampyra or its compouding equivalent? ## Ampyra contains the active ingredient Dalfampridine, it has been proven effective at managing some MS symptoms. This is a very new medication, but we have a few posts on it from people who have been using it, perhaps someone there has posted more information, most have said they've gotten good results from it. Does anyone else have experience using this? ## Hi Callie. I have been on ampyra for about a week and a half. I still cant decide if i see a difference yet. I did notice that my bladder issues have been a little better and i seem 2 be a little steadier. Balance is my main issue too,so i ...
Updated 1 year ago.
14 Replies RSS
I took my first dose of ampyra today and after 7 hours I had a terrible reaction. I have bad neuropathic pain in my legs, and about 7 hours after the dose, I felt like the neuropathy had been kicked up about 100 times. I literally felt like my legs were on fire. I jumped in the pool and immediately called the neuro's office to report the problem. I was told to stop it immediately, which I am very disappointed about. I had an allergic reaction to Tysabri, couldn't take Rebif, have problems with high dose steroids, and now this. I am pretty much to the secondary progressive stage, although I had a massive attack 15 months ago, and am now on Copaxone and Avonex duo therapy since 2/09. I was really hoping Ampyra would help with the walking, (now on a walker) but because of all my al...
Updated 2 years ago.

Possible Dosages for this and Related Drugs:

  • Tablet, Extended Release: 10mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Ampyra: (1 result)

Sorted by National Drug Code
  • 10144-427 12 Hr Ampyra 10 mg Extended Release Tablet by Acorda Therapeutics, Inc.

Other drugs which contain Dalfampridine or a similar ingredient: (1 result)

Possibly related Ampyra Topics:

AMPYRA I have been taking Ampyra for 4 days.I have noticed a decrease in fatigue but headaches daily. The question is will they... 79 replies
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Ampyra and balance My neuro is putting me on ampyra, and I am excited about this. My biggest MS problem is lack of balance. Anyone seen a d... 21 replies
ampyra I took my first dose of ampyra today and after 7 hours I had a terrible reaction. I have bad neuropathic pain in my legs... 14 replies
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Ampyra Er 10 Mg Tablet new walking Treatment for MS. ## Hi! i AM AN MS PATIENT FROM POLAND (UE). I CAN'T BUY AMPYRA FROM THE US BUT I'L... 5 replies
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Ampyra caused an MS exacerbation Hi everyone. I was hopeful that Ampyra would help my walking, which has been challenged these past months (though I have... 3 replies