Active Ingredient(s): Dalfampridine
FDA Approved: * January 22, 2010
Pharm Company: * ACORDA
Category: Multiple Sclerosis

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Ampyra Overview

4-Aminopyridine (4-AP, INN fampridine, USAN dalfampridine) is an organic compound with the chemical formula C5H4N–NH2. The molecule is one of the three isomeric amines of pyridine. It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis,[1][2] and is indicated for symptomatic improvement of walking in adults with several variations of the disease.[3] It was undergoing PhaseI...

Read more Ampyra Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

Recent Ampyra Forums: RSS Feed

Ampyra did not work, walking much worse
35 Replies RSS
I took Ampyra for 9 weeks--twice a day for one week but the insomnia was so bad my neurologist took me off for 1 week, then 1/day a.m. for two more months, but walking was worse, not better, I thought possibly because I was getting so little sleep Since stopping it 8 weeks ago my walking has gotten significantly worse. Over the past several years, my MS has been stable according to MRIs with walking deteriorating very slightly, but after stopping Ampyra, walking and balance are significantly and increasingly worse. I hope my MS has not kicked up again after all these years. In addition to insomnia, the most significant side effect was terrible stomach pains, way beyond the "indigestion" listed in the side effects, and I lost several pounds I didn't want to lose. That pain en...
Updated 3 minutes ago.
Ampyra efficacy
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I quit Ampyra as I only saw a difference for a bit of time. I'm on LDN now and getting my dosage correct. Things improving, it takes time.
Updated 1 month ago.
Going off Ampryra after 3 months
16 Replies RSS
I got off ampyra after taking for 3 months because I felt it did not help my walking and caused other problems. I was not happy putting up with insomnia but was willing to tolerate if it was a tradeoff with walking. Since being off the medicine for one week my walking is terrible and balance worse than when I started. Has anyone else noticed problems when they stopped taking medicine after a 3 month period. I still feel the ampyra did not help but do not understand why I am worse off now than when I started the med. ## Sounds like we had the same results. I tried Ampyra for three months, during which time my walking actually seemed to slow a bit. I stopped using it when I got a nasty UTI, which gave me symptoms similar to an MS exacerbation. It took two rounds of antibiotics to finally ...
Updated 1 month ago.
80 Replies RSS
I have been taking Ampyra for 4 days.I have noticed a decrease in fatigue but headaches daily. The question is will they eventually go away on their own, or do I skip a day and see if they stop or quit til I see the doc ? ## Since last posting I have reduced amount to 1 per 24 hr. headaches are still occuring.2 Excedrin migraine seems to help.I have noticed an improvement in energy. ## I have been taking Ampyra for 4 days now I am feeling like the walking is slightly easier. My backpain has increased slightly but it isn't intolerable, it's ignorable. I'm liking. I have posted and will continue to post updates about my experiences with it on check it out if you'd like ## I have been taking Ampyra for a little over two weeks now, and I have experienced a marked improvement...
Updated 2 months ago.
loss of bladder control
1 Reply RSS
have been taking ampyra 10mg twice daily for 6 wks. the headaches went away after 4wks,the dyspepsia is tolerable but during the last 2 wks bladder control or rather, lack of it, has become a huge issue for me. recently I had 2 episodes of urine incontinence, I can live with the other side effects as a trade off for the improvements in walking but cannot face living in fear of wetting myself in public or having to wear protective products. before ampyra I had minor urgency/ hesitancy episodes but now it's horrible. considering stopping ampyra .advice? ## Hello, Jane! How are you? I'm sorry about the problem that you've had, I agree, that would be horrible. Have you consulted your doctor? You may be able to take something to counteract this side effect, rather than give up th...
Updated 3 months ago.
Walking with ms
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I have been living with ms sense 1991. I've had my up and downs through the years. I've had plenty of falls. Broke my left ankle, then almost a year to the exact date later I broke my right foot. My walking has gotten progressively worse and if tried many kinds of treatment both injections and pills. The latest being ampyra. Nothing seems to work. I also have arthritis in my spine and swollen ankles from high blood pressure so my mobility is very limited. The medications I see advertised for ms seem to be for remitting ms. Not progressive ms which I have now. I'm at a lose of what to ask my doctor I should try now or should I give up and let it take its natural course.
Updated 4 months ago.
Curious if Ampyra is right for me?
6 Replies RSS
I was diagnosed with PPMS. My right leg feels stiff when I walk. I was thinking that Ampyra was intended for the other types of MS. But reading of the side effects, I'm doubting taking it. I am working on getting a Walk Aide. It works wonderfully for me. It's just expensive. So would Ampyra be right for me? ## Unfortunately, the information in your post is very limited, which makes it hard for anyone to advise you on this. Learn more Ampyra details here. What medications do you currently take? Any form of MS can be touchy and unpredictable to treat, so all must be handled with care. Have you consulted a doctor about using it? ## Thanks for your input Verwon. I didn't think about the other meds. I take Baclofen for my spasticity and LDN. I was taking Rebif, but my insurance s...
Updated 4 months ago.
can ampyra make balance worse after stopping use
5 Replies RSS
was able to walk unassisted early in the day but had to use a walker later in the day. Neuro prescribed Ampyra, but when balance issue prevented walking unassisted at all after about a week of use, Dr. said to discontinue immediately. Balance issue continues for almost a year after discontinuing the drug and cannot walk unassisted. Could Ampyra possibly cause some lingering issues, even after its use has been discontinued for a long time? ## Hello, DJ! How are you? I'm more inclined to think it's due to an MS flare, rather than the medication, since it was discontinued so long ago. The FDA lists its typical side effects as possibly including nausea, insomnia, headache, weakness and stuffy nose. Are you on any other medications? ## Thanks for the response Verwon! The company (and...
Updated 5 months ago.
amphyra effects
1 Reply RSS
istarted amphyra six weeks ago after completing eligibality test over an initial four week trial super vised by my neuro the out come of the walking test was a thirty percent improvment in walking speed also some balance and cognitive improvments icommenced full time use two weeks later and apart from the exorbiant cost 195 dollars every four weeks i fully recommend any one prescribed it persist with the trearment ## Hello, Ross! How are you doing? I'm so very glad that this medication is working for you. Have you had any problems with the side effects that the FDA lists, such as nausea, bladder pain, forgetfulness, depression or muscle cramping?
Updated 7 months ago.
so happy to walk a straight line
5 Replies RSS
i am now on my 2nd week of taking Amprya and everyone is noticing my walking better.the left drop foot though is a drag (no pun intended lol) but has gotten alittle better my over all walking has side effects of pain in throat and neck was 2 days,my abdominal pain was 2 days,the itching and tingling was 2 days and all so far passsed.the numbness i normaly have in both my hands that was an MS episode that i never recovered from,was alittle more enhanst,but i would rather deal with all that if my walking approved not that im sprinting over hurls,but feeling really good so far!! good luck to everyone who is taking it. ## That's great, I am so glad that it's working so well for you. So often what gets posted on sites like this are just the complaints about a certain medi...
Updated 9 months ago.

Possible Dosages for this and Related Drugs:

  • Tablet, Extended Release: 10mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Ampyra: (1 result)

Sorted by National Drug Code
  • 10144-427 12 Hr Ampyra 10 mg Extended Release Tablet by Acorda Therapeutics, Inc.

Other drugs which contain Dalfampridine or a similar ingredient: (1 result)

Possibly related Ampyra Topics:

AMPYRA I have been taking Ampyra for 4 days.I have noticed a decrease in fatigue but headaches daily. The question is will they... 80 replies
Ampyra did not work, walking much worse I took Ampyra for 9 weeks--twice a day for one week but the insomnia was so bad my neurologist took me off for 1 week, t... 35 replies
Ampyra and balance My neuro is putting me on ampyra, and I am excited about this. My biggest MS problem is lack of balance. Anyone seen a d... 21 replies
ampyra I took my first dose of ampyra today and after 7 hours I had a terrible reaction. I have bad neuropathic pain in my legs... 14 replies
Ampyra Warning I have to inform everyone I can about this issue. My doctor wants me to take Ampyra and she handed me the Ampyra Patient... 9 replies
Ampyra On ampyra 2 days.Severe dizziness/lightheadedness. Does this get better with continued treatment? Ambien for insomnia? A... 5 replies
Ampyra Er 10 Mg Tablet new walking Treatment for MS. ## Hi! i AM AN MS PATIENT FROM POLAND (UE). I CAN'T BUY AMPYRA FROM THE US BUT I'L... 5 replies
Ampyra's working... oh no, it stopped =( My level in this MS journey is - very weak and stiff on my left side of my body. I use a walker and wheelchair when goin... 4 replies
Ampyra caused an MS exacerbation Hi everyone. I was hopeful that Ampyra would help my walking, which has been challenged these past months (though I have... 3 replies