Simvastatin And Coq10

I was recently told that simvastatin depletes CoQ10, leading to the "weakness" side effect. Anyone heard this?

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I have to agree with that statement, as there are a number of discussions relating to Statin drugs (atorvastatin, cerivastatin, fluvastatin, lovastatin, simvastatin) depleting the body of coenzyme Q10.

Other types of drugs like beta-blockers also deplete the body of this too, but one way to help counteract this is to supplement with CoQ 10. Personally, If I were short on this vital nutrient, I would supplement a minimum of 400-600mg a day while taking one of those drugs that inherently depletes it. That's just me, as I would prefer to be well stocked if I became aware that this was happening to me.

I hope this helps!

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Thank you

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Re: David (# 1)

CoQ10 depletion is definitely a side effect of statin drugs. If you read the drug fact sheet for a statin (e.g. Simvastatin) that the FDA requires pharm companies to publish in the USA, you will not see any mention of this side effect. However, if you read the drug fact sheet for a statin drug (e.g. Simvastatin) that Health Canada requires pharm companies to publish in Canada, you will definitely see a strong warning of this side effect. Health Canada has much more stringent requirements on what pharm companies must divulge in the Canadian drug fact sheets. Furthermore, pharm companies are clearly aware of this issue because there is a pharm company that obtained a US patent for a drug that combines statin + CoQ10 in the same pill. But apparently there are no pharm companies that actually market such a drug.

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