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100+ Topics Found
Sibrafiban Drug Index

Sibrafiban (Ro 48-3657, proposed brand name Xubix) is the double prodrug of Ro-44-3888, which is a platelet aggregation inhibitor. It was being developed for secondary prevention of arterial thrombosis following unstable angina pectoris and acute myocardial infarction (MI).[1] On August 6, 1999, Hoffmann-La Roche announced that the preliminary results from Phase III clinical trials had not shown that sibrafiban was better than aspirin in preventing recurrent ischemic events in...

Sibutramine Drug Index

Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries. Until 2010, it was widely marketed and prescribed as an adjunct in the treatment of obesity along with diet and exercise. It has been associated with increased cardiovascular events and strokes and has been withdrawn from the market in several countries and regions including Australia,[1] Canada,[2] China,[3&am...

Sigmart Nicorandil

Nicorandil is a vasodilatory drug used to treat angina. Angina is chest pain that results from episodes of transient myocardial ischemia. This can be caused by diseases such as atherosclerosis, coronary artery disease and aortic stenosis. Angina commonly arises from vasospasm of the coronary arteries. There are multiple mechanisms causing the increased smooth muscle contraction involved in coronary vasospasm, including increased Rho-kinase activity. Increased levels of Rho-kinase inhibit myos...

Signifor Pasireotide Diaspartate

Pasireotide, sold under the brand name Signifor, is an orphan drug approved in the United States[1] and the European Union[2][3] for the treatment of Cushing's disease in patients who fail or are ineligible for surgical therapy.[4][5][6] It was developed by Novartis. Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin anal...

Signifor Lar Pasireotide

Pasireotide, sold under the brand name Signifor, is an orphan drug approved in the United States[1] and the European Union[2][3] for the treatment of Cushing's disease in patients who fail or are ineligible for surgical therapy.[4][5][6] It was developed by Novartis. Pasireotide is a somatostatin analog with a 40-fold increased affinity to somatostatin receptor 5 compared to other somatostatin anal...

Siklos Hydroxyurea

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia and cervical cancer.[1][2] In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks.[1] It is taken by mouth.[1] Common side effects include bone marrow suppression, fevers, loss of appetite, psychiatric problems, shortness of breath, and headaches.&#...

Sil-Tex Guaifenesin + Phenylephrine

Guaifenesin, sold under the brand name Mucinex, among others,[3] is a medication used as an expectorant, intended to help cough out phlegm from the airways.[3] Chemically it is an ether of guaiacol and glycerine. It is unclear if it decreases coughing.[3] Use is not recommended in children less than 6 years old.[4] It is often used in combination with other medications.[3] It is taken by mouth.[3] ...

Sildaflo Silver Sulfadiazine

Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection.[1] Tentative evidence has found other antibiotics to be more effective and therefore it is no longer generally recommended for second-degree (partial-thickness) burns, but is still widely used to protect third-degree (full-thickness) burns.[2][3] Common side effects include itching and...

Sildec DM Drops Carbinoxamine + Dextromethorphan + Pseudoephedrine

Dextromethorphan, often referred to as DXM, is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. It is in the morphinan class of medications with sedative, dissociative, and stimulant properties (at lower doses). Dextromethorphan does not have a significant affinity for the mu-opioid receptor activity typical of morphinan compounds and exerts its therapeutic effects through several other rec...

Sildec-DM Syrup Brompheniramine + Dextromethorphan + Pseudoephedrine

Brompheniramine, sold under the brand name Dimetapp among others, is a first-generation antihistamine drug of the propylamine (alkylamine) class.[2] It is indicated for the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing. Like the other first-generation drugs of its class, it is considered a sedating antihistamine.[2] It was patented in 1948 and came into medical use in 1955.[...

Sildenafil Drug Index

Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension.[8][4] It is unclear if it is effective for treating sexual dysfunction in women.[8] It is taken by mouth or by injection into a vein.[8] Onset is typically within 20 minutes and lasts for about 2 hours.[8] Common side effects include headaches, heartburn, and flushed sk...

Silenor Doxepin Hydrochloride

Doxepin is a medication used to treat major depressive disorder, anxiety disorders, chronic hives, and trouble sleeping.[8][9] For hives it is a less preferred alternative to antihistamines.[8] It has a mild to moderate benefit for sleeping problems.[10] It is used as a cream for itchiness due to atopic dermatitis or lichen simplex chronicus.[11] Common side effects include sleepiness, dry mouth, constipation, nau...

Silexin Dextromethorphan + Guaifenesin

Guaifenesin, sold under the brand name Mucinex, among others,[3] is a medication used as an expectorant, intended to help cough out phlegm from the airways.[3] Chemically it is an ether of guaiacol and glycerine. It is unclear if it decreases coughing.[3] Use is not recommended in children less than 6 years old.[4] It is often used in combination with other medications.[3] It is taken by mouth.[3] ...

Siliq Brodalumab

Brodalumab (trade name Siliq in the US and Kyntheum in Europe) is a human monoclonal antibody designed for the treatment of inflammatory diseases.[1][2] In February 2017 it received US FDA approval to treat moderate to severe plaque psoriasis in people who have not improved with other treatments.[3] Mechanism of action Brodalumab binds to the interleukin-17 receptor and so prevents interleukin 17 (IL-17) from activating the receptor. This me...

Silodosin Drug Index

Silodosin (known by the trade names Urief in Japan, Rapaflo in North America, and Silodyx or Niksol in the European Union[1]) is a medication for the symptomatic treatment of benign prostatic hyperplasia (BPH). It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate).[2] Contents 1 Medical uses 2 Contraindications 3 Side effects 4 Interactions 5 Pharmacology 5.1 Mechanism of action 5.2 Pharmacokinetics 6 History...

Siltussin DM Dextromethorphan + Guaifenesin

Guaifenesin, sold under the brand name Mucinex, among others,[3] is a medication used as an expectorant, intended to help cough out phlegm from the airways.[3] Chemically it is an ether of guaiacol and glycerine. It is unclear if it decreases coughing.[3] Use is not recommended in children less than 6 years old.[4] It is often used in combination with other medications.[3] It is taken by mouth.[3] ...

Siltuximab Drug Index

Siltuximab (INN, trade name Sylvant; also known as CNTO 328, anti-IL-6 chimeric monoclonal antibody or cCLB8) is a chimeric (made from human and mouse proteins) monoclonal antibody. It binds to interleukin-6.[1][2] Siltuximab has been investigated for the treatment of neoplastic diseases:[3] metastatic renal cell cancer,[4] prostate cancer,[5] and Castleman's disease,[6][7] among ot...

Silvadene Silver Sulfadiazine

Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection.[1] Tentative evidence has found other antibiotics to be more effective and therefore it is no longer generally recommended for second-degree (partial-thickness) burns, but is still widely used to protect third-degree (full-thickness) burns.[2][3] Common side effects include itching and...

Silver Nitrate Drug Index

Silver nitrate is an inorganic compound with chemical formula AgNO3. This salt is a versatile precursor to many other silver compounds, such as those used in photography. It is far less sensitive to light than the halides. It was once called lunar caustic because silver was called luna by ancient alchemists who associated silver with the moon.[7] In solid silver nitrate, the silver ions are three-coordinated in a trigonal planar arrangement.[4] Contents 1 Syn...

Silver Sulfadiazine Drug Index

Silver sulfadiazine, sold under the brand Silvadene among others, is a topical antibiotic used in partial thickness and full thickness burns to prevent infection.[1] Tentative evidence has found other antibiotics to be more effective and therefore it is no longer generally recommended for second-degree (partial-thickness) burns, but is still widely used to protect third-degree (full-thickness) burns.[2][3] Common side effects include itching and...

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