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Drug Index

Rapacuronium bromide (brand name Raplon) is a rapidly acting, non-depolarizing aminosteroid neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them. Due to risk of fatal bronchospasm it was withdrawn from the United ...

Silodosin

Silodosin (known by the trade names Urief in Japan, Rapaflo in North America, and Silodyx or Niksol in the European Union[1]) is a medication for the symptomatic treatment of benign prostatic hyperplasia (BPH). It acts as an α1-adrenoceptor antagonist with high uroselectivity (selectivity for the prostate).[2] Contents 1 Medical uses 2 Contraindications 3 Side effects 4 Interactions 5 Pharmacology 5.1 Mechanism of action 5.2 Pharmacokinetics 6 History...

Sirolimus

Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumor (PEComa).[1][2][8][9] It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants....

Peramivir

Peramivir (trade name Rapivab) is an antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. It is approved for intravenous administration.[1] In October 2009, the U.S. Food and Drug Administration (FDA) issued an emergency use authorization (EUA) for the use of pera...

Rapacuronium

Rapacuronium bromide (brand name Raplon) is a rapidly acting, non-depolarizing aminosteroid neuromuscular blocker formerly used in modern anaesthesia, to aid and enable endotracheal intubation, which is often necessary to assist in the controlled ventilation of unconscious patients during surgery and sometimes in intensive care. As a non-depolarizing agent it did not cause initial stimulation of muscles before weakening them. Due to risk of fatal bronchospasm it was withdrawn from the United ...

Efalizumab

Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis. As implied by the suffix -mab, it is a recombinant humanized monoclonal antibody administered once weekly by subcutaneous injection. Efalizumab binds to the CD11a[1] subunit of lymphocyte function-associated antigen 1 and acts as an immunosuppressant by inhibiting lymphocyte activation and cell migration out...

Drug Index

Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is an oral medication used in addition to diet and exercise for blood sugar control in type 2 diabetes mellitus.[1] The mechanism of action of repaglinide involves promoting insulin release from β-islet cells of the pancreas; like other antidiabetic drugs, a main side effect concern is hypoglycemia.[1] It is sold by Novo Nordisk unde...

Drug Index

Metformin, sold under the brand name Glucophage, among others, is the first-line medication for the treatment of type 2 diabetes,[6][7][8] particularly in people who are overweight.[9] It is also used in the treatment of polycystic ovary syndrome.[6] It is not associated with weight gain[10] and is taken by mouth.[6] It is sometimes used as an off-label augment to attenuate the risk...

Acetaminophen + Butalbital + Caffeine

Butalbital/acetaminophen, sold under the brand name Butapap among others, is a combination medication used to treat tension headaches and migraine headaches.[1][2][3] It contains butalbital, a barbiturate and paracetamol (acetaminophen), an analgesic.[2] Versions also containing caffeine are sold under the brand name Fioricet among others.[4] It is taken by mouth.[2][5] The combinat...

Horse Chestnut, Aesculus hippocastanum

Aesculus hippocastanum, the horse chestnut,[1][2][3] is a species of flowering plant in the soapberry and lychee family Sapindaceae. It is a large deciduous, synoecious (hermaphroditic-flowered) tree.[4] It is also called horse-chestnut,[5] European horsechestnut,[6] buckeye,[7] and conker tree.[8] It is sometimes called Spanish chestnut.[7][9...

Evolocumab

Evolocumab[3] (trade name Repatha) is a monoclonal antibody medication designed for the treatment of hyperlipidemia. Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9 is a protein that targets LDL receptors for degradation and its inhibition thereby enhances the liver's ability to remove LDL-C, or "bad" cholesterol, from the blood.[4] Contents 1 Mechanism 2 History 3 Society and culture ...

Agalsidase Alfa

Alpha-galactosidase (α-GAL, also known as α-GAL A; E.C. 3.2.1.22) is a glycoside hydrolase enzyme that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. Glycosidase is an important class of enzyme catalyzing many catabolic processes, including cleaving glycoproteins and glycolipids, and polysaccharides. Specifically, α-GAL catalyzes the removal of the terminal α-galactose from oligosaccharides.[1] The enzyme is encoded b...

Drug Index

A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid.[2] A supplement can provide nutrients either extracted from food sources or that are synthetic in order to increase the quantity of their consumption. The class of nutrient compounds includes vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential t...

Drug Index

A dietary supplement is a manufactured product intended to supplement one's diet by taking a pill, capsule, tablet, powder, or liquid.[2] A supplement can provide nutrients either extracted from food sources or that are synthetic in order to increase the quantity of their consumption. The class of nutrient compounds includes vitamins, minerals, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential t...

Hydrocodone + Ibuprofen

Hydrocodone/ibuprofen (INNs), sold under the brand name Vicoprofen, is a fixed-dose combination analgesic medication used in short-term therapy to relieve severe pain.[2][3] Vicoprofen combines the analgesic and antitussive properties of hydrocodone with the analgesic, anti-inflammatory, and antipyretic properties of ibuprofen.[4] In contrast to hydrocodone/acetaminophen combination analgesics such as Vicodin, this hydrocodone/ibuprofen avoids s...

Menotropins

Menotropin (also called human menopausal gonadotropin or hMG) is a hormonally active medication for the treatment of fertility disturbances. Frequently the plural is used as the medication is a mixture of gonadotropins. Menotropins are extracted from the urine of postmenopausal women.[1] Contents 1 Description and usage 2 List of hMG preparations 3 See also 4 References Description and usage Urine of postmenopausal women reflects the hypergonadotropic state of menopause...

Drug Index

Ripretinib, sold under the brand name Qinlock, is a medication for the treatment of adults with advanced gastrointestinal stromal tumor (GIST), a type of tumor that originates in the gastrointestinal tract.[2][3] It is taken by mouth.[2][3] Ripretinib inhibits the activity of the kinases KIT and PDGFRA, which helps keep cancer cells from growing.[3] The most common side effects include alopecia (hair loss), fatigu...

Drug Index

Ropeginterferon alfa-2b, sold under the brand name Besremi, is a medication used to treat polycythemia vera.[1][2][3][4] It is an interferon.[1][3] It is given by injection.[1][3] The most common side effects include low levels of white blood cells and platelets (blood components that help the blood to clot), muscle and joint pain, tiredness, flu-like symptoms and in...

Drug Index

Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS).[2] In PD the dose needs to be adjusted to the effect and treatment should not be suddenly stopped.[2] It is taken by mouth.[3] It is approved in the US and UK for inducing emesis (vomiting) in dogs who have ingested toxins or non-sharp foreign material. Common side effects include sleepiness, vomitin...