Fluorouracil

Drug Index

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Can anyone explain the stages and what to look for. I’ve been on Fluorouracil for 23 days suppose to do 4 weeks all over complete face . But face is peeling in some areas and turned a yellowiish crusty in some places. Also cracking and bleeding in tiny spots. Should I keep using it or is this the erosion phase. What to expect next?

I am on effient blood thinner after a heart stent placement. I was just prescribed efudex. will this increase the blood thinning effect ? ## If you're using it topically, the side effects are usually minimal. However, it would be best to double check with your doctor or pharmacist to be certain. Is your INR checked regularly?

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I'm having an unusually severe skin irritation when applying my Fluorouracil creme (5%) this time. This is the 3rd time using this drug, but the first time on my cheek. Is this area, perhaps, more sensitive than the top of my head where I've used in the past ? After 8 days of application 2X a day, my cheek is near "raw". Comments, thoughts or suggestions? Thank you, in advance, for your time. (As background, I had melanoma surgery 3 times on OPPOSITE cheek in past 5 months. ## Hello, Bob! How are you? Yes, the skin on your face is generally more sensitive. However, you should consult your doctor to have it checked out. Is there anything else I can help with? ## Verwon: I appreciate you taking the time to respond to my query. I have started using Aquaphor ointment and am ...

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Need all information about this medication please. ## I have been told to apply Efudex to my lower lip, isn't this crazy? ## Not really. It is listed in the drug monograph that it can be used topically to treat certain cancerous or possibly cancerous conditions. ## Has anyone used it on their lips? Won't it just keep bleeding non-stop? ## Heidi- I've used it on my lips three times. Each time it was an application morning and at bedtime. Though about the second week it gets very sensitive and blister-like lesions appear that means it's working. I applied a product called Acquafor (like Vaseline Jelly) to seal it and protect). The healing takes some time but the outcome is worth it. ## I just used Efudex for 2 weeks on lower lip. from day 7 blistered and ulcerated and wept...

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I used this prescription on my forehead twice a day for 10 days. Removed all my ak's. Has now been about 1 year and a few are returning. You must apply a very thin film. It did turn bright red after about 7 days. Remains that way while peeling. About three weeks after stopping treatment. Not much pain for me. Just too much time hiding at home. Don't use any cosmetics while treating. Never do your whole face at once! ## I agree completely. I did the exact treatment in 2014 and have been using this product on and off since then. Only a few have returned to this day. Works great for me. I experienced minimum sting or itching. You must use a very fine touch of cream and then rub it in. Keep treated areas small. Never exceed over 9 x 9 inch or it will get into your blood and cause pa...

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I read that you should wash the site before application. Are you to wash your hair everyday, twice a day if you apply Fluorouracil 2 x per day? Is it ok to use your regular shampoo. I understand that use of Fluorouracil cream can spread to areas that may not already show signs of precancerous spots. Has anyone noticed this to happen? How far has it spread, entire scalp? Please share any experience you have had with treating scalp.

I've just completed 10 days of fluorouracil + calcipotriene/calcipotriol treatment - in my case, being in México, branded Efudix + Diavonex rather than Efudex + Dovonex - and one of the most annoying parts of it was that the combo cream is so thick (and greasy). It drags painfully against the affected skin and is the worst part of the procedure in my opinion; the duration and severity of the reaction is way less than using fluorouracil on its own, which is a big advantage, but my question is, is there a "lighter" version of these creams? Or, ideally, a solution/lotion? Actually, I know there is a fluorouracil lotion for scalp use, but you'd need a lotion version of the calcipotriene as well to mix properly I'd guess, and I have not been able to find this. Anyway...

I put this combo on face fro 5 days as prescribed. Pretty awful for 2 of the days but all clear after 2 weeks. HOWEVER, then I developed a bad rash on my chest - did not apply cream there. Doctor doesn't know but thinks maybe the absorbed cream went systemic. Cortisone helped. Now a similar rash has spread to my legs and arms. not burning but supper bumpy and itchy. Scrambling to find help. Has anyone experienced a systematic reaction to untreated parts of the body? ## You are definitely having an allergic reaction to Something. Is it this creme or something else you are using causing it. The same thing happened to me and it was a nightmare. I also lost a lot of my hair. See who the manufacturing company is and where they are located-some foreign country?? China?? The easy way is to...

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Harvard Medical recently discovered a new treatment regime for AK. This new four-day Harvard Medical protocol is going to save us all from the Efudex & Fluorouracil nightmare: Adding calcipotriene to 5-FU dramatically reduced AKs I used this 4-day treatment for AK in Dec '18 and it works!! Save yourself from the 3 week fluorouracil nightmare and do this 4-day treatment instead. I made this Youtube video of my experience with this protocol: The treatment resolves actinic keratosis in only 4 days. No longer is the pain and discomfort of the commonly prescribed 3 week Flouracil necessary to clear your skin of these pre-cancerous lesions. Mix 5% Fluoroucil and Calcipotriene 50/50 and apply twice per day for four days. Both of these creams can be purchased through prescription. Your ...

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Fluorouracil, 5-FU

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Fluorouracil

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Fluorouracil, 5-FU

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Fluorouracil, 5-FU

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Fluorouracil, 5-FU

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a cytotoxic chemotherapy medication used to treat cancer.[2] By intravenous injection it is used for treatment of colorectal cancer, oesophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] Side effects of use by injection are common.&...

Oxaliplatin

Oxaliplatin, sold under the brand name Eloxatin, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer.[2] Often it is used together with fluorouracil and folinic acid (leucovorin) in advanced cancer.[2] It is given by injection into a vein.[2] Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts.[2][3] Other serious side effects in...

Drug Index

Oxaliplatin, sold under the brand name Eloxatin, is a cancer medication (platinum-based antineoplastic class) used to treat colorectal cancer.[2] Often it is used together with fluorouracil and folinic acid (leucovorin) in advanced cancer.[2] It is given by injection into a vein.[2] Common side effects include numbness, feeling tired, nausea, diarrhea, and low blood cell counts.[2][3] Other serious side effects in...

Irinotecan Liposome

Irinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer.[4] For colon cancer it is used either alone or with fluorouracil.[4] For small cell lung cancer it is used with cisplatin.[4] It is given intravenously.[4] Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, shortness of breath, and fever.[4] Other se...

Levoleucovorin

Folinic acid, also known as leucovorin, is a medication used to decrease the toxic effects of methotrexate and pyrimethamine.[2][3] It is also used in combination with 5-fluorouracil to treat colorectal cancer and pancreatic cancer, may be used to treat folate deficiency that results in anemia, and methanol poisoning.[3][4] It is taken by mouth, injection into a muscle, or injection into a vein.[3] Side effects ma...