Simdax

Levosimendan

Levosimendan (INN) /livosamndn/ is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax (Orion Corporation). Overall the drug has a two fold mechanism of action. It leads to greater ionotrophy by increasing the calcium sensitivity as it binds to Troponin and this results in a greater positive iontrophic force. Secondly, the drug is able to open ATP sensitive potassium channels in vascular smooth muscle cells,...

Is Levosimendan available in the US? ## The US trade name is Simdax, which is manufactured by Abbott labs. ## Where can I get Simdax in the U.S.? My mother is age 73 and currently has a pacemaker implanted. She has been diagnosed with congenital heart failure and is having a very difficult time walking around for extended periods of time and keeping her energy levels up. She was told about the above-mentioned medication as a probable solution for giving her back some of that energy that she has lost. She understands that it's not a long term solution but would like to explore the option.

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Drug Index

Levosimendan (INN) /livosamndn/ is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It is marketed under the trade name Simdax (Orion Corporation). Overall the drug has a two fold mechanism of action. It leads to greater ionotrophy by increasing the calcium sensitivity as it binds to Troponin and this results in a greater positive iontrophic force. Secondly, the drug is able to open ATP sensitive potassium channels in vascular smooth muscle cells,...

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