Movantik

Naloxegol

Naloxegol (INN; PEGylated naloxol;[1] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation.[2] It was approved in 2014 in adult patients with chronic, non-cancer pain.[3] Doses of 25mg were found safe and well tolerated for 52 weeks.[4] When given concomitantly with opioid analgesi...

I was prescribed Movantik a week ago with the enclosed instructions suggesting that I take 1 tablet in the morning and eat nothing for an hour, which I've haven't done yet because I must have coffee immediately upon waking or otherwise remain nauseous until I do. My question is this: Can I take Movantik after drinking a cup of coffee with cream? Not knowing whether that's ok I've taken the med at bedtime instead for several days now, which A) causes cramps throughout the night + B) was not very effective, i.e. did not produce a BM after I woke up, but I suggesting to me that it likely works better while one is awake and more active after dosing. I'm reluctant to do so however, until I have this question answered. ## Without offering medical advice, all I can say is t...

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Why am I gaining weight every day by taking Movantic (even if I eat just a little or nothing)? ## I have also gained about 10lbs since starting movantik.. ## Have been taking Movantik since 2016. I have gained 40 pounds and have become prediabetic even though I am on a strict diet ## Hello Connie, According to the National Institute of Health during their case study less than 1% of the patients who were given the pill showed symptoms of weight gain and thus they determined that this is not an adverse effect caused by the medicine. This does not mean that you are not being effected by the weight gain, it may simply means that it not common and that if proven to be the cause you would be among the very rare cases. If you are concerned that you are gaining weight despite doing your best to...

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I just picked up a RX for Movantik and am so ready to start it! I have been so constipated for months and bloated too. Is there a better time of day to take it? Morning or night? I read the post about how well it can work the first day or two but does this mean I should take before bed or in the morning? Thank you in advance for any advice! ## The FDA generally suggests it be taken in the morning. Its typical side effects are listed as possibly including stomach pain, diarrhea, increased sweating, yawning, and irritability. Are you on any other medications? Have you started taking this one, yet?

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Hao effective % tage wise is MOVANTIK with the culprit of OIC? I have had a pain pump put in a year ago with 95% Morphine and 5% Marcaine. And oral medicines of morphine and NorcoT10-325 daily for pain breakthrough. I have had to use Milk of Magnesium for a year as well, due to OIC. It gets to be such a burden not to be able to be and feel normal again along with the weight that I need to gain in a bad way. SO BOTTOM LINE WHOM OUT THERE CAN TELL ME IF THIS STUFF WORKS? WHEN LINZESS CAME OUT I TRIED IT BUT WITH NO LUCK. DOES IT REALLY WORK? ## It works VERY well, but plan on staying home the first time you take it, because two or three times that day, you will have the largest bowel movements you could imagine, at least twice as large as the largest you have ever had before, and they wil...

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I have been suddenly taken off of movantik because my insurance no longer covers it. I took it for OIC, it worked very well. This past week I’ve had to go without it and and I have experienced bloating, anxiety, sweats. Also I can't go to the bathroom no matter what I take in its place. Has anyone experienced anything like this? ## What else have you tried? It's kind of hard to make any suggestions, without knowing more details. There is another option available called Relistor, but since it is a name brand, your insurance may not cover it, either. Ref: Resistor Information When I was on opiates for pain, I had luck with just increasing my fiber intake using a fiber supplement. What does your normal diet consist of? Do you take in lots of leafy greens, and whole grains? ##...

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My husband was on Linzess and it caused his blood pressure to go up and had a heart attack. Now the doctor has put him Monvantik and his blood has been going back up. It doesn't say that it causes high blood pressure online, but we are starting to wonder if this is the cause of his problem. Has anyone else had a problem with Monvantik? ## That is not a listed side effect, according to FDA reports, but there is never any way to know how any medication may affect any given person that takes it. Other users have reported similar occurrences, though. Its typical side effects are listed as possibly including nausea, dizziness, headache, diarrhea, and withdrawals (if someone is using opiates.) Is he on any other medications? What does his normal diet consist of? Does he eat a lot of salty...

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Hello, I have been on Hysingla and Norco now for a few years due to chronic back pain and multiple medical issues. I had been on Linzess for 2 years and it worked at first but not any longer and I also have IBS. My Gastro doctor gave me a script today to start Movantik ( I can't take my Linzess for 2 days before I start these ) I would like to know what other people are experiencing on this drug, constipation has become a big problem for me and I really want these to work. I would appreciate any input from others on their experience with it, Thanks so much. ## Hello, Donna! How are you? Have you started taking it, yet? As with any medication, there are people it works great for, but some don't have great results with it. The FDA lists its typical side effects as possibly includi...

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I have multiple sclerosis and my doctor gave me movantik I took it for 3 days and it worked but I went into terrible withdrawal. It worked then it stopped working. another person told me to take it with linzess and I did not go. two nights ago I took miralax I went to the bathroom yesterday a few times however today I am so bloated i am afraid. please help ## Hello, Rifka! How are you? Linzess is known to cause bloating as a side effect as reported by the FDA, the Miralax can also cause it. It can also be a symptom of constipation, thus you've got several good reasons for why you may be bloated. However, if you're concerned, you should consult your doctor, they may be able to help you alleviate it and perhaps give you a more accurate idea as to its cause. Are you on any other me...

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Drug Index

Naloxegol (INN; PEGylated naloxol;[1] trade names Movantik and Moventig) is a peripherally acting μ-opioid receptor antagonist developed by AstraZeneca, licensed from Nektar Therapeutics, for the treatment of opioid-induced constipation.[2] It was approved in 2014 in adult patients with chronic, non-cancer pain.[3] Doses of 25mg were found safe and well tolerated for 52 weeks.[4] When given concomitantly with opioid analgesi...

I am unable to move my bowels from taking Exalgo and other opiods that I have taken for my chronic pain. I have tried taking drugs like Movantik and Amitiza that are supposed to relieve opiod constipation but they have not worked for me. Neither has more fiber, Colace, prunes, miralax etc. Anybody have any amazing remedy??? ## Very sorry about the problem you are having. I've been there, when taking opiates, but increased fiber intake helped me. Have you tried enemas, or suppositories? There are some available via prescription, and some over the counter products, since they are inserted anally, they work directly on the hardened stool. The FDA lists the typical side effects as including irritation, cramping, and diarrhea. Beyond that, you may need to go to the ER for treatment of th...

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What exactly is this pill for? Its supposed to be for constipation. Are there any meds it can't be taken with ? ## Hello, Kari! How are you? Does it also have a 25 on the other side? If so, this tablet is manufactured by AstraZeneca Pharmaceuticals and they list it as being a 25mg Movantik tablet. It is used to treat opiate induced constipation. The FDA lists its typical side effects as possibly include diarrhea, abdominal pain, nausea and headache. Is there anything else I can help with?

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There is a pill out for constipation caused by opioids. I need it found out. There also is a medical term given to this condition. It's new and I saw it on tv earlier this month. But I can't remember what it was called. I need it so I can tell my doctor to prescribe me the medicine for my constipation caused by the opioids that I take for pain from him. Can you help me? ## Hello, April! How are you? Opioid Induced Constipation. The name of one of the medications is Relistor. The FDA lists its typical side effects as possibly including nausea, dizziness, abdominal pain, diarrhea and tremors. Is there anything else I can help with? ## Mpathia RI: Newest opioid induced constipation med is Movantik, Relister and one other. The bad news is you pay $200.00 at the very least with every...

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I am currently prescribed Belbuca 150 mcg/every 6 hrs. with Tramadol 50 mg. for break-through pain due to Ehlers-Danlos Syndrome/Chiari Malformation/Degenerative Disc Disease. My PCP does random urine screens (unannounced) periodically. Last February I had to stop the Butrans Patch due to severe skin blistering/chemical type burns caused by the patch medium, hence the change to Belbuca. I am also prescribed Movantik for OIC and take it as prescribed every morning. I am now showing "positive" for Naloxone/Suboxone on my urine screens and am being treated like I'm an addict -- even though the report from the lab states "patients taking Movantik (a pegylated derivative of naloxone) have been associated with positives on this test". I'm not taking any illicit drugs -...

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If you too are testing positive for hydromorphone but are taking only other opioid medicines (and that includes peripheral antagonists, such as Movantik or Relistor, as well as drugs such as oxycodone or oxymorphone): Please respond with what opioid(s) you are taking, and also if you are taking any probiotics, what bacteria strains are listed on the package? (certain bacteria are known to transform some opioids to hydromorphone) Was a GCMS test done? I'll keep a tally and post the results, hopefully helping everyone with this problem. ## This is just an update: I stopped taking both the probiotics and Movantik, and had another GCMS urine test, which was (finally!) negative for hydromorphone. So, this shows that either Movantik or the probiotics were the cause of the unexpected resul...

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When you take a dose of movantik (naloxegol), does your urine test show a negative or lower amount of opiates in your system?

NDC Database

Movantik 12.5 mg Oral Tablet, Film Coated by Astrazeneca Pharmaceuticals Lp ## Markings: nGL;12;5 ## Shape: Oval ## Color: Pink ## Package Codes: 0310-1969-30, 0310-1969-39, 0310-1969-90, 0310-1969-95 ## Active Ingredients: Naloxegol Oxalate

NDC Database

Movantik 25 mg Oral Tablet, Film Coated by Astrazeneca Pharmaceuticals Lp ## Markings: nGL;25 ## Shape: Oval ## Color: Pink ## Package Codes: 0310-1970-30, 0310-1970-39, 0310-1970-90, 0310-1970-95 ## Active Ingredients: Naloxegol Oxalate

NDC Database

Movantik 25 mg Oral Tablet, Film Coated by Lake Erie Medical Dba Quality Care Products LLC ## Markings: nGL;25 ## Shape: Oval ## Color: Pink ## Package Codes: 55700-383-30 ## Active Ingredients: Naloxegol Oxalate

NDC Database

Movantik 12.5 mg Oral Tablet, Film Coated by Redhill Biopharma Ltd ## Package Codes: 57841-1300-1, 57841-1300-2, 57841-1300-3, 57841-1300-4 ## Active Ingredients: Naloxegol Oxalate