Zopolrestat

Aldose reductase inhibitors are a class of drugs being studied as a way to prevent eye and nerve damage in people with diabetes. Contents 1 Mechanism 2 Examples 3 Diabetic cataract 4 Asthma and COPD 5 References Mechanism Their target, aldose reductase, is an enzyme that is normally present in many other parts of the body, and catalyzes one of the steps in the sorbitol(polyol) pathway that is responsible for fructose formation from glucose. Aldose reductase activity increases as the gl... [wikipedia]