Active Ingredient(s):Tolcapone FDA Approved: * January 29, 1998 Pharm Company: *VALEANT Category:Parkinsons
Tolcapone, sold under the brand name Tasmar, is a medication used to treat Parkinson's disease (PD). It is a selective, potent and reversible nitrocatechol-type inhibitor of the enzyme catechol-O-methyltransferase (COMT). It has demonstrated significant liver toxicity, which has led to suspension of marketing authorisations in a number of countries.
In comparison with entacapone, another nitrocatechol COMT inhibitor, tolcapone has a longer half life (2.9 hours vs. 0.8 hour...
* May have multiple approval dates, manufacturers, or labelers.