Active Ingredient(s): Naldemedine
FDA Approved: * March 23, 2017
Pharm Company: * SHIONOGI INC
Category: Opioid Dependence

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Symproic Overview

Naldemedine (brand name Symproic in the US and Rizmoic in the European Union) is a medication that is used for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. It is a peripherally acting μ-opioid receptor antagonist and was developed by Shionogi.[1] Clinical studies have found it to possess statistically significant effectiveness for these indications and to be generally well tolerated, with predominantly mild to moderate gastrointesti...

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Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source:

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Uses of Symproic pills / New med!

Can Symproic be used for other colon problems besides that which is related to opioid use? I don't take opioids but do have terrible bowel problems. I was given a sample but am leery and learned that the script is $375.00 for 30... Any discounts or samples available? Sounds like the epi pen deal. Sad! Thanks. ## Are there any other uses for Symproic? And why is it so expensive? ## Of no help. Do you know much about it since it's so new? ## It is most commonly used to treat opiate related constipation, according to FDA approval, it contains the active ingredient Naldemidine. Its typical side effects may include nausea, dizziness, diarrhea, stomach pain, and abdominal cramping. Overall, it really depends on what is causing your issues, and what type of issues you are experiencing....


Possible Dosages for this and Related Drugs:

  • Tablet: 0.2mg
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Symproic: (3 results)

Sorted by National Drug Code
  • 59011-523 Symproic .2 mg Oral Tablet by Purdue Pharma Lp
  • 59385-041 Symproic .2 mg Oral Tablet by Biodelivery Sciences International Inc
  • 59630-222 Symproic .2 mg Oral Tablet by Shionogi Inc.

Other drugs which contain Naldemedine or a similar ingredient: (1 result)

Related Symproic Topics:

Uses of Symproic pills / New med!
Can Symproic be used for other colon problems besides that which is related to opioid use? I don't take opioids but ... 4 replies

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