Nerlynx OverviewNeratinib (HKI-272) is a tyrosine kinase inhibitor anticancer drug. Like lapatinib and afatinib, it is a dual inhibitor of the human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. It inhibits them by covalently binding with a cysteine side chain in those proteins. Neratinib has an IC50 of 59 nM against HER2 and shows weak inhibition against KDR and Scr with IC50 values of 0.8 µM and 1.4 µM, respectively. In BT474 cells, ...
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Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Neratinib
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Possible Dosages for this and Related Drugs:
- Tablet: 40mg
NDC Database Records for Nerlynx: (1 result)Sorted by National Drug Code
- 70437-240 Nerlynx 48.31 mg Oral Tablet by Puma Biotechnology, Inc.