Lumacaftor-Ivacaftor

Lumacaftor/ivacaftor, sold under the brand name Orkambi among others, is a combination of lumacaftor and ivacaftor used to treat people with cystic fibrosis who have two copies of the F508del mutation.[3] It is unclear if it is useful in cystic fibrosis due to other causes.[3] It is taken by mouth.[3] Common side effects include shortness of breath, nausea, diarrhea, feeling tired, hearing problems, and rash.[3][4]... [wikipedia]