Active Ingredient(s): Fluorouracil, 5-FU
FDA Approved: * July 29, 1970
Category: Cancer

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Efudex Overview

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a chemotherapy medication used to treat cancer.[2] By injection into a vein it is used for colon cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] When used by injection most people develop side effects.[2]...

Read more Efudex Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Fluorouracil

Recent Efudex Forums: RSS Feed

Applying efudex to my face and how often to shave

I am applying efudex to my face. I usually shave every 2 days. Should I shave everyday so that my facial hairs do not interfere with spreading the cream on my face?

can i reduce efudex application from twice a day to once

I’m in week 4 of a prescribed 5 week treatment on my chest with Efudex . My skin has all the worst symptoms described in blogs. I felt that my skin was too raw to handle the cream twice a day. I have decided to only apply Efudex once a day for the rest of the treatment (12 days). Will this be a problem for my outcome? ## It would be best to speak with your doctor, before making any changes to your usage regimen. The FDA lists its typical side effects as possibly including skin burning, soreness, hyperpigmentation, photosensitivity, and scarring. Which ones are you experiencing? ## All of them. I had to sleep with a cold pack on the treated skin. Now 1 week after my last application (6 weeks total) Less pain and weeping but possibly weeks away to get back to normal. I have learned ...

Efudex on scalp - side effects on hair?

Has anyone used Efudex on their head? I'm interested in any side effects on hair deterioration or loss. ## Hello Hoody, Reportedly this will be determined by the amount of efudex that you need to apply. If applied topically then the medicine will not be absorbed into the bloodstream and thus will not cause hair loss like other forms of chemotherapy treatment. If it is necessary to apply enough cream that it will absorb into the blood stream then you will start to experience typical symptoms associated with chemotherapy such as nasuea, vomiting, hair loss etc. Below is a link to the source of my information. [1] Efudex Treatment I hope this answers your question. Let me know if you would like to know anything else regarding this medication. ## Thanks so much Kevin. Will be a 14 light...

use of Fluorouracil 5% on your scalp

I read that you should wash the site before application. Are you to wash your hair everyday, twice a day if you apply Fluorouracil 2 x per day? Is it ok to use your regular shampoo. I understand that use of Fluorouracil cream can spread to areas that may not already show signs of precancerous spots. Has anyone noticed this to happen? How far has it spread, entire scalp? Please share any experience you have had with treating scalp.

Headaches with Efudex treatment

I am on Day 30 of Efudex treatment on the top of my nose and a small area on my chest. I stopped the cream on Day 28 as the skin was starting to erode. I've had headaches the past two weeks that won't go away with ibuprofen, Goody's headache powders, tylenol... nothing. It's caused me to generally feel like crap. Anyone else have these headaches? ## Headaches are a possible side effect of Effudex, according to FDA reports, other side effects may include skin burning, dizziness, chills, and nasal irritation. How long has it been since you stopped using it, now? Has there been any change? Have you informed your doctor of the problem?

The 3-week Efudex / Fluorouracil nightmare is now unnecessary!!

Harvard Medical recently discovered a new treatment regime for AK. This new four-day Harvard Medical protocol is going to save us all from the Efudex & Fluorouracil nightmare: Adding calcipotriene to 5-FU dramatically reduced AKs I used this 4-day treatment for AK in Dec '18 and it works!! Save yourself from the 3 week fluorouracil nightmare and do this 4-day treatment instead. I made this Youtube video of my experience with this protocol: The treatment resolves actinic keratosis in only 4 days. No longer is the pain and discomfort of the commonly prescribed 3 week Flouracil necessary to clear your skin of these pre-cancerous lesions. Mix 5% Fluoroucil and Calcipotriene 50/50 and apply twice per day for four days. Both of these creams can be purchased through prescription. Your ...

Efudex doesn't have to be a nightmare

I was prescribed Efudix to treat spots on the back of my hands. I have been applying a thin layer daily for 4 weeks. I have had no side effects, no irritation, burning sensations, blistering or pain. The spots have become slightly redder and that's all. Efudix does not have to a nightmare and every case is different. ## That is correct, we are all different, so not everyone will experience side effects while using it. The typical side effects may include skin redness, burning, sun sensitivity, and swelling. Are you still experiencing good results with it? ## Hi. I will touch base with you again early next week. I am meeting the skin doctor on Monday to get their opinion. Still little or no change after 6 weeks. The Pharmacist has suggested twice daily application but I will be guide...

Efudex "Improved Formula"??

I am scheduled to start Efudex Nov. 2 and am apprehensive based on a friend's bad experience and other things I've read. My Dr. said that things have improved dramatically within the last year with a better formula. He said I will use the cream twice daily for 5 days, then he will see me to place a neutralizer on my face, and then I will heal the 2nd week; reducing the experience from a 4 to 2 week timeframe. Has anyone else heard of this or experienced this? ## Hello, Gina! How are you? What type of bad experience did your friend have? As to an improved formula, that might be true, but the active ingredient that could cause any side effects remains the same, so the FDA still lists them as possibly including skin redness, flaking, itching, and peeling. It isn't really a neut...

efudex on forearms and back of hands

I have been using Efudex on my fore arms and the back of my hands for two weeks. Three weeks will be the total time of application. I put the cream on at night and try to sleep. I leave it on overnight and wash it off carefully about noon the next day. How soon after application can I use soap and water on the treated areas? Does it help to wash the Efudex off after an hour? I have been leaving it on for hours. When sleeping should i wear cotton gloves and a long sleeved t shirt? I have done that and now have stopped but I am concerned about accidently getting the cream in my eyes during the night. Thanks for any help with these questions. When I lower my arms, I have a lot of pain, especially when I lower them quickly. Is this normal?

Efudex 5% and Silkis 3

My new dermatologist has prescribed a one-week per month treatment over four months, applying Silkis 3 in the morning and Efudex 5% at bedtime. I have used Efudex before in one spot, with the expected itching and scabs. What happens when I apply these creams all over my face and scalp, which don't have many particular keratosis spots? My job involves working with the public. ## My dermatologist prescribed Efudex and Desonide last week! Beginning tonight... 7 days Efudex and Desonide am and Desonide pm, followed by Desonide twice a day for 3 days, then stop for 3 weeks. Repeat 4 times after that ! ## How did this protocol work for you? Do you react quickly. How soon did the redness go away? I’m using a Efudex and a synthetic D3 derivative gel called Calcipotriol. I mix them 50-...


Possible Dosages for this and Related Drugs:

Fluorouracil, 5-FU
  • Cream: 0.5%, 0.50%, 1%, 4%, 5%
  • Cream, Augmented: 4%
  • Injection: 50mg/ml
  • Solution: 1%, 2%, 5%
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Efudex: (1 result)

Sorted by National Drug Code
  • 0187-3204 Efudex 2 g/40g Topical Cream by Valeant Pharmaceuticals International

Other drugs which contain Fluorouracil, 5-FU or a similar ingredient: (5 results)

Related Efudex Topics:

Efudex-40 (fluorouracil)
Need all information about this medication please. ## I have been told to apply Efudex to my lower lip, isn't this c... 25 replies
Efudex with Dovonex
Just letting everyone know that I just did the newest Efudex treatment protocol which requires mixing 50% Efudex with 50... 10 replies
Efudex 5%
Creme ## I have been taking applying 5% Efudex cream for two days to my lip per my Dr. Orders. So far, I have had no swe... 8 replies
Efudex on scalp - side effects on hair?
Has anyone used Efudex on their head? I'm interested in any side effects on hair deterioration or loss. ## Hello Hoo... 6 replies
Efudex treatment effects
I have used Efudex for four weeks and i now have a lump with a hard crust around it, and it is sore and itchy. What shou... 4 replies
Efudex doesn't have to be a nightmare
I was prescribed Efudix to treat spots on the back of my hands. I have been applying a thin layer daily for 4 weeks. I h... 3 replies
efudex40 application instructions
how and when should I apply efudex to my face? ## This is a drug used to treat certain types of cancer. How often and ho... 3 replies
How to use and side efects ## please give me detailed description of how to apply and how long to apply efudex-40 ## I w... 3 replies
Efudex 5% and Silkis 3
My new dermatologist has prescribed a one-week per month treatment over four months, applying Silkis 3 in the morning an... 2 replies
Efudex (Fluorouracil) Cream 5%
I used this prescription on my forehead twice a day for 10 days. Removed all my ak's. Has now been about 1 year and ... 2 replies

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