Active Ingredient(s): Fluorouracil, 5-FU
FDA Approved: * July 29, 1970
Category: Cancer

* This drug may consist of multiple approval dates, manufacturers, or distributors. If applicable, they would be listed below under "NDC Database Records".

Efudex Overview

Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a chemotherapy medication used to treat cancer.[2] By injection into a vein it is used for colon cancer, esophageal cancer, stomach cancer, pancreatic cancer, breast cancer, and cervical cancer.[2] As a cream it is used for actinic keratosis, basal cell carcinoma, and skin warts.[3][4] When used by injection most people develop side effects.[2]...

Read more Efudex Details
Details May Include Instructions, Side Effects, Interactions, Etc. Drug monograph is from Wikipedia. All text is available under the terms of the GFDL (GNU Free Documentation License). Source: en.wikipedia.org/wiki/Fluorouracil

Recent Efudex Forums: RSS Feed

Efudex "Improved Formula"??

I am scheduled to start Efudex Nov. 2 and am apprehensive based on a friend's bad experience and other things I've read. My Dr. said that things have improved dramatically within the last year with a better formula. He said I will use the cream twice daily for 5 days, then he will see me to place a neutralizer on my face, and then I will heal the 2nd week; reducing the experience from a 4 to 2 week timeframe. Has anyone else heard of this or experienced this? ## Hello, Gina! How are you? What type of bad experience did your friend have? As to an improved formula, that might be true, but the active ingredient that could cause any side effects remains the same, so the FDA still lists them as possibly including skin redness, flaking, itching, and peeling. It isn't really a neut...

efudex on forearms and back of hands

I have been using Efudex on my fore arms and the back of my hands for two weeks. Three weeks will be the total time of application. I put the cream on at night and try to sleep. I leave it on overnight and wash it off carefully about noon the next day. How soon after application can I use soap and water on the treated areas? Does it help to wash the Efudex off after an hour? I have been leaving it on for hours. When sleeping should i wear cotton gloves and a long sleeved t shirt? I have done that and now have stopped but I am concerned about accidently getting the cream in my eyes during the night. Thanks for any help with these questions. When I lower my arms, I have a lot of pain, especially when I lower them quickly. Is this normal?

Efudex 5% and Silkis 3

My new dermatologist has prescribed a one-week per month treatment over four months, applying Silkis 3 in the morning and Efudex 5% at bedtime. I have used Efudex before in one spot, with the expected itching and scabs. What happens when I apply these creams all over my face and scalp, which don't have many particular keratosis spots? My job involves working with the public. ## My dermatologist prescribed Efudex and Desonide last week! Beginning tonight... 7 days Efudex and Desonide am and Desonide pm, followed by Desonide twice a day for 3 days, then stop for 3 weeks. Repeat 4 times after that ! ## How did this protocol work for you? Do you react quickly. How soon did the redness go away? I’m using a Efudex and a synthetic D3 derivative gel called Calcipotriol. I mix them 50-...

Treating wound after 12 weeks of Efudex

My wound is on my forearm & is about a 1 1/2” square. The skin is eroded and indented. Was told to use Neosphorin, keep covered & change bandages twice daily. Does this sound like good advice? ## This procedure is often advised for some types of wounds, but it depends on the severity, cause of the wound, and etc. Neosporin has been known to cause some skin reddening, rash, and itching, as side effects, in some people that use it. What has your doctor advised you to do?

Efudex on scalp - side effects on hair?

Has anyone used Efudex on their head? I'm interested in any side effects on hair deterioration or loss. ## Hello Hoody, Reportedly this will be determined by the amount of efudex that you need to apply. If applied topically then the medicine will not be absorbed into the bloodstream and thus will not cause hair loss like other forms of chemotherapy treatment. If it is necessary to apply enough cream that it will absorb into the blood stream then you will start to experience typical symptoms associated with chemotherapy such as nasuea, vomiting, hair loss etc. Below is a link to the source of my information. [1] Efudex Treatment I hope this answers your question. Let me know if you would like to know anything else regarding this medication. ## Thanks so much Kevin. Will be a 14 light...

Very Sore Lips

I am a new Efudix user (week 3) with solar keratosis patches on my face, 8 of them. I am coping OK though as expected, not feeling pretty at this stage! I've read and re-read patient info. but don't see anything about very swollen and sore lips as being a possible side effect of Efudix cream. My AK patches are down each side of my face, nowhere near my lips. My worst patch is starting to ulcerate/crust, so another fortnight to go at least. I can cope with the discomfort, all except for my lips - any ideas? Hats off to all you guys for your encouragement! ## Have you consulted your doctor? Efudex has been known to cause some generalized reactions, including skin pain, irritation, and sun sensitivity. Are you on any other medications? Are you making sure to stay out of bright sunl...

Allergic reaction?

Used Efudex on back of my hand a year ago with little reaction. Had to use again & this time hand turned into Krakatoa! Scabs & weeping spread beyond immediate application site but understand this can happen. However, also have tiny pin head size blisters among & around the crusting with accompanying itching which I haven’t noted in other experiences on here & wonder if it’s an allergic reaction or part of the “process” & I just need to find something to ease the itching. Any advice really welcome as this time of use is becoming quite scarey ## While those can be normal side effects, it is always best to have your doctor check things out to be sure. Other side effects to Efudex may include skin color changes, swelling, and dryness (the last of...

Efudex-40 (fluorouracil)

Need all information about this medication please. ## I have been told to apply Efudex to my lower lip, isn't this crazy? ## Not really. It is listed in the drug monograph that it can be used topically to treat certain cancerous or possibly cancerous conditions. ## Has anyone used it on their lips? Won't it just keep bleeding non-stop? ## Heidi- I've used it on my lips three times. Each time it was an application morning and at bedtime. Though about the second week it gets very sensitive and blister-like lesions appear that means it's working. I applied a product called Acquafor (like Vaseline Jelly) to seal it and protect). The healing takes some time but the outcome is worth it. ## I just used Efudex for 2 weeks on lower lip. from day 7 blistered and ulcerated and wept...

Efudex with Dovonex

Just letting everyone know that I just did the newest Efudex treatment protocol which requires mixing 50% Efudex with 50% Dovonex (vitamin D) and it was very fast and easy. Four days of application of the combo "lit up" my face and 7 days later my face and scalp were virtually back to normal. Minimal pain, like a sunburn, and no scabbing, pus, etc. I was really scared to do the longer treatment after reading blogs and looking at pictures, but the new treatment is a piece of cake. Plus, according to related articles, it actually works better. A real win-win! "SCOTTSDALE, ARIZ. – A four-day topical combination regimen of 5-fluorouracil (5-FU) and calcipotriene removed almost 90% of facial actinic keratoses – significantly more than with 5-FU monotherapy, in a rando...

The 3-week Efudex / Fluorouracil nightmare is now unnecessary!!

Harvard Medical recently discovered a new treatment regime for AK. This new four-day Harvard Medical protocol is going to save us all from the Efudex & Fluorouracil nightmare: Adding calcipotriene to 5-FU dramatically reduced AKs I used this 4-day treatment for AK in Dec '18 and it works!! Save yourself from the 3 week fluorouracil nightmare and do this 4-day treatment instead. I made this Youtube video of my experience with this protocol: The treatment resolves actinic keratosis in only 4 days. No longer is the pain and discomfort of the commonly prescribed 3 week Flouracil necessary to clear your skin of these pre-cancerous lesions. Mix 5% Fluoroucil and Calcipotriene 50/50 and apply twice per day for four days. Both of these creams can be purchased through prescription. Your ...


Possible Dosages for this and Related Drugs:

Fluorouracil, 5-FU
  • Cream: 0.5%, 0.50%, 1%, 4%, 5%
  • Cream, Augmented: 4%
  • Injection: 50mg/ml
  • Solution: 1%, 2%, 5%
Note: Above list includes dosages for all drugs with the same combination of active ingredients.

NDC Database Records for Efudex: (1 result)

Sorted by National Drug Code
  • 0187-3204 Efudex 2 g/40g Topical Cream by Valeant Pharmaceuticals International

Other drugs which contain Fluorouracil, 5-FU or a similar ingredient: (5 results)

Related Efudex Topics:

Efudex-40 (fluorouracil)
Need all information about this medication please. ## I have been told to apply Efudex to my lower lip, isn't this c... 25 replies
Efudex with Dovonex
Just letting everyone know that I just did the newest Efudex treatment protocol which requires mixing 50% Efudex with 50... 10 replies
Efudex 5%
Creme ## I have been taking applying 5% Efudex cream for two days to my lip per my Dr. Orders. So far, I have had no swe... 8 replies
Efudex on scalp - side effects on hair?
Has anyone used Efudex on their head? I'm interested in any side effects on hair deterioration or loss. ## Hello Hoo... 4 replies
Efudex treatment effects
I have used Efudex for four weeks and i now have a lump with a hard crust around it, and it is sore and itchy. What shou... 4 replies
efudex40 application instructions
how and when should I apply efudex to my face? ## This is a drug used to treat certain types of cancer. How often and ho... 3 replies
How to use and side efects ## please give me detailed description of how to apply and how long to apply efudex-40 ## I w... 3 replies
Efudex 5% and Silkis 3
My new dermatologist has prescribed a one-week per month treatment over four months, applying Silkis 3 in the morning an... 2 replies
Efudex doesn't have to be a nightmare
I was prescribed Efudix to treat spots on the back of my hands. I have been applying a thin layer daily for 4 weeks. I h... 2 replies
Efudex (Fluorouracil) Cream 5%
I used this prescription on my forehead twice a day for 10 days. Removed all my ak's. Has now been about 1 year and ... 2 replies

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