Adderall

Active Ingredient(s): Amphetamine + Dextroamphetamine
Category: ADD / ADHD

Adderall is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also used as an athletic performance enhancer, cognitive enhancer, appetite suppressant, and recreationally as an aphrodisiac and euphoriant. It is a central nervous system (CNS) stimulant of the phenethylamine class.

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Boxed Warning

AMPHETAMINES HAVE A HIGH POTENTIAL FOR ABUSE. ADMINISTRATION OF AMPHETAMINES FOR PROLONGED PERIODS OF TIME MAY LEAD TO DRUG DEPENDENCE AND MUST BE AVOIDED. PARTICULAR ATTENTION SHOULD BE PAID TO THE POSSIBILITY OF SUBJECTS OBTAINING AMPHETAMINES FOR NON-THERAPEUTIC USE OR DISTRIBUTION TO OTHERS, AND THE DRUGS SHOULD BE PRESCRIBED OR DISPENSED SPARINGLY.

MISUSE OF AMPHETAMINE MAY CAUSE SUDDEN DEATH AND SERIOUS CARDIOVASCULAR ADVERSE EVENTS.

Contraindications

Adderall should not be used by patients with the following conditions:

  • Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma.
  • Agitated states.
  • Known hypersensitivity or idiosyncrasy to amphetamine.
  • Patients with a history of drug abuse.
  • In patients known to be hypersensitive to amphetamine, or other components of Adderall®. Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other amphetamine products.
  • Patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis.

Possible Side Effects

Cardiovascular: Palpitations, tachycardia, elevation of blood pressure, sudden death, myocardial infarction. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System: Psychotic episodes at recommended doses, overstimulation, restlessness, irritability, euphoria, dyskinesia, dysphoria, depression, tremor, tics, aggression, anger, logorrhea, dermatillomania.

Eye Disorders: Vision blurred, mydriasis.

Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, intestinal ischemia and other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.

Allergic: Urticaria, rash, hypersensitivity reactions including angioedema and anaphylaxis. Serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported.

Endocrine: Impotence, changes in libido, frequent or prolonged erections.

Skin: Alopecia.

Musculoskeletal: Rhabdomyolysis.

Drug Abuse and Dependence

Adderall (Dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate and amphetamine sulfate tablets (Mixed salts of a single entity amphetamine product)) is a Schedule II controlled substance.

Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to levels many times higher than recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.

Overdosage

Symptoms of amphetamine overdose include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia and rhabdomyolysis. Fatigue and depression usually follow the central nervous system stimulation. Serotonin syndrome has also been reported. Cardiovascular effects include arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Fatal poisoning is usually preceded by convulsions and coma.

References:

  1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f22635fe-821d-4cde-aa12-419f8b53db81&audience=consumer
  2. https://en.wikipedia.org/wiki/Adderall

Dosage List

Adderall 5;dp
Adderall 5 mg Oral Tablet
NDC: 0555-0762
Labeler:
Barr Laboratories Inc.
Adderall 7;5;d;p
Adderall 7.5 mg Oral Tablet
NDC: 0555-0763
Labeler:
Barr Laboratories Inc.
Adderall 1;0;dp
Adderall 10 mg Oral Tablet
NDC: 0555-0764
Labeler:
Barr Laboratories Inc.
Adderall 12;5;d;p
Adderall 12.5 mg Oral Tablet
NDC: 0555-0765
Labeler:
Barr Laboratories Inc.
Adderall 15;d;p
Adderall 15 mg Oral Tablet
NDC: 0555-0766
Labeler:
Barr Laboratories Inc.
Adderall 2;0;dp
Adderall 20 mg Oral Tablet
NDC: 0555-0767
Labeler:
Barr Laboratories Inc.
Adderall 3;0;dp
Adderall 30 mg Oral Tablet
NDC: 0555-0768
Labeler:
Barr Laboratories Inc.
Adderall ADDERALL;XR;20;mg
Adderall XR 20 mg 24 Hr Extended Release Capsule
NDC: 54868-4640
Labeler:
Physicians Total Care, Inc.
Adderall ADDERALL;XR;10;mg
Adderall XR 10 mg 24 Hr Extended Release Capsule
NDC: 54868-4760
Labeler:
Physicians Total Care, Inc.
Adderall ADDERALL;XR;15;mg
Adderall XR 15 mg 24 Hr Extended Release Capsule
NDC: 54868-5140
Labeler:
Physicians Total Care, Inc.

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